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The ongoing conflict between the US and Iran has taken a critical turn with the involvement of US Vice President JD Vance in Pakistan-led mediation efforts. Vance has been working closely with Pakistani officials to facilitate a ceasefire and prevent further escalation. The mediation efforts, which began in late March, have gained significant momentum in recent days.According to sources close to the talks, Vance has been in direct communication with Iranian officials, including Iranian Foreign Minister Abbas Araghchi. The Pakistani government has been playing a crucial role in facilitating the talks, with Field Marshal Asim Munir, the country's army chief, having spoken with Vance and Araghchi.The mediation efforts have produced tangible movement, with Iran confirming receipt of a ceasefire proposal. However, Tehran eventually rejected the plan, calling it 'illogical'. Despite this setback, the talks are ongoing, with Pakistani officials describing the negotiations as being at an advanced stage.Iran's preference for Vance is rooted in his record on foreign intervention. As a senator, Vance argued that Trump's success in office rested partly on avoiding new wars. He also warned that a conflict with Iran would not serve US interests and would be a 'huge distraction of resources'. This stance has been seen as more sympathetic to ending the conflict than other US officials.The mediation efforts have significant implications for the region, with a potential ceasefire having the potential to prevent further escalation and destabilization. The involvement of Vance and other officials has also raised questions about the political calculus of the US administration and its approach to the conflict.

In an urgent 11‑hour appeal posted on X, Pakistani Prime Minister Shehbaz Sharif asked U.S. President Donald Trump to push back the deadline for his proposed Iran deal by two weeks. Sharif also called on Tehran to fully reopen the Strait of Hormuz for the same period, framing the move as a goodwill gesture that could bolster ongoing diplomatic talks aimed at ending the U.S.–Israeli war on Iran. Sharif wrote that “Diplomatic efforts for peaceful settlement of the ongoing war in the Middle East are progressing steadily, strongly and powerfully with the potential to lead to substantive results in the near future,” and added that a temporary cease‑fire across the region would give negotiations a chance to succeed. The White House, through press secretary Karoline Leavitt, confirmed that President Trump is aware of Pakistan’s proposal and that an official response will be forthcoming. Meanwhile, a senior Iranian official told Reuters that Tehran is “positively reviewing” the request. Trump has intensified his rhetoric, warning on Truth Social that the United States would “destroy the Iranian civilization” if Tehran does not fully open the Strait of Hormuz and comply with his terms. Iran has responded by nearly halting maritime traffic through the waterway, which carries about one‑fifth of the world’s oil and LNG shipments, as retaliation for recent U.S.–Israeli strikes on Iranian soil. The Islamic Revolutionary Guard Corps warned it would not hesitate to strike back if U.S. forces target civilian facilities. In parallel, Israel has launched attacks on Iranian railways and bridges, while Iranian forces have struck targets in Bahrain, Qatar and the United Arab Emirates. A Pakistani source speaking to Al Jazeera noted that “we’re at a dangerous escalation, but the possibility of diplomacy can’t be ruled out till the last minute,” emphasizing Islamabad’s commitment to keeping all diplomatic channels open despite internal opposition. Legal experts have warned that Trump’s threats to target civilian infrastructure could amount to a war crime. Yale University professor and U.S. legal scholar Oona Hathaway warned that any such action would become “exhibit A” in future war‑crimes tribunals, noting that there is no statute of limitations for these offenses. As the deadline looms, the international community watches to see whether Trump will grant the requested extension, whether Iran will reopen the strategic strait, and whether diplomatic momentum can translate into a lasting cease‑fire in the volatile Middle East.

In a powerful display of dissent, hundreds of women took to the streets of Havana, Cuba's capital, to protest the de facto oil blockade imposed by the United States. The demonstration, which took place on what would have been the 96th birthday of Vilma Espin, a leader in the Cuban Revolution, saw protesters carrying banners and signs with the slogan 'Tumba el bloqueo' or 'Tear down the blockade'. The protesters are demanding an end to the US campaign that they say has caused widespread suffering and economic hardship.The protest was led by top officials in Cuba's communist government, including Deputy Prime Minister Ines Maria Chapman and Deputy Foreign Minister Josefina Vidal. Vidal denounced the US campaign as a form of collective punishment, stating that 'This policy of abuse has to stop. The Cuban people don't deserve this. It's the most comprehensive, all-encompassing, and longest-running system of coercive measures ever imposed against an entire country.'The US blockade has had a significant impact on Cuba's energy supply, with the country suffering at least two island-wide blackouts in the last month. The blockade has also led to food spoilage, water pumps ceasing to function, and medical patients going untreated. Russia has announced plans to send a second oil tanker to Cuba in defiance of the US blockade.The protest comes as the US and Cuba are in negotiations to lift the recent oil blockade. Deputy Foreign Minister Vidal stated that the talks are in a 'very preliminary' phase. The US blockade has been in place since the 1960s, but the current 'maximum pressure' campaign began under US President Donald Trump in his first term as president.

