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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

The mockumentary, a once-thriving film genre, seems to be losing its luster. Charli XCX's 'The Moment' and 'Spinal Tap II: The End Continues' are recent examples of films that have failed to recapture the magic of their predecessors.Historically, mockumentaries were a staple of comedy, with directors like Christopher Guest and Rob Reiner pushing the boundaries of the genre. Films like 'This Is Spinal Tap' and 'The Rutles: All You Need Is Cash' remain classics, celebrated for their improvisational style and satirical humor.However, the current crop of mockumentaries seems stale, relying on celebrity cameos rather than genuine comedic innovation. Even 'Spinal Tap II,' starring Guest, feels like a nostalgia exercise, struggling to recreate the original's charm.In contrast, smaller, independent projects like 'Rap World' and 'Nirvanna the Band the Show the Movie' are breathing new life into the genre. These films, made on shoestring budgets, use mockumentary techniques to create authentic, humorous stories that resonate with audiences.The decline of the mockumentary genre raises questions about its future. Can it be revitalized, or has it become a relic of the past? Only time will tell, but for now, it seems that the mockumentary needs a fresh perspective to regain its former glory.

Stephen Fry opened his appearance on ITV’s The Assembly with a startling question: “You tried to kill yourself a couple of times. Are you happy to be alive now?” The boldness set the tone for a conversation that veered far from the usual celebrity‑friendly script.The programme distinguishes itself by placing a well‑known guest in front of a panel of young adults with neurodivergence or learning disabilities. Free from the conventional safeguards of mainstream talk shows, the panel asks questions that are simultaneously unconventional and deeply human, prompting guests to respond without the usual rehearsed veneer.For Fry, the format proved liberating. Known for translating complex ideas into accessible language, he used the platform to discuss suicidal ideation, likening the experience to the lingering memory of a broken limb—painful yet now distant. This candidness allowed him to reaffirm why he remains a cultural touchstone.One of the most memorable moments came when a participant asked, “I read that you are bipolar. One of my family has that. How can I help them?” Fry responded with a vivid analogy, describing bipolar disorder as a “rainstorm raging inside you—eventually the sun returns, and it’s the weather, not the person, that changes.” This explanation resonated as both compassionate and educational.The interview oscillated between gravitas and levity. Fry fielded whimsical queries such as “Can you help me meet Céline Dion?” and “How much have you spent on cocaine?” alongside the probing “Are you a top or a bottom?” The juxtaposition amplified the emotional weight of the serious topics.At one point, a young panelist named Luca chose not to ask a question, instead performing William Wordsworth’s poem “The World Is Too Much With Us” with theatrical flair—a rare blend of poetry and performance that underscored the show’s experimental spirit.Another highlight involved Jacob, a panel member who brandished a list of Fry’s past advertising gigs—Heineken, Twinings, Honda, and more—before delivering the punchline, “Is there anything you wouldn’t do for money?” The extended joke built a collective laugh that softened the subsequent, more probing inquiries.Critics have likened the show’s tone to a hybrid of Radio 4’s In the Psychiatrist’s Chair and the cheeky, irreverent style of classic British comedy interviews such as those with Dame Edna Everage or Mrs Merton, creating a unique space where vulnerability and humor coexist.The episode concluded with Nina Simone’s “I Wish I Knew How It Would Feel to Be Free” playing as Fry reflected on his experiences with antisemitism and bipolar disorder. Moved by the music, he rose and danced, offering a visual testament to the therapeutic power of the format.The Assembly aired on ITV1 and is now available for streaming on ITVX.

