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JD Vance, the US Vice-President, has embarked on a high-stakes mission to Islamabad to negotiate a peace deal with Iran, a task that has been likened to a 'poisoned chalice.' Vance's challenge is to secure a durable peace between a rhetorical ceasefire and the resumption of hostilities.Vance, a vocal critic of US wars in the Middle East, now finds himself at the forefront of efforts to end the conflict. His presence at the talks, the highest-level meeting since the Iranian revolution of 1979, underscores the significance of this diplomatic push. However, Iran's negotiators feel emboldened by their recent successes, including control of the strategic Hormuz strait and their resilience in the face of a massive US-Israeli onslaught.The path to negotiations is fraught with hurdles. Iran has set conditions for talks, including the release of its blocked assets, a demand the US has not publicly agreed to. Mohammad Bagher Ghalibaf, Iran's parliamentary speaker, emphasized that these conditions must be met before negotiations can begin. This stance could complicate Vance's efforts to initiate meaningful dialogue.Vance's mission could have far-reaching implications for his potential presidential run in 2028. His credentials as a MAGA supporter have been questioned due to his less-than-enthusiastic approach to the war in Iran. The outcome of these talks could either bolster or undermine his political standing.Tehran's negotiators are known for their tireless and relentless bargaining style, which could put Vance under significant pressure. The US, while able to walk away from the negotiating table, cannot guarantee the free flow of marine traffic from the Persian Gulf, giving Iran key leverage over the White House. This dynamic could have profound implications for the global economy, particularly in terms of fuel shortages and supply chain disruptions.Before departing for Islamabad, Vance indicated that his team had received clear instructions from Donald Trump regarding the negotiations. He expressed a willingness to engage in good faith with Iran but warned against attempts to 'play' the US. The success of these talks remains uncertain, but their impact on global stability and Vance's political future is undeniable.

Arne Slot acknowledges that last season’s Premier League title postponed the inevitable end of an era at Liverpool, but stresses that the club recognised the need for a rebuild when he was appointed to succeed Jürgen Klopp. Two more stalwarts of the Klopp era – Andy Robertson and Mohamed Salah – will exit on free transfers this summer, further signalling the transition. The remaining veterans who delivered league and Champions League glory – Virgil van Dijk, Alisson and Joe Gomez – are now entering the final years of their contracts. The campaign has been harsh, with Liverpool suffering 16 defeats, a tally Slot describes as “unacceptable”. Yet he insists that he, sporting director Richard Hughes, chief executive of football Michael Edwards, and the owners at Fenway Sports Group remain aligned on the causes of the club’s struggles and the path forward. “It’s normal for clubs to go through cycles,” Slot explained. “We were fortunate that last season’s success delayed the start of this cycle, but now we must manage the break‑up of a great Liverpool side.” He highlighted that the departing players have benefited from last summer’s signings, gaining insight into the club’s ethos and work ethic. Despite the recent run of poor results, Slot feels the backing of the board and, surprisingly, the fans. “Support isn’t always shouted daily; it’s felt in the conversations we have and the shared understanding of the challenges,” he said, adding that he has sensed that support since arriving at Anfield. Slot concluded, “Everyone – the ownership, Richard, Michael and the wider club – sees the same issues. We are all aligned on what needs to be done and why.”

The Gulf region breathed a sigh of relief on Tuesday after Iran and the United States agreed to a two-week truce, halting over five weeks of escalating attacks and hostile rhetoric.However, Gulf states are expressing caution, concerned that the US, seeking a swift exit, might agree to terms granting Iran some control over the Strait of Hormuz, a vital waterway through which one fifth of the world's oil and natural liquefied gas passes.Iran had nearly brought traffic through the strait to a standstill in response to joint US-Israeli attacks on its soil since February 28. Under the truce, Iran has agreed to halt attacks for two weeks in exchange for resumed maritime transit in the key waterway.Despite this, Gulf Cooperation Council (GCC) countries are stressing that any deal must result in a permanent, long-term arrangement to keep the strait open. They fear a weakened yet intact Iranian leadership could use the strait as leverage, leaving them under constant threat of disruption and economic blackmail.“There is a quiet but palpable concern that President Trump, eager for a quick political victory, could tolerate some Iranian leverage over the strait in exchange for a fragile truce, prioritising optics over Gulf realities,” said Hesham Alghannam, a Saudi Arabia-based scholar at the Malcolm H Kerr Carnegie Middle East Center.The GCC countries, which have faced near-daily Iranian missile and drone attacks, have welcomed the truce but emphasize that the Strait of Hormuz must reopen. They are also concerned about Iran's future influence over the strait, with a Bahrain-sponsored UN Security Council resolution calling for countries to use defensive missions to keep the maritime chokepoint open being vetoed by Russia and China.A further escalation could have devastating consequences for the GCC economies, undoing decades of work to make the region a safe hub for finance, tourism, and culture. Analysts say GCC countries have stepped up diplomacy in the lead-up to the conflict, but officials across the region have warned Iran should not mistake their inaction as a sign of weakness.“The Gulf will leave no stone unturned if Iran continues to take the path of aggression,” said Hamad Althunayyan, a political analyst and professor at Kuwait University. “The Gulf expects its interests to be represented, and included, in any deal with Iran.”

