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Renewed diplomatic activity is gathering momentum as Pakistan assumes a central mediating role in the stalled US‑Iran conflict. A senior Pakistani delegation, headed by Army Chief Field Marshal Asim Munir, arrived in Tehran to convey messages from Washington, while Prime Minister Shehbaz Sharif embarked on a regional tour that includes stops in Saudi Arabia, Qatar and Turkiye. Iran’s foreign ministry confirmed that Tehran and Washington have maintained contact since the Islamabad talks ended on Sunday, and the White House expressed optimism about convening a second round of peace negotiations in the Pakistani capital. Iran’s warning on the Strait of Hormuz added a sharp edge to the diplomatic push. Adviser Mohsen Rezaei cautioned that continued US enforcement of a naval blockade could prompt Tehran to target American vessels in the strategic waterway. The United States has already tightened restrictions on ships linked to Iranian ports, turning several vessels back before they can dock. In parallel, internal divisions in Washington persisted. The Senate rejected a resolution that would have limited US war powers without congressional approval, underscoring the political friction surrounding the conflict. Key diplomatic developments include: Second‑round talks: The White House announced that a follow‑up peace round with Iran is under discussion and that officials are hopeful a deal can be reached. China’s endorsement: Foreign Minister Wang Yi told his Iranian counterpart that Beijing supports maintaining the momentum of the ceasefire and ongoing negotiations. Saudi‑Pakistani engagement: Crown Prince Mohammed bin Salman met Prime Minister Sharif in Jeddah to discuss regional stability and the US‑Iran dialogue, with Pakistan’s mediation highlighted as a focal point. US‑Qatar dialogue: President Donald Trump consulted with Emir Sheikh Tamim bin Hamad Al Thani on regional developments, emphasizing oil market stability and gas pricing. On the US side, the administration imposed fresh sanctions targeting more than two dozen individuals, companies and vessels tied to Iranian oil magnate Mohammad Hossein Shamkhani. The US Central Command reported that 10 vessels were blocked from leaving Iranian ports within the first 48 hours of the naval blockade, a clear signal of escalating pressure. Israel’s Prime Minister Benjamin Netanyahu reiterated that Israel and the United States share “identical” objectives to contain Iran, while also stating that Israeli military operations would continue unabated. He emphasized the priority of dismantling Hezbollah in Lebanon, marking the first direct talks with Lebanese leaders in decades. In Lebanon, the humanitarian toll deepened. The Health Ministry reported that at least 2,167 people have been killed and more than 7,000 injured by Israeli strikes, with approximately 1.2 million residents displaced since March 2. The UN special rapporteur on housing warned that Israel’s tactics mirror those used in Gaza, calling for an immediate halt to the bombing. Economically, the war’s ripple effects are already manifesting worldwide. World Bank chief economist Indermit Gill warned that the conflict could push the number of people facing acute food insecurity up by about 20 %, adding roughly 300 million individuals to the crisis. Meanwhile, optimism over a potential diplomatic breakthrough sent major US stock indices to record highs on Wednesday. Overall, the convergence of high‑level diplomatic outreach, heightened military warnings, and growing economic concerns underscores a pivotal moment in the US‑Iran war, with Pakistan’s mediation and regional engagements shaping the prospects for a ceasefire.

