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Scientists have made a groundbreaking discovery, identifying a distinct 'neural fingerprint' produced by psychedelic drugs in the human brain when users experience their mind-altering effects.This breakthrough finding emerged from a comprehensive study that combined 11 brain imaging datasets from around the world, involving over 500 brain scans from 267 people in five countries. The research focused on five psychedelic substances: LSD, psilocybin, DMT, mescaline, and ayahuasca.The study revealed that these substances have a shared impact on the brain's behavior, dissolving the usual hierarchy of brain systems and flattening the hierarchy, which may underlie the raw access to one's own consciousness that some people describe during psychedelic experiences.Dr. Danilo Bzdok, a senior author on the study from McGill University in Montreal, Canada, explained that all five drugs change brain function in common ways, despite some differences in how they alter brain activity. The most striking effect was stronger communication between brain networks that engage in higher-level thinking and more primitive networks linked to vision and sensation.The research, published in Nature Medicine, provides a solid foundation for psychedelic research, which is crucial if these drugs are to become widespread therapies for mental health conditions such as depression, schizophrenia, and post-traumatic stress disorder.Dr. Emmanuel Stamatakis, a senior co-author on the study from the University of Cambridge, emphasized the importance of large-scale, coordinated evidence in the field of psychedelic research, which is moving quickly and needs to mature responsibly.

The organiser of the Wireless Festival has reaffirmed that Kanye West, legally known as Ye, will appear on the bill, even as senior UK officials and Jewish organisations demand his exclusion over a series of antisemitic statements and admiration for Adolf Hitler.West’s controversial remarks, including a 2025 song titled “Heil Hitler” and the promotion of a swastika‑bearing T‑shirt, have drawn condemnation from MPs and prompted calls for a government ban. Bridget Phillipson, a senior minister, described his comments as “completely unacceptable and absolutely disgusting,” while Prime Minister Keir Starmer called the booking “deeply concerning.”Melvin Benn, managing director of Festival Republic, the promoter behind Wireless, said the artist is “intended to come in and perform” and stressed that the festival will not provide a platform for “extolling any opinion,” only for the songs that are popular on radio and streaming services. He added, “I am a deeply committed anti‑fascist… I lived on a kibbutz attacked on 7 October and support both a Jewish and a Palestinian state.”In a personal appeal, Benn invoked his experience with a family member’s mental illness, urging the public to extend “forgiveness and hope” to West, whom he described as seeking “second chances” in a “divisive world.” He also asserted that West has a legal right to enter the UK, though ministers are reviewing his entry clearance.Jewish leaders remain unconvinced. Phil Rosenberg, president of the Board of Deputies of British Jews, warned that Benn’s comments “will not reassure many within the Jewish community” and highlighted that West has “proclaimed himself a Nazi” while the festival stands to profit from his appearance.Political opposition has also weighed in. Liberal Democrat leader Ed Davey called for a ban on West’s entry, urging the government to act “tougher on antisemitism.”Commercial fallout has been swift. Pepsi and Diageo have withdrawn their sponsorship, and AB InBev announced it is pulling Budweiser and Beatbox support. PayPal confirmed it will no longer feature in the festival’s promotional materials.West has not performed in the UK since headlining Glastonbury in 2015, and his recent full‑page apology in the Wall Street Journal attributed his inflammatory remarks to bipolar‑1 disorder stemming from a 2002 car‑crash injury. Nonetheless, critics argue that a three‑day stage slot does not constitute a meaningful path to “health and healing.”

At Augusta National, Justin Rose’s name appears twice on the bronze winner’s list beside the victories of Sergio García (2017) and Rory McIlroy (2025) – both wins coming after playoffs that Rose lost. Only Ben Hogan shares the dubious distinction of losing two Masters playoffs, though Hogan later won the tournament twice outright.Rose’s record also includes a second‑place finish in 2015, four strokes behind Jordan Spieth. The only player with more runner‑up finishes without ever winning is Tom Weiskopf, who was second four times in seven years.Now 45 years old and entering his 21st Masters, Rose cannot predict if he will ever get as close again as he did last year, when McIlroy’s birdie putt on the 18th sealed a one‑stroke playoff defeat.“When you realise you’re that close, you can taste the victory,” Rose says. “I lived it as if I’d won, but without the real positive emotion – I sensed everything.” He acknowledges the mental rehearsal of the “what‑if” scenario while maintaining that he “did everything he could” and can live with the result.Rose explains his mental formula: “You can’t make a major win too important in the moment,” because a career inevitably includes “a little bit of heart‑ache and heartbreak.” He believes that to win, a player must also be prepared to be on the losing side.Despite the setbacks, Rose feels he has already demonstrated the necessary skill set. “I’ve pretty much done what it takes to win. I just haven’t walked over the line,” he asserts, emphasizing that he does not feel the need to change his approach.Recent form offers optimism. Earlier this year Rose set a new course record at Torrey Pines and became the first player in 71 years to win the Farmers Insurance Open wire‑to‑wire. He notes that eight players have captured the Masters after finishing second the previous year, suggesting his odds improve when the field is considered.Rose is also mindful of external narratives. “People are wishing me well and thinking it’s my year,” he admits, adding that he must manage expectations and craft his own story rather than buying into others’ predictions.