Doug Allan, a pioneering wildlife cinematographer, died at the age of 74 while on a trek in Nepal, his management firm said, noting he passed away "immersed in nature and surrounded by friends."Best known for his role as principal camera operator on landmark BBC series including Planet Earth, Frozen Planet and The Blue Planet, Allan amassed a remarkable collection of honors, among them eight Emmy Awards, five BAFTAs, and an OBE awarded in 2024 for services to broadcast media and environmental awareness.Born in Dunfermline, Fife, he earned an honours degree in marine biology from Stirling University in 1973 and soon after joined the British Antarctic Survey as a research diver at Signy Island. It was during this period that his passion for filming blossomed, leading to a pivotal encounter with Sir David Attenborough in 1981, which set him on the path to a distinguished career.Allan’s early forays into polar filming began with a 16 mm camera he purchased for an Antarctic expedition, capturing emperor penguins and selling the footage to the BBC—a move that launched his lifelong partnership with the broadcaster.His dedication to extreme‑environment storytelling earned him the Polar Medal twice, underscoring his expertise in filming some of the planet’s harshest locales.In a 2017 interview, Allan revealed he had spent roughly 620 days tracking and recording polar bears. He recounted a memorable moment when a bear’s wet nose brushed a window, likening it to “a squeegee mop cleaning the glass.” Another close encounter saw a hungry walrus seize his legs underwater, which he repelled by striking the animal with his camera.Allan’s visual legacy, described by his representatives as "breathtaking and intimate moments in the natural world," continues to inspire audiences to appreciate and protect Earth’s wonders.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Britain is confronting the most severe energy shock since the early 1970s, as exports of oil, gas and fertiliser from the Middle East have abruptly stopped. The government says a response plan exists, but details remain vague. It is unclear whether the UK is better prepared for the fallout from Donald Trump’s war with Iran than it was for the pandemic six years ago. Ministers are sending a "we have your back" message to the public while simultaneously signalling to financial markets that any assistance will be limited and targeted. Contingency planning is especially difficult when dealing with an unpredictable leader like Trump. Britain’s heavy reliance on imported energy and food means that reassurance can only hold for a short time. The economy entered the conflict already on shaky ground: unemployment rose steadily throughout 2025 and growth stalled to a virtual standstill in the final quarter of that year. The sudden loss of Middle‑East energy and fertiliser supplies now adds a colossal supply shock. Last year, Trump’s “liberation day” tariff hikes served as a dry run for a far more serious confrontation. This time, the war is taking place in a region that is both volatile and crucial to the global economy. In the past two weeks, the repercussions have been felt across Asia – the Philippines declared a state of emergency, Sri Lanka introduced a four‑day work week, and South Korea announced budget measures to help households cope with soaring energy bills. The continent is the most dependent on Gulf‑exported energy, making the impact there the sharpest. The International Monetary Fund warned that the shock will drive higher prices and slower growth worldwide. Shortages push fuel and food prices up, eroding disposable income, prompting businesses to cut staff, and increasing the risk of recession. The UK, already projected to be one of the poorest‑performing major economies in 2026, could see its fresh graduate cohort face a brutal job market. Trump’s claim that the war could end within two or three weeks appears desperate. Even a rapid cease‑fire would leave substantial collateral damage, creating a stagflation scenario that could hurt Republican prospects in the upcoming mid‑term elections. British officials hope a swift resolution will limit economic damage, allowing a short‑term inflation spike to subside and the Bank of England to resume interest‑rate cuts. Treasury plans include scrapping the planned autumn fuel‑duty rise and providing targeted help for the poorest households, though the path is unlikely to be that simple. Currently, the Treasury is hesitant to act boldly for fear of unsettling bond markets. History – the 2008 banking collapse and the 2020 pandemic – shows that governments can act decisively without triggering a market backlash, using tools such as aggressive rate cuts, increased borrowing, and quantitative easing. The Bank of England has warned of a "substantial negative supply shock" and is expected to soften markets for future rate cuts, which are inevitable. Finance Minister Rachel Reeves could mitigate labour‑market pain by reversing recent increases in employers’ National Insurance contributions, subsidising public transport, and even lowering speed limits to conserve energy. The war, like the pandemic and Russia’s invasion of Ukraine, underscores the fragility of global supply chains and the need for greater British self‑reliance. Investing heavily in renewable energy is essential, but the UK also imports roughly 40% of its food and has not run a manufacturing trade surplus since 1982. In a world of disrupted supply lines, a robust plan for economic self‑sufficiency is more urgent than ever. Larry Elliott is a Guardian columnist.

