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A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Formula One has endured a turbulent opening to the season under its new regulations. The sport's governing body, the FIA, is now proposing changes to address safety concerns and driver dissatisfaction. Nikolas Tombazis, the single-seater director for the FIA, is at the heart of the process and is confident that F1 can adapt successfully.Tombazis acknowledges that the new rules have provoked a strong reaction, with some drivers expressing discontent. Oliver Bearman's 190mph crash at Suzuka has raised concerns about the safety of the new regulations, and the FIA is taking a cautious approach to making changes. "Every accident at high speed is always a little bit of a shock," Tombazis says.The FIA is discussing potential changes with teams, powerunit manufacturers, and the commercial rights holder. Meetings are scheduled for April 20 and May 3 to decide on changes to the regulations, which could include adjustments to the parameters of energy recovery and deployment. Tombazis emphasizes that safety is the top priority and that the goal is to find a balance between safety and competitiveness.The new regulations have been a topic of debate, with some drivers, such as Lando Norris and Max Verstappen, expressing dissatisfaction with the current formula. The FIA is working to address these concerns while also ensuring that the sport remains safe and competitive. "We're not expecting people to sugarcoat their comments," Tombazis says, but he is hopeful that a broad consensus can be reached.

The recent Winter Olympics in Milano Cortina showcased the thrilling use of high-speed camera drones, bringing viewers up close to the action. However, this technology has a darker side, as it is also being used in the US military's drone strikes in Iran. The seamless transition from drone-supplied footage of Olympic excellence to drone-supplied footage of war crimes has felt genuinely jarring. The connection between drone racing and drone strikes is not coincidental. Professional drone racing emerged around a decade ago, with the Drone Racing League (DRL) being a prominent competition. The US air force was a longtime sponsor of the DRL, using the competition as a scouting ground to recruit new pilots. The league's emphasis on high-speed, first-person view drones has contributed to the development of technology now used in military contexts. The current conflict in Iran highlights a disturbing trend: the militarization of sports culture. The Trump administration's approach to the war, including the use of Hollywood and gaming imagery in its videos, reflects a broader cultural shift. The US military's actions are being presented as a form of entertainment, with two-minute video montages of "stuff blowing up" being used to brief the president on the war's progress. This phenomenon is not limited to the administration; the language of sports is increasingly being used in discussions of war. Politicians like Marco Rubio and Pete Hegseth are using sports-like terminology to describe military actions, reflecting a degeneration of language in global diplomacy. The Trumpian trash talk has degraded the discourse, with the president's tweets about the war being characterized by their usual boorishness. The article concludes that the culture of sports is central to the chaos unfolding across the Middle East. The blurring of lines between war and sport reflects a deeper societal issue, where the values of competition and entertainment are taking precedence over human life and dignity. As the world teeters on the edge of a military and economic catastrophe, the need for a more nuanced understanding of the relationship between sports, technology, and warfare has never been more pressing.

Conservationists and scientists have warned that the Minerals Council of Australia’s proposal to employ artificial intelligence for faster national environmental approvals could generate “Robodebt‑style” failures, further endangering already vulnerable species.The council has asked the federal government to allocate $13 million for a pilot that would use AI to help companies draft assessment applications and assist regulators in decision‑making.The Biodiversity Council – a consortium of independent experts from eleven universities – told Guardian Australia that while AI may assist with routine tasks, automating whole environmental assessments could lead to opaque, flawed decisions that push threatened species closer to extinction.“Robodebt” refers to the automated welfare‑debt recovery scheme that, between 2015 and 2019, wrongly accused hundreds of thousands of Australians of overpayments, highlighting the danger of opaque algorithmic judgments.Lis Ashby, the Biodiversity Council’s lead on policy and innovation, noted that the cornerstone of Australia’s environmental protection, the Environment Protection and Biodiversity Conservation (EPBC) Act, is riddled with vague language and broad ministerial discretion, which hampers rule‑based decision‑making and would be even more problematic for an AI tool.She added that establishing clear rules in the National Environmental Standards, including explicit definitions of unacceptable outcomes, would accelerate assessment times even without AI and is essential for any future automation.Brendan Sydes, national biodiversity policy adviser at the Australian Conservation Foundation, expressed scepticism, stating that “technology can be a good servant but a poor master.” He urged the government to focus on closing existing data gaps on threatened species and habitats rather than relying on AI.Prof. David Lindenmayer, a forest ecologist at the Australian National University and Biodiversity Council member, highlighted that one‑third of Australia’s threatened species have not been monitored and many others suffer from patchy data, gaps traditionally filled by expert consultation.He warned that AI decisions are only as reliable as the data they are fed, and most threatened species lack publicly available information, even basic location data, risking decisions based on outdated or incomplete evidence.The Albanese government recently passed reforms to the EPBC Act after a 2020 review found the legislation failing to protect species and habitats.Prof. Hugh Possingham, a leading conservation biologist at the University of Queensland, argued that AI models need robust training material, and the past two decades of EPBC approvals are “clearly unsuitable” because the Act has demonstrably failed to safeguard the environment. He suggested that hiring more human assessors would be a more effective way to speed up evaluations.Tania Constable, chief executive of the Minerals Council, dismissed the Robodebt comparison as “disappointing,” insisting the proposal is innovative and could strengthen environmental protection while improving efficiency. She said the AI tools would support human decision‑making for both regulators and project proponents, helping navigate the complexity of EPBC assessments.A federal government spokesperson said budget decisions on the AI trial will be made “in due course,” but the environment department is exploring how AI could simplify application processes. The statement emphasized that “decisions about whether to approve projects must, and will, always be made by assessment officers, not by AI.”Nonetheless, officials acknowledged that AI tools have the potential to save time, reduce uncertainty, and translate technical language for stakeholders.

