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The Challenges of FDA Approval Surviving the long road to FDA approval isn’t just about building great technology — it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain. Lessons from BioticsAI This week on Build Mode, Isabelle Johannessen sits down with Robhy Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an AI copilot for ultrasound to help detect fetal abnormalities. From a $100,000 prototype to FDA clearance, Bustami shares what it actually takes to build in one of the most regulated industries in the world. Building a Medtech Startup In this episode, they break down what it really looks like to build a medtech startup, including where you can’t “move fast and break things” and that every milestone takes time, coordination, and trust. Key Takeaways Team motivation is crucial during the long FDA approval process Finding the right investors is essential for medtech startups Adaptability is key when dealing with uncertain timelines Future Outlook As the medtech industry continues to evolve, startups like BioticsAI will play a critical role in shaping the future of healthcare technology. With the right approach and mindset, these companies can overcome the challenges of FDA approval and make a lasting impact.

Blockx’s Historic Run in the Spanish CapitalBelgian rising star Alexander Blockx has delivered a performance of a lifetime at the Madrid Open, defeating defending champion Casper Ruud 6-4, 6-4 to secure a spot in the semi-finals. The 21-year-old, ranked 69th, has defied all odds to reach the last four, marking his best result on clay to date.Scoreline: Blockx defeated Ruud in straight sets (6-4, 6-4).Ranking Milestone: He is the fourth lowest-ranked player to reach the men's semi-finals in Madrid.Performance: He is 4-2 against top 20 opponents this month, with all four wins coming in the last three weeks.“To be honest, I’m just happy with being here,” Blockx said. “Semi-finals is something I wouldn’t have even dreamed of to begin with.” The conditions in Madrid, characterized by slow clay and high altitude, have seemingly suited Blockx’s aggressive style, allowing him time to settle and dictate points.Ruud’s Historic Fall from GraceCasper Ruud’s loss marks a significant downturn in the Norwegian’s career trajectory. The defeat sees Ruud exit the top 20 for the first time since May 2021, signaling a potential shift in the hierarchy of men's clay-court tennis. Ruud, who had been the defending champion, struggled to find rhythm against the relentless pressure of Blockx’s game.The WTA Final and Alcaraz’s AbsenceOn the women's side, 19-year-old Mirra Andreeva battled nerves to defeat Hailey Baptiste 6-4, 7-6 (8), securing her place in the Madrid final. Andreeva, who turned 19 on Wednesday, boasts an impressive 12-1 record on clay this season. Her victory comes after a dramatic second set tie-break where she saved three set points to overcome the American.Simultaneously, the tournament was dealt a blow with the withdrawal of world No. 2 Carlos Alcaraz. The Spanish superstar is sidelined due to a right wrist injury, a setback that will prevent him from defending his French Open title in three weeks. Alcaraz was present in the stands, however, cheering on his younger brother Jaime in an under-16 tournament.Future Outlook: A New Era DawningThe Madrid Open is rapidly becoming a proving ground for the next generation of tennis talent. With Blockx and Andreeva reaching deep stages, the sport is witnessing a generational transition. For Blockx, a semi-final appearance at a Masters 1000 event is a statement of intent, suggesting he could be a major force to be reckoned with on clay in the coming years. For Ruud, the focus will shift to recovery and recalibrating his game to reclaim his position among the elite.

Salesforce's AI Roadmap Strategy Artificial intelligence continues to advance at a dizzying clip, forcing enterprises to develop and release new products quicker than ever or risk becoming irrelevant to a faster-moving competitor. Salesforce believes it has found a strategy that allows it to keep up even if it isn’t clear where AI is headed next. The customer management software giant is crowdsourcing its AI roadmap in real time. Crowdsourcing AI Development Salesforce is certainly not the only company to work intimately with its customers for feedback on its products. However, it’s notable considering the sheer size of the company, the pace of new product launches or fixes to existing ones, and the granular level of these relationships. These aren’t annual or even quarterly discussions. Salesforce is meeting with some customers as often as once a week. The Benefits of Customer Feedback “The 18,000 customers are a wellspring of information and a wealth of information that is really needed to get to customer success,” Jayesh Govindarajan, executive vice president at Salesforce AI, told TechCrunch in a recent interview. “The stack that we’ve built has resonated with these customers. Over time we can get context to be better, and as it gets better, and LLMs get better, agent systems do more and more fully autonomous behaviors. That’s a long-running innovation track and we’re going to invest in that.” Rapid Product Releases Salesforce credits its customers for the rate of its product releases. The company told TechCrunch that by letting its customers lead the way, it is able to build an AI product roadmap that can quickly react to where AI technology is headed. Customer Success Stories Engine, a travel management platform, meets with Salesforce weekly and gets access to AI tools before they’re released. PenFed, a federal credit union, developed an IT service management (ITSM) workflow on its own using existing tools and agents in Agentforce that worked well for the company. The Future of AI Development This strategy also allows the company to roll out solutions and workflows built by users to its broader customer base too. However, the downside to this approach is that it relies on the classic service sentiment that the customer is always right. Salesforce is hoping they are despite many enterprises still figuring out what role AI will play in their business, and many having yet to find value from the tech.

