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The LeadRobert Smith, a distinguished pharmacologist and professor at St Mary's medical school in London (now part of Imperial College), has died aged 92. His groundbreaking work on how genetic variations affect drug responses helped shape the field of personalized medicine.The Discovery of Debrisoquine PolymorphismBob became well known for his role in the discovery of "debrisoquine polymorphism." In 1975, as one of five volunteer researchers who took debrisoquine, a blood pressure medication, he was the only one to suffer adverse effects (hypotension) and collapse. This led to the discovery of a genetic polymorphism where certain individuals cannot break down specific drugs efficiently. While Bob described this as an "accident waiting to happen," it positioned him at the forefront of pharmacogenetics.Awards and RecognitionSmith's contributions to pharmacology were formally recognized when he became the first recipient of the Paton prize in 1998 for his work in understanding how genes affect drug response. His academic achievements included becoming professor of pharmacology in 1978 and serving as deputy dean of the medical school from 1980-88.Impact on Medicine and SportsSmith's research fundamentally changed how medical professionals understand drug responses, paving the way for personalized medicine approaches. Beyond human medicine, he applied these principles to horse racing, chairing the UK Horserace Scientific Advisory Committee (1979-99) and its pan-European equivalent (1992-2005). He also served as a director of the Horseracing Forensic Laboratory in Newmarket during the 1990s, helping shape anti-doping protocols.Enduring LegacySmith never fully retired, continuing his research as emeritus professor until publishing his last paper in 2020. His legacy extends beyond scientific contributions to include the principles, warmth, kindness and generosity he embodied throughout his career. His work continues to influence pharmacology and personalized medicine, ensuring his impact will be felt for generations to come.

McIlroy’s Early Warning About LIV Golf’s Funding FragilityRory McIlroy told the Guardian he was hearing about potential trouble for LIV Golf as early as March‑April 2026, well before the Public Investment Fund (PIF) confirmed it would pull its funding. He says the Masters champion’s insight underscores how quickly the tour’s financial foundation could shift.Inside the Saudi PIF Funding Withdrawal and Its TimelineThe sequence of events unfolded as follows:March‑April 2026 – McIlroy hears rumours from friends on the LIV circuit.30 April 2026 – PIF publicly announces it will withdraw its support for LIV Golf.Early May 2026 – The news breaks in the immediate aftermath of McIlroy’s successful defence at the Masters.McIlroy noted that the pull‑out “feels like the rug was pulled from under their feet” and that the tour’s reliance on a single sovereign‑wealth fund made it vulnerable to geopolitical shifts.Financial Stakes: Over $5 bn Backed by the Public Investment FundThe PIF has contributed more than $5 bn to LIV Golf since its inception, with an agreement to stay involved until the end of 2026. The sudden shift in priorities leaves the tour facing a massive funding gap and forces players and organisers to reassess their financial models.Implications for the Breakaway Tour and Global Golf LandscapeThe withdrawal has several immediate consequences:Players risk losing salaries, prize‑money guarantees, and sponsorships tied to the PIF.The tour’s credibility is challenged, potentially accelerating a migration back to the PGA Tour or other established circuits.Geopolitical risk becomes a headline factor for any future private‑investment‑driven sports ventures.McIlroy warned that “whenever you have funding tied so much to the geopolitical landscape, that’s a tricky road to navigate.”What Lies Ahead for LIV Golf and Players’ FuturesAnalysts see three plausible paths:Restructuring: LIV seeks alternative investors outside the Saudi sphere, possibly diluting its brand.Consolidation: Top players return to the PGA Tour, leaving LIV as a reduced‑scale series.Collapse: Without a new funding source, the tour could cease operations before the end of 2026.McIlroy, who will compete at the upcoming U.S. PGA Championship, says the situation serves as a cautionary tale for athletes and organisers alike about the perils of over‑reliance on geopolitically‑linked capital.

