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Entertainment May 28, 2026

'Sexy as Hell': Filthy and Hilarious Heated Rivalry Parody Musical Arrives in New York

The unauthorized musical parody of the popular Canadian TV series 'Heated Rivalry' has opened in Ne…
The Rise of Heated Rivalry: From Canadian TV to NYC StageWalking into the Culture Club in West Chelsea, New York, for a performance of Heated Rivalry: The Unauthorized Musical Parody last week, I was met by three ghosts left over from when the space was called the McKittrick hotel and it hosted the immersive spookfest, Sleep No More. The first was the phantom of clever detail: cans of Athletic IPAs for sale, a cute, non-alcoholic nod to the mega-popular series' hockey setting. The second was of unnerving fright, as I realized there would be no booze at this singing satire. Would I be able to make it through 90 minutes of jokes about an overexposed Canadian gay sports romance, with zero quality guarantee and an even lower blood alcohol concentration? At least at the downtown premiere of the popular parody Titanique, long before it proved itself worthy of a handful of Tony nominations, you could stand up and order a bucket of White Claws.But then the third specter materialized, the ghost of immersion and surrender, as this very funny production completely won me over. (I've since learned that a liquor license is forthcoming.) Heated Rivalry, for the uninitiated, is a television show adapted from a series of gay romance novels by Rachel Reid, a straight woman who unwittingly launched a thousand discussions about who gets to be horny over whom, how and when. Fans of the books petitioned for a wider release of the show produced for the Canadian streamer Crave, last November and, some six months later, its formerly unknown stars Connor Storrie and Hudson Williams are in easy contention for the most photographed people alive. Heated Rivalry: The Unauthorized Musical Parody is the latest addition to New York City's musical parody cottage industry, which has led me to a theater lobby where a woman in a branded hockey jersey is telling the stranger next to her that she's seen the series "probably not as many times as you think, but still a lot".The Unauthorized Musical: A Masterclass in ParodyThere was a communal giddiness as everyone filed into the unassuming performance space, where less than 200 folding chairs were arranged around a small stage. Super-fans were giddy that their dreams were coming true, and the more reserved types, perhaps blushing at what they deemed beneath them, were still clearly enjoying themselves. I liked the TV show just fine, a bit underwhelmed at what was broadly discussed as "softcore smut" but felt more in line with the twee "naughtiness" of the romance world. I had worried a musical parody put together in a few months would be a cash-grab; plain fan service for those who can't get enough of those six novels or episodes, not jabbing at the culture so much as stroking its ego. Impressively, as written by Dylan MarcAurele and directed by Alan Kliffer, it satisfies all three camps.Framing is everything, and this romp begins with a faux earnest number, à la Waitress, where three suburban Susans detail their newfound pastime: putting their husbands to bed with some iPad time, knocking back an "Ambien margarita" and reveling in their favorite televised "boy aquarium". From there, "Main Susan" (Ryann Redmond, glorious) recaps the years-long flirtation between the feuding players, innocent Japanese-Canadian "Shane Hollander" (Jimin Moon) and brusque Russian "Ilya Rozanov" (Jay Armstrong Johnson).The obligatory double entendres (a song titled Shane Hollander, Slap that Stick! or a line, by Shane's mom, about the "heavy load" her obviously gay son carries) are expertly delivered right between earnestness and tongue-in-cheek, but it's MarcAurele's ability to mock the story's sillier elements that clinched it for me. Shane, whose thumb-twiddling submissiveness often grated me in the TV show, is played by Moon as a dopey bottom with a hopeless romantic complex. What the series plays out as a forbidden romance writ epic across timelines and borders, MarcAurele presents as Shane's borderline delusion in dealing with an uncaring dom for years on end. "I keep replaying things he said," Shane beams after a hookup, "like, 'Ass up, little whore.'" The score's best number, certainly the one best primed for cabaret nights anywhere, is Liza Minnelli's Maybe This Time send-up where Shane croons, "This fuck felt different from the last fuck. This fuck, he