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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

A New York jury has ruled against Ticketmaster and Live Nation, finding that the concert giant and its subsidiary had a harmful monopoly over big concert venues. The verdict is a significant loss for the companies, which were sued by dozens of states in the US over claims of anticompetitive practices.The jury deliberated for four days before reaching its decision, which could cost Live Nation and Ticketmaster hundreds of millions of dollars. The companies were found to have overcharged consumers in 22 states by $1.72 per ticket. The verdict also opens the door for potential penalties and sanctions, including court orders to divest some entities, such as venues.The civil case, initially led by the US federal government, accused Live Nation of using its reach to smother competition by blocking venues from using multiple ticket sellers. The company's lawyers argued that it is not a monopoly, saying that artists, sports teams, and venues decide prices and ticketing practices.Live Nation Entertainment owns, operates, controls booking for, or has an equity interest in hundreds of venues. Its subsidiary Ticketmaster is widely considered to be the world's largest ticket-seller for live events, controlling 86 percent of the market for concerts and 73 percent of the overall market when sporting events are included.The verdict marks a significant victory for fans and some artists who have long complained about Ticketmaster's high fees and limited competition. The company has faced criticism from artists such as Pearl Jam, which battled the business in the 1990s and filed an antimonopoly complaint with the US Department of Justice.

The frozen assets of Iran, estimated to be over $100bn, have emerged as a significant obstacle in the ongoing talks between the United States and Iran. These assets, which include revenues from oil sales frozen in foreign banks, are a vital component of Iran's economy, which has been severely impacted by sanctions imposed by the US and other nations.The sanctions, in place since 1979, have restricted Tehran's ability to access its own assets, exacerbating the country's economic woes. Mohammad Bagher Ghalibaf, the speaker of Iran's parliament, has emphasized that the release of these frozen assets is a prerequisite for any negotiations.The exact amount of frozen assets is unclear, but experts estimate it to be around $100bn, a sum that is approximately four times what Iran earns annually from hydrocarbon sales. Frederic Schneider, a nonresident senior fellow at the Middle East Council on Global Affairs, noted that this is a substantial amount, especially for a country that has been suffering under decades of US-led sanctions.The frozen assets are held in multiple countries, including Japan, Iraq, China, India, Luxembourg, and Qatar. Iran's economy is in crisis, with decades of sanctions limiting its oil exports and stalling its ability to attract investments and modernize its industry and technology. The release of these assets could provide a significant boost to Iran's economy, allowing it to address its infrastructure needs and stabilize its currency.Roxane Farmanfarmaian, academic director and lecturer in international politics at the University of Cambridge, emphasized that unfreezing Iran's assets would be significant, enabling the country to repatriate its funds earned in hard currency from oil sales and gain control over its currency fluctuations.

The United States is set to move **over 10,000 additional service members** into the Middle East before the end of April, according to officials speaking anonymously to The Washington Post. The reinforcement is intended to heighten pressure on Iran while the current cease‑fire, declared a week ago, remains in force until April 22. Approximately 6,000 troops will embark aboard the USS George H.W. Bush carrier and its escort vessels, which are transiting around Africa to join the existing carrier presence. An additional 4,200 personnel from the Boxer Amphibious Ready Group and the 11th Marine Expeditionary Unit are expected to arrive later in the month. These deployments bring the total number of U.S. forces engaged in the conflict since its start on February 28 to roughly 50,000 troops. With the arrival of the George H.W. Bush, the region will host three U.S. carriers: the newly arrived vessel, the USS Abraham Lincoln, and the USS Gerald Ford, all of which have already taken part in combat operations against Iran. Concurrently, U.S. Central Command (CENTCOM) announced on social media that its naval blockade of Iranian maritime trade is "fully implemented" and that American forces have "completely halted economic trade" to and from Iran by sea. However, maritime‑tracking data released on Tuesday showed several ships departing Iranian ports and navigating the Strait of Hormuz, suggesting the blockade’s effectiveness may be limited. Amid the military buildup, diplomatic channels remain active. President Donald Trump told The New York Post that a new round of negotiations with Iran could be convened in Pakistan within two days, following a marathon session in Islamabad that ended without a breakthrough. The previous high‑stakes talks failed to secure a lasting peace agreement, and the cease‑fire is slated to expire on April 22. According to the Washington Post sources, the fresh troop influx is designed to give the U.S. administration leverage in ongoing talks while preserving the option for "additional strikes or ground operations" if negotiations falter. This dual strategy underscores Washington’s intent to maintain both diplomatic and kinetic pressure on Tehran as the regional conflict evolves.

