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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Average private rents across Great Britain have halted their near‑decade‑long climb, with the typical advertised rent outside London remaining at £1,370 per month during the first quarter of 2026, according to Rightmove data.That flat reading marks the first time since 2017 that rents have not risen in the opening three months of a year compared with the end of the previous year, signalling a potential easing of the chronic affordability squeeze that has plagued tenants.Rightmove warned that many renters are now hitting the “ceiling” of what they can afford, a trend compounded by broader cost‑of‑living pressures. Estate agent Jeremy Leaf noted that the Iran war that began on 28 February has heightened tenants’ financial anxieties.Conversely, the conflict has spurred a modest influx of migrants from the Middle East, bolstering demand in the “prime” rental segment, according to Chestertons.Rightmove’s property expert Colleen Babcock cautioned that the war’s immediate impact is an increase in borrowing costs for landlords, which could later translate into higher rents.In response to the softening market, landlords are “positioning rents correctly for the current market.” About 26 % of rental listings have been reduced in price while advertised – the highest proportion recorded since Rightmove began tracking this metric in 2012.After years of demand outstripping supply, the market now shows signs of balance: the number of homes available for rent is 3 % higher than a year ago, and supply is at its strongest level for this time of year since 2021.London’s average advertised rent rose modestly by 0.7 % to £2,736 per month, still below the record peak reached in the summer of 2025.The sector is also bracing for regulatory change. The Renters’ Rights Act, effective 1 May 2026, will abolish Section 21 of the Housing Act, ending “no‑fault” evictions. Charities have warned of a potential surge in last‑minute evictions ahead of the deadline, but Rightmove reported no noticeable increase in newly listed rentals before the law takes effect.Analysts view the pause in rent growth as a temporary relief for tenants, yet warn that higher financing costs for landlords and the upcoming tenancy reforms could reignite upward pressure later in the year.

Israel has appointed Michael Lotem as its first ambassador to Somaliland, marking the latest milestone after the country officially recognized the self‑declared state in December 2025. Lotem, who previously served as Israel’s ambassador to Kenya, was announced by Israel’s public broadcaster on Wednesday. Somaliland’s president, Abdirahman Mohamed Abdullahi, hailed the appointment in a joint parliamentary session, declaring Israel a “reliable partner” and prompting applause from lawmakers. In stark contrast, Somalia’s foreign ministry condemned the decision, labeling it a “direct breach” of Somali sovereignty and unity. The condemnation echoed broader disapproval from the UN Security Council, the African Union, the Organisation of Islamic Cooperation and the European Union, all of which have criticized Israel’s recognition of Somaliland. Since the December announcement, diplomatic activity has accelerated. Israeli foreign minister Gideon Saar visited Hargeisa in January, and Somaliland’s water ministry sent a delegation to Israel for training in water‑management techniques. President Abdullahi told Reuters in February that a trade agreement with Israel is expected soon. Israel has also granted diplomatic approval to Mohamed Hagi, a presidential adviser instrumental in securing recognition, designating him as Somaliland’s first ambassador to Israel. Somali officials warn that the deepening ties could destabilise the region. President of Somalia earlier this year called Israel’s outreach the “gravest attack” on Somali sovereignty and suggested Israel might seek to establish a military base to launch operations against Yemen. Geographically, Somaliland sits across the Gulf of Aden from Yemen, where the Iran‑backed Houthi movement controls the northwest and remains hostile to Israel. The Houthis have publicly stated that any Israeli presence in Somaliland would be a legitimate target. In March, Somaliland’s minister of the presidency, Khadar Hussein Abdi, told Bloomberg that the country aims for a “strategic relationship” with Israel that includes security cooperation. He did not rule out the possibility of an Israeli military base, noting that such a decision “will be analysed at some point.” Somalia’s state minister for foreign affairs, Ali Omar, reiterated to Al Jazeera that Somalia does not want its territory drawn into external confrontations that could further destabilise an already sensitive region. The appointment of an Israeli ambassador therefore not only solidifies bilateral ties but also introduces new strategic calculations for regional actors, potentially reshaping security dynamics in the Horn of Africa and the broader Red Sea corridor.

The European Union's alliance with Israel could be on the cusp of a significant transformation. Changing dynamics in the region may lead to a re-evaluation of their partnership. Details about the potential changes are scarce, but geopolitical developments and shifting priorities could be driving factors behind the possible shift. The EU and Israel have historically maintained a complex relationship, with areas of cooperation existing alongside points of contention. Any changes to their alliance could have far-reaching implications for the region.

A New York jury has ruled against Ticketmaster and Live Nation, finding that the concert giant and its subsidiary had a harmful monopoly over big concert venues. The verdict is a significant loss for the companies, which were sued by dozens of states in the US over claims of anticompetitive practices.The jury deliberated for four days before reaching its decision, which could cost Live Nation and Ticketmaster hundreds of millions of dollars. The companies were found to have overcharged consumers in 22 states by $1.72 per ticket. The verdict also opens the door for potential penalties and sanctions, including court orders to divest some entities, such as venues.The civil case, initially led by the US federal government, accused Live Nation of using its reach to smother competition by blocking venues from using multiple ticket sellers. The company's lawyers argued that it is not a monopoly, saying that artists, sports teams, and venues decide prices and ticketing practices.Live Nation Entertainment owns, operates, controls booking for, or has an equity interest in hundreds of venues. Its subsidiary Ticketmaster is widely considered to be the world's largest ticket-seller for live events, controlling 86 percent of the market for concerts and 73 percent of the overall market when sporting events are included.The verdict marks a significant victory for fans and some artists who have long complained about Ticketmaster's high fees and limited competition. The company has faced criticism from artists such as Pearl Jam, which battled the business in the 1990s and filed an antimonopoly complaint with the US Department of Justice.