asked if I would stay."If reading that inspires eyerolls – totally – Moon (and the rest of the cast, which includes Cherry Torres and Ryan Duncan) are so winning in their deliveries, so in on the joke without reducing their project into one, that it's impossible to resist. As the icy-hot Ilya, Johnson has the less showy role and plays it mostly straight, which makes his song about an outcast childhood made tragic by his impossibly "big ass, cold heart" that much funnier. And, well, let's face it: Johnson and Moon are sexy as hell, and charming to boot. Kliffer's inventive staging, with choreography by Brooke and Tiffany Engen on a resourceful set by Sully Ross, goes long on bunny-hopping glee.The Off-Broadway Parody Boom: A New RenaissanceThe Canadian Kliffer, previously artistic director of famed improv spots like Second City and Asylum NYC, where he helped launch Titanique's improbable boom, later told me that these parodies rarely come together with such speed, let alone quality. He'd loved MarcAurele's Pop Off, Michelangelo! in London and M3gan spoof stateside, and had just bought into Heated Rivalry, courtesy of its amorously optimistic fifth episode, when the writer texted him with the idea. The resulting work fits attractively between the out-and-out bawdiness of the Titanic send-up and the relentless Millennial nostalgia of Ginger Twinsies, which parodied the 90s Parent Trap remake last summer, and Kliffer notes that this very queer, very funny moment downtown – which also includes Cole Escola's Oh, Mary! – points to "a little bit of an Off-Broadway renaissance."This particular renaissance seems to be defined by parodies that are loving but not saccharine, willing to mock their source material while still celebrating what made it appealing in the first place. The success of these shows suggests a hunger for theater that doesn't take itself too seriously but still delivers genuine theatrical craft. In a city where Broadway ticket prices can be prohibitive, these intimate, affordable productions offer a different kind of theatrical experience – one that feels more accessible and immediate.Cultural Impact: Beyond the ParodyHeated Rivalry exists at the intersection of several cultural conversations. The original series, based on novels by Rachel Reid, sparked discussions about who gets to tell LGBTQ+ stories and how those stories should be represented. The parody doesn't shy away from these questions but instead uses humor to explore them. By exaggerating certain elements of the original series, the musical actually highlights what made it compelling in the first place.The show also represents the growing visibility of LGBTQ+ stories in mainstream entertainment. What began as niche content has become a cultural phenomenon, with the original series gaining international attention and its stars becoming unlikely celebrities. The musical parody capitalizes on this popularity while simultaneously commenting on it, creating a meta-narrative that appeals to both fans and newcomers.Moreover, the success of Heated Rivalry reflects a broader trend in entertainment where audiences are increasingly drawn to content that acknowledges and plays with its own artificiality. In an era of heightened awareness about media consumption, audiences seem to appreciate works that don't pretend to be anything other than what they are – crafted, performed, and enjoyed.The Future of Parody Theater: What's Next?As the Off-Broadway scene continues to evolve with these clever parodies, we can expect to see more adaptations of popular TV shows and movies hitting the small stage. The success of Heated Rivalry, following in the footsteps of Titanique and other parody hits, suggests that there's a sustainable market for this type of entertainment.What's particularly interesting is how these parodies are pushing the boundaries of traditional musical theater. They're more immediate, more self-aware, and more willing to break the fourth wall than many conventional productions. This approach seems to resonate with younger audiences who are accustomed to interactive media and meta-commentary.Looking ahead, we might see parodies of other recent cultural phenomena – perhaps streaming hits, viral social media trends, or even political events. The key to success, as demonstrated by Heated Rivalry, will be balancing genuine affection for the source material with sharp, intelligent humor that offers something new to the conversation.
#Heated Rivalry #Musical Parody #New York Theater
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Environment May 28, 2026

