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Breakthrough Cancer Drug Reveals Hidden TumorsA smart drug that stops cancer cells "hiding" from treatment can shrink tumours by at least 30% in six of the world's most common forms of the disease, according to early trial results. While immunotherapy treatments have improved survival rates for many patients, their effectiveness can stall or fail when tumour cells hide and then spread.How the Smart Drug WorksResearchers in Oxford have developed a drug designed to stop cancer cells concealing themselves from the immune system, allowing immunotherapy treatments to identify and destroy them. In a trial spanning the UK, France, Spain and Australia, 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers were given the experimental drug, GRWD5769, alongside the immunotherapy treatment cemiplimab.The smart drug was able to remove "invisibility cloaks" from tumour cells, exposing them to the parts of the immune system that attack infections and diseases. This allowed the cemiplimab immunotherapy to pinpoint and destroy the cancer.Trial Results Across Cancer TypesResearchers, led by the Christie NHS foundation trust in Manchester, England, found that tumours shrank in 26 patients. Of those, 15 experienced tumour reductions of at least 30%. All participants had previously failed to respond to treatment, and most had no options left when they joined the study.GRWD5769 was shown to shrink tumours in all six cancer types included in the trial. The drug halted progression of the disease for at least six months in 18% of cervical cancer patients, 32% of liver cancer patients, 36% of bladder cancer patients, 38% of those with neck and head cancer, and more than half of bowel (51%) and lung (55%) cancer patients.Significance for Cancer TreatmentImmunotherapy enlists T-cells – immune system cells that attack infections and diseases – to hunt and destroy cancer. Although it has revolutionised cancer care, it fails in about two-thirds of patients. This is because immunotherapy struggles when tumours hide from the immune system.Tumours can evade the immune system by manipulating an enzyme called ERAP1 (endoplasmic reticulum aminopeptidase 1). By altering this enzyme, cancer cells can hide from a patient's T-cells. GRWD5769 solves this problem by inhibiting ERAP1, which removes cancer's invisibility cloak and makes tumour cells visible to T-cells that could not previously find them.Future Outlook for Cancer TreatmentThe findings were presented at the American Society of Clinical Oncology's annual meeting in Chicago, the world's largest cancer conference. Prof Fiona Thistlethwaite, the principal investigator, noted: "For a drug that is given as a tablet, this is very impressive. It's early days, and we need further studies, but this is a new drug with a new mechanism that clearly helps immunotherapy perform more effectively."The tablets, which were developed by Oxford-based Greywolf Therapeutics and were tolerated well by patients. The trial remains ongoing, with a larger study planned. Cancer Research UK's research information lead, Dr Samuel Godfrey, noted: "Immunotherapy has transformed treatment for some cancers but it doesn't yet work for everyone. This trial seems to show how this new drug could make immunotherapy more effective, including in some cases where immunotherapy had previously failed."

The Lead Israel's expanding military offensive in southern Lebanon has devastated centuries of history, with many treasured archaeological and cultural sites lying in the path of the invasion. Despite a so-called ceasefire, Israeli forces have captured key historical sites, including the 900-year-old Beaufort Castle. Destruction of Historical Sites Lebanon's landscape is layered with thousands of years of history, but the ongoing conflict has put many of its most treasured sites in danger. The ancient city of Tyre, a UNESCO World Heritage Site, has been affected by Israeli attacks, with bombings falling close to its ruins. The medieval Beaufort Castle, overlooking Nabatieh, was directly hit. Lebanon's Cultural Heritage at Risk Lebanon currently has six UNESCO World Heritage Sites, including Tyre, which contains the remains of one of the most important cities of the ancient Phoenician world. The country's Culture Minister, Ghassan Salame, warned that Israeli attacks on the south are putting heritage sites in 'serious danger'. Over 200,000 people have been displaced from Tyre and its surrounding area, with over a million displaced across Lebanon. UNESCO Enhanced Protection Lebanon is home to at least 39 cultural sites granted provisional enhanced protection by UNESCO. Several of these sites are in the south, in areas affected by the ongoing Israeli military operations. The designation provides the highest level of legal protection for cultural heritage under international law. Notable Protected Sites Beaufort Castle: A 12th-century Crusader fortress perched 700 meters above southern Lebanon. Temple of Eshmun: A Phoenician healing site near Sidon, dedicated to the god Eshmun. Historic Centre of Saida (Sidon): A historic port city with ancient tell, fishing harbor, and sea and land castles. Chhim Archaeological Site: A Roman and Byzantine village in the Chouf region. The Chehabi Citadel: A Crusader stronghold and seat of power for the Chehab emirs. Qabr Hiram (Tomb of Hiram): A monumental stone tomb associated with the Phoenician king of Tyre. The Future of Lebanon's Heritage The destruction of Lebanon's cultural heritage has significant implications for the country's identity and history. As the conflict continues, there is a growing concern about the long-term impact on Lebanon's rich cultural legacy.

