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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

The Clash Over AI in Garden Design The Chelsea Flower Show, a prestigious event in the gardening world, has become a platform for a heated debate over the use of artificial intelligence (AI) in garden design. This year's show, held at the Royal Hospital gardens in Chelsea, London, features a garden designed entirely by AI, sparking concerns among horticulturalists that their work could be automated. The Role of AI in Garden Design Matt Keightley, an award-winning designer who has created gardens for figures including Prince Harry, is using AI to design his garden for the show. He is launching a new app, Spacelift, which can replicate the work of garden designers and create spaces from scratch. Keightley believes that AI can give people a starting point and the confidence to create their own gardens. The Concerns of Horticulturalists Horticulturalists have expressed alarm that their work could be automated in this way. Andrew Duff, the chair of the Society of Garden and Landscape Designers, argues that successful garden design is an art form that requires creativity, collaboration, experience, and human connection. He believes that AI cannot replicate the insight, empathy, and personal engagement that comes from working with a skilled garden designer. The Future of Garden Design The use of AI in garden design raises questions about the future of the industry. While some designers see AI as a useful tool, others are concerned that it could replace human designers. Tom Massey, a Chelsea gold medallist, believes that AI-designed gardens would be inferior because they lack the physical body and interaction with a natural space that a human designer can provide. The Impact on the Industry The debate over AI in garden design has significant implications for the industry. As AI technology continues to evolve, it is likely to change the way gardens are designed and created. While some designers see AI as a threat, others believe that it could be a valuable tool that expands the market for garden design. The Prediction As the use of AI in garden design becomes more prevalent, it is likely that we will see a shift in the way gardens are designed and created. While AI may not replace human designers entirely, it is likely to play an increasingly important role in the design process. The industry will need to adapt to these changes and find ways to work with AI in a way that benefits both designers and clients.

First Ascent: The Allure of Carn Ffoi’s Jagged EdgeThe Guardian’s Country Diary captures a solitary climber’s obsession with a dark, looming rock outcrop on the brow of a Pembrokeshire hill. From a modest “home away from home,” the author watches the storm‑washed landscape settle, the wind drying the volcanic stone and setting the stage for a daring bouldering session.On‑Ground Details: Route‑Finding Without a GuidebookWithout a phone or detailed topos, the climber relies on a hand‑drawn booklet of routes that proves indecipherable. Instead, he scouts a potential line on the lee side of the boulder, warms his fingers, and visualises the climb in his mind before committing to the overhanging block.Physical Metrics: Climb Length, Elevation Gain, and Weather ConditionsClimb height: approximately 4‑5 metres of vertical gain.Elevation gain from base to summit: ~12 m above sea level.Wind: post‑storm gusts around 15‑20 km/h, drying the rock surface.Temperature: mild coastal chill, roughly 12 °C.Why This Matters: Highlighting Remote Coastal Climbing in WalesThe piece underscores a growing niche of climbers seeking untouched tors along the Welsh coast. The volcanic geology offers a texture “rough as old bark,” while the surrounding landscape—sandy Trefdraeth Bay, gorse scrub, and distant fishing boats—provides a dramatic backdrop that differentiates these sites from inland crags.Looking Ahead: Future Exploration of Pembrokeshire’s TorsAfter topping the boulder, the author spots a freshly‑moulted adder, a reminder of the area’s rich biodiversity. The encounter, combined with the panoramic sea view, suggests that Pembrokeshire’s tors will continue to attract adventurous climbers and nature enthusiasts alike, encouraging more detailed route documentation and sustainable access initiatives.

The Leadership Challenge British Prime Minister Keir Starmer, fighting for his political survival after dozens of his own MPs called for him to resign, promised to press ahead with plans to reform the country before an expected meeting with his potential leadership rival Wes Streeting, the health secretary. Calls for Resignation Starmer has so far defied calls to quit from Labour MPs, who blame him for heavy losses in local elections last week and say he has failed to deliver reforms since coming to power in a landslide 2024 election victory. More than 80, or almost a quarter, of the prime minister's elected MPs have called for Starmer to go, and four junior ministers have resigned in protest. The Meeting with Streeting The meeting in Downing Street will take place before King Charles gives a speech at the opening of parliament – a grand ceremony led by him and used by the government to set out its political priorities and legislative agenda for the year ahead. A public statement is not expected to follow the Streeting-Starmer meeting to keep the attention on the speech, according to British media reports. The Future of Starmer's Leadership Despite the turmoil, Starmer will take part in parliament's grand opening on Wednesday. He said in a statement on Tuesday evening: 'Britain stands at a pivotal moment: To press ahead with a plan to build a stronger, fairer country or turn back to the chaos and instability of the past.' The implementation of the government's plans remains uncertain, and if Starmer were to be removed, his successor would not be bound to follow the same plan.

