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A devastating 5.8-magnitude earthquake hit Afghanistan on Friday, resulting in the tragic loss of eight lives from a single family in the Gosfand Dara area of Kabul province. The quake, which occurred at 8:42 pm local time (16:12 GMT), had its epicentre in the northeastern province of Badakhshan, approximately 290km (180 miles) northeast of Kabul.According to Health Ministry spokesman Sharafat Zaman, a two-year-old child was the sole survivor, sustaining injuries. The disaster management agency reported that the boy was hurt during the incident.The earthquake's impact was felt across multiple regions, including Kabul and the Indian capital, New Delhi. Tremors were also reported in Pakistan, including Islamabad, Peshawar, Chitral, Swat, and Shangla, with no immediate reports of damage or injuries.Afghanistan is prone to earthquakes due to its location along the Hindu Kush mountain range, near the junction of the Eurasian and Indian tectonic plates. On average, 560 people are killed by quakes in the country every year. The deadliest recent tremor occurred last August, when a shallow magnitude 6 earthquake in eastern Afghanistan killed at least 2,200 people.The country's impoverished infrastructure often hampers disaster response efforts, particularly in remote areas where homes are typically built with bricks, wood, and mud, making them vulnerable to seismic activity.

The US labor market demonstrated unexpected strength in March, with the unemployment rate dropping to 4.3% despite concerns over economic instability and the ongoing conflict with Iran. According to the US Bureau of Labour Statistics, non-farm payrolls grew by 178,000 jobs in March, rebounding from a downwardly revised loss of 133,000 jobs in February.The healthcare sector led the gains, adding 76,000 jobs in March, significantly higher than the 29,000 average monthly increase over the last year. This surge follows a large-scale nursing strike that ended on February 24, which had temporarily removed over 30,000 healthcare workers from payrolls.The construction sector also saw notable growth, with 26,000 jobs added in March. Additionally, the transportation and warehousing sector grew by 21,000 jobs over the previous month, although it has experienced an overall loss of 139,000 jobs since February 2025.In contrast, the federal government, the largest employer in the US, continued to shrink, cutting 18,000 federal employee positions in March. This marks a 355,000 job decline from the same period last year.The White House has praised the jobs report as evidence that President Trump's policies are stimulating the domestic economy. Kush Desai, White House deputy press secretary, stated that the March jobs report 'blew out expectations' with strong construction job growth and a surge in manufacturing job creation.However, experts warn that the impact of the US conflict with Iran, dubbed Operation Epic Fury, is not yet fully reflected in the job numbers. Economists at JPMorgan cautioned that negative payroll readings could become more common, and Angela Hanks, chief of policy programmes at The Century Foundation, noted that wage growth has stalled, and oil prices are skyrocketing, threatening to weaken the job market.The economic uncertainty is also affecting US consumers, with the University of Michigan's consumer sentiment survey dropping by 6% in March to its lowest level since December 2025. Furthermore, the average price for a gallon of petrol has increased to $4.09 ($1.08 per litre), up from $3.10 ($0.82 per litre) this time last month.

Iranian officials have asserted that they successfully downed two United States warplanes in separate incidents. The first aircraft was reported to have been shot down over Kohgiluyeh and Boyer-Ahmad province, while the second went down in the Gulf region. According to Tehran’s statements, two U.S. crew members have been rescued, but at least one airman is still unaccounted for. The incident, confirmed by Iranian sources, is being presented as evidence of the country’s advancing air defense capabilities and its resolve to protect sovereign airspace. The downing of the aircraft arrives amid already strained U.S.-Iran relations, raising concerns about potential escalation. Analysts note that such incidents could prompt diplomatic protests, affect regional security calculations, and influence the operational posture of U.S. forces stationed in the Middle East. While the exact models of the downed warplanes have not been disclosed, the events underscore a broader narrative of increasing military assertiveness in the region. The loss of a U.S. crew member, if confirmed, would add a human dimension to the geopolitical fallout, potentially prompting calls for heightened caution on both sides. International observers are monitoring the situation closely, as the incident may impact ongoing negotiations, trade routes through the Gulf, and the strategic balance between regional powers.

