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The Plant That Changed MedicineGoat's rue or French lilac, Galega officinalis, is a wild plant often grown in gardens for its clusters of attractive lilac or white flowers. For centuries, the plant was used to treat diabetes. Its key ingredient was later identified as galegine, which lowers blood glucose levels but has toxic side-effects.From Natural Remedy to Synthetic SolutionEventually, galegine led to the development of the synthetic drug metformin, now the classic treatment for diabetes by controlling blood sugar. Metformin has none of the toxic side effects of galegine and is now one of the most prescribed drugs in the world. For many years, however, metformin was vilified and banned in many countries because of its association with galegine.The Emergence of a Medical MultitaskerMetformin is now becoming something of a super drug for its anti-cancer effects, cardiovascular protection, delaying the onset of diabetes, and helping some people lose weight. It may even lower the risks for cognitive decline, dementia, strokes, slow aging and increase life expectancy.Understanding the MechanismExactly how metformin achieves all these remarkable wonders is not entirely understood, but it is not bad for a drug that originally came from an attractive wild plant. The scientific community continues to research the multiple pathways through which this simple compound derived from a garden plant can have such profound effects on human health.

The Lead: Historic Labor Agreement Averts World Cup StrikeA landmark eight-year contract agreement between New York's hotel workers union and the hospitality industry has secured significant wage increases and benefits for nearly 27,000 workers, avoiding a threatened strike during the upcoming FIFA World Cup. The deal establishes housekeepers' earnings at more than $100,000 annually while providing free family healthcare and expanded workplace rights.The Event Details: Groundbreaking Contract TermsThe agreement between the Hotel and Gaming Trades Council and the Hotel Association of New York City represents one of the most comprehensive labor deals in the hospitality sector. Key provisions include:50% wage increases over eight yearsHousekeepers' pay rising from nearly $40/hour to more than $61/hourFree family healthcare for all workersIncreased pension contributionsNew benefit funds for workersExpanded rights at workUnion president Rich Maroko emphasized that "wage increases were our primary focus in this contract cycle because the cost of living for our members has been increasing so dramatically." Meanwhile, Hotel Association president Vijay Dandapani acknowledged the "tremendous economic headwinds" facing the industry while expressing pride in providing "the best pay and benefits in the country."The Data Analysis: Financial Impact on Workers and IndustryThe financial implications of this agreement are substantial for both workers and the hospitality sector. For hotel housekeepers, the deal represents a more than 50% increase in hourly wages, translating to annual earnings exceeding $100,000 when factoring in overtime and benefits. This places New York hotel workers among the highest-paid in their profession nationally.For the industry, the agreement comes amid significant challenges. Dandapani noted that 20,000 hotel rooms have been lost since the COVID-19 pandemic, with demand not fully recovered. Despite these challenges, New York City maintains the highest average room rates of any major US city at approximately $335 per night, coupled with the nation's highest occupancy rate.The Impact Analysis: Changing Labor Dynamics in HospitalityThis agreement signals a significant shift in labor relations within New York's hospitality sector and potentially across the nation. The substantial wage increases and comprehensive benefits package reflect the growing power of organized labor in an industry historically characterized by lower wages and limited benefits.The timing of the deal is particularly noteworthy, coming as the city prepares to host eight World Cup matches, including the final at New Jersey's MetLife Stadium. The agreement averts what could have been a disruptive strike during one of the city's most high-profile international events, ensuring smooth operations for visitors and maintaining New York's reputation as a premier global destination.Mayor Zohran Mamdani welcomed the deal as "a win for our hospitality industry, our economy and for a city that works best when the people who keep it running can afford to live here, too," highlighting the broader implications for economic equity in the city.The Prediction: Future of Hotel Rates and Labor RelationsLooking ahead, the agreement is likely to have lasting effects on New York's hospitality landscape. Industry analysts anticipate that hotel room rates may need to rise further to offset the increased labor costs, potentially making the city even more expensive for visitors. However, the higher wages could also stimulate local economic activity as workers have more disposable income.The successful negotiation of this deal during a period of economic uncertainty may set a precedent for future labor agreements in the hospitality sector nationwide. As the industry continues to recover from pandemic-related challenges, the balance between worker compensation and operational sustainability will likely remain a central focus for hoteliers and unions alike.For the upcoming World Cup, the agreement ensures that New York can present its best face to international visitors, with well-compensated staff providing high-quality service during the tournament. However, the long-term impact on the city's competitiveness as a tourist destination remains to be seen as higher operational costs may affect pricing and availability.