New research indicates that individuals carrying the red‑hair allele have been evolutionary winners in Europe for more than 10,000 years. The study, led by Harvard scientists, examined DNA from nearly 16,000 ancient remains and over 6,000 living Europeans, providing robust proof that human biology continues to evolve long after farming began. Researchers identified 479 genetic variants that show clear signs of positive selection. Among these are genes linked to red hair and fair skin, as well as variants that affect susceptibility to coeliac disease, diabetes risk, baldness and rheumatoid arthritis. The authors suggest that the advantage of red hair may stem from its association with lighter skin, which enhances vitamin D synthesis in low‑sunlight environments—a crucial benefit for early European farmers. Prior to this work, only about 21 traits had been documented as having risen through natural selection, such as lactase persistence. The scarcity of earlier examples had led some to argue that directional selection was rare after modern humans left Africa. By leveraging an unprecedented volume of ancient genomic data and advanced computational methods, the team demonstrated that selection pressures intensified during the transition from hunter‑gatherer societies to agricultural ones, reshaping hundreds of genes across West Eurasia. "With these new techniques and the sheer scale of ancient DNA, we can now observe how selection sculpted our biology in near real‑time," said Dr. Ali Akbari, the study’s first author. Beyond vitamin D, the rise of certain disease‑related alleles poses intriguing puzzles. A mutation that heightens the risk of coeliac disease emerged around 4,000 years ago and has steadily increased, implying that carriers may have enjoyed other survival advantages despite the autoimmune threat. Similarly, the immune‑regulating gene TYK2, which markedly raises tuberculosis susceptibility, grew in frequency between 9,000 and 3,000 years ago before declining, hinting at a complex balance between pathogen defense and disease risk. The analysis also uncovered negative selection against genetic profiles that promote a high body‑fat percentage, supporting the classic “thrifty genes” hypothesis: traits advantageous for storing energy during scarce hunter‑gatherer periods became detrimental once agriculture ensured a steadier food supply. "This work lets us assign both place and time to the forces that have shaped us," noted Prof. David Reich, senior author and Harvard Medical School geneticist. While the findings are confined to West Eurasian populations, they raise broader questions about whether similar evolutionary dynamics occurred elsewhere. The full study appears in Nature.

Piteå IF, a team in Sweden's top women's football division, Damallsvenskan, is struggling to stay competitive due to its remote location in northern Sweden. The club is entering its 17th season as a top-division side, but faces significant challenges, including high travel costs to away games.The club's managing director, Emelie Lövgren, notes that 13 of the 14 teams in the league are based in the south of Sweden, making travel a major expense. A trip to the southernmost city, Malmö, is 908 miles one-way, while even a trip to Uppsala costs around £8,000 (95,000KR) per season.Lövgren emphasizes that the club is prioritizing cost-cutting over performance, which she describes as the 'saddest part.' The club has sold several key players, including goalkeeper Lauren Brzykcy to Bristol City, to balance its finances. Wages are increasing by 15-20% annually, making it difficult for Piteå IF to keep up.The club's sporting director, James Burgin, notes that it's a 'complete catch-22' to attract and retain players in the squad. The club is exploring solutions, including external investment and raising awareness about the struggles faced by northern teams.Lövgren concludes that change needs to come centrally to support northern teams and ensure the long-term viability of women's football in the region.

At a high‑profile meeting in Downing Street, Prime Minister Keir Starmer told senior executives from Meta, Google, TikTok, X and Snap that the status quo "can’t go on like this" and that immediate, tangible steps are needed to protect children online. Government ministers are now weighing a legal under‑16 age restriction for all social‑media platforms, alongside proposals to curb addictive design elements such as infinite scrolling, autoplay videos and push notifications. During the discussion, Starmer urged the tech leaders to act with "more urgency on internet safety for children" and warned that continued inaction places young users at risk. He emphasized that a world where access is limited but safety is ensured is preferable to one where "harm is the price of participation." While the companies present offered no comment, they have already rolled out a suite of child‑safety tools: Meta’s teen‑account option for users under 18, TikTok’s family‑pairing feature that lets parents set screen‑time limits, and compliance with the UK’s Online Safety Act. The legislation obliges platforms to suppress violent, hateful or abusive content and to keep explicit material, self‑harm, suicide and eating‑disorder content off children’s feeds. The government’s child online‑safety consultation has already attracted 47,000 responses. It explores a formal minimum age of at least 16, as well as restrictions on features that encourage endless usage. The consultation closes on 26 May, after which ministers have pledged “swift action” on the findings. In the House of Lords, a peer‑led amendment to the education bill seeks to introduce a default ban, giving ministers a 12‑month window to decide which apps fall under the age limit. Although MPs have rejected the amendment twice, Conservative peer John Nash is pressing to reinstate the clause. Starmer remains cautious about a blanket ban, fearing it could push teenagers onto the dark web or leave them ill‑prepared for responsible digital use at 16. Nonetheless, Australia’s recent nationwide ban has shifted the political calculus: more than 60 Labour MPs signed a letter in January urging the UK to follow suit. Child‑safety advocates are divided. The Molly Rose Foundation, founded after the tragic death of Molly Russell, warns that an under‑16 ban would punish children for industry failures and calls for stronger enforcement of the Online Safety Act instead. Conversely, Esther Ghey, mother of murdered teenager Brianna Ghey, and Children’s Commissioner for England Rachel de Souza support the introduction of smartphones for under‑16s with built‑in social‑media restrictions.

