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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

Rising fortunes among the ultra‑rich under the Trump administration have ignited a wave of tax‑reform campaigns across the United States. In California, volunteers like Karen Sanchez are gathering signatures for a one‑time 5% wealth tax targeting the state’s 200‑plus billionaires to offset federal cuts to hospitals, education and food‑assistance programs.At least ten states are exploring similar measures. Washington recently enacted its first income‑tax aimed at roughly 20,000 millionaire households, while Massachusetts and Minnesota already channel wealth‑tax proceeds into preschool, K‑12 meals and transportation infrastructure.On the federal front, Senators Bernie Sanders and Representative Ro Khanna have introduced the “Make Billionaires Pay Their Fair Share Act,” proposing an annual 5% levy on billionaire net worth. Khanna argues that the ultra‑wealthy fund private health insurers, defense contractors and political campaigns, creating a stark fairness gap.Data from Oxfam shows that in the twelve months after Trump’s re‑election, billionaire fortunes grew at a rate three times faster than the average annual growth of the previous five years. Meanwhile, the federal minimum wage has remained stagnant at $7.25 for fifteen years, underscoring the widening economic divide.A Data for Progress poll released last fall found that 70% of Americans believe the economic system favours corporations and the wealthy. “People are angry and want change,” says Amy Hanauer of the Institute on Taxation and Economic Policy (ITEP), noting that activists are leveraging every level of government to seek relief.The movement draws on a two‑decade history of class‑based activism, from the Occupy Wall Street protests to Senator Sanders’ 2016 campaign that foregrounded wealth‑tax proposals. Yet inequality has deepened: CEOs of the five largest U.S. firms now earn, on average, **$52 million** annually—over a thousand times the typical worker’s salary.Political spending by billionaires has also exploded. A recent New York Times analysis reveals that billionaire contributions rose from **0.3% of campaign funds in 2008** to **19% in 2024**, amounting to more than **$3 billion** from roughly 300 ultra‑rich donors, many of whom supported candidates opposing wealth taxes, including former President Donald Trump.The war in Iran has further inflamed resentment, with the United States spending **$11.3 billion** in the first week of bombardment—far exceeding the annual budgets of agencies such as the CDC, EPA and the National Cancer Institute.Local victories are feeding the momentum. New York City’s mayoral race saw Zohran Mamdani win on a platform that includes taxing the rich to fund affordable housing, groceries and transit. Councilmember Chi Ossé led a 1,500‑person march to the state capitol, urging Governor Kathy Hochul to permit a city‑level millionaire tax, a move that now has backing from some state Democrats.Beyond New York, states like Rhode Island, Hawaii, Pennsylvania, Virginia, Illinois and New Mexico are debating various wealth‑tax mechanisms, including the popular “mansion tax” on high‑value home sales. Currently, **17 localities** have adopted such taxes, most passed between 2018 and 2023.California’s gubernatorial race has become a flashpoint. Billionaire‑backed candidates Matt Mahan and Tom Steyer are vying to replace Governor Gavin Newsom, with the tech elite—such as Sergey Brin and Joe Lonsdale—pouring money into campaigns opposing the billionaire tax. Of the 30 billionaires who have contributed to the race, **25 supported Mahan**, who has positioned himself as a staunch anti‑tax candidate.For Sanchez, the stakes are personal. The proposed tax seeks to replace **$100 billion** in federal health‑care funding cut by Trump’s “One Big Beautiful Bill Act,” which threatens hospital closures and layoffs in the nation’s fourth‑largest economy. She aims to collect **875,000 signatures** by late June to secure the initiative on the November ballot.“It’s creating a network of groups all working toward a common good,” Sanchez says, reflecting a broader sentiment that collective action could finally translate the public’s demand for fiscal fairness into concrete policy.

The author's poignant essay explores the intricacies of family relationships, particularly the painful silence that can accompany estrangement. Years of strained relations between two sisters ultimately led to a difficult decision: not to inform the estranged sister about their terminally ill sister's condition.The author recounts a meeting with her two sisters, V, who had been living with cancer for 15 years, to discuss her wishes for a peaceful death at home. The absent sister, who lived abroad, was not invited. The author chose not to disclose V's condition to their estranged sister, citing the potential for additional pain.As the author navigated the complex web of family dynamics, she communicated with the estranged sister about their mother's illness, but kept V's condition private. This decision, though made out of love and respect for V's wishes, left the author with a profound sense of sadness.The essay is a thought-provoking exploration of the challenges of family estrangement and the difficult choices that can arise during times of loss. The author's reflections on her own experiences serve as a backdrop for a broader discussion on the complexities of human relationships.Circle of Wonders, by Kathryn Heyman, is a novel that likely delves deeper into these themes.

