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Podcast Overview: Health, Defense, and Culture ConvergeThe Guardian’s science podcast brings together three seemingly unrelated but timely topics: a looming hantavirus threat, unprecedented UFO transparency from the Pentagon, and research suggesting that arts participation may decelerate the ageing process.WHO Alerts Nations to Growing Hantavirus ThreatWHO chief Dr. Tedros Adhanom Ghebreyesus warned on 12 May 2026 that countries should brace for an increase in hantavirus infections, citing recent spikes in rodent‑borne cases across Europe and Asia.Pentagon Releases First Declassified UFO DossiersOn 8 May 2026, the U.S. Department of Defense published its initial batch of previously secret files documenting reports of Unidentified Aerial Phenomena (UAP), marking the first major transparency effort under the current administration.UCL Research Connects Arts Participation to Slower AgeingA study from University College London released on 12 May 2026 found a statistical link between regular cultural engagement and a reduced pace of biological ageing, measured via epigenetic clocks.Numbers Behind the HeadlinesWHO estimates a 15% rise in hantavirus cases year‑over‑year in affected regions.The Pentagon’s release includes 124 documents covering 67 sightings from 2004‑2025.The UCL study surveyed 7,500 adults aged 40‑70, with frequent arts participants showing a 0.3‑year slower epigenetic age.Why These Stories Matter Across SectorsCombined, the three reports highlight a growing intersection of public health vigilance, governmental transparency, and the measurable health benefits of cultural activity. The hantavirus alert underscores the need for stronger zoonotic surveillance, while the UFO files set a precedent for openness that could reshape defense‑science dialogue. Meanwhile, the arts‑ageing link adds weight to policies that fund cultural programs as preventative health measures.Looking Ahead: Surveillance, Transparency, and Cultural HealthGoing forward, nations are likely to boost rodent‑control programs and invest in rapid diagnostic tools for hantavirus. The Pentagon may continue releasing UAP data, potentially prompting new aerospace research initiatives. Health agencies could incorporate cultural participation metrics into longevity strategies, encouraging broader public access to the arts as a low‑cost, high‑impact health intervention.

The Earliest Known Dental TreatmentNeanderthals used stone drills to treat cavities almost 60,000 years ago in what is the earliest known evidence of dental treatment. This groundbreaking discovery challenges previous assumptions about Neanderthal capabilities and reveals their sophisticated approach to medical care.The Discovery in SiberiaThe single molar, unearthed in a cave in southern Siberia's Chagyrskaya site, features a deep hole that appears to have been created using a sharp, thin stone tool during the lifetime of the tooth's owner. The tooth, dated to be 59,000 years old, was found alongside the remains of Neanderthals and thousands of stone tools that have been excavated at the site.Scientific Evidence of Ancient DentistryThe lower molar features a deep hole in the centre of the tooth extending into the pulp cavity. Microscopic X-ray imaging revealed changes in mineralization that indicated severe tooth decay. Researchers conducted experiments on three modern human teeth to demonstrate that a hole of the same shape and patterns of microscopic grooves could be created by manually rotating a narrow, elongated tool made from local jasper between two fingers. Penetrating the dentin using this approach took between 35 and 50 minutes of continuous work.Expert Analysis of the ProcedureDr. Kseniya Kolobova, an archaeologist at the Siberian branch of the Russian Academy of Sciences, noted that this discovery "powerfully reinforces the now well-supported view that Neanderthals were not the brutish, inferior cousins of outdated stereotypes but a sophisticated human population with complex cognitive and cultural capacities."A dental professor who reviewed images of the tooth rated the Neanderthal's work as "a decent job." Justin Durham, a professor of orofacial pain at Newcastle University and the British Dental Association's chief scientific adviser, stated: "If I was marking this for a dental student, I wouldn't give it an A, but given the circumstances it's pretty impressive."Implications for Understanding Neanderthal CapabilitiesThis discovery represents the first time dental drilling has been demonstrated outside of Homo sapiens, and it is the oldest example of such behavior by more than 40,000 years. The smoothed edges of the drilled cavity and wear patterns inside it suggest the individual survived and continued to chew with the tooth for some time after the procedure.Dr. Lydia Zotkina, an archaeologist at the Russian Academy of Sciences and co-author, emphasized the remarkable strength of will required: "What struck me, and continues to strike me, is what an incredibly strong-willed person this Neanderthal must have been. They must have surely understood that although the pain of the procedure was greater than the pain of the inflammation, it was only temporary and had to be endured."This finding adds to previous evidence of Neanderthals caring for the sick and vulnerable group members, including an adult man with a withered arm and deformities in both legs, and a child with Down's syndrome who survived until at least the age of six. The latest discovery reveals not only compassion, but an impressive level of self-control by the patient and advanced technical skills by the practitioner.