Swimmers Disturb Wildlife at Hampstead Heath During Heatwave

Dozens of swimmers entered wildlife ponds on Hampstead Heath during record 35C temperatures, distur…
The LeadNature groups have pleaded with swimmers to give wildlife a wide berth after dozens of people swam in a nature pond on Hampstead Heath among nests of baby birds during record-breaking temperatures in London.The Wildlife Disturbance IncidentSwans and their 12-day-old cygnets were disturbed by hordes of splashing revellers in the north London park on Monday as London reached record 35C temperatures. In one video, a swan was seen poking an unhatched egg with its beak after it fell into the water during the chaos.Conservationists responded with dismay after a video was shared on social media of the scenes, which the City of London called "utterly appalling". Coots, moorhens and swans were seen guarding their eggs and young as people obliviously splashed around them.There are large signs around the pond urging people not to swim as it is a wildlife conservation area. The unseasonably hot weather has meant that people have been going into water sources en masse to cool off, coinciding with the nesting season for water birds.Conservation ConcernsThe RSPB said it was "a crucial time of year for breeding birds which just want to nest and care for their young in peace". The bird charity urged people to swim in authorised, lifeguarded spaces rather than nature reserves."Along with the dangers of swimming in unauthorised places, there is a significant risk of disturbing wildlife. Many species are already under huge pressure and disturbance can make a parent abandon their nest, putting eggs and chicks at risk. Everyone has a part to play in protecting nature so we'd urge people to be responsible and give birds and other wildlife plenty of space when outdoors this summer," it said.Swans of Hampstead Heath, the Instagram account that raised the alarm about the birds, posted: "We are currently in peak nesting season. There are still eggs waiting to hatch, ducklings and chicks only days/weeks old, and for the first time in years, swans have successfully nested on this pond, with cygnets now just 13 days old. Restricting these birds to a small section at the back of the pond makes it incredibly difficult for them to access the natural food they need to survive."When nests are disturbed, the adult birds often flee, leaving their young to be eaten by predators or die of starvation.Official Response and EnforcementThe chair of the City of London Corporation's Hampstead Heath, Highgate Wood and Queen's Park committee, alderman Gregory Jones KC, said: "The recent conduct of some visitors swimming in non-lifeguarded ponds is utterly appalling. Entering other non-lifeguarded water bodies is extremely dangerous, against our bylaws, and causes significant harm to wildlife habitats.""We always seek to engage with visitors first, but the constabulary will take enforcement action where necessary, including issuing fines or making arrests."Broader Environmental ContextThe nature campaigner and barrister Paul Powesland said: "I am not defending the people in the video, but scenes like this are an almost inevitable consequence of the destruction of outdoor lidos and the poisoning of rivers across London. It's madness for a city the size of London to have only one set of wild swimming ponds; conveniently located in one of the wealthiest areas."There have, however, been warnings of cold water shock and drownings as lakes, rivers and the sea are much colder than the air temperatures at present.
#Hampstead Heath #wildlife conservation #heatwave
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Sports May 28, 2026

