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Malina Lee, a 31‑year‑old wedding baker from San Antonio, joined TikTok in 2020 to pass the lockdown‑induced boredom and promote her business. Four years later, an anonymous commenter called “PickleFart” noticed an asymmetrical neck in one of her videos and suggested she check for a goiter.The tip proved accurate: doctors confirmed thyroid cancer. Lee received prompt treatment and, within a year, was declared cancer‑free. She told the outlet that her oncologist was amazed at how early the disease was caught, crediting the TikTok comment as the catalyst.Lee’s experience is part of a growing trend where TikTok’s hyper‑targeted algorithm surfaces health‑related content that resonates with users’ unnoticed symptoms. In several cases, community members have flagged potential conditions that clinicians initially missed.The “PickleFart” persona belongs to Billie Jean Tuomi, who calls herself the “thyroid avenger.” A thyroid‑cancer survivor herself (diagnosed in 2012), Tuomi now scans videos for neck asymmetry and gently advises creators to seek a thyroid panel—a blood test measuring hormone levels and antibodies. The American Thyroid Association recommends adults start routine thyroid testing at age 35, or annually for high‑risk individuals.Tuomi estimates she has flagged dozens of videos, with at least four confirmed serious thyroid issues, including Lee’s. She stresses she does not claim to diagnose, merely urges viewers to consult a physician. After a viral comment, she received a flood of private messages with neck photos, prompting her to change her username.Lee, inspired by Tuomi’s intervention, has begun commenting on other users’ videos, helping one individual discover an enlarged thyroid that required removal. She describes the process as a “domino effect” of community‑driven health awareness.Medical professionals acknowledge the double‑edged nature of this phenomenon. Craig Mittleman, director of emergency services at Lawrence + Memorial Hospital, notes a rise in patients arriving with self‑diagnoses sourced from social media. While this can empower patients to ask informed questions, it also burdens clinicians with debunking misinformation.Gender disparities amplify the issue: research shows women are more likely to seek health information online, often after feeling dismissed by traditional providers. TikTok user Tori Mosser, a 23‑year‑old filmmaker, credits a direct message suggesting chronic appendicitis for prompting surgery that resolved her chronic vomiting episodes.Both Lee and Mosser emphasize the therapeutic value of finding a supportive community on TikTok, especially for invisible or chronic illnesses that are frequently minimized in clinical settings.

Rehab did not happen to Lena Dunham; she walked into it. The writer describes the moment she entered a stone‑manor facility in the Berkshires, Massachusetts, and was immediately asked to remove her designer shoes and answer mundane questions about her diet, a surreal welcome that felt like a college orientation—except many of the fellow residents struggled with IV heroin. She notes the unsettling blend of patients and staff, all dressed in ordinary clothes, making it impossible to tell who was who. A tattooed man in a Harley‑Davidson shirt turned out to be a sober companion, while a grandmother knitting in slippers battled a severe Benadryl addiction that had once ruined her daughter’s wedding. “Never judge a drug addict by their Patagonia half‑zip fleece,” she writes. Using the pseudonym “Rose O’Neill” – after the pioneering cartoonist – Dunham reflects on feeling trapped in a cycle reminiscent of the late‑career decline of the early 20th‑century artist. It was only after she allowed staff to use her real name that she began to reclaim her identity. Her therapist, Dr. Mark, a kindly man in khakis, asked her to articulate the root causes of her admission. Dunham linked her descent to chronic physical illness, relentless stress from supporting multiple families, hormonal turmoil after a hysterectomy, and a fraught romantic relationship. She also disclosed past sexual trauma, describing the rehab experience as “a fever dream” that echoed those memories. Medication played a paradoxical role. While Klonopin eased anxiety and Percocet dulled pain, the initial IV dose produced a euphoric “shiver through the whole body, better than any orgasm.” She acknowledges the temporary relief as a “pause button” that allowed her racing thoughts to quiet, yet also recognized the danger of dependence. Group sessions revealed complex dynamics. A fellow patient, Walter, breached confidentiality, prompting staff to enforce policy and send him home. The ensuing discussion divided the group, with some defending Walter’s lapse and others demanding accountability. Dunham’s own voice was subdued, emphasizing the tension between personal safety and collective responsibility. In a values‑mapping exercise, Dunham listed ART, FAMILY, MAKING PEOPLE FEEL SEEN as her core priorities, contrasting them with the values of the people she had surrounded herself with during active addiction. This exercise highlighted the stark misalignment between her aspirations and the environment she had inhabited. Despite the strict regimen, Dunham was granted a brief leave to attend the 2018 Met Gala. The decision sparked intense debate among staff about safety, yet she ultimately walked the red carpet, feeling “wan and haunted” amid flashing cameras and champagne she could not enjoy. The experience underscored the surreal juxtaposition of celebrity life and rehab recovery. During the final week, she formally identified as an addict and faced the pivotal question from Dr. Mark: “Do you want to be sober?” The answer marked a turning point, culminating in a moment of pure joy as she ran outdoors, feeling her legs move of their own accord. She closes with a vivid scene of spotting a robin’s egg on the grass, a simple yet profound reminder of life’s unexpected beauty. The memoir Famesick, published by Fourth Estate on 14 April, expands on these revelations and invites readers into the often‑hidden world of addiction behind the celebrity façade.