The Skyboxification of FootballIn What Money Can't Buy, his 2012 critique of a world where everything is for sale, Michael Sandel laments what he calls "the skyboxification of American life". Price gouging and profiteering, Mr Sandel notes, can exclude millions from communal experiences that should unite people, rather than divide them according to the size of their wallets. That is "not good for democracy, nor is it a satisfying way to live".World Cup Ticket Pricing Strategy Under FireAhead of the men's World Cup in the United States, Canada and Mexico next month, millions of football fans would readily agree with the Harvard philosopher. Gianni Infantino, the president of the sport's global governing body, Fifa, has predicted that this summer's tournament will be the "greatest and most inclusive … ever". But the lead-up has been overshadowed by a ticketing strategy that is almost surreally indifferent to the battered traditions of "the people's game".Exorbitant Price Points RevealedIn the latest phase of an opaque, manipulative process, Fifa has tripled the price of some of the best seats for the World Cup final in New Jersey to $32,970 (for the 2022 final in Qatar, top whack was about $1,600). On Fifa's Resale/Exchange Marketplace, tickets for the final have ranged from $8,970 to a laughable $11,499,998.85. For the US's opening group game against Paraguay in Los Angeles, the cheapest tickets initially offered were priced at $1,200. Even Donald Trump worried that might be too much for ordinary Americans to afford.Dynamic Pricing and Financial BarriersA dynamic pricing system means that a few tickets may become cheaper closer to the tournament. Many are likely to become still more expensive. These are ridiculous, exploitative prices that undermine the integrity of the world's most avidly followed sporting event. To add insult to financial injury, fans who bought early at prohibitive cost are discovering that the goalposts have now moved, as seats with the best views are hived off for even more lucrative hospitality packages.Impact on Football's Democratic TraditionFactor in accommodation and transport costs for travelling fans, and it is clear that access to the most monetised World Cup in history has been priced way beyond the means of most football lovers. But Mr Infantino has remained blithely dismissive in the face of the groundswell of protest, noting merely that the competition is being staged in a "market in which entertainment is the most developed in the world. So we have to apply market rates."Market Rates vs Democratic ValuesThis is self-serving nonsense. It is difficult to take anything Fifa's president says seriously after his decision to award a peace prize to Mr Trump. But such words betray a dismaying inability to consider wider responsibilities beyond a dollar-denominated bottom line. The best World Cups have been sporting and cultural festivals, enriched by the presence of passionate supporters from host cities and around the world. Only those with impressively deep pockets will be able to maintain that tradition in June and July.The Future of Inclusive FootballIn his book, Mr Sandel writes: "The more things money can buy, the fewer the occasions when people from different walks of life encounter each other." Next month, Mr Infantino will no doubt be waxing lyrical about the ability of the World Cup to bring people together and cross divides. Pious talk of inclusivity will ring very hollow if only the well-off can enter a stadium to actually watch a game.

The Return of a Snooker ClassicThe BBC has announced the revival of the beloved snooker gameshow Big Break after a 24-year hiatus. The show, which originally aired from 1991 to 2002, will return with seven-time world champion Stephen Hendry joining presenter and comic Paddy McGuinness as co-hosts. The revival comes as part of a trend of 1990s game shows making a comeback on British television.New Format with Familiar FacesIn the new series, Hendry will take on the trick-shot challenges previously performed by the late John Virgo, while McGuinness will fill the shoes of original host Jim Davidson. The BBC promises a "reimagined" version of the show with "an addictive mix of fast-paced snooker frames with a relaxed, comedic atmosphere." Each episode will feature three contestants competing for cash prizes, with professional snooker players providing assistance.Nostalgia Meets Modern EntertainmentThe revival of Big Break reflects a growing trend of networks capitalizing on nostalgia while updating classic formats for contemporary audiences. The BBC recently found success with another 1990s favorite, Gladiators, while ITV has also brought back darts gameshow Bullseye. This strategy allows broadcasters to leverage built-in audience recognition while potentially attracting new viewers with updated production values and presentation styles.Legacy and Future of Snooker on TelevisionStephen Hendry's involvement adds significant credibility to the revival, as he appeared in the first episode of Big Break in 1991. His participation not only honors the show's history but also connects with the current generation of snooker fans. The show's return comes at a time when snooker continues to maintain popularity in the UK, with China emerging as a growing force in the sport through players like Wu Yize.What's Next for the Revived GameshowWith 20 half-hour episodes commissioned for BBC Two and iPlayer, Big Break is positioned to become a regular daytime fixture. The show's success will likely depend on its ability to balance nostalgia with fresh elements that appeal to both original fans and new viewers. If successful, the revival could pave the way for more classic gameshows to return to British television, continuing the current trend of reimagining beloved formats for modern audiences.

The Lead English National Opera (ENO) is making its debut in Manchester with 'Angel's Bone', a Pulitzer Prize-winning opera by Du Yun and Royce Vavrek. The production, directed by Kip Williams, explores themes of human trafficking and exploitation. Behind the Scenes at Aviva Studios The opera is being staged at Manchester's Aviva Studios, a cutting-edge arts venue that has hosted major pop acts and performance artists. The Warehouse, part of Aviva Studios, provides a unique setting for the opera, with its vast space and hi-tech capabilities. The Creative Vision Director Kip Williams was drawn to the opera's bold and innovative score, which blends different genres, from Gregorian chant to electronic music. The production will feature a strong architectural element and an expansive video component. The Impact of 'Angel's Bone' The opera's themes of human trafficking and exploitation are particularly relevant in today's world. The production aims to raise awareness about these issues and encourage audiences to reflect on their own moral responsibilities. A New Era for ENO The Manchester debut marks a significant moment for ENO, which has been working to revitalize its image and reach new audiences. The company's decision to stage 'Angel's Bone' in Manchester demonstrates its commitment to innovation and risk-taking.