The England and Wales Cricket Board (ECB) is facing criticism from parents of learning‑disability cricketers who say the board has permitted non‑disabled players to compete in the Disability Premier League (DPL), jeopardising the league’s role as the top feeder for England’s mixed‑disability side.Parents of former England internationals Jai Charan and Alex Jervis claim their sons were replaced by players who do not meet the ECB’s learning‑disability (LD) criteria. An anonymous parent estimates that 12 of the 64 players drafted in December were not disabled, a figure that, if accurate, would represent a significant breach of the league’s purpose.The DPL is intended to be the pinnacle of the pathway to the England Mixed‑Disability team. Under the ECB’s affiliation with Virtus – the global federation for athletes with intellectual impairments – any cricketer seeking an LD spot must demonstrate an IQ of 75 or below, as assessed by an educational psychologist.Owen Jervis, volunteer manager of Yorkshire’s disability team, alleges that several neurodiverse athletes have been fielded despite failing the LD assessment. He notes that most neurodiverse players would not satisfy the eligibility thresholds, citing professional bowler Em Arlott, diagnosed with ADHD and autism in 2023, as an example of a mainstream player with a neurodiverse profile.While the ECB is not legally bound to apply Virtus rules to a domestic competition, critics argue that the inclusion of non‑disabled players undermines the league’s integrity. “You can’t call it a Disability Premier League if the players aren’t disabled,” said Tracey Jervis.Another parent highlighted that his son, a learning‑disability cricketer, is now confined to county disability cricket rather than mainstream county cricket, where many England‑qualified players develop. He warned that the DPL has become an “old‑boys’ club” where selection is driven by personal connections rather than merit.The shift to a mixed‑disability format – combining learning, physical and deaf impairments in the same squads – has further reduced available spots. Parents claim that players without a qualifying LD are occupying key batting and bowling positions, relegating genuine LD athletes to peripheral roles such as fielding or carrying equipment.Owen Jervis raised these concerns with Richard Hill, the ECB’s events and competition manager for disability cricket, in September 2024. Hill acknowledged “several challenges” linked to high‑functioning conditions and said the ECB was drafting an action plan, though Jervis says the situation has worsened.Jai Charan, who debuted for the England LD team in 2023 and holds the DPL’s best bowling average and strike‑rate, and Alex Jervis, a decade‑long LD representative and three‑time LD Ashes winner, were reduced to non‑playing roles in the 2025 season. Charan’s father, Shanial Charan, expressed his disappointment: “My son has the best stats in the league yet he isn’t selected – it feels like discrimination within disability cricket.”The ECB responded that the DPL offers top‑level competition for 60 mixed‑disability players annually, with a strict quota for physical, learning and deaf impairments, making selection highly competitive. It acknowledged ongoing debates about eligibility and indicated a review slated for 2027 to potentially adjust criteria.

