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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

Liverpool's humiliating 4-0 defeat to Manchester City in the FA Cup quarter-finals has raised concerns about the team's form and manager Arne Slot's future. Slot criticized his team's performance, particularly in the 10 minutes after halftime, where he felt they lacked the 'fighting spirit' needed to compete at a high level. The manner of the defeat will heighten scrutiny of Slot's future, especially with Liverpool's upcoming Champions League quarter-final against Paris Saint-Germain. A similar performance in that tie could prove detrimental to Slot's position as manager. Erling Haaland scored a hat-trick for Manchester City, contributing significantly to their eighth consecutive FA Cup semi-final appearance. Slot emphasized the need for his team to improve defensively and show a better reaction to the loss, particularly against top-tier teams like PSG. Liverpool's Dominik Szoboszlai echoed Slot's sentiments, stating that the team's 'fighting spirit wasn't there enough.' The defeat marks Liverpool's 15th of the season, their most since the 2014-15 season. Liverpool's struggles have been compounded by Mohamed Salah's missed chances, including a penalty when City were 4-0 ahead. Slot, however, chose not to single out individuals, instead focusing on the team's overall performance and the need for improvement.

Daniel Peretz, the Southampton goalkeeper on loan from Bayern Munich, has expressed his pride in representing Israel during a tumultuous period marked by war and geopolitical conflict. With his family in Tel Aviv, Peretz shares the challenges of balancing his international duties with the safety concerns of his loved ones.Peretz's excitement about facing Arsenal in the FA Cup quarter-finals is palpable, but he also acknowledges the gravity of the situation in Israel. His family adheres to air raid sirens by heading to bunkers and safe rooms, a routine that has become all too familiar. Despite the distance, Peretz stays connected with his family, ensuring they are safe and focused on their instructions.When asked about playing for Israel being bittersweet, Peretz notes that the only bitter aspect is not qualifying for the World Cup and not playing at home. Israel's home games have been held in Hungary for the past three years, but Peretz hopes for a future where they can play at home with their fans.Peretz is known for his positive outlook and has a close relationship with his idol, Manuel Neuer. He recalls his first encounter with Neuer, feeling nervous but inspired. Peretz also shares his experiences with Harry Kane's penalty techniques, noting that saving one in 10 against Kane is a good statistic.As Southampton prepares to face Arsenal, Peretz emphasizes that while they have respect for their opponents, they are not afraid. He believes that if anyone doubts their abilities, they shouldn't participate. With a 14-game unbeaten run in all competitions, Peretz and his team are confident in their abilities.Peretz's future at Southampton is also a topic of discussion, with a £7m buy option in place. He is open to staying but acknowledges that promotion to the Premier League could impact his decision. For now, he is focused on finishing the season strongly.

More than 100 United States‑based international law scholars have signed an open letter denouncing the recent US‑Israeli strikes on Iran as a violation of the United Nations Charter and potentially amounting to war crimes. The letter, released on Thursday, asserts that the campaign – launched on February 28 – proceeded without UN Security Council authorization and without credible evidence of an imminent Iranian threat. According to the scholars, the legal basis for force against another state exists only in self‑defence against an actual or imminent armed attack, or when expressly sanctioned by the Security Council. Iran has not attacked the United States or Israel, and the Security Council did not approve the operation. The experts organize their concerns into four categories: the legality of the war decision, the conduct of hostilities, threatening rhetoric from senior officials, and what they describe as the dismantling of civilian‑protection safeguards within the US defence establishment under Secretary of Defense Pete Hegseth’s “gloves‑off” approach. Among the most alarming incidents highlighted is the strike on a primary school in Minab, Iran on the first day of the conflict, which killed at least 175 people, the majority of them children. The letter also cites attacks on hospitals, water treatment facilities, and energy infrastructure, emphasizing that schools, health facilities, and homes have been targeted. The signatories condemn public statements by senior US officials, including a mid‑March remark by former President Donald Trump that the United States might strike Iran “just for fun,” and early‑March comments from Pentagon chief Pete Hegseth dismissing “stupid rules of engagement.” They argue that such rhetoric reflects an “alarming disrespect” for international humanitarian law, which is designed to protect civilians and combatants alike. Financially, the letter notes that the war is costing US taxpayers up to $2 billion per day, underscoring the broader economic burden of the conflict. The open letter was co‑authored by prominent legal scholars such as Yale Law School’s Oona Hathaway, former State Department legal adviser Harold Koh, NYU’s Philip Alston, and former Human Rights Watch chief Kenneth Roth. While the authors focus on the United States’ conduct, they warn of a heightened risk of atrocities throughout the region. Emphasizing the need for consistent application of international law, the scholars write: “We urge US government officials to uphold the UN Charter, international humanitarian law, and human rights law at all times, and to publicly make clear US commitment to and respect for norms of international law.”

