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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

King Charles's upcoming visit to the White House to meet with Donald Trump is poised to be a delicate diplomatic situation. The king will have to navigate a complex web of potential insults and controversies, including Trump's past comments about the UK's military assets, his criticism of British politicians, and his unconventional social media posts.Historically, Charles has had his share of awkward encounters with US presidents. During his visit to President Nixon in 1970, officials awkwardly presented Nixon's daughter Tricia as a potential match for the then-young prince. Later, during a visit to Ronald Reagan, Charles was handed a cup of tea with the bag still in it, leaving him unsure of how to proceed.In contrast, Charles's meetings with the Clintons and Bushes were uneventful, and his 2015 meeting with Obama was notable for his frank discussion on climate change, which, although not necessarily polite, was a significant moment.However, the current situation with Trump is particularly challenging. Trump has publicly criticized the UK's military assets, including the HMS Queen Elizabeth and HMS Prince of Wales, bearing the names of members of the royal family. Additionally, Trump has made derogatory comments about Pope Francis, which could complicate relations between the US and the Vatican.The king will also have to address Trump's recent social media post featuring an AI-generated image of himself as Jesus, which could be seen as blasphemous or insensitive. Given Trump's unpredictable nature, it's uncertain what he might say or do during the visit.While it would be unprecedented for the king to cancel the visit, the situation is already out of the ordinary. It remains to be seen how Charles will navigate this complex diplomatic situation and maintain the dignity of his office.

Manchester United interim manager Michael Carrick strongly criticized the red card decision given to defender Lisandro Martínez during the team's 2-1 loss to Leeds United at Old Trafford. Martínez was sent off in the 56th minute for pulling the hair of Dominic Calvert-Lewin, a decision Carrick described as 'shocking' and one that may prompt an appeal.The red card could result in a three-match ban for Martínez, potentially sidelining him for United's upcoming fixtures against Chelsea, Brentford, and Liverpool. This comes at a critical time as Harry Maguire is also facing a possible suspension for his second yellow card in as many games.Carrick questioned the severity of the red card, stating, 'The arm [is] in the face of Lisandro and he is off balance and grappling. He goes to touch his shirt and gets a red card for it.' He emphasized that the incident did not constitute aggressive behavior, adding, 'It is not aggressive, there is no jolt, no tug.'The manager also expressed concern over another incident involving Noah Okafor's goal for Leeds, suggesting that Dominic Calvert-Lewin impeded Leny Yoro in the buildup. 'The goal, Leny Yoro gets a forearm smash in the back of the head. I don’t know how that doesn’t get overturned,' Carrick remarked.Leeds United's manager, Daniel Farke, reflected on the historic victory, stating, 'I feel tired, relieved, proud of the boys. The first league win here in over 40 years is amazing.'

The Department for Culture, Media and Sport, acting on Historic England’s advice, has awarded Grade II* listed status to a limestone rubble barn on a grassy knoll in the Lake District, joining an elite roster that includes Battersea Power Station and the London Coliseum.Dubbed “Henry’s Castle,” the structure was most recently used as a shelter for livestock, but research suggests it may date back to the 14th century and originally served a high‑status function that remains unknown.Only 5.8% of England’s listed buildings achieve the Grade II* level, indicating they possess “more than special interest.” The barn’s unusual features – a corbelled chimney stack, a stepped garderobe, and a plastered interior showing signs of fire – set it apart from ordinary field barns.Historic England’s listing team leader, Sarah Charlesworth, described the building as “one of those rare structures that raises more questions than it answers,” underscoring its intrigue for scholars and visitors alike.Lake District National Park’s built‑environment adviser, Rose Lord, recalled her 2022 visit, noting that despite layers of animal manure the barn’s architecture hinted at something “very special” – a construction far beyond typical agricultural outbuildings.Four years of meticulous work by archaeologists, architects, and conservation engineers have restored the barn’s most striking element: an oak roof featuring a hand‑finished, chamfered and pegged central truss, a technique associated with high‑quality carpentry of the 14th or 15th centuries.Experts speculate on the barn’s original purpose, ranging from a defensive lookout or hunting lodge to a luxurious summer house. Historic England notes similarities to bastles – fortified farmhouses common along the Anglo‑Scottish border – though the building’s location south of the border makes a strict classification unlikely.Originally converted to domestic use in the 16th or 17th century and later repurposed as a field barn by the 19th century, the structure takes its name from former owner farmer Henry Willison.Lord called the new listing the “cherry on the cake” for the restoration project, highlighting that most buildings of comparable significance have already been recorded in earlier surveys. Interpretation panels and an owl‑nesting box are slated for installation in the coming weeks, adding educational and ecological value to the site.

