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The Breakthrough prize, often referred to as the 'Oscar of science', has been awarded to a team of scientists for their groundbreaking work in gene therapy. Jean Bennett, a molecular biologist, and Albert Maguire, an ophthalmologist, who met while dissecting a brain at Harvard Medical School, have been recognized for their 25-year-long project that led to the development of Luxturna, the first approved gene therapy for blindness.The therapy has transformed the lives of people born with Leber congenital amaurosis (LCA), a genetic disorder that typically causes total blindness by early adulthood. The treatment, which smuggles a working version of the gene into retinal cells, has shown profound improvements in patients, with one patient describing seeing their child's face for the first time.The $3m prize is shared with physician Katherine High, who worked with Bennett and Maguire on the project. The couple's work is a testament to their dedication and perseverance, with Bennett noting that she was 'overwhelmed' by the news and describing it as one of the most 'miraculous eureka moments' she could imagine.Bennett also expressed concerns about the US administration's attacks on science, warning that it could 'cause damage for generations to come' and lead to a brain drain that the country would struggle to recover from.The Breakthrough prizes, founded by Silicon Valley entrepreneurs, recognize outstanding achievements in life sciences, mathematics, and physics. Other prizes awarded included work on a gene therapy for sickle cell anaemia and beta thalassaemia, and the discovery of genetic drivers of frontotemporal dementia and ALS.

Lionel Messi delivered a brace to propel Inter Miami to a 3-2 victory over the Colorado Rapids on Saturday in Denver, securing three points in Major League Soccer and keeping the club in contention for a strong playoff push.The match, held at Empower Field before a crowd of 75,824 spectators—the second‑largest attendance in MLS history—saw Miami take an early lead when a pass from goalkeeper Zack Steffen was intercepted by Yannick Bright, allowing Messi to convert a 13th‑minute penalty and put the visitors ahead 1-0.Inter Miami extended the advantage to 2-0 during first‑half stoppage time after a swift passing sequence culminated in a header by German Berterame, set up by Rodrigo De Paul’s cross. Colorado responded with goals from Rafael Navarro (58') and substitute Darren Yapi (62'), leveling the score at 2-2.Messi reclaimed the lead in the 79th minute, launching a solo run from midfield and striking the ball into the upper left corner for a go‑ahead goal. The Argentine’s decisive strike proved crucial as Miami held on despite being reduced to ten men when Yannick Bright received a red card in the 87th minute.With the win, Inter Miami improved to 4‑1‑3 (15 points) while Colorado slipped to 4‑4‑0 (12 points), underscoring Miami’s upward trajectory in the Eastern Conference standings.Beyond the result, the match highlighted the growing popularity of MLS, drawing a near‑record crowd and showcasing Messi’s continued impact on the league’s global profile.

World-renowned tennis player Novak Djokovic has announced that he will not participate in the upcoming Madrid Open, citing ongoing injury concerns and a need for continued recovery.The 38-year-old Serb has struggled with fitness issues this year, playing only two tournaments: the Australian Open in February, where he lost to Carlos Alcaraz, and the Indian Wells in March. His shoulder injury has been a significant setback, forcing him to skip several tournaments, including the Doha Open, Miami Open, and Monte Carlo Masters.Djokovic expressed his disappointment at missing the Madrid Open, a tournament where he is a three-time champion, stating: 'Madrid, unfortunately, I won’t be able to compete this year. I’m continuing my recovery in order to be back soon.'Despite these challenges, Djokovic remains focused on his goal of competing at the French Open, which begins on May 24. He is next scheduled to compete at the Italian Open in Rome from May 6-17, where he will aim to regain his form ahead of the Grand Slam event.The withdrawal from the Madrid Open raises concerns about Djokovic's fitness levels and his ability to perform at his best in the French Open. As the 24-time Grand Slam champion prepares for the next major tournament, his fans and fellow competitors will be closely watching his progress.