Sir Craig Reedie, a giant of the Olympic movement, has passed away at the age of 84. He served as chair of the British Olympic Association for over a decade and was instrumental in securing the 2012 Olympics for London.Reedie was also the president of the World Anti-Doping Agency (WADA) during a tumultuous period when Russia was found guilty of state-sponsored doping. He recommended banning Russia from the 2016 Rio Games, although this was ultimately rejected by the International Olympic Committee.Tributes have poured in for Reedie, with Sebastian Coe, the World Athletics president, describing him as a mentor, wise counsel, and great friend. Coe credited Reedie with playing a pivotal role in London's successful bid to host the 2012 Olympics.Reedie's dedication to the Olympic movement and clean sport has been widely praised. Dame Katherine Grainger, the current BOA chair, highlighted his tireless efforts to promote Olympic sport and his commitment to fair play.

The peptide-testing industry has seen a significant surge in demand, with laboratories testing thousands of unregulated substances claiming to support weight-loss and wellness. This growth is largely driven by the injectable peptide craze, with experts warning about the lack of reliable safety data and quality control.Peptides are short chains of amino acids, which can be found naturally in the body or made synthetically in laboratories. They include active ingredients in prescription weight-loss drugs, such as Wegovy, as well as experimental compounds pushed online by the booming biohacking and anti-ageing industries.Laboratories, such as Finnrick in Texas, have reported a substantial increase in testing requests, with around 60,000 samples processed annually, including roughly 2,000 orders from the UK since 2024. About a third of the products analysed failed basic quality checks, with issues including incorrect identity, purity, and quantity.Experts, including Dr. Luke Turnock and Peter Magic, have highlighted the risks associated with these unregulated substances, including potential long-term harms such as increased cancer risk and damage to organs. The large profit margins have also drawn nefarious actors into the supply chain.The UK is a significant market for peptides, with 2,000 testing orders since 2024, tied with Canada for third place globally. The Royal Pharmaceutical Society's Prof Amira Guirguis emphasized the need for oversight, traceability, and quality assurance in the peptide market.

Conservationists and scientists have warned that the Minerals Council of Australia’s proposal to employ artificial intelligence for faster national environmental approvals could generate “Robodebt‑style” failures, further endangering already vulnerable species.The council has asked the federal government to allocate $13 million for a pilot that would use AI to help companies draft assessment applications and assist regulators in decision‑making.The Biodiversity Council – a consortium of independent experts from eleven universities – told Guardian Australia that while AI may assist with routine tasks, automating whole environmental assessments could lead to opaque, flawed decisions that push threatened species closer to extinction.“Robodebt” refers to the automated welfare‑debt recovery scheme that, between 2015 and 2019, wrongly accused hundreds of thousands of Australians of overpayments, highlighting the danger of opaque algorithmic judgments.Lis Ashby, the Biodiversity Council’s lead on policy and innovation, noted that the cornerstone of Australia’s environmental protection, the Environment Protection and Biodiversity Conservation (EPBC) Act, is riddled with vague language and broad ministerial discretion, which hampers rule‑based decision‑making and would be even more problematic for an AI tool.She added that establishing clear rules in the National Environmental Standards, including explicit definitions of unacceptable outcomes, would accelerate assessment times even without AI and is essential for any future automation.Brendan Sydes, national biodiversity policy adviser at the Australian Conservation Foundation, expressed scepticism, stating that “technology can be a good servant but a poor master.” He urged the government to focus on closing existing data gaps on threatened species and habitats rather than relying on AI.Prof. David Lindenmayer, a forest ecologist at the Australian National University and Biodiversity Council member, highlighted that one‑third of Australia’s threatened species have not been monitored and many others suffer from patchy data, gaps traditionally filled by expert consultation.He warned that AI decisions are only as reliable as the data they are fed, and most threatened species lack publicly available information, even basic location data, risking decisions based on outdated or incomplete evidence.The Albanese government recently passed reforms to the EPBC Act after a 2020 review found the legislation failing to protect species and habitats.Prof. Hugh Possingham, a leading conservation biologist at the University of Queensland, argued that AI models need robust training material, and the past two decades of EPBC approvals are “clearly unsuitable” because the Act has demonstrably failed to safeguard the environment. He suggested that hiring more human assessors would be a more effective way to speed up evaluations.Tania Constable, chief executive of the Minerals Council, dismissed the Robodebt comparison as “disappointing,” insisting the proposal is innovative and could strengthen environmental protection while improving efficiency. She said the AI tools would support human decision‑making for both regulators and project proponents, helping navigate the complexity of EPBC assessments.A federal government spokesperson said budget decisions on the AI trial will be made “in due course,” but the environment department is exploring how AI could simplify application processes. The statement emphasized that “decisions about whether to approve projects must, and will, always be made by assessment officers, not by AI.”Nonetheless, officials acknowledged that AI tools have the potential to save time, reduce uncertainty, and translate technical language for stakeholders.