The Lead The United States Centers for Disease Control and Prevention (CDC) has released data showing that deaths from drug overdoses fell by nearly 14 percent in 2025, continuing a third consecutive year of decline. Drug Overdose Deaths in Decline The data released on Wednesday shows that the US saw nearly 70,000 predicted overdose deaths in 2025, down from more than 81,000 in 2024. The downward trend has been welcomed in the US, which has struggled with a devastating overdose crisis fuelled largely by synthetic opioids. The Data Analysis Overdose deaths peaked during the COVID-19 pandemic, with 110,000 recorded in 2022, a surge associated with social isolation and obstacles to accessing treatment services. Experts have attributed the decline to various factors, such as wider availability of the overdose treatment naloxone, commonly sold under the brand Narcan. The Impact Analysis Testing strips that can detect fentanyl are also more common now, and regulatory changes in China have limited access to the chemicals used to manufacture the drug. While overdose deaths declined in most US states in 2025, seven states saw increases. In Arizona, Colorado and New Mexico, overdose deaths increased by 10 percent or more. The Prediction “I’m cautiously optimistic that this represents really a fundamental change in the arc of the overdose crisis,” Brandon Marshall, a Brown University researcher who studies overdose trends, told The Associated Press news service. The administration of President Donald Trump has pointed to the decrease overall as validation of its crackdown on drug trafficking.

The Geopolitical Chess Game of the Trump-Xi SummitWhen President Donald Trump meets with his counterpart, Xi Jinping, a new item will be added to the long list of issues of mutual interest and potential disagreement between the United States and China: the war in Iran. US officials have suggested that China should play a greater role in pushing Iran to reopen the Strait of Hormuz, but analysts say Beijing will require concessions from the US, likely over Taiwan, if it were to aid in resolving the crisis.Iran as a New Front in US-China RelationsAlthough the Iran issue is not really the central issue for either party in this summit, according to Christopher Heurlin, an associate professor of government and Asian studies at Bowdoin College, it represents a new dimension in the complex relationship between Washington and Beijing. China is a major importer of Iranian and Middle East oil, so its economy could come under strain from the disruption caused by Tehran's Hormuz blockade and the US naval siege on Iran.The Strategic Calculus Behind China's InvolvementWhile Beijing has amassed oil reserves that have helped it weather global energy shortfalls, such resources are finite, so China has an interest in opening the strait. At the same time, if Washington – Beijing's chief strategic competitor – is weakened globally from the Iran conflict, which is increasingly looking like an unwinnable war for many observers, China could gain geopolitical advantage. Inderjeet Parmar, professor of international relations at City St George's, University of London, noted that Trump heads to China "chastened" by the shortcomings of the Iran war.The Taiwan Factor in Iran NegotiationsA major priority for Beijing is Taiwan, the self-governing island that China claims as its own. If Xi were to help Trump in his push to reopen Hormuz, the assistance would not come for free, analysts say. China may demand opposition to Taiwanese independence in exchange for putting pressure on Iran to reopen Hormuz. Trump is yet to sign off on the latest arms package to Taiwan – worth $14bn – which has been approved by Congress, and Chinese officials are expected to press him on this issue during the summit.Contrasting Approaches to Middle East CrisisWhile China and the US both want Hormuz to open, their preferred approaches to achieve this goal don't align. China has been calling for restraint from all sides, while Trump has been threatening Iran with enormous military attacks almost daily. In April, Xi proposed a "four-point plan to safeguard and promote Middle East peace and stability" that reflected a preference for multilateralism and diplomacy in contrast with Trump's reliance on military power to advance his goals in the region.The Future of US-China Relations Beyond the SummitAlthough the United States seeks to continue to cooperate with China, the relationship between the two countries has soured in recent years over several points of tension: trade practices, sanctions, Beijing's claims to the South China Sea, the COVID-19 pandemic, and the status of Taiwan. Since returning to the White House in January 2025, Trump and his administration have put less emphasis on the great power competition, with Trump's most recent National Security Strategy aiming to shift its focus to the Western Hemisphere. However, tariffs and trade remain a major irritant in the relationship, and Iran and Taiwan could exacerbate tensions in the coming months.