In the devastated streets of Gaza City's Tuffah neighborhood, residents are taking matters into their own hands to rebuild their homes. Mohammed al-Jadba, a 31-year-old father of 10, is using stones from the rubble of his destroyed house and mud to construct a new shelter. His home, once a four-storey building, was reduced to rubble during Israel's genocidal war on Gaza.With Israeli restrictions on imports preventing the entry of essential construction materials like cement, Gaza residents are forced to get creative. Mohammed has been collecting iron, window frames, and door frames from his old house to use in his new build. The mud, mixed with human hair collected from barbershops, is being used to stick everything together.The United Nations estimates that it will cost $70bn to fully reconstruct Gaza, with 92% of residential buildings damaged or destroyed. An urgent $20bn is needed within the first three years to initiate basic recovery and restore essential services. However, reconstruction efforts have been hindered by continued Israeli restrictions on the entry of construction materials and heavy machinery.As a result, Palestinians in Gaza have focused on partial reconstruction, using available materials to make damaged homes habitable. The United Nations Development Programme (UNDP) has worked on over 230 housing units, benefiting more than a thousand people. However, these interventions are temporary solutions, and the real solution remains elusive.Abdel Nasser al-Jalousi, a 55-year-old resident of Khan Younis, has benefited from partial rehabilitation projects. His heavily damaged home has been made habitable with tarpaulins used as substitutes for walls, doors, and room partitions. However, he stresses that these materials are not a long-term fix and will need to be replaced every season.The scale of the crisis remains severe, with over 213,000 families living in tents and widespread damage during winter storms. The situation highlights the need for political will and massive resources to rebuild Gaza and provide sustainable solutions for its residents.

President Donald Trump has unveiled a bold budget request, seeking $1.5 trillion for military spending, a nearly 40% increase from the previous year. This ambitious proposal underscores the White House's priorities, emphasizing military strength and law enforcement.The budget request, while not legally binding, sets the stage for intense congressional negotiations. It includes a proposed $455 billion increase over fiscal year 2026, separate from an emergency request of $200 billion for the US-Israeli conflict with Iran.The plan involves significant shifts in funding, with $73 billion in cuts to domestic programs, including initiatives to counter climate change, boost renewable energy, and support equality and access in housing, education, and healthcare. Instead, funding would be redirected to projects such as Trump's Golden Dome missile defense system, critical minerals investment, US shipbuilding, and troop salary increases.Trump's proposal also emphasizes immigration enforcement, calling for continued funding for the Department of Homeland Security and Immigration and Customs Enforcement to support his mass deportation campaign. The request includes a 13% increase for the Department of Justice, focusing on violent crime.The budget plan faces challenges, including a potential deadlock in Congress over funding for ICE and Customs and Border Patrol. The administration suggests passing the budget through a mechanism known as reconciliation, which could be achieved with a simple majority in Congress.The US military expenditure has steadily increased, reaching $997 billion in 2024, according to the Stockholm International Peace Research Institute. The country consistently spends more on its military than the next nine countries combined, raising questions about priorities in defense and domestic spending.