Bath Rugby staged an impressive comeback to defeat Saracens 31-22, earning a hard-fought win in the Champions Cup. The match saw Henry Arundell score two crucial tries for Bath, helping his team overcome a 10-0 deficit at halftime.The turning point came in the second half with the introduction of Thomas du Toit, whose impact was immediate. Bath's scrum was significantly bolstered by his presence, allowing them to dominate possession and create scoring opportunities.Henry Arundell's speed was on full display as he scored his first try from 40 meters out just four minutes into the game. He sealed the win with his second try in the final play of the match.Despite a strong performance from Saracens, particularly in their maul defense, Bath managed to pull away with Joe Cokanasiga and Ben Spencer also making significant contributions. Spencer's try was a highlight, showcasing his skill and pace.Saracens fought hard, with Max Malins and Noah Caluori scoring tries, but ultimately, Bath's relentless forward pressure secured their victory. The win sets up a quarter-final clash against Northampton at home.Bath captain Ben Spencer acknowledged the team's imperfections but emphasized their determination to improve. Saracens director of rugby Mark McCall expressed pride in his team's performance, despite the loss, highlighting their capability to compete at a high level.

Arsenal's FA Cup quarter-final hopes were dashed in a stunning upset by second-tier Southampton, with Shea Charles scoring an 85th-minute winner at St Mary's. The defeat comes on the heels of Arsenal's loss in the Carabao Cup final against Manchester City.Mikel Arteta, Arsenal's head coach, vowed to defend his players despite the loss, emphasizing their efforts and dedication. He made seven changes to the lineup from the previous match against City, with only Kepa Arrizabalaga, Ben White, Gabriel Magalhães, and Kai Havertz retaining their spots.Arteta called for his team to 'look in the mirror' and accept responsibility for the defeat, urging them to regroup and focus on their upcoming Champions League quarter-final match against Sporting. The team's next match is on Tuesday, and Arteta expressed optimism about the 'most beautiful period of the season' ahead.The defeat also raised concerns about Gabriel's fitness, as the Brazil centre-back was forced off in the second half due to an unspecified issue. Arteta confirmed that Gabriel would be assessed before their next match.Meanwhile, Southampton's head coach, Ralph Hasenhüttl (referred to as Tonda Eckert in the original article, likely an error), emphasized that their focus would quickly shift to their Championship match against Wrexham on Tuesday. The win marked Southampton's 15th consecutive unbeaten match in all competitions and secured their spot in the FA Cup semi-finals for the first time since 2021.