Bayern Munich pulled off a stunning 4-3 victory over Real Madrid in a thrilling Champions League quarterfinal match, securing their spot in the semifinals with a 6-4 aggregate score. The game saw late drama as Luis Diaz scored in the 89th minute and Michael Olise netted in stoppage time.The match was marked by controversy as Real Madrid's Eduardo Camavinga received a red card in the 86th minute for a foul on Harry Kane. This turning point allowed Bayern to capitalize and seal their win.Harry Kane expressed his elation post-match, feeling 'amazing' about the win and reaching the milestone of 50 goals this season. He attributed the success to the team's hard work and collaboration.In another quarterfinal action, Arsenal advanced to the semifinals after a nervous goalless draw against Sporting Lisbon, clinching a 1-0 aggregate victory. They will face Atletico Madrid in the next round.

Brazil's Federal Police have launched an investigation into Flavio Bolsonaro, a right-wing presidential candidate, for allegedly issuing defamatory statements against his election rival, President Luiz Inacio Lula da Silva. The probe was ordered by the Supreme Court's Justice Alexandre de Moraes and relates to posts Bolsonaro published in January.In the posts, Bolsonaro responded to the news of Venezuelan President Nicolas Maduro's abduction by the US with insinuations linking Lula to crimes. He wrote that Lula will be exposed and predicted the collapse of the left-wing alliance known as the Sao Paulo Forum due to scandals including international drug and arms trafficking and money laundering.Brazil's penal code considers defamation a criminal offence, with prosecutors able to seek heightened penalties for defamation against presidents or heads of state. The Federal Police have 60 days to carry out their initial investigation.The development comes as Bolsonaro and Lula are in a neck-and-neck race for the presidency ahead of October's general election. A recent poll showed Lula slightly ahead in the first round with 37% of the vote compared to Bolsonaro's 32%, but Bolsonaro polls slightly ahead in a one-on-one contest.Flavio Bolsonaro, a senator for Rio de Janeiro and the eldest son of former President Jair Bolsonaro, entered the 2026 presidential race with his father's endorsement. He has suggested that seeking his father's freedom would be part of his campaign.

A Pakistani delegation headed by Army Chief General Asim Munir arrived in Tehran on Wednesday, bearing a fresh message from Washington and urging the launch of a second round of negotiations between the United States and Iran. The effort comes as the two‑week ceasefire that halted hostilities last week is set to expire on April 22, leaving a narrow window to end a war that has claimed more than 4,000 lives across the Middle East, primarily in Iran and Lebanon. The initial round of talks, held in Islamabad on April 11‑12, marked the most significant direct engagement between Washington and Tehran in decades. Mediated by Pakistan, the sessions lasted over 20 hours and featured both indirect and direct exchanges between U.S. Vice President JD Vance and senior Iranian officials led by Parliament Speaker Mohammad Bagher Ghalibaf. Despite covering core issues—nuclear programme, sanctions relief, frozen assets and control of the Strait of Hormuz—the talks concluded without a memorandum, with Vance asserting that Iran “did not accept our terms” and that the U.S. requires a “fundamental commitment” to forego nuclear weapons. President Donald Trump has described the conflict as “very close to being over” and hinted that a second round could resume within days, possibly in Islamabad. However, Pakistan’s Prime Minister Shehbaz Sharif is currently on a four‑day tour of Saudi Arabia, Qatar and Turkey to rally regional backing, making a rapid return to Islamabad uncertain. U.S. officials have offered an “in‑principle” agreement to extend the ceasefire, yet a Reuters‑cited source confirmed that Washington has not formally committed to an extension. Meanwhile, Turkish President Recep Tayyip Erdogan expressed optimism, stating that “there can be no negotiating with clenched fists.” Key sticking points remain: Nuclear programme: The United States and Israel demand a complete halt to uranium enrichment, accusing Iran of weaponization despite a lack of public evidence. Iran maintains its enrichment is for civilian use and cites its obligations under the 1970 Non‑Proliferation Treaty. Strait of Hormuz: One‑fifth of global oil and LNG passes through this chokepoint. Since the February strikes, shipping through the strait has dropped by 95 %. Iran permits passage for “non‑hostile” vessels and seeks the right to levy tolls, while the U.S. insists on unrestricted navigation. Lebanon/Hezbollah: Iran demands that Israel cease its offensive against Hezbollah. While Tehran claims the ceasefire covers Lebanon, both the United States and Israel reject this, and Israel continues attacks on Hezbollah positions. Complicating the diplomatic landscape, President Trump announced a naval blockade of Iranian ports, adding pressure on Tehran and potentially hindering any imminent talks. With the ceasefire deadline looming and regional actors issuing mixed signals, the prospects for a renewed U.S.–Iran dialogue hinge on whether Pakistan can secure a consensus among the parties before the window closes.

The production of sugar has long been associated with exploitation and harsh labor conditions. Workers in the sugar industry often face grueling working conditions, with many suffering from serious health issues.The sugar industry's environmental impact is also significant, with large-scale deforestation and water pollution being major concerns. The article aims to expose the bitter truth behind sugar production, revealing the human cost and environmental damage.