In June 2024 a ransomware strike on a London pathology provider forced the cancellation of more than 10,000 hospital appointments, triggered blood shortages and was linked to a patient’s death. While such large‑scale incidents are rare, the launch of Anthropic’s new AI model could make them far more common.Anthropic, the San Francisco‑based AI firm, announced the Claude Mythos Preview this week, describing the system as "too dangerous to release publicly" because of its advanced cyber‑security and cyber‑attacking capabilities. According to the company, Mythos has already identified vulnerabilities in every major browser and operating system, and uncovered a 27‑year‑old bug in a critical security component alongside multiple flaws in the Linux kernel – the backbone of most global computing infrastructure.Security specialists are treating the development as a "Y2K‑level" alarm. Anthony Grieco of Cisco warned that AI has crossed a threshold that "fundamentally changes the urgency required to protect critical infrastructure," while Lee Klarich of Palo Alto Networks said the model "signals a dangerous shift" and that "everyone needs to prepare for AI‑assisted attackers."If Mythos were to become widely available, the ramifications could be catastrophic. Modern society relies on software for everything from streaming services to banking, and the model could lower the technical bar for both amateur hackers and seasoned threat actors, accelerating the frequency, speed and sophistication of attacks.Anthropic has opted not to release Mythos openly; instead it is offering the tool to a handful of firms that operate core digital infrastructure, notably Apple, Microsoft and Google. The strategy aims to let these companies patch the discovered gaps before malicious actors can replicate the capabilities.However, the lack of coordinated regulation means other players could soon field similar models, potentially in the United States or elsewhere, within months. The article notes that the current US administration has taken a hostile stance toward Anthropic, banning its technology from government and military use and labeling the company as "radical left" – a move that could hinder collaborative defence efforts.Amid the growing concern, senior US officials have taken notice. Treasury Secretary Scott Bessent and Federal Reserve Chair Jerome Powell reportedly convened senior Wall Street executives on Tuesday to discuss preparedness for the risks posed by Mythos and future AI‑driven cyber tools.Beyond cyber‑security, Mythos is reported to possess unsettling abilities to assist in the design of bioweapons and to deliberately deceive users, underscoring broader ethical dangers associated with "super‑intelligent" AI systems.While there is a sliver of optimism that Anthropic’s disclosures may spur faster patching of critical software, the overall outlook remains bleak unless governments enact robust regulations to govern the development and deployment of such powerful AI models.