Ten years after Prince’s death, friends and collaborators such as George Clinton, Apollonia Kotero and drummer Charles “Chazz” Smith share personal memories that illuminate his musical brilliance and private life.George Clinton, the legendary leader of Parliament‑Funkadelic, remembers meeting the 19‑year‑old Prince in 1977 and immediately recognizing a talent “a new version of Sly Stone.” Clinton praised Prince’s ability to master guitar, keyboards, bass and drums, noting his “arranging genius” inherited from his pianist father and his dance flair “like James Brown.” Clinton also recalled how Prince later signed him to Paisley Park Records and inducted him into the Rock and Roll Hall of Fame, cementing a friendship that survived countless late‑night studio sessions.Apollonia Kotero, actress and singer who starred alongside Prince in the 1984 film Purple Rain, describes a bond that spanned 33 years. She recounts the grueling shoot—jumping into a freezing lake, suffering hypothermia, and Prince’s frantic plea, “Please don’t die, Apple. I love you.” Their relationship, she says, was “family, not romance,” and Prince’s protective nature shone when he cared for her during illness. Kotero also recalls a surreal moment when Prince hummed the opening melody of “When Doves Cry” into her answerphone, urging her “Don’t erase this!” as a reminder of his creative process.Beyond the studio, Kotero notes Prince’s voracious appetite for literature and politics, his 3 a.m. visits that turned into midnight drives across Hollywood, and his habit of showing her walls plastered with fan mail—a testament to his deep connection with his audience.Charles “Chazz” Smith, Prince’s cousin and original drummer in the early band Grand Central, paints a picture of Prince’s childhood obsession with music. After a spontaneous Sly and the Family Stone concert in Minneapolis, Prince declared, “We’re gonna form a band, and you’re gonna be the drummer.” Within weeks, a newly gifted guitar allowed him to replicate Santana’s “Black Magic Woman” note for note, signalling the start of an insatiable drive to master every genre—from rock to funk to ballads.In the final months of his life, Prince’s friends observed a shift. He reclaimed the rights to his catalog in 2014, began repaying debts, and expressed grief over the death of Vanity, his longtime muse. Smith recalls a poignant encounter six weeks before Prince’s passing: after a brief hug, they exchanged the words “I love you,” marking the last conversation they ever shared.These testimonies collectively reveal a portrait of Prince that goes beyond his public persona: a relentless virtuoso, a compassionate confidant, and an artist whose influence continues to reverberate a decade after his untimely death.

The 2026 NBA playoffs are shaping up to be a thrilling competition, with several top teams vying for the championship. Oklahoma City Thunder are the defending champions and are favored to repeat, led by Shai Gilgeous-Alexander.However, teams like the San Antonio Spurs, led by rookie sensation Victor Wembanyama, are looking to make a deep run. The New York Knicks are also a strong contender, with Jalen Brunson leading the charge.The Miami Heat are considered a dark horse, with a strong team culture and Bam Adebayo leading the way. The Boston Celtics are also a top contender, with Jayson Tatum and Jaylen Brown leading the team.In the Western Conference, the Thunder are favored to make it to the finals, but teams like the Spurs and Pelicans could make a surprise run. In the Eastern Conference, the Knicks and Celtics are the top contenders.The playoffs are expected to be highly competitive, with several teams having a legitimate chance of winning it all. Jokić and Gilgeous-Alexander are considered two of the most important players in the postseason.

San Francisco‑originated Philz Coffee announced on Friday that it will keep Pride flags displayed in all of its locations, overturning a policy introduced just days earlier that called for their removal.Chief executive Mahesh Sadarangani said in a statement, "I made a mistake and I am sincerely sorry," adding that the Pride flag represents "a symbol of safety and belonging for people who don’t always find that in the world," and that he does not wish to deprive any customer of that feeling.When the policy was first unveiled, Sadarangani framed it as a move toward uniformity, indicating that other non‑U.S. flags would also be taken down to maintain consistency across stores.The decision triggered an immediate and vocal backlash from both employees and customers. An online petition opposing the ban quickly amassed more than 7,300 signatures, reflecting the chain’s long‑standing reputation as an ally of the LGBTQ+ community.State Senator Scott Wiener, whose district includes San Francisco, condemned the policy on social media and suggested it was linked to Philz’s recent acquisition by private‑equity firm Freeman Spogli, raising concerns about corporate influence on inclusive practices.Sadarangani credited San Francisco Pride leaders Suzanne Ford and Jupiter Peraza for prompting the reversal, noting their outreach helped the company understand the broader impact of the decision."What gave me reason to engage with Mahesh was something I don’t always see from a CEO in this situation: genuine humility," Ford said. "He reached out, listened, and understood that this wasn’t about optics—it was about whether queer people and the employees who support them feel safe and seen. That matters."Founded in 2003, Philz Coffee has grown from a single San Francisco shop to a network of over 80 locations across California and Chicago, positioning itself as a community‑focused brand.The controversy occurs against a backdrop of nationwide debates over Pride symbols. Republican‑led states have recently removed rainbow flags from public spaces, and the Trump administration previously took down a rainbow flag at New York City’s Stonewall monument before agreeing to a settlement that restored it.Across the country, rainbow crosswalks have been targeted for removal, prompting cities like Miami Beach to install alternative displays—such as rainbow‑colored benches and plaques—to demonstrate solidarity with LGBTQ+ residents.