The Lead: Arsenal's Title Charge Arsenal moved two wins away from the Premier League title after a dramatic late VAR decision denied West Ham an equalizer in a crucial match. The decision to disallow Pablo Fornals' injury-time goal has sparked debate about whether Arsenal were lucky or if referee Chris Kavanagh made the correct call in one of the biggest VAR decisions of the season. The VAR Controversy: Title Deciding Moment The match between West Ham and Arsenal was defined by a contentious VAR review that ultimately denied the home side an equalizer. The panel on Football Weekly questioned whether Pablo fouled David Raya, and whether Arsenal have been "hoisted by their own set-piece petard." The discussion also touched on how many replays are too many in modern football, with the technology coming under scrutiny once again. The Title Race: City Keep Pressure Manchester City kept the pressure on Arsenal with a comprehensive 3-0 victory over Brentford. Pep Guardiola's side maintained their challenge for the title as they look to defend their crown. The result means the title race remains firmly alive with just two games remaining in the season. Liverpool Frustration: Slot Under Fire Liverpool's frustrating campaign continued with another draw against Chelsea, this time ending 1-1. The result saw Arne Slot face boos from Liverpool fans as his team's hopes of Champions League qualification fade. The draw extended Liverpool's winless run to multiple matches, raising questions about the Dutch manager's future at the club. European Race: Bournemouth's Unlikely Push Bournemouth continued their unlikely push for a Champions League place with another positive result. The Cherries have been one of the surprise packages of the season, and their European push adds an intriguing subplot to the final weeks of the Premier League campaign. Mid-Table Battles: Brighton's Response Brighton bounced back emphatically from recent poor form with a convincing victory. The Seagles have shown their quality throughout the season and will be looking to secure a strong finish to what has been a challenging campaign for Roberto De Zerbi's side. Survival Battle: Spurs' Hopes Tottenham's survival hopes remain alive as they prepare for a crucial match away to Leeds. The north London club has been embroiled in a relegation battle for much of the season, and their fate will likely be decided in the final matches of the campaign. Scottish Drama: Celtic's Old Firm Advantage Celtic gained the advantage in the Scottish Premiership after the Old Firm match against Rangers. The Glasgow derby always has significant implications for the title race north of the border, and this result has given Celtic a potentially decisive edge in their pursuit of the championship. Championship Controversy: Spygate 2.0 The Championship playoffs were overshadowed by "Spygate 2.0" as Southampton were charged with alleged spying during their playoff semi-final against Middlesbrough. The controversy has cast a shadow over the crucial matches that will determine which teams gain promotion to the Premier League, adding an extra layer of drama to the end of the season. Women's Football: FA Cup Semi-Finals The Women's FA Cup semi-finals provided exciting action as the competition reaches its business end. The tournament represents one of the most prestigious prizes in women's football, and the semi-final stage features the teams still in contention for the coveted trophy. International Debate: Mbappé Petition Philippe questioned the kick-out petition involving Kylian Mbappé, which has been gathering pace. The French superstar's situation has become a talking point in international football, with fans and pundits debating the merits of the petition related to his playing style and approach. League One Drama: Rochdale's Return Rochdale achieved a dramatic return to the EFL, securing promotion from League Two. The club's journey back to the third tier of English football represents a significant achievement for the team and their supporters, adding to the excitement of the end of the season.