Pelé’s 1958 World Cup Shirt Goes to AuctionPelé’s legendary blue No 10 shirt, worn when the 17‑year‑old scored twice in Brazil’s 5‑2 victory over Sweden, is expected to fetch over $6 million (£4.5 million) at a Sotheby’s sale in New York next month.Historic Significance of the Blue No 10 JerseyThe shirt represents the moment Brazil won its first World Cup, cementing Pelé’s place in football history. After the final, Pelé gave the shirt to teammate Didi, whose family kept it until it was donated to the Museu dos Esportes Edvaldo Alves Santa Rosa in 1993.1958 World Cup final – Brazil 5, Sweden 2Pelé scored two goals at age 17Shirt remained in private hands for three decades before entering a museum collectionValuation and Comparable Sales Highlight Market SurgeSotheby’s estimates the final price will be nearly 100 times the £59,000 it fetched at a Christie’s London auction in 2004. For context:Diego Maradona’s “Hand of God” jersey sold for $9.3 million in 2022Lionel Messi’s six Qatar‑2022 shirts fetched $7.8 million in 2023Sports‑memorabilia market has grown dramatically over the past five years, according to Sotheby’s vice‑president of sport strategy Brendan HawkesWhat the Sale Means for the Sports Memorabilia MarketThe anticipated price places the Pelé shirt among the most valuable single‑item football artefacts, signalling strong collector appetite for historically pivotal pieces. Hawkes notes that the market’s “boom” is driven by a blend of nostalgia, scarcity, and the cultural weight of iconic moments.Outlook: Future Prices and Collector TrendsIf the shirt reaches or exceeds the projected £4.5 million, it will set a new benchmark for vintage football apparel, likely encouraging auction houses to seek other early‑era items. Analysts expect continued price inflation as younger fans, now affluent, enter the market and as institutions digitise provenance records, further legitimising high‑value sales.

A 68‑year‑old metal‑detecting enthusiast from Somerset has unearthed a rare gold Roman ring, prompting a £78,000 acquisition by the South West Heritage Trust and sparking new insights into late‑Roman life in southern England. The Unexpected Discovery of a Gold Roman Ring in Somerset While scanning a field near Ilminster, Kevin Minto initially thought he had found a coin, then a brooch, before realizing the object was an exquisitely crafted gold ring. Dating to around AD 297, the ring weighs 48 g and features an intaglio gemstone depicting the goddess Victoria in a two‑horse chariot. Location: fields near Ilminster, Somerset Discoverer: Kevin Minto, former soldier and lorry driver Companion find: a hoard of 297 Roman coins and other artefacts Initial reaction: “It was like being hit by an express train,” Minto recalled £78,000 Acquisition and the Economic Ripple for the Finders The South West Heritage Trust announced it had purchased the ring and the associated coin hoard for £78,000. The payment was split between the landowner and Minto, who shared his half with a fellow detectorist. The windfall allowed Minto to clear his mortgage and reduce his lorry‑driving schedule. Purchase price: £78,000 Mortgage paid off for Minto Reduced driving to four days a week, with a plan to cut to three Landowner received 50% of the proceeds Heritage Significance and What It Reveals About Late Roman Somerset Senior curator Amal Khreisheh described the ring as “unparalleled” for Britain, noting its large size, heavy gold content, and sophisticated intaglio work. The find suggests the presence of wealthy Romans—perhaps a governor, merchant, or large landowner—in the Ilminster area during a period of unrest (286‑296 AD). It also highlights important trade routes that passed through south Somerset. Rare combination of large gold mass and intricate gemstone engraving Potential ceremonial or high‑status personal use Provides clues to Roman economic activity and social hierarchy in the region Future Plans: Tours, Education, and Ongoing Research The ring will embark on a primary‑school tour this month and feature in an “Ilminster Ring Discovery Day” at the town’s art centre in August. Its permanent home will be the Museum of Somerset in Taunton. Further metallurgical analysis is planned to determine whether the gold was sourced locally or imported, and archaeologists hope to link the ring to the lead‑lined coffin found nearby. School‑tour itinerary across Somerset primary schools Permanent display at the Museum of Somerset Upcoming scientific analysis of gold composition and gemstone origin Potential excavation of related burial sites