Bosnia's Unexpected Journey to World Cup 2026

Bosnia and Herzegovina's surprising qualification for the 2026 World Cup, their journey under coach…
Bosnia's Unexpected World Cup JourneyBosnia and Herzegovina's qualification for the 2026 World Cup comes as a surprise to many observers. A team that had managed only four wins in their previous 19 matches across two qualification cycles reached a turning point when Sergej Barbarez took over in 2024. The campaign that followed was chaotic, emotional and occasionally irrational, which still feels like the most authentic description of Bosnian football itself. Barbarez's side somehow found a way through it all, eliminating Wales and Italy in dramatic playoffs and reaching the World Cup for only the second time in the country's history.The Barbarez RevolutionThe former captain had waited years for the job, so long that he had not coached anywhere in the meantime. He played professional poker and enjoyed retirement before the Bosnian FA finally got in touch. He gathered close friends and former teammates around him: Emir Spahic became sporting director, while Sasa Papac and Zlatan Bajramovic joined the coaching staff. In Barbarez's first year, 16 players made their debuts, most of them raised and developed abroad, from Sweden and Germany to Austria and the United States. That became the foundation of this new Bosnia side.Group B Fixtures12 June v Canada, Toronto (3pm local, 8pm BST)18 June v Switzerland, Los Angeles (noon local, 8pm BST)24 June v Qatar, Seattle (noon local, 8pm BST)The Coach's PhilosophyBosnia do not play especially beautiful football under the coach and systems change regularly – usually between 4-2-3-1 and 4-4-2 – but formations quickly become secondary once matches turn emotional, and with Bosnia they usually do. The team's identity is built around aggressive defending, direct football and quick transitions. Barbarez may have gone winless in his first eight matches and come under heavy criticism, but he insisted that he first needed to rebuild the squad's mentality.The Poker Coach Who Became a National HeroSergej Barbarez spent years criticising the way Bosnian football was run and had almost stopped expecting the call from Sarajevo altogether, having first expressed an interest in the role in 2009. Fifteen years later he took charge of the national team – with no previous coaching experience – for the first team against England at the age of 52. A former captain and cult figure, Barbarez arrived promising honesty, emotional connection and a complete reset after years of dysfunction around the national team. After playoff victories over Wales and Italy, his status only grew further; the win against Italy transformed him from poker-playing outsider into one of Bosnia and Herzegovina's most important ever sporting figures.The Veteran Leader: Edin DzekoThere are normal footballers and then there is Edin Dzeko. Even at 40, everything still somehow revolves around Edin. Bosnia and Herzegovina's captain remains the country's greatest footballer, their all-time leading goalscorer and the reference point of an entire generation. Younger players in the squad speak about him with a reverence bordering on disbelief. Dzeko no longer dominates matches physically the way he once did at Wolfsburg or Manchester City, but his understanding of space, timing and pressure moments remains elite. During the playoffs he again delivered when Bosnia needed him most. "As long as I feel I can help, I'll be here," he said recently. Bosnia would not be at this World Cup without him.The Rising Star: Kerim AlajbegovicKerim Alajbegovic, at 18, may already be the most naturally gifted attacking talent Bosnia and Herzegovina have produced since Miralem Pjanic. The midfielder, who spent a season with Red Bull Salzburg before Bayer Leverkusen triggered a buyout clause, is arriving at the tournament with the fearless attitude some players have at that age. It is not only his technique that stands out, but his personality too. Barbarez trusted the 18-year-old to take penalties in both playoff shootouts – and Alajbegovic responded with complete calmness. Elegant between the lines and fearless in possession, he feels like the face of Bosnia's next generation.The Unsung Hero: Tarik MuharemovicBosnia and Herzegovina spent years producing centre-backs who defended first and worried about the football later. However, Tarik Muharemovic feels like the first one shaped by an entirely different mindset. Born in Slovenia and developed in Austria before moving through Italian football with Juventus and Sassuolo, the left-footed defender has quietly become one of the players Barbarez trusts most. He is not especially loud, aggressive or dramatic, which, for a defender, normally makes people in Balkan football suspicious. Instead Muharemovic solves problems calmly, carries the ball forward and gives Bosnia something they lacked for years – composure.Tournament OutlookBosnia are unlikely to dominate many matches in Group B – against Canada, Switzerland and Qatar – but they have enough quality, emotional energy and unpredictability to become one of the tournament's more uncomfortable teams. With a blend of experienced leadership in Dzeko and emerging talent in Alajbegovic, Barbarez has created a squad that embodies the chaotic yet passionate spirit of Bosnian football.
#Bosnia and Herzegovina #World Cup 2026 #Sergej Barbarez
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Health May 28, 2026