The Road to a Fourth Term The Confederation of African Football (CAF) says it is backing FIFA President Gianni Infantino’s bid for a fourth term as head of football’s global governing body. In a statement after a meeting before the FIFA Congress in Vancouver, CAF said it had “unanimously agreed” to support Infantino when the FIFA chief stands for re-election in 2027. Infantino's Background and Previous Terms Infantino took over as head of FIFA in 2016 in the wake of the corruption scandal that led to the downfall of his predecessor Sepp Blatter. He was re-elected to the post in 2019 and 2023. The Exception to FIFA's Term Limit Although FIFA statutes limit FIFA presidents to three terms in office, Infantino is allowed to run for re-election next year after the body ruled that his first, partial term from 2016 to 2019 after Blatter’s ouster did not count towards the total. International Support for Infantino CAF’s decision to support Infantino comes after South American football’s governing body, CONMEBOL, also pledged to support the Swiss-Italian official earlier in April.

Saudi PIF Announces End of Funding After the 2026 SeasonThe Public Investment Fund (PIF) confirmed that its financial support for the breakaway LIV Golf league will stop at the close of the 2026 season. In a statement, PIF said the “substantial investment required over a longer term is no longer consistent with the current phase of PIF’s investment strategy.”New LIV Golf Board Targets a Multi‑Partner Investment ModelGene Davis of Pirinate Consulting Group and Jon Zinman of JZ Advisors have been appointed to a newly created board, with Davis serving as chair. Their mandate is to secure long‑term financial partners to replace Saudi capital, while a committee of independent directors will explore strategic alternatives beyond the PIF horizon.Financial Footprint: $5.3 bn Spent Since Launch$1 bn allocated to marquee contracts for players such as Bryson DeChambeau, Brooks Koepka, Phil Mickelson, Cameron Smith and Jon Rahm.$5.3 bn spent by LIV Golf from its 2022 launch; projected to reach $6 bn by year‑end.$30 m prize fund per tournament.Goal for 10 of 13 teams to be profitable this year.Implications for the Global Golf LandscapeThe funding withdrawal reshapes the power balance between LIV Golf and the established PGA Tour. Without PIF backing, LIV must prove its franchise‑team model can attract alternative capital, a challenge that could affect player retention, especially for top signings like DeChambeau and Rahm. The PGA Tour, meanwhile, continues to negotiate pathways for former LIV players, offering limited‑time returns but with strict conditions.Outlook: Funding Strategies and Player RetentionAnalysts expect LIV Golf to pursue a consortium of private investors, media rights deals, and possibly a public‑stock component to sustain operations beyond 2026. Success will hinge on delivering consistent profitability across its teams and maintaining the allure of its $30 m prize pools. If alternative financing falls short, the league may face a talent exodus as contracts expire, potentially accelerating a convergence with the PGA Tour’s ecosystem.

The Lead-Up to the 76th FIFA Congress The 76th FIFA Congress is set to take place in Canada, with leading figures of the football world gathering to discuss key issues. The meeting will be overshadowed by the US-Israeli war on Iran and its team's participation in the World Cup. Iranian Delegation's Absence The Iranian delegation will not attend the congress due to issues with Canadian immigration officials. Iranian football officials turned back upon arrival at Toronto's Pearson airport, citing 'unacceptable behaviour of immigration officials.' Human Rights Concerns at the World Cup Human rights group Amnesty International has called on FIFA President Gianni Infantino to use the congress to declare how human rights will be safeguarded at the World Cup. Amnesty urged Infantino to detail 'how he will ensure that the world's biggest sporting tournament does not become a stage for repression and a platform for authoritarian practices.' The #SaveTheCaps Campaign Fans are using the congress in Vancouver to bring attention to the #SaveTheCaps campaign against the potential relocation of the Major League Soccer team Vancouver Whitecaps to Las Vegas. Vancouver Southsiders, the self-proclaimed 'largest support group' of the Whitecaps, has called for a public demonstration ahead of Thursday's congress. What's on the FIFA Congress Agenda? The annual FIFA Congress brings together representatives of all 211 member associations to make key decisions regarding world football governance, finances, and regulations. Thursday's congress will focus on operational and financial issues related to the 48-team World Cup – the largest ever tournament.