In the spring of 2002, the modest Free Butt pub on Brighton’s seafront buzzed with a restless energy. Future stars such as Natasha Khan, then a university art student, danced atop the bar while the Yeah Yeah Yeahs thundered through their first UK dates. Behind the scenes, band frontmen like Guy McKnight of Eighties Matchbox B‑Line Disaster served pints, and budding engineers like Steve Ansell of Cat on Form fine‑tuned the sound. The atmosphere felt like a rite of passage, where any performer could slip from a cramped stage to national attention.Unlike the neatly branded scenes of New York’s garage‑rock revival or London’s Libertines‑driven hype, Brighton’s early‑2000s scene resisted a single aesthetic. Rock groups emerged from rehearsal rooms and tiny clubs with wildly different looks and sounds, creating a cultural mosaic rather than a monolithic movement.Electrelane’s guitarist recalls recording their debut Rock It to the Moon in a studio once owned by the Levellers, and crafting their sophomore effort inside a former public toilet. These unconventional spaces proved surprisingly fertile, underscoring the city’s DIY spirit.By the turn of the millennium, the big‑beat dominance of Fatboy Slim and Skint Records had faded, making way for a grassroots rock surge. Sea Power relocated from Reading to Brighton, drawn by the city’s “dilapidated charm and fresh sea air”. Their self‑organized Club Sea Power nights at the Lift offered a chaotic yet liberating platform that eventually caught Rough Trade’s attention.Women played a pivotal role in shaping the scene’s infrastructure. Promoters Lisa Lout and Anna Moulson, both still active, booked seminal shows—including the Strokes’ first UK gig at the Lift in 2001—and helped launch the Great Escape festival. Their efforts ensured that bands such as the Pipettes, Electrelane and Bat for Lashes could share stages and media coverage.Artists recall the city’s palpable sense of belonging. Rose Dougall of the Pipettes describes a landscape where “alternative culture was on every street, from vintage shops to the colour of the houses,” and where “small venues made it feel attainable to launch a project.” Similarly, Brakes frontman Eamon Hamilton contrasts Brighton’s walk‑able, collaborative vibe with London’s darker, more competitive energy.Music journalism mirrored the scene’s intensity. Everett True and photographer Steve Gullick launched Careless Talk Costs Lives in 2002, a deliberately short‑run magazine that championed female writers and bands at a time when the industry was still heavily male‑dominated.As rents surged through the 2010s, many of the cheap flats, rehearsal rooms and iconic venues that underpinned the scene vanished. The Free Butt closed, independent record stores shuttered, and the once‑abundant low‑cost infrastructure dwindled, prompting a migration of creative energy down the coast to places like Margate, Ramsgate, Folkestone and Shoreham.Nevertheless, the remnants of Brighton’s network continue to nurture new talent, from the Kooks to Dream Wife and Gazelle Twin. The city’s strength lies not in a singular sound but in its capacity to host a “constant collision of wildly dissimilar bands,” allowing artists to develop authentically and fearlessly.

The vastness of space has always been a profound source of inspiration and terror for humanity. The recent launch of the Artemis II space mission brought this into sharp focus, as the tiny Orion craft and its four-person crew drifted silently through the void, further and further from home. This sense of cosmic isolation is a feeling that video games have long sought to capture.In his autobiography, Apollo astronaut Michael Collins described the experience of being left alone in the command module while Neil Armstrong and Buzz Aldrin walked on the moon: 'I am alone now, truly alone, and absolutely isolated from any known life. I am it. If a count were taken, the score would be three billion plus two over on the other side of the moon, and one plus God knows what on this side.'Games like Elite, No Man's Sky, and Outer Wilds have attempted to evoke this sense of solitude and vulnerability. Outer Wilds thrusts players into a time loop on a doomed planetary system, while Xenonauts 2 challenges players to manage Earth's defenses against alien invaders. These games, and others like them, concentrate not on generational starships or laser wars, but on small crews in tiny pods, the weight of the universe stacked against them in the dark.Other notable mentions include Alien: Isolation, Freelancer, Homeworld, and Out There, which all capture the minimalist elements of space travel – often just isolated noises and details. As Tracey McGarrigan noted, even classic games like Solaris on the Atari 2600 managed to evoke a sense of loneliness and awe.For those interested in exploring these themes further, the article recommends checking out Xenonauts 2, available on PC, with an estimated playtime of over 30 hours.

Ben Delo, a British billionaire convicted in the US for failing to implement adequate anti-money-laundering controls in his cryptocurrency business, has donated £4m to Reform UK, the party founded by Nigel Farage. Delo, who is now based in Hong Kong, made the donation since the start of the year, before the government's cap on donations to political parties by British citizens living abroad.Delo, 42, who was pardoned by Donald Trump last year, is moving back to the UK and therefore will not in future be subject to the new rules for donors. He explained his motivations for turning to Reform UK, saying England was his home and that “the biggest obstacle to national recovery is the entrenched self-deception of our elites”.In his article for the Telegraph, Delo wrote that he had donated £4m to help Nigel Farage build Reform UK into a “genuine alternative party of government”. He cited his dissatisfaction with the current political culture, stating that “the official culture of government now forces everyone to be chronically dishonest”, citing expression of views on transgender people.Delo was convicted in the US in 2022 after pleading guilty to violating the Bank Secrecy Act by failing to implement adequate anti-money-laundering controls at BitMEX, the trillion-dollar cryptocurrency exchange he co-founded. He has poured more than £100m into philanthropy and supports more than 50 organisations ranging across the political spectrum and public life.Nigel Farage welcomed Delo's support, saying it would help Reform attract more of the skills and talents needed to get ready for government. “Ben’s support will help Reform attract more of the skills and talents we need to get ready for government,” Farage told the Telegraph.