Milking It: Inside America’s Lactation Rooms – In Pictures

The Guardian’s photo‑essay offers a visual exploration of lactation rooms across American workplace…
Visual Tour of U.S. Workplace Lactation Spaces The photo series walks readers through a variety of lactation rooms, from sleek corporate suites to modest community‑center setups. Each image captures the balance between privacy, comfort, and functionality that employers aim to provide. Privacy: Curtains, lockable doors, and sound‑proofing are common features. Comfort: Reclining chairs, footrests, and adjustable lighting appear in most locations. Convenience: Nearby sinks, refrigeration for milk storage, and charging outlets support daily nursing routines. Why Lactation Rooms Matter for Employee Well‑Being Beyond aesthetics, these spaces address critical health and equity concerns. Providing dedicated rooms helps reduce stress for nursing parents, supports infant nutrition, and aligns with broader diversity‑inclusion goals. Improved maternal health outcomes by facilitating continued breastfeeding. Enhanced employee retention as parents feel valued and supported. Compliance with state and federal regulations that mandate reasonable accommodations for nursing mothers. Future Outlook for Workplace Breastfeeding Support As more companies publicize their family‑friendly policies, the visual narrative suggests a trend toward standardized, high‑quality lactation environments. Continued advocacy and policy reinforcement are likely to expand access, especially in smaller firms and remote work settings.
#The Guardian #lactation rooms #workplace wellness
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Tech May 28, 2026

Snowflake and AWS Forge a $6B AI Infrastructure Alliance

Snowflake and AWS have locked in a landmark $6 billion, five-year agreement that prioritizes AWS's …
The Strategic Shift Toward Custom Silicon Snowflake's decision to deepen its reliance on AWS is driven by the explosive demand for AI processing power. The deal specifically targets AWS's proprietary Graviton ARM-based CPUs, which are increasingly vital for the inference and agent phases of AI workflows that GPUs cannot handle alone. By integrating Snowflake's Cortex AI tool, the partnership aims to streamline data operations, allowing enterprises to query databases using natural language and generate automated reports more efficiently. Financial Implications of the AI Boom This contract represents a massive financial milestone. While AWS has generated $7 billion from Snowflake since 2012, this new deal brings the total value to nearly the same level in a single contract. Furthermore, Snowflake reports that AWS spending has doubled in 2025 to $2 billion annually, highlighting the rapid monetization of AI tools. This data confirms that enterprises are aggressively accelerating their cloud spending to stay competitive in the generative AI era. Disruption in the AI Chip Market The move signals a broader trend where cloud providers are weaponizing their own hardware to undercut Nvidia. By offering "better price-performance," AWS aims to capture market share from Nvidia, a strategy already seen with Meta. This creates a bifurcated market where companies can choose between Nvidia's training dominance and AWS's cost-effective inference capabilities. The reliance on Graviton chips offers a more affordable option for cloud providers, allowing them to pass savings directly to customers. The Future of the AI Compute War As AI agents become more prevalent, the demand for high-performance CPUs will skyrocket. We can expect more multibillion-dollar contracts like this one, forcing Nvidia to innovate aggressively with its own Vera chip. The cloud giants are effectively building their own ecosystems, making it harder for third-party hardware vendors to maintain a monopoly. The winners in this space will be the companies that can optimize their data infrastructure for the specific chips they are using.
#Snowflake #AWS #Graviton
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World Wide May 27, 2026