Washington, D.C. – The U.S. Senate voted 47‑52 to reject a resolution that would have limited President Donald Trump’s power to wage war against Iran, marking the fourth defeat of the measure despite weekly attempts by lawmakers. The vote follows a two‑week ceasefire agreed upon last week, though subsequent negotiations in Islamabad failed to produce a longer‑term deal. Both sides have indicated openness to a second round of talks. President Trump’s earlier threats, including a statement on April 7 that a “whole civilisation will die tonight,” intensified congressional calls for constraints on his war‑making authority. Party lines largely dictated the outcome: Republican Rand Paul voted in favor, while Democrat John Fetterman broke with his party to oppose the resolution. Supporters argue that Trump acted beyond constitutional limits when he joined Israel in launching the February 28 offensive. The U.S. Constitution reserves the declaration of war for Congress, allowing presidents to act unilaterally only in cases of immediate self‑defence. Senator Chris Murphy, speaking before the vote, described the conflict as a “bungled, mismanaged war” that has failed to meet the administration’s objectives. He criticized the lack of transparency and oversight, noting that the war is costing “billions of dollars every week,” has claimed “over a dozen American lives,” and is destabilising economies worldwide. Republican Senator Jim Risch defended Trump’s actions, dismissing the resolution as “same old, same old” and asserting that the president has both the right and duty to act. The House of Representatives is slated to consider its own war‑powers resolution this week, with a higher likelihood of passage given growing wariness among some Republicans. Even if both chambers approved the measure, Trump could veto it, requiring a two‑thirds supermajority to override. Under the War Powers Act of 1973, Congress must either authorize the military action or approve a 30‑day extension when the conflict reaches its 60‑day mark at the end of April. Failure to do so would legally compel the president to begin withdrawing forces. U.S. blockade updates: U.S. Central Command reported that no vessels have successfully breached the blockade of Iranian ports in the Strait of Hormuz over the past 48 hours, with nine ships complying with orders to turn back. The U.S. Navy warned that vessels attempting to transit will be boarded for interdiction and seizure. Treasury Secretary Scott Bessent announced a forthcoming set of financial measures described as the “financial equivalent” of military attacks, while noting that some sanctions had been lifted to ease soaring global energy prices. White House spokesperson Karoline Leavitt said the administration has not formally requested an extension of the ceasefire, which is set to expire next week, but expressed optimism about a second round of talks in Islamabad. Iran’s state‑run television reported that a high‑level Pakistani delegation arrived in Tehran to coordinate new negotiations. Meanwhile, Major‑General Ali Abdollahi of the IRGC warned that the ongoing naval blockade could jeopardise the fragile ceasefire, describing it as a “prelude to a violation of the ceasefire.”

When fighting erupted in Sudan’s streets in April 2023, families fled their homes, cities and even the country itself. Three years on, the exodus continues, with millions still on the move.The Norwegian Refugee Council (NRC) surveyed 1,293 displaced households in Sudan, Chad and South Sudan, exposing a grim cycle of loss. Each forced relocation strips survivors of the last remnants of their former lives.According to the findings, about 90 % of respondents have lost their homes and nearly three‑quarters report having no income. Food scarcity has become critical: more than 80 % of households in Sudan and virtually all in South Sudan regularly skip meals.Within Sudan alone, over nine million people remain displaced, while an estimated 28.9 million face acute hunger. The cumulative trauma is evident—by the fourth displacement, almost two‑thirds of individuals feel completely exhausted and depleted of resources, and roughly 65 % have been separated from family members.Despite these hardships, a remarkable degree of solidarity persists. In Sudan and Chad, one in three aid recipients continue to share their limited supplies with neighbors, strangers and newly arrived families.“In Sudan now, you are always running,” says Amina, who escaped Khartoum with four children and only the clothes on her back after her husband vanished in the early days of the fighting. “Running from war. Running for food.”Education has collapsed: only 45 % of displaced children across the three nations attend school regularly, while 18 % of households have been forced to send children to work.The NRC’s conclusion is stark. While resilience and generosity have kept the humanitarian response afloat, communities are signaling that they can no longer bear the burden alone. The mutual support that has acted as an “invisible backbone” is now stretched to its breaking point.This photo essay is provided by the Norwegian Refugee Council.

In the midst of Israel's ongoing attacks on Lebanon, which have resulted in the displacement of at least one million people, migrant workers are taking initiative to support their communities. Myra Aragon, a Filipino migrant, runs a community center called Tres Marias in a Beirut suburb, providing meals to around 200 people daily, mostly migrant workers.Aragon's efforts are part of a larger trend of migrant solidarity in Lebanon. With many migrant workers facing restrictions and discrimination due to the country's kafala labor system, they are organizing themselves to help those in need. Tres Marias is one of at least three food kitchens run by migrant workers in Lebanon, serving not only migrants but also occasionally Lebanese families.The war has exacerbated existing challenges for migrant workers, with many facing displacement, discrimination, and limited access to shelters. However, Aragon and others like her are working to provide food and a sense of community to those affected. As Aragon notes, 'Food is unifying... It is a way for people to learn about food from the Philippines, and it makes people feel cared for and seen.'Despite the danger and uncertainty posed by the war, Aragon remains committed to her work, stating, 'This war is a lot worse than the last one... But as the war carries on, I will continue to cook and distribute food to those who need it.'