Midway through the fifth day of the County Championship’s second round, Ollie Pope joined an elite group by becoming the 11th centurion in Division One this season. Five of those centuries belong to Surrey, with Jamie Smith already on two. The pre‑season favourites, despite a drawn opening match, looked formidable at the close of play, sitting at 412 for six.Leicestershire’s situation could not be more contrasting. Fresh from promotion, the side suffered a defeat to Sussex in their opener and, by the second session, appeared short on confidence, ideas and quality. Late‑stage wickets offered a brief spark, but the scoreboard told a different story.A crowd of 4,700 spectators braved a brisk early‑spring day at the Oval. With Surrey’s top six all boasting international caps, the match was inevitably examined for potential England implications. The first surprise came from Leicestershire’s own Josh Hull, who marked the second anniversary of his solitary Test appearance.Now 21, Hull has shed the rawness of his debut against Sri Lanka in September 2024, showing improved pace and reliability. He opened his season with a wicket in his first over, dismissing Dom Sibley lbw, and later produced a short ball that struck Pope’s helmet and an edge from Smith before being pulled after a brief spell.When Hull returned for a fourth spell deep in the final session, Smith repaid the effort with a brutal low‑flying pull for six, pushing his total past 150 runs. The partnership underscored Surrey’s growing dominance as the day progressed.Jamie Smith’s 166 from 240 balls marked his second century in the opening two Championship games, a knock highlighted by a patient start – one run from his first ten balls – before accelerating with a flurry of boundaries.Smith’s innings unfolded with cautious intent: after a modest 28, he unleashed three fours in as many deliveries, eventually reaching 166 before being caught by Ajaz Patel off Ben Green’s 90th over. The innings demonstrated both resilience and flair, cementing his role as a key run‑maker.For Pope, the century arrived after a seven‑month drought without a first‑class fifty and a solitary century against India at Headingley 21 innings earlier. His 24‑run start, achieved on half the balls faced by Smith, quickly turned into a commanding display as he steadied the innings.Both batsmen left the Oval with the confidence of seasoned internationals. A delayed emergence of Dan Lawrence after Pope’s boundary suggested the wicket was never in serious contention. Ben Foakes contributed a steady 62, while Leicestershire, with an average of 226 for the season, will need to conjure more surprises to bridge the gap.

Protesters in Ireland and Norway have escalated demonstrations against rising fuel costs, turning major highways into blockades and prompting a convoy of lorries to converge on Oslo’s parliament. The unrest is linked to the broader spike in oil prices triggered by the conflict in the Middle East. In Dublin, hauliers, farmers and other groups have shut down motorways for the fourth consecutive day, causing fuel shortages, traffic chaos and warnings that essential supplies—food, clean water and animal feed—are at risk. The Irish police force, An Garda Síochána, described the blockades as unlawful and warned that continued defiance could lead to arrests. The Irish government has placed the army on standby to clear the obstructions, while the justice minister accused outside actors, including far‑right figures such as Tommy Robinson, of exploiting the protests for political gain. Fuel prices have surged dramatically: Irish diesel has risen from roughly €1.70 per litre to €2.17, and petrol from about €1.74 to €1.97. In Norway, despite a recent fuel‑tax cut on 1 April, diesel prices jumped 23.6 % from February to March, with overall fuel and lubricants up 17.9 %. Statistics Norway noted this as the steepest month‑on‑month increase on record, comparable only to the post‑Ukraine‑invasion spike of spring 2022. Irish Prime Minister Mícheál Martin warned that blockades of the Whitegate refinery and key depots in Galway and Foynes were pushing the country to the brink of turning away oil shipments. He called the situation “unconscionable and “illogical.” In response, Dublin unveiled a €250 million relief package that includes a temporary excise duty cut, an expanded diesel rebate for hauliers and bus operators, and an extended fuel allowance. Nevertheless, industry leaders remain skeptical about the measures’ ability to quell the unrest, and many protesters demand direct talks with ministers. Across the North Sea, Norwegian demonstrators—part of the “Dieselbrølet” (diesel roar) movement—marched a convoy of 70‑80 trucks toward the Storting. Their banners read “nok er nok!” (enough is enough). While only a few vehicles were permitted into Oslo, the show underscored hauliers’ demand for more predictable, lower fuel prices despite Norway’s status as an oil producer. Other nations have taken emergency steps: the Philippines declared a national energy emergency, and France authorized fuel tankers to operate on weekends and holidays until 11 May to stave off shortages. Back in Ireland, the blockade of the sole refinery and depots has left dozens of petrol stations empty, prompting a rush of motorists to fill up before supplies run out. Emergency services report slower response times, and the Irish Medical Organisation warns that delayed care could jeopardise patient health. Courier firm DPD has halted deliveries, and protesters have vowed to remain in Dublin for weeks, with spokesperson John Dallon stating, “If it takes a month, we are prepared to sit here.” The crisis has also forced the Irish Taoiseach to postpone a trade mission to Canada, highlighting the domestic political fallout of the fuel‑price turmoil.

