Health
Jun 17, 2026
Antidepressants and Antipsychotics as Opioid Alternatives for Pain Relief
A new study suggests that antidepressants and antipsychotics could serve as alternatives to opioids…
The Opioid Crisis and the Search for Alternatives
A range of other medications could serve as alternatives to powerful opioids for pain relief in emergency departments, according to a new study.
Examining Non-Opioid Medications for Pain Relief
The review paper examined non-opioid medications available in the emergency department at San Francisco general hospital and examined existing medical literature to figure out which ones might provide pain relief.
The Role of Antidepressants and Antipsychotics in Pain Management
The study provides recommendations for the most common types of pain that patients experience in emergency departments; abdominal pain, back pain, chest pain, fracture pain and headache. Common pain medications like acetaminophen and non-steroidal anti-inflammatory drugs like ibuprofen showed the potential to relieve every type of pain examined.
Targeted Applications for Psychotropic Medications
Other drugs in the study had more targeted applications; ketamine, a common anaesthetic, showed promise for chest pain; a serotonin norepinephrine reuptake inhibitor (SNRI) antidepressant showed promise for back pain, and several types of antipsychotics showed promise for headache and abdominal pain.
The Future of Pain Management
While these alternatives might be helpful to some patients, doctors must both review the evidence and what’s going on with the individual patient in front of them. Medications that help people sleep better and experience less anxiety might also make pain easier to deal with physically and mentally.
#Opioids
#Antidepressants
#Antipsychotics
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