For the first time, two preliminary pencil sketches by E.H. Shepard for the beloved children's book Winnie-the-Pooh have been made public. These unseen drawings were created before the book's publication in 1926 and showcase Shepard's early thoughts on bringing A.A. Milne's iconic character to life.The sketches, shared by Shepard's family to mark the centenary of the book, provide insight into the artist's creative process. One drawing, captioned 'Climbing very cautiously up the stream,' depicts Pooh and his friends Christopher Robin, Piglet, and Owl. It was intended for Chapter VIII, where Christopher Robin leads an expedition to the North Pole.The sketch shows Pooh, Christopher Robin, Piglet, and Owl on an adventure. Photograph: Courtesy of Peter HarringtonThe other sketch is a delicate study for Chapter III, where Pooh and Piglet go hunting and nearly catch a Woozle. According to Philip W Errington, a senior specialist at Peter Harrington Rare Books, these drawings showcase Shepard's 'absolute, vibrant creativity' and exceptional skill in rendering movement.The drawings will be exhibited at Peter Harrington Rare Books in London as part of a special exhibition starting on April 17. Errington noted that it is 'extraordinarily rare to encounter preliminary drawings of Winnie-the-Pooh that capture what might be called the first moment of inspiration.'

LIV Golf, a breakaway tour backed by Saudi Arabia's Public Investment Fund (PIF), is facing an uncertain future as the fund is expected to withdraw its support in 2026. This development has significant implications for the careers of several leading golfers who made lucrative switches to LIV. The PIF's expected withdrawal could leave many golfers in career limbo, with some, such as Bryson DeChambeau and Jon Rahm, potentially having a pathway back to the PGA Tour. However, the future for others who joined LIV is far more uncertain. The tour's executives recently attended a summit with the PIF in New York, where the financial impact of the Middle East crisis was discussed. LIV's chief executive, Scott O'Neil, has attempted to reassure staff and players that the tour's season will continue as planned, but the lack of commitment beyond 2026 has fueled speculation and concern. Since its inception in 2021, LIV is understood to have burned through more than $5bn of PIF money. Despite this, the tour has made strides towards becoming more commercially viable, attracting blue-chip sponsors such as Rolex and HSBC. The PGA Tour has smoothed a path for some LIV golfers to return, including Brooks Koepka and Patrick Reed. However, the scenario for others is far less obvious, particularly for those who lack the pull to return to the PGA Tour. The DP World Tour, formerly European Tour, may benefit from LIV's potential demise, given its willingness to re-engage with LIV players. The uncertainty surrounding LIV's future also has implications for women's golf in Europe, with the PIF Saudi Ladies International and other events potentially being affected if the kingdom diverts attention away from the sport.

Officials from the Palestine Football Association have been denied entry to Canada ahead of a crucial FIFA meeting in Vancouver. The Palestine Football Association had requested FIFA to intervene with Canadian immigration authorities on their behalf.The annual FIFA Congress is set to take place in Vancouver on April 30, serving as an unofficial kickoff to the World Cup, which begins on June 11 in Mexico City. The Palestinian officials had hoped to address the issue of Israeli football clubs playing competitive matches in what the PFA argues is occupied Palestinian territory in the West Bank.Following a submission by the PFA to Congress in 2024 on the issue, FIFA undertook to investigate claims of illegal matches in the occupied territories. However, the report published in March saw FIFA rule it would 'take no action' over the claims. The Palestine Football Association president, Jibril Rajoub, is understood to be one of the three individuals denied a Canadian visa, alongside the PFA's general secretary and head of legal affairs.The decision to deny the officials visas comes amid general concern over access to the World Cup, with travel bans already in place in the United States, affecting Haiti, Iran, Côte d'Ivoire, and Senegal. FIFA President Gianni Infantino has stated that there will be no adverse effects on travel for teams or supporters at the tournament.