Jon Rahm, the 2023 Masters champion, has declared his commitment to representing Europe in next year’s Ryder Cup. This announcement is expected to boost Luke Donald’s confidence as he prepares to defend Europe’s title. Rahm has been embroiled in a dispute with the DP World Tour due to his participation in the LIV Tour without consent, resulting in substantial fines. Despite dropping his appeal against the sanctions, Rahm remains optimistic about finding a resolution. He revealed that he is in negotiations with the DP World Tour and is hopeful of securing a deal by September. “Yes,” Rahm stated when asked about his confidence in playing for Europe at Adare Manor. He emphasized that he did not think pursuing a legal route was beneficial for any party involved and expressed faith in reaching a mutually agreeable solution with the DP World Tour. Rahm mentioned that he has been making concessions in the negotiations and plans to support the DP World Tour, naming several events he would be interested in participating in, including the Irish Open, Wentworth, and the Spanish Open. “I’m not planning to play until September,” Rahm noted. “So that’s a bit of a positive. If I were unable right now, it doesn’t matter since I’m not planning to tee it up until after August like I have done in my career.”

Iranian officials have urged young people to form human chains around the country's power plants, as tensions escalate with the US and Israel. The call to action comes as US President Donald Trump threatens massive strikes on civilian infrastructure if Iran doesn't reopen the Strait of Hormuz.Iranian media showed people gathering outside electricity stations, waving Iranian flags and holding up banners. In Dezful, people gathered on a 1,700-year-old bridge. The country's president, Masoud Pezeshkian, said 14 million people had signed up to fight for their country and declared their readiness to sacrifice their lives in defence of Iran.The US and Israel carried out waves of preparatory strikes that appeared to knock off course the chances of a last-minute ceasefire deal before Trump's 8pm ET (1am BST) deadline for Iran to reopen the strait. Attacks on civilian infrastructure amount to war crimes, legal experts say.Alireza Rahimi, identified by Iranian state television as the secretary of the Supreme Council of Youth and Adolescents, issued a video message calling on young people to form human chains around power plants. He asked them to gather on Tuesday at 2pm around the power plants, which he described as national assets and capital.Iran has formed human-chain demonstrations, also known as human shields, in the past around its nuclear sites at times of heightened tensions with the west. A man in Tehran said his household had collected basic necessities and equipment to charge their mobile phones, in preparation to flee the capital if necessary.The indirect negotiations between the US and Iran are continuing, largely by passing messages through Pakistan. However, the intermediaries said they feared that Israel was bombing the chances of reaching an agreement.

Researchers at Rothamsted Research in Harpenden, Hertfordshire, have made a groundbreaking discovery in the field of food safety. By utilizing Crispr genome editing, they have successfully developed wheat that can be used to make bread with reduced levels of acrylamide, a toxic compound classified as a probable carcinogen.The innovation lies in the reduction of free asparagine, an amino acid in wheat that converts into acrylamide when bread is toasted, fried, or baked. Field trials over two years demonstrated that gene-edited wheat can have significantly lower concentrations of free asparagine without impacting crop yields. This translates into lower acrylamide formation in food products, making toasted bread safer for consumption.In tests, bread and biscuits made from the edited wheat showed substantially reduced acrylamide levels, with some bread samples having concentrations below detectable limits even after toasting. The Crispr editing targeted the gene responsible for asparagine production, achieving a reduction of up to 93% in free asparagine in dual-edited lines.Compared to conventional methods that achieved a 50% reduction in free asparagine but resulted in a 25% yield penalty, the Crispr-edited wheat offers a more efficient and effective solution. Dr. Navneet Kaur, a lead researcher, highlighted the potential of Crispr technology to deliver precise, beneficial changes in crop genetics, emphasizing the importance of supportive regulatory frameworks to unlock benefits for agriculture and food systems.The UK has become a global hub for gene editing research since Brexit, with the Genetic Technology (Precision Breeding) Act of 2023 facilitating the development and marketing of genetically modified crops. However, the future of these advancements may be influenced by negotiations with the EU over sanitary and phytosanitary agreements.Prof. Nigel Halford, who led the study, noted that low-acrylamide wheat could help food businesses meet safety standards without compromising product quality or incurring major costs, ultimately reducing consumers' dietary exposure to acrylamide.