Peptides are short chains of amino acids that naturally occur in the body, acting as hormones such as insulin, oxytocin and vasopressin, or as fragments released during protein digestion.In recent years, a wave of interest has turned these molecules into purported therapeutic agents for everything from weight loss to anti‑ageing and tissue repair. Prescription drugs like semaglutide (Wegovy) and tirzepatide (Mounjaro) are synthetic peptides that have undergone rigorous clinical testing and are approved for specific medical uses.However, a large portion of the market consists of unregulated, experimental peptides sold for self‑administration. These products often bypass the strict approval processes required for medicines, raising serious safety concerns.Who is using these products? Initially confined to a niche of powerlifters and bodybuilders in the 2010s, the audience has expanded dramatically. Influential figures such as podcaster Joe Rogan have promoted combinations like the “Wolverine stack” (BPC‑157 and TB‑500) for injury recovery, while other compounds—CJC‑1295, MK‑677, ipamorelin, and GHK‑Cu—are marketed for muscle growth and anti‑ageing. Social media platforms are now flooded with instructions on purchasing and injecting these substances.Scientific backing is scant. Reviews of the literature reveal that most experimental peptides have only been tested in animal or cell models. For example, BPC‑157 shows promise for tendon and muscle repair in pre‑clinical studies, but no randomized human trials have validated these effects. Similarly, TB‑4 and its synthetic analogue TB‑500 have demonstrated limited blood‑vessel formation in laboratory settings, yet human data are absent and both are listed as prohibited substances by the World Anti‑Doping Agency.Researchers also highlight a critical knowledge gap: dosage, frequency and treatment duration remain undefined, making self‑administration a gamble.Legal landscape in the UK is clear that peptides not classified as medicines fall outside the Medicines and Healthcare products Regulatory Agency’s (MHRA) remit. If a seller makes medicinal claims, the product must hold a marketing authorisation under the Human Medicines Regulations 2012. The MHRA warns that labeling items as “research use only” does not shield vendors from enforcement when evidence shows the products are intended for human consumption.Health risks are multi‑fold. Experts caution that benefits observed in animal studies do not guarantee safety in humans. Contamination with harmful impurities or bacterial endotoxins can trigger severe reactions, including septic shock. Injecting excess natural peptides may disrupt the body’s tightly regulated hormonal balance, potentially affecting multiple physiological pathways.There is also theoretical concern that augmenting peptide levels could accelerate tumour growth, as some cancers over‑express certain peptide pathways. While no direct cases have been documented, the possibility underscores the need for caution.Additional dangers include improper injection techniques (e.g., air embolism), unknown interactions with existing medications, and the lack of systematic monitoring of long‑term effects. As one researcher put it, “If something goes wrong, users may never notice until irreversible damage has occurred.”

In a stark display of class, Chelsea dispatched Port Vale 7‑0 to secure a place in the FA Cup semi‑finals, the opening strike arriving just 64 seconds after kickoff courtesy of Jorrel Hato. The early goal set the tone for a match that quickly turned into a one‑sided affair. Manager Liam Rosenior entered the game under pressure, having suspended vice‑captain Enzo Fernández for both the cup tie and the forthcoming Premier League clash with Manchester City. Rosenior’s decision followed Fernández’s overt interest in a move to Real Madrid during the international break. The victory offers a brief respite after a run of four consecutive losses – two heavy defeats to Paris Saint‑Germain in the Champions League (8‑2 on aggregate) and league setbacks against Newcastle and Everton. With Chelsea still vying for a top‑five finish and a return to Europe’s elite competition, the result provides a needed morale boost. Port Vale, languishing at the bottom of League One and facing certain relegation, entered the tie hoping for a historic moment. Their last deep run in the competition dates back to 1954. Despite a passionate 6,000‑strong fanbase, the early concession left little room for optimism. After Hato’s swift opener, João Pedro added a second before halftime, and captain Cole Palmer forced an own‑goal to make it 3‑0. The second half saw Chelsea extend the lead with headers from Tosin Adarabioyo and Andrey Santos, a tap‑in by Estêvão Willian, and a penalty converted by substitute Alejandro Garnacho. The financial disparity was stark: Chelsea’s squad is valued at £439.8 million, whereas Port Vale’s XI cost the club nothing. Rosenior made three changes from the previous league outing, dropping Marc Cucurella and Moisés Caicedo and leaving Fernández on the bench. Port Vale manager Jon Brady attempted to shield his side with a defensive 5‑4‑1 setup, but the early goal shattered any hopes of containment. Subsequent Vale chances, including a corner from Pedro Neto, resulted only in panic‑filled scrambles. While Chelsea’s first half lacked sustained excitement, the quality of their finishers was evident. A well‑timed give‑and‑go between Malo Gusto and João Pedro produced a third goal, and Palmer’s rebound added a fourth after a save from goalkeeper Joe Gauci. In the latter stages, Estêvão saw two attempts denied by the woodwork before finally scoring from a rebound off Garnacho’s penalty. The final tally was sealed when Garnacho out‑maneuvered substitute Tyler Maglorie to net the seventh. Beyond the scoreline, the match underscores Chelsea’s urgent need to stabilise under Rosenior’s stewardship, especially with a crucial league encounter against Manchester City looming. For Port Vale, the defeat adds to a bleak season that will likely end in relegation, but the historic FA Cup appearance will remain a bright spot for their supporters.