De Zerbi Frames Final-Day Match as Fight for Club DignityRoberto De Zerbi told his players that the upcoming game against Everton matters more than last season’s Europa League final because the club’s entire dignity is at stake. He emphasized that staying in the Premier League is the ultimate prize for Tottenham.Spurs' Survival Scenario and Upcoming FixturesSpurs lost 2-1 at Chelsea on Tuesday and now need a home draw on Sunday, 19 May 2026 to guarantee survival. Meanwhile, West Ham United sit two points behind with an inferior goal difference and face Leeds at home.Tottenham: 37 points, goal difference ‑ 3West Ham: 35 points, goal difference ‑ 5Everton: 35 points, goal difference ‑ 4Points, Goal Difference and the Numbers Shaping the BattleThe relegation fight hinges on three key metrics:Points: A draw gives Tottenham a safe 38 points.Goal difference: Tottenham must maintain at least a two‑goal advantage over West Ham.Head‑to‑head: Everton’s result against Leeds could also shift the balance.Richarlison’s late goal in the Chelsea loss highlighted Tottenham’s ability to rally in the final minutes, a factor De Zerbi hopes to replicate.What Staying Up Means for Tottenham and the Premier LeagueSurvival preserves the club’s financial health, sponsorship deals, and the ability to retain key players. It also keeps a London‑based giant in the top flight, maintaining the league’s marketability and broadcasting appeal.Outlook: What Comes After the Final Day?If Tottenham secure the draw, they will focus on rebuilding under De Zerbi, targeting a top‑half finish next season. A relegation would trigger a managerial review and likely a squad overhaul, while West Ham’s fate would hinge on their own result against Leeds.

The Revelation of a Second Cancer Diagnosis Kylie Minogue has revealed that in early 2021 she was diagnosed with cancer for a second time, after diagnosis and successful treatment for breast cancer in 2005. Details of the Diagnosis and Treatment The pop star discussed the previously unannounced diagnosis in a new Netflix documentary entitled Kylie, available from today. “My second cancer diagnosis was in early 2021. I was able to keep that to myself … Not like the first time,” she said, referring to her highly publicised first treatment. 2005: Diagnosed with breast cancer, treated and given the all-clear. 2021: Diagnosed with cancer for a second time, kept private. The Impact on Her Life and Music Minogue said that after her treatment, she struggled “to find the right time” to announce it publicly, including after the huge success of her Grammy-winning 2023 single Padam Padam. “I don’t feel obliged to tell the world, and actually I just couldn’t at the time because I was just a shell of a person,” she said. “I didn’t want to leave the house again at one point. Padam Padam opened so many doors for me but on the inside I knew that cancer wasn’t just a blip in my life. And I really just wanted to say what happened so I can let go of it. I’d sit through interviews and every opportunity I thought, ‘now’s the time’, but I kept it to myself.” The Netflix Documentary The new Netflix documentary is in three parts, and directed by Michael Harte, who edited Netflix’s successful four-part documentary on David Beckham. As well as Minogue, it features interviews with her sister Dannii, and former duet partners Jason Donovan and Nick Cave, among others. The Importance of Check-Ups Minogue added in the promotional materials accompanying the launch: “There are so many people for whom cancer is part of their life and, I get it; you just want to move on and put it in the past or park it to the side. But, check-ups are incredibly important. It can be daunting and triggering but please be mindful of just how vital they are - and reach out for help if you need it, you’re not alone.”

The Verdict and Its Implications A federal jury in Oakland, California, has handed a resounding victory to Sam Altman and OpenAI in their long-standing courtroom battle with Elon Musk. The unanimous verdict, delivered after less than two hours of deliberation, found Altman, OpenAI, and its president, Greg Brockman, not liable for Musk's claims that they unjustly enriched themselves and broke a founding contract made with Musk when founding the startup. The Impact on OpenAI's Future Plans The jury's decision provides OpenAI with a stamp of approval for its for-profit plans, already in motion, and a clear path ahead to go public later this year at around a $1tn valuation. Musk's demands that Altman be removed as CEO and that the for-profit arm of the company transfer about $150bn to the nonprofit arm would have jeopardized the blockbuster initial public offering. The Data Analysis The ruling is likely to reassure investors and the broader AI sector because it avoids a potentially chaotic outcome that could have challenged OpenAI's commercial structure, Microsoft partnership, and future fundraising plans. According to Sarah Kreps, a professor and director of the Tech Policy Institute at Cornell University, purely nonprofit models are difficult to sustain at the cutting edge of AI development. The Impact Analysis The trial highlighted a broader disconnect between the people building AI systems and many of the people increasingly expected to live and work alongside them. The decision also leaves many questions unresolved, such as how these systems should be governed, who benefits from them economically, and whether the pace of deployment is becoming disconnected from broader public comfort with the technology. The Prediction OpenAI's plans now seem all but guaranteed, given that the world's richest person couldn't put a stop to them. Wall Street is likely breathing a sigh of relief. However, Musk's lawyers said he would appeal the case, and critics argue that the trial's outcome does not necessarily equate to justice or accountability for the people of California.