Barcelona’s aspirations for a Champions League title were extinguished for the second consecutive season when they fell 2‑1 to La Liga rivals Atletico Madrid in the quarter‑finals, losing 3‑2 on aggregate.Coach Hansi Flick acknowledged the disappointment, noting that the squad believed it could progress: “It’s tough because everyone really believed that we could make it happen today,” he said after the match.Despite the exit, Flick remains optimistic that the experience will accelerate the development of the club’s young core, which includes teenage sensation Lamine Yamal, midfielder Frenkie de Jong, and forward Pedri. The starting XI’s average age is under 25, positioning Barcelona as one of Europe’s most youthful line‑ups.Defensive frailties were starkly exposed. Barcelona conceded 20 goals in 12 Champions League matches and failed to keep a single clean sheet. In both legs of the tie, defenders were sent off for fouls that led directly to Atletico’s goals – Pau Cubarsi in the first leg and Eric Garcia in the second – highlighting the risks of Flick’s high defensive line.Financial constraints limit the club’s ability to splash on marquee signings. Veteran striker Robert Lewandowski is out of contract at 38, and the future of on‑loan winger Marcus Rashford remains uncertain. Additional questions loom over the contracts of Ferran Torres, Ronald Araujo and defender João Cancelo beyond the summer.Nevertheless, Barcelona’s domestic form remains strong. They sit nine points clear of Real Madrid in La Liga and retain the confidence that a league title is within reach, even as the quest for a sixth Champions League crown continues.De Jong emphasized the positive trajectory: “We’re growing every year. We have a young team, with a lot of talent and a lot of quality that can already compete for every competition.”Looking ahead, Flick hopes that a year of added experience will see Yamal, Pedri and Cubarsi return as battle‑hardened leaders capable of taking Barcelona further in Europe.

President Donald Trump declared that the war with Iran is "very close to over," even as Washington maintains a naval blockade of the strategic Strait of Hormuz. In Washington, D.C., Israeli and Lebanese ambassadors convened for uncommon direct talks, seeking a cease‑fire while Israel pressed for Hezbollah’s disarmament. Trump also hinted at a possible second round of negotiations with Tehran, suggesting talks could resume in Pakistan within days. The United States, however, is set to let a temporary sanctions waiver on stranded Iranian oil expire, tightening economic pressure on Tehran. The International Committee of the Red Cross and Red Crescent Societies delivered its first shipment of medical supplies and humanitarian aid into Iran since hostilities began, offering a modest lifeline to civilians. Inside Tehran, minor explosions caused limited damage and injuries, underscoring ongoing instability. Iran estimates its war‑related losses at $270 billion and plans to seek reparations. On the diplomatic front, the United Nations' IAEA chief Rafael Grossi noted that the duration of any uranium‑enrichment moratorium would be a political decision, reflecting the delicate balance of future negotiations. In the United States, the Senate is poised to vote as early as Wednesday on a Democratic initiative to restrict the president’s war powers, signaling growing congressional scrutiny of the conflict. Former defence official David Sedney warned that the Hormuz blockade is backfiring, increasing pressure on Washington as global trade routes are disrupted and domestic support wanes. Meanwhile, CENTCOM Commander Admiral Brad Cooper affirmed that the blockade of Iranian ports is fully operational and that U.S. forces retain maritime superiority in the region. President Trump publicly rebuked Italy’s Prime Minister Giorgia Meloni for not joining U.S. actions against Iran, describing her stance as lacking courage. U.S. Treasury Secretary Scott Bessent announced that American forces will intercept Chinese tankers carrying Iranian oil through the Hormuz Strait, effectively cutting off Iran’s oil exports while allowing non‑Iranian cargo to pass. Israel has proposed a long‑term troop presence extending up to 8 km into southern Lebanon until Hezbollah is dismantled, and continues air strikes aimed at encircling the strategic town of Bint Jbeil. Former U.S. Assistant Secretary of State Jeffrey Feltman highlighted a growing divergence between U.S. and Israeli priorities, noting Israel’s heightened concern over Iran’s ballistic‑missile program. In Lebanon, Israeli raids have resulted in multiple civilian casualties, with reports of villages being razed in a manner likened to Gaza. Hezbollah has rejected the ongoing Israel‑Lebanon talks, while public opinion remains split between hopes for peace and opposition to negotiations. The International Monetary Fund warned that any further escalation could push the global economy toward recession. It cut its 2026 growth forecast for the Middle East and North Africa to 1.1 % from 3.9 %, citing disruptions to Gulf oil and gas exports. On the markets, stock indices rose while oil prices slipped, reflecting renewed optimism for a diplomatic resolution and the reopening of the Hormuz Strait.