The Birth of a Classic The Bluetones' lead singer Mark Morriss and guitarist Adam Devlin share the story of their hit song 'Slight Return', from its humble beginnings to its massive success in the 90s. Mark Morriss' Vocals and the Song's Early Days We were still a three piece: Adam Devlin, my brother Scott and myself. We hadn’t met Eds Chesters yet, so we didn’t have a drummer. We were spending a lot of time writing songs, trying to hone this west coast, mid-60s, Crosby, Stills & Nash sound – even though it was the 90s and we were from Hounslow in London. Slight Return was the fourth or fifth song we wrote. Scott wrote the chord progressions and structure, but didn’t have any words or melody. He recorded guitar into a cassette player, then played that back on a second cassette player so he could record himself playing along to what he’d just recorded, in a very rudimentary way of four-tracking. We liked it, but we weren’t skipping around the room going: “My God, we’re going to be millionaires.” That came later. The Song's Rise to Fame It went down well at our early shows. It was catchy and memorable. We recorded a demo version and sold it on blue 7-inch vinyl at our gigs. When we got signed to A&M, they were keen for it to be a single, but we felt like it would be short-changing our fanbase, which was about 200 people, who had already bought it. We had to be talked around by the label, who said: “We can hear it being played on the radio.” But they wanted us to change the song’s name because Slight Return isn’t actually in the lyrics. The title in part refers to the last line of the song: “I’m coming home but just for a short while.” It’s also a kind of sideways tribute to Jimi Hendrix’s Voodoo Child (Slight Return). When we finally succumbed and let them release it as a single, lo and behold, it went ballistic. Adam Devlin's Perspective on the Band's Journey We thought we could write half-decent songs, so we cobbled together a set that would get us on the London circuit. I remember Scott bringing in a faster, simpler version of Slight Return. I fleshed out the guitar parts and put in a guitar solo. Mark worked out the vocal melodies, and we added a coda – the instrumental that fades out at the end, which originally had a sample from Tom Courtenay in Billy Liar, which was all very 60s. We had very different ideas from the record label and thought Can’t Be Trusted should have been the single. By then, I was living in another shared house in Wimbledon that didn’t have a washing machine. I was in the launderette when our manager phoned and said: “You’ve gone in at No 2.” I don’t think we were ready for it being so successful. The Legacy of Slight Return We've been playing it for 30 years. One tour, we’d got so bored with it, we didn’t even play it, which was a mistake because people thought we’d gone up our own arses. We learned our lesson: it’s the song everyone wants to hear. People get confused because Slight Return isn’t actually in the lyrics. I was at a farmers’ market recently when one of the stallholders said: “You were in that band who sang Where Did You Go?” I said: “Yes, but that’s not what it’s called.”

Lead: A Literary Voice Finds Moral Guidance in the Vatican’s AI EncyclicalIn a recent Guardian column, Francine Prose expresses gratitude to Pope Leo XIV for his extensive encyclical, Magnifica Humanitas: On Safeguarding the Human Person in the Time of Artificial Intelligence. She argues that the Pope’s moral framing offers a useful counter‑point to the prevailing techno‑optimism that dominates discussions about AI’s creative potential. Pope Leo XIV Issues a Groundbreaking AI EncyclicalThe Vatican’s new letter, spanning more than 40,000 words, tackles both the promises and perils of rapidly evolving artificial intelligence. It opens with a biblical analogy—choosing between a modern Tower of Babel or a city where “God and humanity dwell together”—and proceeds to trace the Church’s historical stance on labor, authority, and scientific progress. Key Data Points from the EncyclicalLength: > 40,000 words (approximately the size of a short novel)Chapter 3 titled “Technology and Dominance: The Grandeur of Humanity in Light of the Promises of AI”Explicit warnings about AI used solely to maximize profit, manipulate privacy, and exacerbate economic inequality Impact Analysis: Moral Framing Meets AI GovernanceThe encyclical’s central claim—that AI lacks experience, embodiment, and moral conscience—reinforces a growing call for human‑centered AI policy. By positioning AI as a tool that can amplify existing power imbalances, the Pope adds a religious‑ethical voice to debates traditionally dominated by technologists, legislators, and industry leaders. This could influence future regulatory approaches, especially in regions where the Catholic Church holds cultural sway. Future Outlook: How Religious Ethics May Shape AI DevelopmentProse notes that while the document may not halt AI‑driven profit motives, it provides a framework for civil society to demand accountability. If embraced by policymakers, the encyclical could inspire legislation that protects privacy, safeguards employment, and ensures AI serves the common good rather than a privileged few. Conversely, pushback from Silicon Valley suggests a contested path ahead, with tech leaders questioning the Vatican’s technical expertise. Conclusion: A Call for Human‑Centred InnovationUltimately, Prose argues that the Pope’s vision—rooted in compassion, justice, and the intrinsic value of human relationships—offers a “beneficent” compass for navigating AI’s ethical terrain. Whether the Church’s moral authority will translate into concrete policy remains uncertain, but the encyclical undeniably enriches the global conversation about technology’s role in society.