Tiger Woods, the renowned golfer, was arrested on March 27 for driving under the influence (DUI) in Florida after his car crashed on a residential road. According to body camera footage, Woods told a Sheriff's deputy that he was 'talking to the president' during the incident.The footage shows Woods appearing astonished as he was handcuffed after failing a sobriety test. He was found to have hydrocodone in his possession, a painkiller that contains an opioid. Woods claimed he had taken 'a few' medications earlier in the day but denied drinking any alcohol.Woods, 50, pleaded not guilty to the charges and later announced that he would be stepping away indefinitely 'to seek treatment and focus on my health'. The incident has raised concerns about Woods' health and well-being, particularly given his history of surgeries, including seven back surgeries and over 20 surgeries on his right leg.

President Donald Trump escalated rhetoric on Thursday, stating that the United States has yet to begin a full‑scale campaign against Iran’s remaining infrastructure and hinting that bridges and electric power plants could be next targets. The comment followed the release of video showing a U.S. strike on the newly completed B1 bridge that connects Tehran to Karaj, an attack that Iran reports killed eight people and injured 95. Iranian Foreign Minister Abbas Araghchi condemned the strike on civilian infrastructure, describing it as evidence of the “defeat and moral collapse” of the aggressor. In a statement posted on X, he warned that such attacks would not force Iran to surrender. The conflict, now entering its fifth week, has begun to ripple through regional and global markets. Instability around the Strait of Hormuz—a vital conduit for oil and gas—has prompted nations to scramble for alternative shipping routes. Satellite images this week captured smoke over Iran’s Qeshm Island, underscoring the heightened risk to infrastructure near the strategic waterway. Amid stalled negotiations with Iran’s new leadership, Trump’s intensified language comes as the United Nations Security Council prepares to vote on a resolution that could authorize member states to use “defensive means” to keep the strait open. Araghchi warned that any provocative action in the Council would only worsen the situation. Iranian media have begun listing potential retaliation targets, naming major bridges in Kuwait, Saudi Arabia, the United Arab Emirates and Jordan as possible future strike points. The semi‑official Fars News Agency highlighted these crossings as vulnerable following the Karaj bridge attack. The Islamic Revolutionary Guard Corps (IRGC) claimed responsibility for recent strikes on U.S.-linked industrial sites in the Gulf, including steel facilities in Abu Dhabi and aluminium plants in Bahrain. The IRGC warned that if attacks on Iranian industries continue, “the next response will be much more painful” and will focus on the occupier’s core infrastructure. Health infrastructure has also suffered. Iran’s Health Ministry reported that U.S. and Israeli raids severely damaged the Pasteur Institute of Iran, a key research center for diseases such as cholera and COVID‑19. Ministry spokesperson Hossein Kermanpour called the strike “a direct assault on international health security.” WHO Director‑General Tedros Adhanom Ghebreyesus echoed the condemnation, noting that the institute is now unable to deliver health services. The WHO has documented more than 20 attacks on Iranian healthcare facilities since the start of March. In a separate claim, Iranian officials said air defenses downed a second U.S. F‑35 fighter jet over central Iran, suggesting the pilot’s survival was unlikely. The United States has not responded to the allegation. Israel’s military reported a fresh barrage of Iranian missiles, which triggered air‑defence alerts and caused damage to homes, vehicles, and a train station in Tel Aviv. The widening hostilities, combined with threats to critical energy and health infrastructure, highlight the growing regional volatility and its potential to disrupt global markets.

Rory McIlroy is focused on achieving more in golf after his 2025 Masters win, which marked his fifth major and a grand slam. He expressed no concerns about maintaining motivation, citing his physical and mental well-being at 36.McIlroy emphasized his desire to continue winning and has his sights set on several goals, including:Defending his Masters titleWinning an Open at St AndrewsMatching Nick Faldo's record of six major wins for a European golferHe credits his caddie, Harry Diamond, for providing crucial support during his Masters victory. McIlroy also reflects on his approach to regular tour events, suggesting they are now less of a priority compared to major tournaments.McIlroy's global golfing ambitions are clear, having taken the Green Jacket to countries like India and Australia. He aims to balance his schedule to maintain peak performance in major tournaments while still competing in other events.His idol, Tiger Woods, serves as a contrast, having struggled with letting go of the sport. McIlroy, on the other hand, envisions a future where he can compete at a high level into his 40s, inspired by players like Justin Rose who remains competitive at 45.