The Legacy of a Scientific Pioneer My husband Peer Bork, who has died unexpectedly aged 62, was a bioinformatician with a remarkable ability to identify new directions in science and carry out world-class research to push them forward. Revolutionizing Microbiome Research During his career, he progressed from the statistical analysis of the sequences of individual protein molecules, via the analysis of the human genome, to the bioinformatics analysis of whole microbial communities. Peer pioneered the computational analysis of the human microbiome, introducing the concept of gut enterotypes – in work that was highlighted in many newspaper articles as well as on the radio and TV. He went on to study microbial ecosystems worldwide and, at the time of his death, was involved in expanding a consortium that he had initiated to systematically document coastal ecosystems in Europe. All these studies required the creation of bioinformatics tools – software and curated datasets – which are now widely used by the scientific community in academia and industry. A Life in Science Peer was born in the former East Berlin, where his father, Joachim, worked in economic statistics, and his mother, Regina, had an administrative job in the construction industry. Owing to his mathematical abilities, he won a place at a high school specialising in mathematics and science, the Heinrich-Hertz-Oberschule. After military service on the border between East and West Germany, he studied biochemistry at the University of Leipzig. He followed this with a PhD in bioinformatics under the supervision of Jens Reich at the Central Institute for Molecular Biology of the Academy of Sciences of the GDR in Berlin. International Scientific Career After the fall of the Berlin Wall in 1989, Peer joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1991 as a visiting scientist. He and I met there and married in Canterbury, Kent, in 1994. We had two sons, Udo and Robin, and family life involved many trips between Germany and Britain. EMBL became Peer's scientific home and he rose up the ranks to become interim director general in 2025. He was dedicated to furthering EMBL – an intergovernmental research organisation with six sites, including the European Bioinformatics Institute near Cambridge. He was an outstanding mentor. Awards and Recognition He made science both challenging and fun. Among his awards, which included honorary doctorates and the 2009 Royal Society and Académie des Sciences Microsoft award, he was particularly proud of the Nature award for mentoring in science he received in 2008. Final Scientific Journey He died in Taiwan, where he was due to speak at an international conference on the microbiome. He loved to travel and make friends all over the world. Peer is survived by me, his sons, by a granddaughter and his mother.

The Global Obesity Landscape: Not a Uniform EpidemicA continuing rise in obesity around the world is not inevitable, research suggests, with rates in some countries levelling off or potentially in decline. Researchers say focusing on what has been described as a global epidemic of obesity hides large variations in trends across different countries, sexes and age groups.Majid Ezzati, a professor of global environmental health at Imperial College London and author of the study, said: "I think the thing that's really important is this diversity exists even across countries that have really similar economic, environmental, technological features. So countries may look the same on the surface of it but obesity looks different."Comprehensive Analysis Reveals Complex PatternsWriting in the journal Nature, the international team, which involved a network of almost 2,000 researchers, described how for each country they calculated the change in the prevalence of obesity each year between 1980 and 2024. They drew on data from 4,050 population-based studies involving 232 million participants aged five years and above.They found that the prevalence of obesity increased in almost all countries over the 45-year period. However, in most high-income countries, a rapid rise in the prevalence of obesity has been replaced by a slower increase, a plateau, or a potential decline.Regional Variations in Obesity PrevalenceThe rate of growth in obesity is slowing in adults in the US and UK, reaching a prevalence of 40-43% and 27-30% respectively in 2024. Obesity is increasing steadily in Finland, has plateaued in Germany and may have started to decline in France, where 24-25%, 20-23% and 11-12% of adults respectively were thought to have the condition in 2024.Slowdowns were often seen in children and adolescents before adults. For the former group, the slowdown started as early as 1990 in Denmark and rates stabilised in most high-income countries by the mid-2000s. Obesity has plateaued in boys and girls in the UK, US, Germany and Japan at prevalences of 10-12%, 20-23%, 7-12% and 3-7% respectively.Meanwhile, obesity among young people and adults in many low-income and middle-income countries continues to rise and in some cases this is accelerating.Understanding the Drivers Behind Divergent TrendsThe team say it is important now to unpick what is behind the trends in different countries. The situation is complex: while there may be shared reasons for obesity, such easy access to unhealthy foods or a decrease in physical activity, the team say country-specific factors rooted in social, economic and policy considerations could also be important, from perceptions around body image to the presence or absence of interventions such as healthy school meals.Naveed Sattar, a professor of metabolic medicine at the University of Glasgow, who was not involved in the work, said the study highlighted how obesity trends were diverging sharply across countries. "English-speaking nations are doing particularly poorly, with the UK now among the countries with the highest obesity levels worldwide," he said.Sattar said it was encouraging that some countries appeared to have reached a plateau in obesity rates. "Understanding what has worked in those settings is crucial as it could help shape more effective public health strategies for the UK," he said, although he noted there could be country-specific aspects or customs at play.Future Outlook and Potential InterventionsHe said the rapid rise in obesity across many developing countries was especially concerning, not least as it could result in increases in diabetes and cardiovascular conditions.He added: "Looking ahead, it will be important to see how wider use of effective weight-loss medicines affects obesity trends, particularly in the UK and the United States. Recent signs of stabilisation in the USA suggest there may be room for cautious optimism. Combining evidence-based medicines with strong public health measures could begin to shift obesity rates in the right direction."