Eid Celebrations in Gaza Overshadowed by Israeli Attacks

Muslims in Gaza attempted to celebrate Eid al-Fitr amid ongoing Israeli attacks, with festivities s…
The Holy Celebration Amidst Conflict Muslims in Gaza attempted to observe Eid al-Fitr, the festival marking the end of Ramadan, under the shadow of continued Israeli military operations. Despite the significance of the religious holiday, celebrations were muted as families grappled with safety concerns, displacement, and limited access to basic necessities. Restricted Festivities in War-Torn Region Traditional Eid activities, including communal prayers, family gatherings, and festive meals, were severely hampered by the ongoing conflict. Many Gazans remained in shelters or avoided public spaces due to the constant threat of airstrikes and ground operations. The usual joy and communal spirit of the holiday were replaced by anxiety and uncertainty as residents navigated the dual challenges of observing religious traditions while ensuring their safety. Humanitarian Crisis Deepens The conflict has exacerbated an already dire humanitarian situation in Gaza, with critical shortages of food, clean water, medical supplies, and fuel. International aid organizations have reported increasing difficulties in delivering assistance as infrastructure continues to be damaged. The Eid period, typically a time of abundance and sharing, has instead highlighted the scarcity and suffering experienced by the civilian population. Regional Tensions Escalate The timing of the Israeli operations during Eid has drawn condemnation from various regional actors and international observers. The conflict has contributed to rising tensions across the Middle East, with neighboring countries expressing concern over the potential for wider regional destabilization. The situation has also sparked renewed debates about the Israeli-Palestinian conflict and the prospects for a lasting peace agreement. International Response and Future Outlook Global powers have called for de-escalation and increased humanitarian access to Gaza, though diplomatic efforts have yet to produce a ceasefire. The continuation of hostilities during Eid has complicated international mediation efforts and may influence future relations between Israel and neighboring countries. As the conflict persists, the immediate future remains uncertain for Gazans caught between religious observance and the harsh realities of war.
#Gaza #Eid #Israeli attacks
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Science May 27, 2026

China's Historic Shenzhou-23 Mission: A Year in Orbit for Lunar Ambitions

China has launched its Shenzhou-23 mission with three astronauts to the Tiangong space station, mar…
The Lead: China's Bold Leap into Long-Duration SpaceflightChina has launched its Shenzhou-23 mission in which an astronaut will spend a full year in orbit for the first time, a crucial step in Beijing's ambition to send humans to the moon by 2030. The Long March 2-F rocket lifted off from the Jiuquan launch centre in north-western China on Sunday, carrying three astronauts to the Tiangong space station.The Mission Details: Historic Crew CompositionThe mission marks the first spaceflight ever undertaken by an astronaut from Hong Kong: Lai Ka-ying, 43, who previously worked for the territory's police. The other crew members are the space engineer Zhu Yangzhu, 39, and the former air force pilot Zhang Zhiyuan, also 39, who will be travelling into space for the first time.The Scientific Objectives: Preparing for Deep SpaceThe crew is expected to undertake numerous scientific projects in life sciences, materials science, fluid physics and medicine. A key experiment will be the full-year stay in orbit by one of the crew to study the effects of a long stay in microgravity, part of China's preparations for future lunar and possible Martian missions.Richard de Grijs, an astrophysicist and professor at Macquarie University in Australia, said the main challenges would be long-term effects on humans, including bone density loss, muscle wasting, radiation exposure, sleep disturbance and behavioural and psychological fatigue. He also underlined the importance of reliable water and air-recycling systems and the ability to manage potential medical emergencies far from Earth.The Lunar Ambitions: China's Moon RoadmapThe Shenzhou-23 mission is part of China's goal to land astronauts on the moon before 2030 in a race with Nasa's Artemis programme. Beijing is also testing the equipment required to reach its goal, with an orbital test flight of its Mengzhou spacecraft set for 2026. It will replace the ageing Shenzhou line and will carry China's astronauts to the moon.China hopes to have built the first phase of a manned scientific base, known as the International Lunar Research Station, by 2035. It also plans to welcome its first foreign astronaut, from Pakistan, to the Tiangong station by the end of this year.The Global Context: China's Space Program EvolutionBeijing has significantly expanded its space programmes over the last 30 years, injecting billions of dollars in a push to catch up with the US, Russia and Europe. It landed the Chang'e-4 probe on the far side of the moon, a world first, in 2019, and a rover on Mars in 2021.China has been formally excluded from the International Space Station since 2011, when the US banned Nasa from collaborating with Beijing, prompting it to develop its own space station project. This isolation has accelerated China's indigenous space capabilities, making the Shenzhou-23 mission a milestone in both scientific achievement and geopolitical space competition.
#China #Space #Shenzhou-23
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Science May 27, 2026