The Dominance of Adolescence The Netflix drama Adolescence, which won universal acclaim for its chilling portrayal of violence by disaffected teenage boys, has dominated the Bafta TV awards. The four-part series, where each episode was filmed in a single take, won the award for best limited drama, while Stephen Graham, who co-created the show, took the best leading actor prize. The Winners' Circle Graham, who had been nominated eight times before, talked about being inspired by the TV show Scully as a child. “For any other young kid, no matter where you’re from, anything is possible.” “We’re not saving lives,” he said. “But we have the opportunity to tell the human condition. And we have the obligation to tell beautiful stories.” Owen Cooper, who became a household name for his performance as 13-year-old Jamie Miller, who is arrested for murdering a girl at his school, also bagged the best supporting actor award. Other Notable Wins Other winners on the night included the crime series Code of Silence for best drama and Narges Rashidi for best leading actress in Prisoner 951, the true story of Nazanin Zaghari-Ratcliffe, the Briton imprisoned for six years in Iran. The documentary Gaza: Doctors Under Attack took the spoils in the current affairs category. The Impact of the Awards The Bafta TV awards have once again highlighted the best in British television, with a range of genres and shows being recognized. The dominance of Adolescence and the wins by other notable shows and actors demonstrate the high quality of television being produced in the UK. The Future of British Television As the television industry continues to evolve, the Bafta TV awards will remain a key event in showcasing the best of British television. With shows like Adolescence and Code of Silence pushing the boundaries of storytelling and performance, the future of British television looks bright.

The Modern-Day Rivalry Takes Center StageAs everyone expected, it will be the irresistible force against the immovable object at Wembley in three weeks' time. Hull KR and Wigan, two dominant forces in rugby league, have set up a historic Challenge Cup final showdown that could be viewed as rugby league's equivalent of Ali v Frazier or Prost v Senna. This marks the first time in history that these champion teams will do battle for what is arguably rugby league's most prestigious prize.Path to the Final: Dominance DisplayedBoth teams have demonstrated their superiority over the rest of the domestic field in reaching the final. Wigan were resplendent with the ball and defensively faultless in embarrassing local rivals St Helens 32-0. Hull KR, by their own coach's admission, saw what Wigan did and decided to emulate it. The reigning holders were sensational, leading with their defensive efforts to strangle Warrington into submission and lay the platform for their attacking players to take control, winning 32-12.The Reigning Champions: Hull KR's Return to FormThere was no doubting that victory in the World Club Challenge over Brisbane in February, coupled with the early-season trip to Las Vegas, took its toll on the Robins. But they are now resembling the team who dismantled all in front of them throughout 2025 to win all three trophies on offer. With players of the ability of Mikey Lewis and Tyrone May, Hull KR's all-conquering half-back pairing that caused havoc all afternoon, they look near enough unbeatable.The Impact on Rugby League's LandscapeSuper League has had plenty of teams who have dominated for periods of time and left the chasing pack behind. But two at the same time? It is a moment that could, and perhaps should, be sold to the masses if the game's administrators have any clout about them. Neutrals could not fail to be captivated by this rivalry. While it would be great to see more clubs emerge from the pack, what a joy it will be to see two historic teams go toe-to-toe in the sport's biggest match once again.A Final for the AgesWigan has the time-honoured trait the rest of Super League are craving in games like these: when the stakes are at their highest, Hull KR and Wigan produce the best they have to offer. If they each do that at Wembley, we could be set for one of the great Challenge Cup finals. Circle Saturday 30 May in your diary because we could be set for a final for the ages between two sides in pursuit of yet more history.

Lucas Herbert held his nerve in the final round of LIV Golf Virginia to claim his first LIV title, bank $5.5 million and lock a spot at the 2026 US Open in New York.Herbert’s Breakthrough Victory at LIV Golf VirginiaThe 30‑year‑old Australian entered the final day with a five‑shot lead that was whittled down to one after a dramatic surge from Sergio Garcia. Herbert steadied his play with a three‑under‑par 69, finishing four shots ahead to post a 24‑under total for 72 holes.Winning score: 24 under parFinal round: 69 (‑3)Runner‑up: Sergio Garcia (70)Third place: Bryson DeChambeau (66)Financial Windfall: $US4 million Prize and $5.5 million BankedThe victory delivered a life‑changing cheque of $US4 million (≈ $A5.54 million) and added to Herbert’s season earnings, bringing his total banked amount to $5.5 million. The prize not only boosts his personal finances but also reinforces LIV Golf’s reputation for “mega‑money” payouts.Implications for the US Open Field and Australian GolfBy securing the US Open exemption, Herbert joins an elite group of players who have won on all four major circuits – the PGA Tour, DP World Tour, PGA Tour of Australasia and now LIV Golf. His win adds depth to the US Open roster and highlights the growing influence of Australian talent on the global stage.Herbert becomes the first LIV winner to earn a US Open spot this season.Ripper GC teammates Cameron Smith, Marc Leishman and Elvis Smylie celebrated, underscoring the club’s rising dominance.What Lies Ahead for Herbert and the LIV CircuitLooking forward, Herbert will aim to translate his Virginia form into a strong US Open performance, while LIV Golf continues to attract top‑ranked players with its lucrative prize structure. Analysts expect his victory to spur further Australian participation in LIV events and intensify the rivalry between LIV and traditional tours.