Arslanbek Makhmudov, the towering Russian boxer, is gearing up to face Tyson Fury at the Tottenham Hotspur Stadium in London on Saturday night. The 6ft 5½in Makhmudov, who tips the scales at around 270lbs, brings a formidable physical presence to the ring, with 19 of his 21 victories ending in a stoppage.Makhmudov, known for his respectful demeanor, has been praising Fury, calling him 'the professor' and acknowledging his exceptional boxing IQ. However, he believes that spiritual strength will play a crucial role in the fight, stating, 'Inshallah, it is spiritual.'Despite being the underdog, Makhmudov is confident in his abilities, citing his hard-hitting power and mental toughness. He has also drawn inspiration from his past experiences, including a surreal encounter with a bear in Moscow, which he described as 'very terrible.'Makhmudov's faith plays a significant role in his life, and he credits it for giving him the strength and confidence to face Fury. He prays five times a day and believes that with God on his side, he can overcome any obstacle, including a 60,000-strong pro-Fury crowd.Fury, known for his trash-talking, has surprisingly echoed Makhmudov's respectful tone, with Makhmudov appreciating the friendly banter between them. The two fighters have a mutual respect for each other's skills, with Makhmudov acknowledging Fury's legendary status in the boxing world.

The Guardian’s weekly podcast roundup highlights a varied selection of new audio series, offering listeners everything from light‑hearted celebrity banter to hard‑hitting investigative journalism.Funny You Ask – In a delightfully candid moment, Mindy Kaling exclaims, “Oh, this is a quizshow?!” upon hearing Ike Barinholtz’s latest podcast, which blends trivia with rambling conversation about topics as eclectic as Chevy Chase and New Jersey Italian cuisine. The show positions itself as a breezy, low‑stakes alternative to the crowded celebrity‑interview market.Assume Nothing: What Happened to Mary Glasgow? – Host Nathan Edgar revisits the 1991 tragedy at Stradreagh mental hospital, where nursing assistant Mary Glasgow died after a patient altercation. Through interviews with Glasgow’s daughter Emma, the series treats the case as both a detective narrative and a memorial, probing whether the incident was an isolated mishap or a symptom of systemic failures.Single Ladies in Your Area – Comedians Amy Gledhill and Harriet Kemsley continue their third series, a witty exploration of 30‑something singledom. Recent guests have included Jameela Jamil and Catherine Bohart, who discuss topics ranging from “mean flirting” to the quirks of a “lesbian louche life.”The Overturn – Partnering with the Future Justice Project charity, Marnie Duke examines potential wrongful convictions, notably the case of former sub‑postmaster Robin Garbutt, imprisoned for his wife’s murder. The series asks whether the broader Post Office scandal could cast doubt on the prosecution’s narrative.Amityvilleville – Host Alex Goldman (of Hyperfixed and Reply All) teams up with Vice writer Caroline Thompson to watch all 91 films inspired by the Amityville haunting, beginning with the 1979 classic The Amityville Horror. Their commentary blends humor with genuine enthusiasm for the genre’s most bizarre entries.

In a recent statement, the Italian Prime Minister emphasized that the Gulf region is fundamental to Europe's security. The comment reflects a growing recognition of the strategic partnership between European nations and Gulf states, highlighting the importance of cooperation on defence, energy and geopolitical stability.