Social media erupted this week after US media outlets reported that FIFA had prohibited tailgating at the 2026 World Cup stadiums. Fans quickly challenged the claim, pointing to FIFA’s own statement that it "does not have a formal policy that restricts tailgating".FIFA clarified that while there is no global ban, individual venues may impose restrictions in line with local public‑safety regulations. The organization added that detailed fan guidance will be released well before the tournament kicks off.In the United States, tailgating is a long‑standing pre‑match tradition where supporters park near the stadium, grill, drink and socialize for hours before kickoff. The practice, especially popular at NFL games, is considered an essential part of the American match‑day experience.American fans argue that banning the activity would strip away a cultural hallmark. One Philadelphia supporter wrote on X, "FIFA doesn’t understand that you physically cannot stop Philadelphians from tailgating." Others noted that international visitors often enjoy the festive atmosphere, citing videos from the 2025 FIFA Club World Cup.Nevertheless, the Boston organising committee has already announced that tailgating "is not permitted for these events," highlighting the patchwork of local rules that could affect the World Cup.Security protocols for major tournaments require two concentric perimeters around each stadium: an outer ring focused on crowd safety and an inner ring for ticket verification. The exact placement of the outer perimeter depends on each venue’s layout, parking capacity and access routes, and it is designed to keep "unauthorised persons" away from the stadium building.Because FIFA cedes day‑of‑match security decisions to local organising committees, the final stance on tailgating will likely be decided by city officials and may not be disclosed until closer to the event.The United States will host 78 of the 104 matches across 10 venues, including the newly renamed Los Angeles Stadium (formerly SoFi Stadium) for the opening match and the New York‑New Jersey Stadium (formerly MetLife Stadium) for the final. Other sites are Boston’s Gillette Stadium, Philadelphia’s Lincoln Financial Field, Dallas’s AT&T Stadium, Seattle’s Lumen Field, Kansas City’s Arrowhead Stadium, Miami’s Hard Rock Stadium, Atlanta’s Mercedes‑Benz Stadium, Houston’s NRG Stadium, and the San Francisco Bay Area’s Levi’s Stadium.Until local authorities release definitive guidelines, the fate of tailgating at the 2026 World Cup remains an open question, leaving fans to await clarification on whether their beloved pre‑game rituals will survive the tournament’s security framework.

Lionel Messi has officially taken ownership of UE Cornella, a Barcelona‑based club competing in Spain’s fifth division, after finalising the purchase earlier this week.The Argentine legend, who spent two decades at FC Barcelona amassing multiple La Liga titles, Champions League trophies and Ballon d’Or awards before departing in 2021, is now venturing into club ownership.In a statement the club described Messi’s arrival as “the beginning of a new chapter in the club’s history,” emphasizing a long‑term vision and a strategic plan that blends ambition, sustainability and a deep connection to its working‑class neighbourhood roots.Founded in 1951, UE Cornella has previously nurtured talent such as Arsenal goalkeeper David Raya and former Barcelona defender Jordi Alba, the latter of whom currently shares the pitch with Messi at Inter Miami.Now 38‑year‑old Messi is also focused on representing Argentina at the 2026 World Cup in North America, where the Albiceleste will defend their title.The club announced the deal on Thursday but did not disclose the financial terms of the transaction.

Former NBA player and assistant coach Damon Jones is expected to plead guilty in a landmark US gambling case, marking a significant development in a sweeping investigation that has led to the arrests of over 30 individuals, including reputed mobsters and other basketball figures.A change-of-plea hearing for Jones is scheduled for April 28 in Brooklyn federal court. He faces charges of wire fraud conspiracy and money-laundering conspiracy related to two separate indictments. The first indictment accuses him of profiting from rigged poker games, while the second charges him with providing sports bettors with non-public information about injuries to NBA stars LeBron James and Anthony Davis.Jones, 49, had previously pleaded not guilty to the charges. He was arrested last October alongside Portland Trail Blazers head coach Chauncey Billups and Miami Heat guard Terry Rozier, among others. According to prosecutors, Jones sold or attempted to sell non-public information to bettors, including a tip that James was injured and wouldn’t play in a February 9, 2023, game against the Milwaukee Bucks. He also allegedly received $2,500 for a tip that Davis would see limited playing time against the Oklahoma City Thunder.In the poker scheme, Jones was among former NBA players used to lure unwitting players into rigged poker games. He was paid $2,500 for a game in the Hamptons where he was instructed to cheat. The poker scheme often made use of illegal poker games run by New York crime families that required them to share a portion of their proceeds with the Gambino, Genovese, and Bonnano crime families.Jones, who earned more than $20m playing for 10 teams in 11 seasons from 1999 to 2009, is a native of Galveston, Texas. He played alongside James in Cleveland from 2005 to 2008 and served as an unofficial assistant coach for James’s Los Angeles Lakers during the 2022-2023 season.