Coordinated strikes by United States and Israeli forces hit Tehran, Isfahan and several other Iranian cities on Tuesday, prompting widespread power outages and extensive damage to civilian sites. The Ministry of Energy confirmed that shrapnel from the raids ruptured a primary power‑transfer line, but the outage was restored within a few hours. Among the most critical targets was the Tofigh Darou pharmaceutical complex in the Karaj industrial zone. The facility, which supplies over 90% of Iran’s domestically produced medicines—including cancer and multiple‑sclerosis treatments—sustained heavy damage from multiple projectiles. In central Iran, Isfahan endured a barrage of heavy bunker‑buster bombs over a nearby mountainous area, likely aimed at military installations. The explosions triggered secondary blasts that illuminated the night sky and produced reverberating shockwaves across the city. North‑west of Tehran, in Zanjan, a building identified as the administrative department of the Hosseinieh Azam religious centre was struck, resulting in at least four fatalities and several injuries. Iranian authorities now claim that more than 2,000 people have been killed by US‑Israeli attacks since the conflict erupted on 28 February, with residential blocks, schools, hospitals and historic sites also affected. Additional targets this week included civilian nuclear facilities, major steel producers, petrochemical plants, and the Iran University of Science and Technology, where an imaging satellite was developed. A professor linked to Iran’s missile programme and his two children were assassinated at their home in northern Tehran. U.S. President Donald Trump reiterated threats to strike Iran’s oil and gas infrastructure, power plants and water‑desalination facilities. Despite the onslaught, the Islamic Revolutionary Guard Corps (IRGC) continues to project defiance. A spokesperson for the Khatam al‑Anbiya Central Headquarters declared that Tehran’s adversaries are “humiliated and on the path of destruction,” while senior commander Ali Fadavi warned that American warships are vulnerable and allegedly transmit false transponder signals. The IRGC also released footage of ballistic missiles aimed at Israel and surrounding nations, and claimed to have downed two U.S. MQ‑9 Reaper drones, promising retaliatory strikes against technology firms linked to the United States and Israel. Domestically, the judiciary announced the execution of two members of the foreign‑based Mojahedin‑e‑Khalq (MEK) group, labeling them terrorists. This follows a series of recent executions tied to the January protests and broader dissent. Authorities also issued new indictments against roughly 200 individuals accused of assisting the U.S. and Israel, including alleged “mercenaries” who disseminated strike footage abroad. Penalties for national‑security offenses now encompass asset confiscation and capital punishment. President Masoud Pezeshkian convened his first cabinet meeting since the war’s onset in a makeshift, blue‑covered space, emphasizing that any peace negotiations will safeguard Iran’s “dignity, security and national interests.” Israel’s Channel 14 reported that Pezeshkian sought greater negotiating leverage with the United States, a request allegedly rebuffed by IRGC chief Ahmad Vahidi.

David Attenborough’s voice returns to British screens in ‘Secret Garden’, a BBC One series launched to celebrate the network’s 100th birthday. Unlike his classic wildlife documentaries, the show turns the lens toward the UK’s own backyards, exploring how gardens can rival tropical rainforests in biodiversity.Series producer Bill Markham explains that the programme deliberately avoids the usual “lions and tigers” spectacle, aiming instead for a relatable, garden‑centred narrative. He notes that British gardens collectively cover more area than all national nature reserves combined, and that an average garden can host up to 2,600 different species.The series tackles the contentious issue of domestic cats. With 9.5 million pet cats in Britain, Attenborough reveals they may kill around 55 million birds each year. Simple measures—such as fitting cats with bells—can slash hunting success by one‑third, while raising bird feeders reduces fatalities further.Markham stresses that the current predator‑prey balance is “unfair on the prey”, noting that cats are “the biggest predator in our gardens” yet are constantly fed, leading to an unsustainable population. He cites ecologist Dr Davide Dominoni, who suggests that keeping cats indoors during the breeding months of April and May could dramatically lower bird deaths.Beyond cats, the series examines other garden‑linked wildlife challenges. Each year, over 30 million pheasants—an Asian species—are released into the countryside, where they prey on native insects, reptiles, and amphibians. Markham argues that despite the countryside lobby’s claim that pheasant shooting sustains rural jobs, the practice “mess‑es with the ecology”.‘Secret Garden’ also showcases rare footage, including a pine marten hunting sand martins, an otter preying on ducks, and intricate mayfly battles reminiscent of the famed “snakes vs. iguana” scene from Planet Earth II. These moments underline the hidden drama unfolding in everyday green spaces.Markham hopes the series will soothe the growing eco‑anxiety many feel about climate change. He points out that the UK boasts roughly 25 million gardens, with 80 % of the population having access. Simple actions—like planting a native tree to boost caterpillar supplies for birds—can make a measurable difference.While the show may provoke cat owners and countryside advocates, Markham believes the nation’s love for “animals, gardens and David Attenborough” will drive a collective re‑thinking of garden stewardship. As Attenborough reflects, his first encounter with nature likely occurred in his own garden, setting him on the path to becoming the world’s most renowned naturalist.‘Secret Garden’ airs from 5 April on BBC One and iPlayer.