Courtney Lawes has confirmed a one‑year deal with the Sale Sharks, a move that reignites hopes of a return to the England squad after two seasons in France’s Pro D2 with Brive.Approaching his 38th birthday in February, Lawes retired from Test rugby following the 2023 World Cup but insists he can still compete at the highest level. Sale’s director of rugby, Alex Sanderson, expressed enthusiasm about the former Northampton stalwart joining the Manchester‑based side.Sanderson emphasized that the signing was not driven by a paycheck: “He’s still got the ability and experience to play great rugby this season and possibly beyond.” He added that Lawes is “robust, dynamic around the park and hits hard, but his skill set makes him far more than a mere banger.”Lawes’ résumé includes 105 caps, participation in four World Cups, two Premiership titles, two Challenge Cup trophies, and three Six Nations championships. The veteran believes his body feels “good” and that retiring now would be a regretful decision.Speaking on his “un‑retirement” from international duty, Lawes said, “I’d love to play for England again, but first I want to perform well for Sale and see what happens afterward.”Sale, however, faces a potential manpower crunch ahead of their Champions Cup quarter‑final in Dublin against Leinster. England internationals Luke Cowan‑Dickie and Bevan Rodd are sidelined for the rest of the season, and hooker Nathan Jibulu awaits the outcome of a disciplinary hearing after being cited for biting former Harlequins teammate Will Hobson.The alleged incident occurred during Sale’s 26‑17 victory over Harlequins at the Twickenham Stoop. If Jibulu is suspended, Sale’s forward options will be further depleted, with brothers Tom and Ben Curry already unavailable.Despite the controversy, Jibulu remains a contender for England’s summer tour, as head coach Steve Borthwick evaluates his options ahead of the Nations Championship clash with South Africa in Johannesburg on 4 July. Sanderson praised the 23‑year‑old, noting, “He’s good now, he’ll be brilliant – he has the attributes to be an international hooker.”

James Gunn's early feature film Slither, initially released in 2006, is being re-released in cinemas ahead of its 20th anniversary. The film, a comedy horror with a heavy focus on body horror, was Gunn's first feature-length project. At the time, it was met with commercial disappointment but has since garnered attention due to Gunn's subsequent success with major franchises such as Guardians of the Galaxy and Superman.The film's plot revolves around an alien lifeform that crash-lands on Earth and takes over a small town in South Carolina. The alien larvae, resembling flaccid phallic worms, infect the townspeople through various orifices, turning them into evil minions or hideously swollen incubators. The movie features Michael Rooker, Elizabeth Banks, and Nathan Fillion in key roles.Despite its thinly conceived science fiction elements and reliance on rubbery practical effects and lame jokes, which align more closely with the style of Troma, a production company where Gunn got his start, the film does showcase Gunn's early experimentation with comic timing and musical cues. A notable scene features a killing spree set to Air Supply's 'Every Woman in the World', a technique Gunn would later refine in his Guardians of the Galaxy films.The cast, including Michael Rooker and Elizabeth Banks, appears to be enjoying the film's humor, bringing some bright spots of wit and amusement to the movie. Slither is set to re-release in UK cinemas on April 10 and will be available on digital platforms from May 1.

The conflict in Iran has underscored how fragile a world built on fossil fuels truly is, with disruptions to oil, gas and fertilizer shipments adding millions of tonnes of greenhouse‑gas emissions to an already critical climate system.While Saudi Arabia and other petrostates blocked any mention of a fossil‑fuel phase‑out at the UN COP30 summit last November, a new diplomatic effort is gathering momentum outside the UN framework.On 28‑29 April, Colombia will host the First International Conference on the Just Transition Away from Fossil Fuels. Unlike UN negotiations, the summit will be decided by majority vote, preventing a handful of countries from derailing progress.The event is co‑sponsored by Colombia – the world’s fifth‑largest coal exporter – and the Netherlands, home to Royal Dutch Shell. Organisers have invited nations that supported the COP30 roadmap, as well as sub‑national leaders such as California Governor Gavin Newsom, a potential 2028 U.S. presidential contender.Delegates, described as a “coalition of the willing”, will share concrete plans to shift their economies away from fossil fuels while safeguarding workers and communities. Climate activists, Indigenous representatives and trade‑union leaders will also contribute ideas for turning the abstract goal of decarbonisation into actionable policy.One focal point will be the reduction of the $7 trillion per year in global fossil‑fuel subsidies, a figure that the International Energy Agency warns could be trimmed without harming the livelihoods that depend on these funds. UN Secretary‑General António Guterres has urged the International Energy Agency to create a platform that aligns the decline of fossil‑fuel investment with rapid clean‑energy expansion.The real leverage of this coalition lies in its economic weight. The 85 countries that backed the COP30 roadmap together account for a gross national product of $33.3 trillion—surpassing the United States’ $30.6 trillion and far exceeding China’s $19.4 trillion.If the Just Transition conference produces a credible, market‑oriented plan, it could send a clear signal to investors and policymakers that the era of oil, gas and coal is ending, prompting a reallocation of capital away from stranded‑asset risks.Adding California’s $4.1 trillion GDP to the coalition’s total would create an economic bloc of roughly $37.4 trillion, approaching the combined $50 trillion output of the United States and China.Newsom has repeatedly positioned California as a climate leader, noting that two‑thirds of the state’s electricity now comes from non‑carbon sources and that its economy has risen from the world’s sixth to fourth largest. He pledged that California will fill the void left by the United States’ retreat from the Paris Agreement by competing in global green‑technology markets.Public opinion supports such a shift: between 80 % and 89 % of the world’s population wants stronger climate action. The upcoming conference therefore represents a pivotal chance to translate widespread demand into a coordinated, economically powerful push for a fossil‑fuel‑free future.