Iranian President Masoud Pezeshkian has urged the American people to look beyond the distortions and narratives surrounding the US-Israeli war on Iran and ask a critical question: whose interests are being served by this conflict?In an open letter addressed to the US public, Pezeshkian questioned whether President Donald Trump's 'America First' policy is truly a priority for the US government. He emphasized that the massacre of innocent children, destruction of cancer-treatment facilities, and boasting about bombing a country 'back to the stone ages' only serve to damage the United States' global standing.Pezeshkian also rejected portrayals of Tehran as a threat, noting that Iran had been attacked twice while its negotiators were engaged in nuclear talks – once by Israel in June 2025, with the US briefly joining in, and again at the end of February this year.The Iranian president stressed that attacking Iran's vital infrastructure, including energy and industrial facilities, directly targets the Iranian people and constitutes a war crime. Such actions, he argued, generate instability, increase human and economic costs, and perpetuate cycles of tension.Pezeshkian's letter comes amid escalating tensions, with Trump threatening to 'blast Iran into oblivion' unless the Strait of Hormuz is reopened. The US president also claimed that Iran's 'new regime president' had requested a ceasefire – a claim denied by Iranian officials.The Iranian leader also questioned whether the Trump administration was manipulated by Israel in launching the war against Iran. He asked whether America has entered this aggression as a proxy for Israel, influenced and manipulated by that regime.

Coordinated strikes by United States and Israeli forces hit Tehran, Isfahan and several other Iranian cities on Tuesday, prompting widespread power outages and extensive damage to civilian sites. The Ministry of Energy confirmed that shrapnel from the raids ruptured a primary power‑transfer line, but the outage was restored within a few hours. Among the most critical targets was the Tofigh Darou pharmaceutical complex in the Karaj industrial zone. The facility, which supplies over 90% of Iran’s domestically produced medicines—including cancer and multiple‑sclerosis treatments—sustained heavy damage from multiple projectiles. In central Iran, Isfahan endured a barrage of heavy bunker‑buster bombs over a nearby mountainous area, likely aimed at military installations. The explosions triggered secondary blasts that illuminated the night sky and produced reverberating shockwaves across the city. North‑west of Tehran, in Zanjan, a building identified as the administrative department of the Hosseinieh Azam religious centre was struck, resulting in at least four fatalities and several injuries. Iranian authorities now claim that more than 2,000 people have been killed by US‑Israeli attacks since the conflict erupted on 28 February, with residential blocks, schools, hospitals and historic sites also affected. Additional targets this week included civilian nuclear facilities, major steel producers, petrochemical plants, and the Iran University of Science and Technology, where an imaging satellite was developed. A professor linked to Iran’s missile programme and his two children were assassinated at their home in northern Tehran. U.S. President Donald Trump reiterated threats to strike Iran’s oil and gas infrastructure, power plants and water‑desalination facilities. Despite the onslaught, the Islamic Revolutionary Guard Corps (IRGC) continues to project defiance. A spokesperson for the Khatam al‑Anbiya Central Headquarters declared that Tehran’s adversaries are “humiliated and on the path of destruction,” while senior commander Ali Fadavi warned that American warships are vulnerable and allegedly transmit false transponder signals. The IRGC also released footage of ballistic missiles aimed at Israel and surrounding nations, and claimed to have downed two U.S. MQ‑9 Reaper drones, promising retaliatory strikes against technology firms linked to the United States and Israel. Domestically, the judiciary announced the execution of two members of the foreign‑based Mojahedin‑e‑Khalq (MEK) group, labeling them terrorists. This follows a series of recent executions tied to the January protests and broader dissent. Authorities also issued new indictments against roughly 200 individuals accused of assisting the U.S. and Israel, including alleged “mercenaries” who disseminated strike footage abroad. Penalties for national‑security offenses now encompass asset confiscation and capital punishment. President Masoud Pezeshkian convened his first cabinet meeting since the war’s onset in a makeshift, blue‑covered space, emphasizing that any peace negotiations will safeguard Iran’s “dignity, security and national interests.” Israel’s Channel 14 reported that Pezeshkian sought greater negotiating leverage with the United States, a request allegedly rebuffed by IRGC chief Ahmad Vahidi.