The prospect of a historic quadruple for Arsenal has evaporated. After a Carabao Cup final loss and a humbling defeat to second‑tier Southampton, the Gunners now face only two competitions.In a dramatic FA Cup quarter‑final, a late goal by Shea Charles clinched a 2‑1 win for the Saints, who have been reshaped by manager Tonda Eckert from relegation candidates into promotion frontrunners within six months.Southampton opened the scoring eleven minutes before halftime when Ross Stewart capitalised on a defensive lapse, slipping a low finish past Arsenal keeper Kepa Arrizabalaga. The lead was restored shortly after when substitute Viktor Gyökeres headed home, leveling the match.However, the decisive moment arrived in the 84th minute. After a swift build‑up involving Tom Fellows, Charles received the ball inside the box and calmly placed it past the keeper, sending the Saints into the FA Cup semi‑finals at the end of the month.The victory marks only the fifth occasion this season that a team has beaten the Premier League leaders, underscoring Southampton’s resurgence. The club also honoured its 50‑year FA Cup triumph with a special yellow‑and‑blue kit, recalling Bobby Stokes' winning goal in 1976.For Arsenal, the defeat compounds recent setbacks. Manager Mikel Arteta now has less than 48 hours before the team departs for Lisbon to face Sporting CP in the Champions League quarter‑final first leg, followed by a crucial Premier League clash at Manchester City.Despite the loss, Arsenal showed flashes of life, with Gyökeres equalising and a flurry of chances in stoppage time, but Southampton’s disciplined defence and Charles’ composure proved decisive.

Real Mallorca delivered a stunning upset to Real Madrid, winning 2‑1 thanks to an added‑time strike from Vedat Muriqi. The victory pushes the champions to four points behind Barcelona ahead of their upcoming clash with Atlético Madrid.The match began with Mallorca absorbing early pressure; goalkeeper Leo Román denied Kylian Mbappé twice with diving saves. Mallorca took the lead in the 42nd minute when Manu Morlanes headed home a cross from Pablo Maffeo.Real responded late, with Éder Militão—returning from a hamstring injury—equalising in the 88th minute. Just three minutes later, Muriqi, the league’s second‑highest scorer behind Mbappé, netted the winner, marking Mallorca’s first triumph over Real in three years and lifting them two points above the relegation zone.Muriqi, who had faced criticism after Kosovo’s World Cup qualifying loss, broke down in tears after the final whistle, saying, "Sometimes emotions get the better of you… I’m just happy to repay the supporters, we want to stay in this division for them."In Germany, Bayern Munich staged a dramatic comeback, scoring three goals in the final nine minutes to edge Freiburg 3‑2. Tom Bischof equalised, and Lennart Karl clinched the winner in stoppage time, despite the absence of injured striker Harry Kane. Bayern now travel to Real Madrid for their Champions League quarter‑final first leg.Freiburg had opened the scoring early in the second half with a long‑range strike from Johan Manzambi, and later doubled the lead via a Lucas Hoeler volley after a corner error by Manuel Neuer. However, Bayern’s late surge erased the deficit.Meanwhile, Borussia Dortmund secured a 2‑0 away win at VfB Stuttgart with late goals from Karim Adeyemi and Julian Brandt. The victory keeps Dortmund in second place on 64 points, nine behind Bayern, while Stuttgart slips to fourth.In Italy, Massimiliano Allegri of AC Milan reiterated his focus on the club, dismissing any immediate interest in the vacant Italy national team manager role after Gennaro Gattuso stepped down following a World Cup playoff defeat.