The World's Longest Football DerbyCarlisle and Barrow will play each other next season in the Cumbrian derby in the National League. The clubs are located at opposite ends of Cumbria and the distance between the two grounds is some 78 miles by car. But this is not the greatest distance between two teams involved in a 'derby'.When considering derbies, we are looking for matches between teams that are linked based upon their proximity or geography, rather than simply historical rivalries like the 'clásico' between Real Madrid and Barcelona.UK Derbies: The Cumbrian ContenderWithin the UK, the Cumbrian derby certainly looks the furthest derby by distance. If we are staying in England, the closest we can get to 78 miles is the A49 derby between Shrewsbury Town and Hereford United, separated by 51 miles, although it should be said that the two teams have not met since the latter was dissolved in 2014.In England, thoughts immediately go to Crystal Palace and Brighton, dubbed the M23 derby, but a quick search reveals that Selhurst Park is a mere 46 miles from the Amex Stadium. It is also 46 miles that separate the stadiums of Plymouth Argyle and Exeter City, the Devon derby. Just behind are Ipswich and Norwich – the East Anglian derby (AKA El Tractico or the Old Farm) – with Portman Road and Carrow Road 45 miles apart.International Long-Distance DerbiesFarther afield, we must mention the derby between Persib Bandung and Persija Jakarta, who take part in the Indonesia derby, or Laga Klasikal as it is locally known, with Persib's Gelora Bandung Lautan Api Stadium lying 108 miles away from Persija's Jakarta International Stadium in Indonesia's capital.Italy is fertile ground for a host of famous derbies, and it is here that we find some of the longest-distance derbies. Of course there is the Derby d'Italia between Milan and Juventus, with 85 miles separating San Siro and Juve's Allianz Arena in Italy's north-west. The Derby di Sicilia between Palermo and Catania spans a whopping 134 miles across the breadth of Sicily, while the Derby delle Isole (Derby of the Islands) between Palermo and Sardinian club Cagliari goes even further – a full 250 miles across the Tyrrhenian Sea.The Champion: New Zealand's 386-Mile DerbyOur winner, though, comes from New Zealand's North Island. With Auckland FC only entering the A-League Men in 2024-25, the New Zealand derby between themselves and Wellington Phoenix is still very much in its infancy but has already blossomed into something substantial. In February, just the sixth edition of the derby, a comical own goal from Wellington goalkeeper Josh Oluwayemi sparked a 5-0 thrashing by Auckland, prompting Phoenix coach Giancarlo Italiano to resign immediately after the defeat. With 386 miles between the two grounds, the NZD is our clear winner.The Evolution of Geographic DerbiesThe existence of such long-distance derbies challenges our traditional understanding of what constitutes a local rivalry. In an era where football has become increasingly globalized, these geographic matchups represent unique connections between communities separated by vast distances. The New Zealand derby, in particular, showcases how even in a country with a relatively small population, football can create intense rivalries across significant geographical divides.The Future of Long-Distance DerbiesAs football continues to evolve, we may see more long-distance derbies emerge, particularly in regions with expanding leagues or where new clubs are formed to serve underserved areas. The New Zealand derby between Auckland and Wellington Phoenix is a prime example of how modern football infrastructure and scheduling can create meaningful rivalries regardless of distance. With the increasing popularity of travel and fan engagement, these long-distance derbies may become even more significant in the future of football culture.Double Winners in FootballDeji Elerewe has won the title with both Bromley (League Two) and Lincoln (League One) this season. Has any other player managed the same feat?We covered this answer 10 years ago in a previous Knowledge, but regular contributor Dirk Maas has come in clutch with some additions, although he does clarify that he has limited his search to the top five leagues in Europe in this century.There are several examples of players winning titles with different teams in the same season, including:Jonas Urbig with Köln (2. Bundesliga) and Bayern Munich (Bundesliga) in 2024-25Leigh Griffiths with Celtic (Scottish Premiership) and Wolverhampton (League One) in 2013-14Urby Emanuelson with Ajax and Milan in 2010-11Daniel Amartey with Leicester City and FC Copenhagen in 2015-16Timothy Weah with Paris Saint-Germain and Celtic in 2018-19Khvicha Kvaratskhelia with Napoli and PSG in 2024-25There are also alternative cases where seasons happen at different times of year, such as David Beckham achieving this by picking up an MLS winner's medal with LA Galaxy and a Ligue 1 winner's medal with Paris Saint-Germain in 2012-13.