The Indonesian Legislative Breakthrough Indonesia has taken a historic step by passing legislation that classifies domestic workers as employees. Last month, the country’s parliament approved a law ensuring that more than four million domestic workers are entitled to health insurance, paid days off, and pensions. Additionally, the legislation explicitly outlaws the hiring of workers under the age of 18. The Scale of the Global Domestic Workforce The challenges extend far beyond Indonesia’s borders. The International Domestic Workers Federation estimates that there are approximately 75 million people in the sector worldwide. This demographic faces "lower wages, fewer benefits and fewer legal or social protections than other workers," with three-quarters of them being women. Because they work in private homes, they are isolated, often receive little or no time off, and are particularly vulnerable to abuse. The Vulnerability of Migrant Domestic Workers A growing number of these workers are migrants, including around 3 million Indonesians working in Asia or the Gulf. These individuals are especially vulnerable due to exorbitant fees from job agencies that lead to debt bondage, language barriers, and the isolation of being far from family. Experts describe the kafala sponsorship system in many Gulf states as giving a "veneer of legality to slaveholding," as employers often hold identity documents and visas are tied to a single household. Organizing for Change in Isolation Despite these obstacles, activists are finding ways to organize. While only a few dozen countries have ratified the 15-year-old International Labour Organization convention, it has catalyzed global organizing efforts. Social media is also playing a critical role in raising awareness and coordinating action among physically isolated workers. Campaigners emphasize that lobbying individual legislators and helping workers share their stories are critical strategies, noting that pressure from local workers can even help improve conditions for migrant workers, as seen in the case of South Korea.

A Tennis Legend's Academic JourneyWhen Billie Jean King left college in 1964, she had a clear purpose. Within a few years, she had become the top-ranked tennis professional in the world. Over a trailblazing career, she won 39 championships, a Presidential Medal of Freedom and a congressional Gold Medal – all while pushing publicly for gender and pay equality.Last year, she finally returned to finish the degree in history she started more than six decades ago. On Monday, she graduated at 82 years old.The Commencement Celebration"It is a privilege for me to be here as a member of your graduating class," King said at her commencement. "Yeah baby, only 61 years!"King recalled growing up in a working-class family, the daughter of a firefighter father and homemaker mother."Like so many of my fellow graduates, I am the first member of my immediate family to graduate college, like many of you," King said.Early Life and Tennis BeginningsShe chose Cal State Los Angeles, then known as Los Angeles State College, because the tennis coach, Scotty Deeds, trained men and women together. He said it would help give her the level of competition she needed to excel."Their approach to winning in tennis was revolutionary at the time," King said of Deeds and the women's coach Dr Joan Johnson. "Even today most collegiate D-1 and D-2 tennis teams do not have the women and men practice together. Scotty and Dr Johnson had it right and they took the extra step for their student athletes."King distinguished herself as a tennis champ in college, winning Wimbledon doubles while enrolled. King was 18 and her partner, Karen Hantze, was 17, making them the youngest team to win at the time.A Lifelong Commitment to EqualityBut King told the crowd that her true motivation since childhood had been to fight discrimination, a calling she first remembered feeling at age 12, when she realized that virtually everyone at the tennis clubs where she trained was white."I asked myself, where is everybody else?" King said. "From that day forward, I committed my life to equality and inclusion for all. Tennis is a global sport and it became my platform, but equality was my dream – to make the world a better place."She added: "We can never understand inclusion unless we've been excluded."King, one of the first openly gay professional athletes, founded the Women's Tennis Association in 1973 and successfully campaigned to get the US Open to pay equal purses at the US Open. That same year, she defeated Bobby Riggs in a historic match billed "The Battle of the Sexes" – a feat later dramatized in a Hollywood film staring Emma Stone and Steve Carell.Legacy and Final WordsKing ended her speech with words of advice for her fellow graduates."Have fun," King said. "Be fearless. And make history."