The recent ceasefire between the US and Iran offers a glimmer of hope for the energy crisis that has been exacerbated by the conflict in the Strait of Hormuz. However, the deal's stability is already being questioned, with Iran claiming that Israel's attacks on Lebanon breach the agreement. Even if the ceasefire holds and hundreds of tankers stranded in the Gulf start to transit once more, analysts fear that it will not be enough to return the flow of oil, gas, chemicals, and other vital items to pre-crisis levels. An estimated 2,000 vessels with about 20,000 seafarers onboard have been trapped in the Gulf since the outbreak of the conflict. Shipping analysts and owners have cautioned that even a temporary ceasefire does not provide a sufficient guarantee that it is safe to make the passage, particularly because Iran's foreign minister has stated that transit will be under Iranian military management. Many questions remain for shipowners and their captains over whether it is safe to navigate through the strait. The disruption has been compounded by the forced shutdown of oil and gas production across the Gulf as storage facilities reached capacity. In addition, many key energy production sites have been damaged by drone attacks. Experts have said it could take months or years to fully restore the Gulf's energy production. Energy markets have fallen sharply on the hope that millions of barrels of crude oil and gas trapped in the Gulf could soon help to relieve a crisis that the International Energy Agency has said is more serious than the energy flashpoints in 1973, 1979, and 2022 combined. However, traders are also expected to price in a continuing 'geopolitical risk premium' to reflect uncertainty over whether the ceasefire will hold.

Footage captured on the streets of Tehran shows small groups of citizens gathering around Enghelab Square – a historic rally point for pro‑regime supporters – some waving Iranian flags, others draped over their backs. The atmosphere is far from uniform; debates and arguments erupted shortly after the ceasefire announcement, reflecting a spectrum of emotions from shock to tentative hope.The video, posted by Majid Nouri – son of former prison official Hamid Nouri – includes his running commentary. He notes that the discussions began around 3 a.m. and continued into the morning, with participants expressing both anger and disbelief. "In no way do we trust America," Nouri declared, echoing a sentiment he says is shared by virtually every Iranian.Pro‑government demonstrators were heard chanting "Death to America, death to Israel, death to compromisers!" and burning U.S. and Israeli flags, according to the Associated Press. The chants persisted despite attempts by organizers to calm the crowd, underscoring the depth of anti‑Western feeling among hardliners.While the ceasefire halted active hostilities, the war has already claimed at least 1,900 lives in Iran. With internet services largely blacked out, gauging the broader public mood is challenging, but pockets of Tehran reported subdued celebrations in the early hours of Wednesday.Local resident Ali, a 31‑year‑old, summed up the prevailing uncertainty: "Most people here don’t trust the US and still don’t know exactly what is going to happen, so they are unsure whether they should be happy or worried." He warned that the ceasefire’s two‑week duration offers no guarantee of lasting peace.Business owners are beginning to test the waters. Hamid, a 43‑year‑old shopkeeper whose grocery and cleaning‑supplies store closed after the February bombings, said, "Today feels like there is no war," and he has reopened his shop, hoping to recover lost income for his family.Iranian officials are framing the pause as a diplomatic victory. Former foreign minister Ali Akbar Velayati posted on X that the conflict has reshaped the global power balance, positioning Iran within a new multipolar order. President Masoud Pezeshkian praised the ceasefire as the fruit of the blood of Iran’s “great martyred leader” and the collective will of the people.Strategically, the ceasefire highlights Tehran’s ability to disrupt the vital Strait of Hormuz, a chokepoint for global oil shipments. Analysts note that this leverage could bolster Iran’s negotiating stance, even as former U.S. President Donald Trump previously warned that a full‑scale clash would threaten "a whole civilisation." As sunrise illuminated the capital, daily life resumed with shops reopening and traffic returning to the streets, yet the prevailing mood remains a blend of exhaustion, cautious optimism, and lingering mistrust of the United States.

Pakistan's diplomatic efforts have yielded a significant breakthrough, securing a temporary ceasefire between the US and Iran. The development comes after intense negotiations led by Pakistan's Prime Minister Shehbaz Sharif and Army Chief Asim Munir.The crisis had escalated to a point where Pakistan's government and military were deeply concerned about the potential consequences for the country's economy, defense, national security, and sectarian harmony. A defense pact with Saudi Arabia meant that if Riyadh entered the war, Pakistan would be drawn into it as well.Behind the scenes, Munir and Asim Malik, the country's head of army intelligence and national security adviser, played a crucial role in mediating the ceasefire. Munir's strong personal rapport with US President Donald Trump and his longstanding relationship with Iran's Revolutionary Guards were instrumental in brokering the deal.China emerged as a key player in the negotiations, with Pakistani officials claiming that Beijing directly encouraged Iran to accept a ceasefire, promising to act as a guarantor of Iran's safety in any talks. This included assurances that Iranian leaders would not be assassinated if they traveled for negotiations.The ceasefire deal was secured by 4am in Islamabad, with both the US and Iran agreeing to a temporary and fragile truce. Michael Kugelman, south Asia fellow at the Atlantic council, described it as Pakistan's 'biggest diplomatic win in years'.Pakistani officials have expressed concerns that Israel and the United Arab Emirates could still try to sabotage the peace process. However, the successful brokering of the ceasefire has been hailed as a 'shining moment' in Pakistan's history and a 'first step' towards peace.