The Trump-Xi Summit: A Pivotal Moment in US-China Relations Donald Trump's state visit to China this week – the first by the US president in nearly a decade – comes amid a time of geopolitical upheaval, a new and intractable conflict in the Middle East, and a sometimes rocky relationship between the world's two major superpowers. There is much for Trump and Xi Jinping to discuss, but a few key issues are likely to dominate the agenda. Five Critical Issues on the Summit Agenda The high-stakes meeting between the two leaders addresses several pressing matters that could reshape the global landscape: The Iran Conflict and Hormuz Strait Crisis Trump is eager for China to lean on Tehran to advance peace talks and reopen the strait of Hormuz. To now, Beijing has sat back and watched the US struggle against Iran, at least publicly. But with about half of China's crude oil imports passing through the strait, Xi does want the waterway unblocked. China knows its exports will suffer if a global recession results from an oil supply crisis. Complicating the picture, the US this week put sanctions on several Chinese firms accused of assisting Iranian oil shipments and supplying satellite imagery allegedly used in Iranian military operations, claims that Beijing denied. Trump's arrival comes after Iran's foreign minister, Abbas Araghchi, visited Beijing last week. Taiwan: The Flashpoint in US-China Relations Beijing is keen to push the US on Taiwan, with Trump saying he is prepared to raise the issue of arms sales to the island, which China claims as a breakaway territory despite never having ruled it. In December, Trump authorised an $11bn arms package for Taiwan, the largest weapons sale ever to the island, but no shipments have been made yet. Xi may seek changes in how the US refers to Taiwan. Ideally, from the perspective of Beijing, this would be a statement from Washington "opposing" Taiwan's independence rather than "not supporting" it. Taiwan will be watching closely. Just two weeks ago, China's foreign minister in a phone call with Marco Rubio urged the US to "make the right choices" on Taiwan. With Trump known to veer off script, John Kirby, a former US state department and Pentagon spokesperson cautioned: "They just have to be so extraordinarily precise when you're talking about Taiwan because, quite frankly, the stakes are enormously high." The AI Cold War: Technological Supremacy at Stake China and the US are locked into a race on artificial intelligence that is becoming something of a technological cold war. In April, the White House accused China of stealing US AI labs' intellectual property on an industrial scale, claims Beijing denied. Meanwhile, Beijing has been frustrated by Washington's reluctance to allow Nvidia to export its most powerful processing chips to China. In January, the White House said Nvidia could export its second most powerful chip, the H200, but no shipments have been sent yet. Analysts and ethics leaders hope Trump and Xi will discuss non-binding AI guidelines, including sharing information about AI misuse and safety, which are seen as critical guardrails amid the advent of AI weaponry and military adoption. Trade War: Rare Earth Minerals and Economic Leverage Trump has repeatedly threatened China over trade, imposing tariffs above 140% last year. But Xi held some cards of his own and did not fold. Instead, China blocked exports of its rare earth minerals and magnets to the US. Trump, finally, backed down. The US has depleted notable levels of its weapons arsenal in the war against Iran, with many weaponry components requiring critical minerals that are linked to supply chains dominated by China. China is expected to announce purchases related to Boeing airplanes, American agriculture and energy, US officials have said. In turn, Beijing wants the US to ease curbs on exports of advanced semiconductors. Beijing also wants to reduce barriers to investment in the US, and hopes to establish a Board of Investment to match the Trump-back Board of Trade. Fentanyl: The Drug War and Political Posturing Fentanyl is a key item on Trump's agenda this week, Politico reported, citing an administration official granted anonymity to preview the closed-door sessions. The US has long accused Chinese businesses of knowingly supplying the chemical precursors to Mexican cartels who use them to make the drug. Trump knows that being seen to press China hard over fentanyl and precursors plays well with his Maga base. But Trump lost important leverage on the fentanyl front when China defied his tariffs threats. In March, the US and China clashed over fentanyl and trade at a UN drugs meeting. China wants to be removed from the state department's annual list of "major drug transit or illicit drug producing countries", due to be updated in September.