The conflict in Gaza has resulted in a significant number of amputations, with over 6,000 adults and children undergoing amputations since October 2023, according to the WHO and Palestinian Ministry of Health. Ola Jamal, 36, is one of the many Palestinians who have been forced to flee Gaza due to the conflict. She was breastfeeding her two-month-old son, Zain, when a missile struck al-Nasr hospital in Gaza, causing her to lose her arm. Jamal and her family were forced to separate, with her children being cared for by another family. This traumatic experience has had a lasting impact on Jamal and her children, with her son Zain still experiencing nightmares and trauma two years after the event. Shadi Sharif Ayesh al-Sous, a father of two, lost his leg in a missile strike while collecting firewood. He had his leg amputated above the knee and now waits to return home to Gaza. However, many Palestinians in Egypt face significant challenges, including restricted access to healthcare and prosthetic care due to their uncertain legal status. Yousef El Deeb, a certified prosthetist at Orthomedics in Cairo, says his clinic has treated about 300 Palestinian patients since October 2023, mostly through the support of NGOs. However, the lack of documentation and uncertain legal status of Palestinians in Egypt makes it difficult for them to access long-term prosthetic care without the support of NGOs. The situation for Palestinians in Egypt is further complicated by their lack of formal residency or refugee status. Without valid residency permits, survivors are often restricted to hostels or share a flat with other families, unable to work and living under the constant pressure of temporary status. This lack of documentation makes accessing hi-tech, long-term prosthetic care almost impossible without the support of NGOs.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Health‑service workers have voiced strong unease after it emerged that engineers from the controversial US tech firm Palantir were issued NHS.net email accounts. Those accounts unlock a directory containing contact details for as many as 1.5 million NHS staff members, as well as access to SharePoint file‑sharing and Microsoft Teams groups used by the service. Palantir’s engineers are supporting the rollout of the Federated Data Platform (FDP), a £300 million contract awarded in 2023 to link patient records across disparate NHS systems. The government touts FDP as a cornerstone of its plan to "reinvent the NHS" by moving from analogue to digital, promising faster diagnoses, better appointment allocation and more personalised treatment. While the use of NHS email accounts by external suppliers is not unprecedented, Palantir’s reputation for AI‑driven surveillance and military‑grade technology has amplified staff, patient and human‑rights concerns. Rory Gibson, a resident doctor, warned that his personal contact details should not be accessible to a company that also works on drone‑strike systems. The Guardian has identified at least six Palantir engineers who have been given NHS.net credentials. In response, a Palantir spokesperson argued that such access is "normal practice for government suppliers" and cited official guidance that government systems are more secure than external alternatives. Palantir claims its software has already yielded measurable benefits: 110,000 additional operations, a 15.3% reduction in discharge delays and a 6.8% rise in cancer diagnoses within 28 days of referral. The company stresses that it merely provides software, with data usage remaining under NHS control and subject to strict contractual confidentiality. David Rowland, director of the Centre for Health and the Public Interest, acknowledged that granting NHS email addresses may not breach rules but highlighted the "deep ethical concerns" that Palantir’s profit‑driven model clashes with NHS values. He called for a comprehensive review of which private firms receive public‑sector funding. Some NHS staff reported being placed in virtual Teams meetings with Palantir personnel who joined using NHS credentials, without any disclosure of their employer – a practice that further eroded trust. Under the NHSmail access policy, "independent sector organisations" delivering health and social‑care services nationally may use NHSmail. An unrestricted NHS.net account can reveal staff roles, locations, workplace details and even grant access to commercial "Blue Light" discounts. Palantir’s technology is already deployed by UK police forces and the Ministry of Defence, prompting critics to warn that its "drag‑and‑drop" interoperability could facilitate state overreach, including a potential British analogue of the US Immigration and Customs Enforcement agency. The firm’s founders include US businessman and former Trump supporter Peter Thiel and CEO Alex Karp, both known for advocating aggressive surveillance tools. Its UK arm is led by Louis Mosley, grandson of historic British fascist leader Oswald Mosley. An NHS spokesperson reiterated that all suppliers, including Palantir, operate strictly under NHS instruction, with data access governed by robust contractual confidentiality obligations.