Executive Lead: Trump Dismisses Domestic Economic Pain While Pursuing Iran DealDonald Trump asserted that the growing financial pressure on Americans from the Iran war does not influence his drive for a peace settlement, emphasizing instead the goal of preventing Iran from acquiring a nuclear weapon.White House Remarks Highlight Iran‑Centric StrategySpeaking to reporters at the White House before boarding a plane to China, Trump said, “I don’t think about Americans’ financial situation. I think about one thing: We cannot let Iran have a nuclear weapon.” The statement was made on Tuesday, 13 May 2026, just days before the U.S. midterm campaign intensifies.Economic Data Pointing to Rising Cost‑of‑Living PressuresU.S. inflation rose 3.8% in April, the fastest pace since 2023.Average gasoline price topped $4.50 per gallon, the highest in four years.Food prices up nearly 4% month‑over‑month.Airline fares increased by more than 20%.Energy‑related costs have surged following the U.S. and Israel attacks on Iran in late February.Political and Economic Impact Ahead of the MidtermsThe remarks arrive as the 2026 midterm election narrative is increasingly dominated by affordability concerns. While Trump downplays the domestic fallout, rivals such as Marco Rubio frame the U.S. as “very fortunate” compared with other nations facing sharper price spikes. Consumer confidence, according to a University of Michigan survey, has slipped to 2022‑level lows, echoing past inflation spikes.Outlook: Trump’s Optimistic Forecast vs. Market RealitiesTrump predicted that a resolution to the war would trigger a “massive drop in the price of oil” and propel the stock market “through the roof,” heralding a new “golden age.” Energy Secretary Chris Wright has cautioned that fuel prices may not fall below $3 per gallon until next year, and analysts note that inflationary pressures remain entrenched. The divergence between Trump’s bullish outlook and prevailing economic indicators will likely shape voter sentiment as the election approaches.

The Artist's Journey Through Love and LossFalling in and then out of love is a universal experience that often brings sadness, grief and heartbreak, and with time, hope and healing. Photographer Diana Markosian used her camera lens to document these complex feelings in her new project, Replaced.She brings the viewer on her journey of having, losing and reclaiming love, in a project that blurs documentary and fiction. "[The moments] no longer existed in the way they had, and I wanted to reclaim them," she says. "I wanted to feel that I could exist in my own story again."Recreating Intimate Moments Through ArtTo document their relationship, Markosian and her team worked with an actor to play her ex-partner. Each intimate image from the series, taken over three months, is a replica of an exact moment once shared with her ex and now shared between her and the actor. Her connection to him deliberately led to his being cast as her partner in the series so that the experience would feel as real as possible.With the actor, she visited Miami, Paris, Naples, Capri and Nice, all places she had once traveled to with her ex-partner. "These locations carry an existing weight of romantic myth," she says. "They are already shaped by cultural narratives of love, desire and idealized experience."The Emotional Toll of ReenactmentShe stayed at the same hotels and did the activities they had once done together, describing the experience as painful but cathartic. "It hurts so much, watching myself be replaced, watching those memories erased, and I didn't want to live in this any more," she says. "I'm so grateful that the project happened quickly."One of the most tender moments she recreates with the model appears in an image of them seated in a bathtub, holding one another with a red light glowing around them. Their vulnerability allows the viewer to reflect on a delicate moment between two people whose past love no longer exists, fostering empathy and prompting the audience to reflect on their own past relationships.Art as a Tool for Processing EmotionsCreating these intimate photographs enabled her to contemplate her journey. "I wanted to acknowledge how these same spaces can be reoccupied," she says, before adding: "If anything, [the project] just showed me how much I loved this person."For the past 16 years, Markosian has not let go of her camera, often using it to reach back and understand her past. "Art has given me a way of processing. I was studying writing, and suddenly found myself holding a camera and not wanting to let go of it; it became just a friend in my life," she says.A Career Built on Memory and ReconnectionShe first picked up a camera at 20, during graduate school at Columbia University. After graduating with a master's degree in journalism, she wanted to see the world, so she moved back to Moscow, Russia, where she was born. There she taught herself how to use the camera.Today, her lens serves as a tool for reconnecting with her past life and reclaiming it as her own. In her previous, highly regarded photo monograph Inventing My Father, she demonstrates her unique ability to reveal the unseen past through her images. Working on the book for 10 years, she depicts her journey of finding her father after 15 years of no contact, following her move to California in 1996 from Armenia, where he lives."Father, my previous work of the past decade, it's all rooted in memory, and I think what's beautiful about memory, there's a blend of fiction, interpretation, and it's very subjective," she says. "So I think I love existing in that territory because none of it is really real."

A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.