The Curated April Reading List from Writers and Readers The Guardian asked a handful of authors and avid readers what they were enjoying in April, producing a vivid snapshot of the books that are shaping conversations in literary circles today. Highlights from Emerging and Established Authors Luke Kennard praises All In by Claire Powell – a meta‑beach read that captures contemporary Englishness with merciless affection. Luke Kennard also recommends Ghosts by Argentine writer César Aira, a short novel about squatters haunted by beautiful specters. Luke Kennard is reading A Place of Greater Safety by Hilary Mantel, a vivid portrait of Camille in the French Revolution. Rosie (Guardian reader) highlights Jesus Christ Kinski by Benjamin Myers, a layered tale of performance, cancel culture, and artistic ego. Sophie Ratcliffe (writer) shares her current obsessions: The Aspern Papers by Henry James, Antiquities and Other Stories by Cynthia Ozick, and Calamities by Renee Gladman. Kate (Guardian reader) recommends Flashlight by Susan Choi, a mystery that weaves Japanese culture, Korean occupation, biracial identity, and MS. What the Recommendations Reveal About Current Literary Trends Analyzing the list shows three clear patterns: Meta‑narrative & genre‑blending: Both All In and Flashlight combine genre conventions with literary depth. International & translated voices: César Aira and Cynthia Ozick illustrate growing appetite for non‑English perspectives. Historical re‑examination: Works by Hilary Mantel and Benjamin Myers signal renewed interest in revisiting past eras through contemporary lenses. Why These Picks Matter for the Publishing Landscape Publishers can read this roundup as a signal that: Investments in translation rights are likely to yield strong critical and commercial returns. Books that straddle literary and genre expectations are resonating with both writers and readers, encouraging hybrid marketing strategies. Historical fiction that tackles under‑explored viewpoints (e.g., the French Revolution from a musician’s angle) is gaining traction, suggesting editorial room for fresh archival projects. Looking Ahead: What April’s Choices Signal for 2026 Reading Habits If the April selections are any indication, the second half of 2026 will likely see: A surge in short‑form and novella‑length works that deliver intense, self‑contained experiences. Greater demand for cross‑cultural narratives, especially those that blend personal memoir with broader historical context. Continued enthusiasm for authors who can weave social commentary into compelling storytelling, positioning books as both entertainment and cultural critique. Publishers, booksellers, and literary festivals would do well to spotlight these trends, ensuring that the voices highlighted this April remain at the forefront of the conversation.

The Lead A new social enterprise called Build, launched by EnviroCentre in Ottawa, aims to train immigrants in retrofitting homes to combat the climate crisis. The program provides training in insulation installation, air sealing, and other retrofitting skills to help reduce greenhouse gas emissions. Immigrants Learning to Retrofit Homes John Mava, an immigrant from Nigeria, and Allan Kanobana, an immigrant from Rwanda, are among the first mentees of Build. They are learning the fundamentals of health and safety, PPE use, and other theories, while also getting their warehouse ready for opening. The warehouse is where mentees will learn practical skills, such as insulation and drywall installation and conducting pre- and post-retrofit home assessments. The Data Analysis Buildings are one of the top-five greenhouse gas emitters in Canada, according to the federal government’s most recent overview of Canada’s GHG emissions. To achieve its goal of net zero emissions by 2050, Canada needs to retrofit about 600,000 homes each year. The construction industry is facing a shortage of skilled workers, with more than 245,100 construction workers projected to retire by 2032, leading to a shortage of more than 61,400 workers. The Impact Analysis The program aims to create a positive and welcoming space for mentees, particularly in an industry that has historically been male-dominated and lacking in diversity. Build also plans to provide a toolkit for employers to help them remove toxic behaviors in the construction environment. The program expects to take on two more mentees by the end of the year and retrofit the homes of hundreds of clients in the Ottawa area. The Prediction The success of Build's program could have a significant impact on reducing greenhouse gas emissions in Canada. With the right training and support, immigrants can play a crucial role in addressing the climate crisis. As Mava said, 'We’ll reduce the emissions and then the kids will be happy in the future.'

The Military Court Begins Trial of Soldiers Accused of Acid AttackThe trial of four soldiers linked to the Strategic Intelligence Agency started on Wednesday in a Jakarta military court, charging them with a premeditated acid assault on activist Andrie Yunus that left him blind in one eye and burned over 20% of his body.Attack date: 12 March 2026Victim: Andrie Yunus, 27‑year‑old human‑rights activistAccused: Four soldiers, all tied to the Strategic Intelligence AgencyLegal Stakes: Charges, Potential Sentences, and Prosecutorial ClaimsProsecutors allege the soldiers acted out of anger over Yunus’s anti‑military activism, not under official orders. Each faces a maximum of 12 years in prison for premeditated assault. The agency’s chief has resigned, though no public reason was given.Broader Implications for Indonesia’s Democratic BackslidingThe case is being watched as a barometer of Indonesia’s shifting civil‑military balance. Under President Prabowo Subianto, legislation now permits active‑duty officers to hold civilian posts, reversing reforms from the post‑Soeharto era. Analysts warn this erodes civilian oversight and fuels a climate of intimidation for critics.International Reaction and Human‑Rights ConcernsThe United Nations condemned the attack, with High Commissioner for Human Rights Volker Turk calling it a “cowardly act of violence” and Special Rapporteur Mary Lawlor labeling it “horrific.” Amnesty International highlighted the trial’s location in a military court as a risk to impartiality and noted that at least 14 individuals may have been involved, yet only four are indicted.What the Future Holds for Civil‑Society Oversight of the MilitaryRights groups argue the trial’s outcome will set a precedent for accountability. If the soldiers receive substantive sentences, it could embolden civil‑society calls for tighter civilian control. Conversely, a lenient verdict may deepen fears of impunity and accelerate democratic decline, prompting further international scrutiny and possible sanctions.