The Significance of Eid al-Adha Muslims around the world have begun celebrating Eid al-Adha, the “Festival of Sacrifice”, which falls on the 10th day of Dhul Hijjah, the 12th and final month of the Muslim lunar calendar. The Hajj Pilgrimage One of the biggest holidays in the Muslim calendar, it coincides with the last day of the annual Hajj pilgrimage in Saudi Arabia. More than 1.7 million people are taking part in the Hajj this year, slightly up from 2025. Celebrations Amid Challenges In Gaza, where Israel’s months-long offensive has devastated neighbourhoods and displaced most of the population, many families are marking Eid in tents and crowded shelters, with little meat or festive clothing. The Rituals of Eid al-Adha Eid al-Adha commemorates the Quranic story of Prophet Ibrahim’s willingness to sacrifice his son Ismail as an act of obedience to God. The day is marked with the sacrifice of an animal – usually a sheep, goat or cow – and the distribution of its meat among family, neighbours and those in need. The Global Observance On Tuesday, pilgrims prayed on Mount Arafat, where Prophet Muhammad is believed to have delivered his final sermon. They then spent the night out in the open at Muzdalifah, halfway between Arafat and Mina, where they collected pebbles for the symbolic stoning of the devil.

The Rise of AI-generated History Influencers “I have just arrived in Tudor London, 1536,” a young woman in a green puffer jacket tells the camera. “I’m going to check in at my room in the inn, get into the market. Then, later I am meeting the actual king – yep, Henry VIII – in person.” On YouTube and other social platforms, users are flocking to watch AI-generated “history influencers”, characters that vlog their travels to historical settings. The Popularity of Chloe VS History One of the most popular channels is Chloe VS History, with more than 610,000 Instagram followers and 15m views on YouTube. Viewers can watch Chloe try eel pie at a Tudor market, explore the first-class suites on the Titanic and take a plunge in an ancient Roman bath. The format has been replicated by other channels, such as Janella Through Time, Nova VS History and Esmetimetravels. Popular destinations include ancient Rome, Pompeii, the wild west and England during the Black Death. The Creator's Vision The creator of Chloe VS History, 32-year-old Jonathan Laramy, said the goal was to “get younger people more interested” in different periods of history. “History is a very visual experience, but it’s just not taught that way,” he said. “It’s taught via a textbook. And that is not compatible with lots of students. So why not use the technology we have to bring that to life in a really visceral way? The Impact on History Education Adam Smith, a historian at Oxford University, believes the format could “massively enhance” how history is taught to young people. “What these AI [videos] are doing is connecting with that visceral, tangible sense of: ‘Oh my God, that could have been me, that was an earlier version of me.’ It’s quite a deep-seated psychological need in many people, to understand themselves in time.”

The Wigmore Hall's 125th Anniversary Celebration Wigmore Hall, a renowned venue for classical music, marked its 125th anniversary with a special gala concert. The event was a partial recreation of the hall's inaugural concert in May 1901, which featured a starry lineup including Ferruccio Busoni and Eugène Ysaÿe. A Tribute to the Past The concert began with a performance of the national anthem, 'God Save the King,' followed by a new piano version of Thomas Adès' 2023 guitar piece 'Vesper (for Henry Purcell).' Adès also performed Beethoven's Op. 109 piano sonata, which showcased his dramatic and polished style. Musical Highlights Thomas Adès performed a new piano version of his 2023 guitar piece 'Vesper (for Henry Purcell)' and Beethoven's Op. 109 piano sonata. Louise Alder and pianist Joseph Middleton performed three Schubert songs, ending with 'Erlkönig,' which was almost like a mini-opera. Alina Ibragimova played the second half of Bach's first Partita for solo violin, in B minor, with freshness, precision, and elegance. Cédric Tiberghien joined Ibragimova for Beethoven's Romance in G and performed Brahms's Paganini Variations. The Venue's Legacy Wigmore Hall has a rich history dating back to 1901 when it was built by Bechstein, a piano manufacturer. The hall has continued to host concerts through the years, including performances by notable artists like David Bowie. Despite facing economic challenges, the venue remains a London home for solo recitals, chamber music, and song. Looking to the Future The Wigmore Hall's 125th anniversary festival continues until June 7, with all concerts being broadcast on BBC Radio 3 and available on BBC Sounds for 30 days. This celebration is a testament to the venue's enduring legacy and its commitment to showcasing classical music.