Morning Snapshot: UK Bond Market Bruised by Political Turbulence Good morning, and welcome to our rolling coverage of business, the financial markets and the world economy. The UK bond market is bruised this morning after a day of political turbulence drove up Britain’s borrowing costs. Rising Yields: 10‑Year Gilt Above 5% – Highest Since 1998 UK long‑term bond yields hit their highest levels in 28 years on Tuesday, pushing the 10‑year gilt yield back above 5%, the highest level since 1998. Numbers at a Glance: Yield Spike and Borrowing Cost Implications 10‑year gilt yield: > 5% (first time above 5% since 1998) Yield rise triggered by fears of a left‑leaning Labour government and potential fiscal expansion. Higher yields mean investors demand greater compensation, increasing the cost of borrowing for the UK Treasury. Political Shockwaves: Labour Leadership Uncertainty and Reform’s Rise Investors are wary that a shift to the left under Keir Starmer could lead to higher spending and larger deficits. At the same time, the prospect of Nigel Farage entering Downing Street after Reform’s gains in the recent local elections adds another layer of uncertainty. Senior analyst Ipek Ozkardeskaya of Swissquote notes that the market is "grappling with their own political shakeups" and that the combination of fiscal concerns and inflation outlook is driving yields up. Market strategist Bill Blain of Wind Shift Capital cautions that investors may not view Reform as a "safe pair of hands" for managing the bond market and public spending. Looking Ahead: What the King’s Speech Could Mean for Debt Markets The UK government will outline its legislative agenda in the King’s Speech later today, which could provide some respite for Keir Starmer amid ministerial resignations and calls for his departure. 10am BST: IEA monthly oil market report 10am BST: Eurozone GDP report (latest estimate for Q1 2026) 1.30pm BST: US producer prices inflation report for April 3pm BST: Bank of England policymaker Catherine L. Mann to release speech on “The UK’s international exposures and vulnerabilities”

Executive Summary: Labour’s Leadership Crisis DeepensThe Guardian column highlights how recent local election defeats have pushed Labour MPs toward demanding Keir Starmer's removal, yet the author insists the party needs a robust battle of ideas rather than a frantic scramble for the premiership.Local Election Fallout Triggers Backbench DissentCatastrophic results in the May 2026 local and devolved ballots provided concrete evidence that Labour is heading toward "electoral oblivion." A growing cohort of MPs believes the trajectory will not improve without a change in leadership, intensifying calls for a challenge to Starmer.Absence of Quantitative Data Limits Financial Impact AssessmentThe article does not present specific polling numbers or fiscal figures, so a precise financial impact cannot be calculated. The lack of hard data underscores the reliance on qualitative judgments about voter sentiment and party morale.Implications for Labour’s Electoral Prospects and Party UnityPolicy vacuum: Starmer’s pragmatic but vague messaging has left the party without a clear programme, eroding voter confidence.Factional tension: Efforts to purge the "Corbyn legacy" have been perceived as monolithic, alienating the party’s left wing.Communication breakdown: Repeated U‑turns and unclear immigration and fiscal policies have weakened the party’s narrative.These factors combine to threaten Labour’s ability to present a coherent alternative to the Conservatives, risking further electoral decline.Outlook: Potential Leadership Contest and Strategic ReorientationIf Starmer refuses to acknowledge his role in the party’s malaise, pressure for a leadership contest will likely intensify. A credible challenger would need to articulate a detailed policy platform that moves beyond incremental change, offering voters a distinct vision for post‑Brexit Britain.

The Lead Modella Capital, a low-profile investment group, has snapped up the former WH Smith high street business for a significantly reduced price, sparking concerns over the chain's future. The Event Details WH Smith's high street arm was sold to Modella Capital last summer for £76m, including £52m in cash. However, the deal was later reduced to £40m, with only £10m paid upfront. The chain has since been rebranded as TG Jones. The Data Analysis Original sale price: £76m Reduced sale price: £40m Upfront payment: £10m Potential store closures: up to 150 Jobs at risk: thousands The Impact Analysis The restructure plan has raised concerns over the impact on the high street and the jobs of thousands of employees. The chain's decline reflects the changing shape of UK high streets and shopping habits. The Prediction The future of TG Jones remains uncertain, with retail insiders expecting further store closures. The chain's ability to compete with online retailers and cut-price rivals will be crucial to its survival.