Rory McIlroy has made history by winning his second Masters title, holding off a strong challenge from world No 1 Scottie Scheffler to claim a one-shot victory at Augusta.This impressive win cements McIlroy's status as one of golf's all-time greats, making him only the fourth player in the tournament's 90-year history to win successive titles at Augusta. McIlroy's sixth major puts him level with Nick Faldo and one beyond the great Spaniard Seve Ballesteros, who won five.Donald Trump, the former US President who has played golf with McIlroy in the past, was quick to congratulate the Northern Irishman on his achievement. Using his Truth Social platform, Trump wrote: 'Congratulations to Rory McIlroy on another Great Championship, The Masters! He performed tremendously under intense pressure, something which few people would be able to even think about doing. With each year, Rory is becoming more and more a LEGEND!'Trump also expressed his excitement for McIlroy's next appearance at the Cadillac Championship at Trump National Doral in Miami later this month, praising the quality of professional golfers today.

Australian sprint prodigy Gout Gout stunned the athletics community on Sunday at the national championships in Sydney, clocking a legal 19.67 seconds over 200 m. The performance not only smashed his own previous national record of 20.02 seconds but also made him the first Australian to dip below the coveted 20‑second barrier. Gout’s coach and mentor, Di Sheppard, summed up the achievement with a wry grin: “How long’s a piece of string?” – a nod to the seemingly limitless potential the teenager now displays. The run placed Gout ahead of his compatriot Aidan Murphy, who finished a close second, and sparked immediate comparisons with Jamaican legend Usain Bolt. While Bolt’s all‑time best stands at 19.19 seconds (set in 2009), Gout’s 19.67 at the age of 18 already eclipses the Jamaican great’s performance at the same age, according to his camp. Only one other under‑20 athlete has ever posted a faster time – Erriyon Knighton – whose 2022 effort remains unratified after a subsequent ban. James Templeton, the 18‑year‑old’s manager, said the result was “thrilling but not shocking”, recalling that Gout ran 19.84 seconds the previous year with a marginal wind assistance, a time the team always considered his realistic benchmark. Gout himself has been fixated on breaking the sub‑20 mark ever since an illegal run earlier in his career. “I wrote down 19.75 and kept telling myself I’d hit it,” he explained. “Then I hit 19.67 – gotta love it.” Despite the historic run, the teenager shows no intention of slowing down. “I’ve just turned 18, so I definitely think I can go faster,” he said. “It’s about building consistency and there’s no pressure – I’m the only one out there.” Looking ahead, Gout will compete in the under‑20 junior championships this week, opting to skip the 200 m in Queensland and focus on the 100 m. He will then travel overseas for a high‑profile showdown with Olympic champion Noah Lyles over 150 m at the Golden Spike meet in Ostrava, scheduled for June. Should Gout continue his upward trajectory, the athletics world may soon witness a new challenger to Bolt’s long‑standing age‑group record, reshaping expectations for the next generation of sprint talent.