When Corentin Roudaut arrived in Paris a decade ago, he swapped his student‑era bike for a car, daunted by the city’s traffic and lack of cyclist protection. After a protected lane opened on Boulevard Voltaire in the 11th arrondissement, he reclaimed his two‑wheel commute and now volunteers with the cycling advocacy group Paris en Selle, witnessing a city that has shed its car‑centric image.Roudaut notes that the shift “started slowly but really accelerated in the last ten years,” with a growing network of bike routes that is becoming safe and nearly complete in many districts.Mayor Anne Hidalgo’s 12‑year agenda reshaped Paris’s urban fabric. Since taking office in 2014, her administration planted 155,000 trees, created several hundred kilometres of segregated bike lanes, pedestrianised 300 school streets, and banned cars from the banks of the Seine. Former parking spaces have been turned into green plazas and café terraces, reducing the risk of children being hit while walking to school.As Hidalgo departs on Sunday, her legacy is touted as a blueprint for progressive European cities, especially as some national governments retreat from green initiatives.Nevertheless, the reforms have sparked pushback. Motorists object to the loss of road space, and recent referendums on higher parking charges for SUVs and further school‑street pedestrianisation suffered low voter turnouts. Right‑wing mayoral candidate Rachida Dati described the new public‑space regime as “anxiety‑inducing,” though she stopped short of promising a reversal.In a candid interview, Hidalgo described the Seine‑bank pedestrianisation as “a tough battle” that, once won, left residents reluctant to revert to car traffic. She highlighted a generation of children who have never known cars on those riverbanks, prompting awe‑filled reactions from visitors.Urban scholars attribute the rapid change to Paris’s tight administrative boundaries, which limit suburban influence on city transport decisions, and to groundwork laid by previous mayors. Yet they stress that political courage was essential to implement measures that inconvenienced drivers while delivering social and environmental benefits.Environmental epidemiologist Audrey de Nazelle of Imperial College London, a Paris native, praised the transformation as “fabulous” and warned that many cities lack the bravery to pursue similar legacies.A recent report placed Paris among 19 global cities that cut two major toxic air pollutants between 2010 and 2024. While Brussels and Warsaw saw faster declines in fine‑particle matter, London outpaced Paris in reducing nitrogen‑dioxide levels.By contrast, Berlin—despite opening a new inner‑city motorway and scrapping 30 km/h speed limits on key streets—still records a higher share of cyclists than Paris.Transport researcher Giulio Mattioli argues that Paris simply needed to add bike lanes to unlock latent demand, noting that the city started from a lower baseline but quickly caught up with peers.However, the transformation remains uneven. The extensive suburbs continue to be dominated by cars, hemmed in by the 35 km Boulevard Périphérique ring road. Analyst Jean‑Louis Missika of think‑tank Terra Nova stresses that “as long as this motorway encircles Paris, the Greater Paris metropolis will remain an administrative construct devoid of urban reality.” He calls for dismantling or repurposing the ring road to achieve a truly post‑car metropolis.

Bath Rugby staged an impressive comeback to defeat Saracens 31-22, earning a hard-fought win in the Champions Cup. The match saw Henry Arundell score two crucial tries for Bath, helping his team overcome a 10-0 deficit at halftime.The turning point came in the second half with the introduction of Thomas du Toit, whose impact was immediate. Bath's scrum was significantly bolstered by his presence, allowing them to dominate possession and create scoring opportunities.Henry Arundell's speed was on full display as he scored his first try from 40 meters out just four minutes into the game. He sealed the win with his second try in the final play of the match.Despite a strong performance from Saracens, particularly in their maul defense, Bath managed to pull away with Joe Cokanasiga and Ben Spencer also making significant contributions. Spencer's try was a highlight, showcasing his skill and pace.Saracens fought hard, with Max Malins and Noah Caluori scoring tries, but ultimately, Bath's relentless forward pressure secured their victory. The win sets up a quarter-final clash against Northampton at home.Bath captain Ben Spencer acknowledged the team's imperfections but emphasized their determination to improve. Saracens director of rugby Mark McCall expressed pride in his team's performance, despite the loss, highlighting their capability to compete at a high level.