The $240M Renaissance of the La Brea Tar Pits: A Window into the Ice Age

The La Brea Tar Pits and Museum in Los Angeles is undergoing a massive $240 million renovation to m…
The Urban Pompeii of Los AngelesThe La Brea Tar Pits and Museum, a cornerstone of Los Angeles' cultural landscape, is preparing to close its doors in July 2026 for a comprehensive overhaul. This $240 million renovation aims to reimagine the visitor experience while preserving the site's status as the world's only urban, active ice age excavation site.A $240M Transformation of the Ice AgeThe project, led by the Natural History Museums of Los Angeles County and designed by the New York firm Weiss/Manfredi, will transform the interior exhibition spaces and the surrounding 13-acre park. New walkways and bridges are planned to create a dynamic environment, though the existing structure will remain largely intact.Project Timeline: Closing in July 2026, reopening in 2028.Design Firm: Weiss/Manfredi (known for Brooklyn Botanic Garden and Olympic Sculpture Park).Scope: Interior updates, landscape features, and new bridges.Preserving the Past: The Value of the CollectionThe site holds over 2 million fossils, including mastodons and saber-toothed cats. The preservation quality is exceptional, retaining collagen for accurate carbon dating, which provides invaluable data on the past ecosystem. The site is often described as "Pompeii, but in the middle of a massive city."Bridging the Gap Between Science and SocietyEmily Lindsey, the museum's associate curator, emphasizes the site's critical role in scientific literacy. It offers a unique opportunity to showcase the scientific process publicly, countering current mistrust of science by making it accessible and understandable to the public.The Future of Urban PaleontologyThe reopening in 2028 is expected to set a new standard for urban natural history museums, potentially increasing attendance and serving as a model for integrating scientific research directly into public spaces.
#La Brea Tar Pits #Los Angeles #Paleontology
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Business May 27, 2026

BioOrbit Launches Box‑E to Grow Ultra‑Pure Cancer Drug Crystals in Space

UK biotech startup **BioOrbit** sent its microgravity‑crystallisation unit **Box‑E** to the Interna…
On 15 May, **BioOrbit** launched its compact **Box‑E** payload aboard a **SpaceX** rocket, beginning a six‑week orbital trial to grow ultra‑pure protein crystals for self‑injectable cancer therapies. Box‑E’s Orbital Test: Microgravity Enables Ultra‑Pure Protein Crystals The microwave‑sized unit will float aboard the International Space Station, where microgravity eliminates the disruptive effects of Earth’s gravity on crystal formation. The resulting crystals are more stable, allowing drug formulations that are impossible to achieve on the ground. Mission duration: ~6 weeks in orbit Target output: thousands of litres of fluid per box per year Goal: Produce cancer‑drug crystals that can be stored in a fridge and self‑injected £9.8 Million Funding Round and UK Space Agency Contract Last month **BioOrbit** closed a **£9.8 million** Series A round led by **LocalGlobe** and **Breega**, earmarked for the orbital test and scaling of the hardware. Earlier in March the company secured a **£250,000** contract from the UK Space Agency to manufacture drugs in microgravity. Potential Disruption of Cancer Treatment Delivery Current immunotherapies such as Merck’s **Keytruda** require lengthy IV infusions in hospitals. By crystallising the active protein, **Box‑E** could enable high‑concentration, low‑viscosity formulations suitable for pen‑injectors, reducing treatment time from hours to minutes and extending shelf‑life. Roadmap to Commercialisation and Market Size **BioOrbit** projects that, if orbital tests succeed, multiple **Box‑E** units could be stacked to meet the demand of a blockbuster drug within a handful of boxes. The company estimates a market of **$22.7 trillion** for in‑space manufacturing across sectors, with pharmaceuticals a key segment. Clinical trials and regulatory approval are expected to take at least five years before the new formulations reach patients. Future Outlook for Space‑Based Pharma Beyond cancer, the crystallisation platform could be applied to the roughly 70 % of top‑selling drugs that are currently administered intravenously. Partnerships with major pharma groups are already being explored, and competitors such as **Varda Space Industries** are also pursuing in‑orbit drug processing, signaling a burgeoning industry.
#BioOrbit #Box‑E #SpaceX
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