History’s Greatest Fails pairs author Elizabeth Day with historian Dan Jones to explore celebrated historical missteps. After a witty reunion anecdote about their Cambridge days, the duo tackles the myth of Richard III’s villainy and promises a future episode on Henry VIII and Anne Boleyn, dubbed the "Ross and Rachel of early modern history."Strangely follows presenters Poppy Damon and Luke Jones as they plunge into off‑beat news stories, such as the macabre tale of a surgeon who amputated his own legs and the obscure origin of Neil Hopper’s "eunuch‑maker" moniker. The show balances factual depth with a tongue‑in‑cheek tone.Passenger Seat is a slow‑burn true‑crime podcast produced by Pennsylvania writer Tom Joudrey. The inaugural season recounts the 2012 kidnapping of Jennifer Hurst in Ohio, unraveling the puzzling motive behind the crime and the surprising gratitude she later expressed in court.Big Bro With Kid Cudi marks rapper Kid Cudi’s entry into the "celebrity podcast industrial complex". His first interview features Kylie Jenner, who drops the usual Kardashian PR veneer to discuss family dynamics, her upcoming acting role in the film The Moment, and a brief nod to Timothée Chalamet.Northern News reunites comedian Amy Gledhill with Ian Smith to spotlight odd and delightful headlines from the north of England that often slip under the radar. Regular contributors such as Stevie Martin, Alison Spittle and Phil Wang add extra comic flair.

Rory McIlroy has joined an elite club by defending his Masters crown at Augusta National, becoming just the fourth golfer ever to win the tournament back‑to‑back. The Northern Irish star edged out world No. 1 Scottie Scheffler by a single shot, marking his sixth major championship and cementing his place in golf history. Speaking after the victory, McIlroy emphasized that the win is a stepping stone, not a final destination. “I just won my sixth major and I feel like I’m in a really good spot with my game and my body,” he said. “I still have things I want to achieve and I want to enjoy the journey.” His parents, Rosie and Gerry, who missed the 2025 ceremony, were present this year, adding a personal dimension to the triumph. “It’s amazing to have them here,” McIlroy remarked, noting that their presence reinforced his motivation and gratitude. Despite the celebratory mood, McIlroy’s performance was far from flawless. He hit only 55% of fairways and recorded 48 of 72 greens in regulation over four rounds. A six‑shot lead after 36 holes evaporated by the 54‑hole mark, and a wayward drive into the trees on the final tee underscored the pressure he faced. Reflecting on the difficulty of the feat, McIlroy admitted, “I don’t make it easy. I used to win by eight shots in my early 20s. This year I realised it’s just really difficult to win the Masters.” He described the moment of uncertainty on the 18th tee as “the greatest stress,” highlighting the thin margin between victory and defeat. Looking ahead, McIlroy signaled that his ambitions extend beyond the Masters. While he plans to take a brief break, he dismissed the notion of a post‑victory lull, stating, “I don’t think I’ll go through that lull of motivation… I still want to enjoy it as well.” With his back‑to‑back Masters titles now secured, the golfer’s next targets remain speculative, but his confidence suggests a continued push for further major victories and possibly a career Grand Slam.

In a significant political shift, Hungary's opposition party Tisza, led by Peter Magyar, has emerged victorious in the parliamentary elections, defeating the ruling Fidesz party of Viktor Orban, who has led the country for 16 years.According to early results, Tisza is projected to win 52.49 percent of the vote, while Fidesz secured 38.83 percent. This outcome marks a substantial change in Hungary's political landscape.Conceding defeat, Orban stated that the situation was “understandable and clear,” and he congratulated Magyar on his success. In response, Magyar thanked Hungary for its support and confirmed Orban's congratulatory message.The international community has reacted positively to the election results. Estonia's Prime Minister Kristen Michal praised Hungarians for making a “historic choice for a free and strong Hungary in a united Europe.” European Commission President Ursula von der Leyen hailed Magyar's victory, saying, “Hungary has chosen Europe.”Similarly, France's President Emmanuel Macron, Germany's Chancellor Friedrich Merz, Lithuania's President Gitanas Nauseda, Norway's Prime Minister Jonas Gahr Store, and Poland's Prime Minister Donald Tusk have all congratulated Magyar and expressed their support for Hungary's commitment to European values.Ukraine's President Volodomyr Zelenskyy also welcomed the outcome, emphasizing the importance of cooperation and stability in Europe. He expressed readiness for meetings and joint work to benefit both nations and promote peace and security in Europe.