Zara Larsson, the 28-year-old Swedish pop sensation, is taking the music world by storm with her album 'Midnight Sun'. With three songs in the US Hot 100 and fourth biggest female artist on global Spotify, Larsson's career is moving at lightning speed. Larsson's journey to stardom began at 16 with her debut single 'Uncover'. However, it was her zeitgeist-hijacking album 'Midnight Sun' that reinvented her as a rave nymph, blending brash electro-pop and drum’n’bass. The album's success can be attributed to its genuine youthfulness, ultra-fun, and uber-femme vibe, which has resonated with fans worldwide. Larsson's lyrics have the immediacy of a voice note sent to a crush, and she is startlingly frank about her insecurities. Her music is a reflection of her unapologetic camp and accessible twist, making her a standout in the industry. Larsson has always been vocal about sex positivity, women's rights, and her support of Palestine. She declined to perform at Eurovision's halftime show in protest at Israel's inclusion and lost a $3m brand deal after joking about abortion on social media. Despite the challenges of fame, Larsson thrives on attention and sees her current hot streak as an opportunity to build and create. With her deluxe edition of 'Midnight Sun' coming soon, Larsson is set to take the music world by storm.

The current global landscape is marked by uncertainty, with Donald Trump's policies contributing to a sense of instability. As the world grapples with the implications of the Iran war, including a potential global shortage of jet fuel, the UK is reevaluating its relationships. Keir Starmer, leader of the Labour Party, has argued that a closer partnership with Europe is in Britain's national interest. This stance is echoed by Rachel Reeves, highlighting the need for the UK to strengthen its ties with the EU to mitigate the risks of a global economic crisis. The article notes that 63% of Britons would vote to rejoin the EU if a referendum were held today, according to recent YouGov polling. This sentiment is reflected in the growing popularity of a youth mobility scheme that would allow young people to work and study abroad, a proposal that has gained traction even among Leave voters. Starmer's ally, Nick Thomas-Symonds, has been negotiating a deal that would align with EU rules on food and drink, potentially leading to the relabelling of certain products like marmalade. While challenges remain, including competitive trade interests, the article suggests that Europe is choosing unity in the face of crisis. The author, Gaby Hinsliff, argues that Britain has learned from its past mistakes and is now seeking to build a new relationship with the EU at speed. While rejoining the EU is not imminent, the will and political courage are needed to seize this second chance.

The world of Major League Baseball has witnessed a significant transformation in pitching, with velocity and accuracy reaching unprecedented levels. This arms race is largely attributed to advances in pitching analytics, often developed by individuals without a traditional baseball background.Rob Friedman, known as PitchingNinja online, has authored a new book titled 'Unhittable: How Technology, Mavericks and Innovators Engineered Baseball's New Era of Pitching Dominance.' The book explores how technology and data analysis have revolutionized the art of pitching.In the past, pitchers like Bob Feller were renowned for their speed, but today's pitchers routinely exceed triple digits on the radar gun. Friedman notes that technology brings out the best in everybody, allowing pitchers to refine their skills and achieve remarkable results.The use of heat maps, slow-motion cameras, and AI has become commonplace in analyzing pitching performance. These tools help quantify not just velocity but also accuracy, enabling pitchers to deliver the ball to the plate with precision.Paul Skenes of the Pittsburgh Pirates, last year's National League Cy Young winner, and Nolan McLean of the New York Mets are examples of pitchers benefiting from analytics. Friedman praises McLean's exceptional skills, describing his stuff as 'absolutely nasty.'The debate surrounding pitcher-friendly conditions continues, with some arguing that the game has become too favorable to pitchers. Friedman counters that pitchers are on offense, and their performance is a reaction to the hitter's actions.Injuries to pitchers are on the rise, and while there is no consensus on the cause, Friedman suggests that excessive velocity may contribute to the problem. He cites Trevor Bauer as an example of a pitcher who successfully adopted analytics and training methods to enhance his performance.The intersection of analytics and tradition remains a contentious issue, with some players and coaches skeptical of data-driven approaches. Friedman advocates for a bridge between both sides, emphasizing that analytics provide valuable information to inform pitching decisions.