The Meta AI Reorganization Meta is recenter itself around artificial intelligence, the tech giant is mandating more than 7,000 workers to move to new teams, and it’s radically changing some employees’ jobs. The Guardian has learned that some of these reassigned employees will shift to two new teams: one building AI cloud infrastructure and another that’s building an internal AI agent codenamed Hatch. The Details of the Reassignment Late last week, Meta employees received a notice that engineers had been “selected” for reassignment and would begin reporting to the cloud infrastructure and Hatch teams by the end of this week. Meta made a similar move last month when it reshuffled at least 1,000 engineers onto a new data labelling team called Applied AI, or AAI – at first giving them the option to volunteer, but later telling workers, “transfers aren’t optional.” The Impact on Employees This rapid-fire reorganization is stirring up discontent within Meta during an already volatile era. “The new orgs showcase a shift in top level management strategy towards micro-authoritarianism,” said a Meta engineer, who requested anonymity because they are not authorized to speak to the press. Instead of empowering employees, it feels like Meta’s attitude has shifted to, “‘No, we tell you what to do, and command and order is the way forward,’” this employee told the Guardian. The Future of Meta's AI Ambitions OpenAI, Google and Anthropic’s consumer AI products are already in the lead, so Meta has been playing catch-up in the AI race. In January, Mark Zuckerberg said in an earnings call that the company will spend up to $135bn on AI infrastructure this year “to train leading models and deliver personal super intelligence to billions of people and businesses around the world”.

Google's Ambitious Entry into AI Design Space Google announced at its annual I/O event on Tuesday that it's launching Pics, a new AI-powered design and image generation app for Google Workspace. The tech giant says it designed the app to be accessible to everyone, from teachers to small business owners. With Pics, users can generate everything from social media graphics and invitations to marketing materials and mockups using simple text prompts, without needing any editing skills or advanced tools. Pics: Google's New AI-Powered Design Tool By giving users an easy way to generate visuals, Google is looking to take on popular design apps like Canva, as well as products from AI-native competitors like Claude Design from Anthropic. Google's entry into the space signals that AI-powered design is fast becoming a core competitive arena — with real stakes for any business that depends on visual content. The new app is launching to a group of testers at I/O and will be rolling out to Google AI Ultra subscribers this summer, Google says. The company acknowledges that although AI models today can generate high-quality images, it's still difficult to modify just one part of an image. If you get an image that's almost perfect but want to change a small detail, you have to write an entirely new prompt and hope the AI doesn't alter too much. That's why Pics not only generates images but makes them easily editable. Users can enter a prompt, and Pics will generate what they need. Gemini powers the editing layer, making every element in a generated design or image fully adjustable. You can write a new prompt to make changes, but you can also simply click the part you want to change and leave a comment — much like leaving feedback in Google Docs. You can also edit directly, without leaving a comment or writing a prompt. For example, if you create a birthday party invitation and want to change the time listed on the card, you can do so manually. Pics is powered by Nano Banana 2, which Google says is a strong fit for the app because it supports precise text rendering, real-world knowledge, and detailed visual output. Pics is also built natively into Google Workspace, enabling visual collaboration across its apps. Redefining Visual Content Creation Google's Pics represents a significant shift in how visual content can be created and modified. The tool's ability to allow users to make precise changes to specific elements of an image without regenerating the entire design addresses a key limitation in current AI image generation technology. This granular control could democratize design for non-designers while also providing professionals with a powerful new tool in their workflow. The integration with Google Workspace is particularly noteworthy, as it positions Pics as more than just a standalone design tool. By embedding it within the broader ecosystem of Google productivity apps, Google is creating a seamless workflow for creating, collaborating on, and finalizing visual content. This approach could give Google a competitive advantage over standalone design platforms that lack such deep integration with other productivity tools. The Future of AI in Design and Collaboration As Pics rolls out to Google AI Ultra subscribers this summer, we can expect to see how the market responds to Google's entry into the AI design space. The tool's success will likely depend on its ability to deliver on its promise of easy-to-use yet powerful design capabilities, as well as how well it integrates with users' existing workflows. Google's move also signals that AI-powered design tools are becoming increasingly mainstream, with major tech companies recognizing the importance of AI in creative workflows. This could accelerate innovation in the space, leading to more sophisticated tools that further bridge the gap between human creativity and AI assistance. Once you're happy with your design, you can download, copy, print, or share it with others. You can also pass it to someone else for a final round of edits before it goes out, Google says. This collaborative aspect, combined with the AI-powered generation and editing capabilities, suggests that Pics is designed not just to replace traditional design tools but to enhance them with AI capabilities that make the design process more accessible and efficient.