Aaron Pierre delivers a storming, almost hypnotic performance as Randle P. McMurphy, instantly igniting the stale atmosphere of a 1960s American psychiatric ward. His swagger‑filled stride and sudden, childlike scampers create a compelling contrast that keeps the audience on edge.From the opening moments, McMurphy clashes with the authoritarian Nurse Ratched (Olivia Williams), provoking the other patients to rebel, play, and celebrate life beyond the ward’s walls. Pierre’s physicality—alternating between boisterous hugs and a frantic, vulnerable laugh—captures the character’s chaotic charisma.Director Clint Dyer, fresh from his acclaimed 2022 Othello, reshapes the narrative by casting the inmates almost entirely with Black actors. This choice injects a fresh political dimension, turning the patients into “pawns in a system designed to disempower.” Each time Ratched addresses them as “boys,” the line feels like an implicit sneer.While the script does not overtly discuss race—apart from Chief Bromden’s (Arthur Boan) Indigenous background—the production foregrounds the systemic misogyny embedded in both the novel and the 1963 Dale Wasserman adaptation. McMurphy’s mantra, “I fight and fuck,” teeters between liberated individualism and a problematic reclamation of alpha‑male tropes.Olivia Williams, who stepped into the role of Nurse Ratched late in rehearsals, gives the character a “ramrod spine and starched smile.” Her performance underscores the unchecked cruelty of a regime where the doctor (Matthew Steer) is a peripheral, snickering figure, leaving Ratched’s authority unchecked and increasingly vicious.Ken Kesey’s own experience as a government‑run LSD guinea‑pig informs the play’s visceral critique of psychiatry. The production’s lighting, designed by Chris Davey, erupts in scarlet and blue hues that echo the anti‑psychiatry movement of the 1960s, while the depiction of medication, group therapy, and electroconvulsive therapy feels deliberately brutal.Staged in the round at the Old Vic, the audience becomes a “ring of often appalled observers.” Ben Stone’s set design, with its white and pond‑green tiles beneath a soaring ceiling, creates a claustrophobic floor that simultaneously aspires upward—mirroring the characters’ yearning for freedom.The ensemble, led by Giles Terera’s refined Dale Harding, adds subtle layers of tension through nuanced tics and gestures. Dyer bookends the show with a reference to Congo Square in New Orleans, a historic site of Black and Indigenous resistance, framing the play’s cruelty through a lens of cultural resilience—though the production remains largely filtered through a male gaze.The production runs at the Old Vic until 23 May 2026, offering London audiences a bold, politically charged reinterpretation of a classic American drama.

The chief executive of Stack BTC, a bitcoin company promoted by Nigel Farage, has departed as the venture seeks to assure investors of its potential for long-term value. Stack BTC was launched earlier this year with significant fanfare, counting Farage and former chancellor Kwasi Kwarteng among its initial shareholders.The company, originally founded in 2021 by Jai Patel under the name Kasei Investment Holdings, has undergone a rebranding. Its aim is to encourage investments in cryptocurrencies, particularly targeting individuals over 45. However, its previous iteration, Kasei, faced liquidation last year due to adverse market conditions and an inability to raise further capital.Stack BTC's strategy involves accumulating bitcoin and operating as a venture capital firm, investing in smaller companies and reinvesting revenue in bitcoin. The company's share price is expected to correlate with the price of bitcoin. Farage invested £215,000 in the company, and on paper, the value of his stake appears to have increased by more than £200,000.Jai Patel's departure was announced on Wednesday, with the company stating that the move is part of efforts to strengthen the executive team and deliver long-term value for shareholders. Patel has been replaced by David Galan, a former real estate executive with experience in capital markets and mergers & acquisitions.CryptoUK's Ian Taylor expressed skepticism about the company's prospects, suggesting that the involvement of Farage and Kwarteng may deter potential investors. Taylor noted that the company's approach appears to be a PR branding exercise rather than a genuine investment opportunity.