Israeli and U.S. forces launched a series of air strikes on Tuesday that struck Tofigh Daru Research and Engineering Company, one of Tehran’s largest producers of anaesthetics and anti‑cancer medicines. The state‑run firm, owned by the Social Security Investment Company, saw its drug‑production line damaged, according to an official post on X. In the north‑western city of Zanjan, a separate strike hit the Husseiniya Azam, a Shia congregation hall adjacent to a mosque. Iranian Red Crescent teams rescued two people from the rubble; one of the victims died and several others were injured. Further attacks were reported in the western province of Kermanshah, where a civilian contracting company in Qasr‑e Shirin – a border town with Iraq – was hit. One person was killed and eight injured, the Mehr news agency said. Heavy bombing was also confirmed in Isfahan, a strategic hub for Iran’s defence industry and home to key nuclear facilities such as Natanz. Local officials indicated that the strikes may have targeted “military sites,” though the exact locations and damage assessments remain unclear. Iranian officials condemned the operations. Former foreign minister Javad Zarif denounced the targeting of the pharmaceutical plant as a deliberate attack on a medical facility, calling the aggressors “desperate” and accusing them of “diabolical delusions.” Governor‑level security official Akbar Salehi echoed these concerns, noting that the strikes appeared aimed at military installations without specifying which ones. The broader conflict has already claimed 1,937 Iranian lives since the joint U.S.–Israeli campaign began on 28 February, while 20 Israelis have been killed. Recent Israeli interceptions using the Iron Dome and David’s Sling systems have limited damage on Israeli soil, but impact sites were reported in Tel Aviv, Bnei Brak and Petah Tikva. Amid the escalating violence, diplomatic channels remain active. U.S. Secretary of State Marco Rubio told Al Jazeera that communications between Washington and Tehran continue, primarily through intermediaries, and that the U.S. aims to achieve its war objectives “in weeks, not months.” Pentagon chief Pete Hegseth added that negotiations to end the conflict are “very real, ongoing and gaining strength.” Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed a retaliatory strike, saying it hit an Israeli container ship in the Gulf with a ballistic missile and that Iranian drones targeted a group of U.S. Marines near a UAE military base. Public sentiment in Iran has turned sharply hostile, with pro‑state demonstrations erupting in Tehran as citizens protest the continued air raids. The atmosphere, described by Al Jazeera’s Tohid Asadi as a “cloud of mistrust,” reflects growing frustration over diplomatic dead‑ends and the relentless cycle of attacks.

Palantir’s senior UK representative has warned ministers against yielding to ideologically motivated campaigners as they explore the possibility of terminating a £330 million NHS contract for the company’s Federated Data Platform (FDP).The FDP, an AI‑enabled system intended to unify patient information across the health service, is part of a broader portfolio that includes contracts with the Ministry of Defence, several police forces and the UK’s financial regulator.Louis Mosley, executive vice‑chair of Palantir UK, told The Times that abandoning the deal would jeopardise patient care and hinder progress on the NHS’s most pressing challenges. He highlighted that the platform is projected to generate £150 million in benefits by the end of the decade, delivering a £5 return for every pound spent.According to the Financial Times, senior officials have begun informal discussions about activating a break clause that would allow the FDP’s operation to be transferred to an alternative provider once the system becomes fully operational next year.Palantir, a US‑based data‑analytics firm with ties to the Israeli and US militaries and former U.S. Immigration and Customs Enforcement contracts, has faced sustained opposition from the British Medical Association, which has long criticised the use of its technology in patient‑care settings.Health officials acknowledge the reputational risk, noting that the controversy now extends beyond traditional Labour‑left and Green Party critics. A Department of Health and Social Care spokesperson emphasised that the FDP is designed to improve care coordination, accelerate cancer diagnoses and increase treatment capacity, while maintaining strict data‑security safeguards.Health Secretary Wes Streeting, speaking on the Guardian Politics Weekly podcast, recognised public unease about Palantir’s political affiliations, referencing founder Peter Thiel’s right‑wing connections. He reassured listeners that Palantir does not have direct access to patient data, stating, "The platform is operated by us; Palantir never sees the data."Adoption of Palantir’s technology within the NHS has risen from 118 to 151 organisations since June, though it remains short of the government’s target of 240 organisations by year‑end. Labour backbencher Clive Lewis noted that the issue is becoming a visible concern for voters, reflecting broader anxieties about AI and foreign‑owned infrastructure in critical public services.

In Mexico, a mother's determination to navigate the country's beleaguered cancer care system has become a defining feature of her daily life. Faced with a healthcare system in crisis, she finds herself unceasingly vigilant in her quest for adequate treatment.The situation in Mexico's healthcare sector is marked by significant challenges, particularly in the realm of cancer care. Patients and families are often left to struggle with accessing timely and effective treatment, leading to a heavy emotional and financial toll.For this mother, the reality of her child's health battle is a harsh reminder of the system's shortcomings. Her story serves as a poignant example of the human cost of healthcare deficiencies and the resilience of those affected.

Tim Sweeney, the CEO of Epic Games, the company behind the popular online game Fortnite, has issued an apology after facing backlash for laying off an employee with terminal brain cancer. The layoff not only resulted in the loss of income for the employee's family but also meant they would lose their life insurance. The controversy began when Jenni Griffin, the wife of Mike Prinke, a laid-off employee, shared their story on social media. She revealed that her husband was fighting terminal brain cancer and that the layoff meant they would lose his life insurance. Griffin expressed her concerns about the financial burden they would face, including the cost of a funeral and burial. Sweeney responded to Griffin's post, apologizing for not recognizing the situation earlier and promising that Epic Games would solve the insurance issue for the family. He stated that the company would provide a solution to ensure the family receives the necessary support. Epic Games announced the mass layoffs on March 24, citing a downturn in Fortnite engagement and a need to make major cuts to keep the company funded. Sweeney justified the layoffs by saying that the company was spending significantly more than it was making. Affected employees were offered a severance package, including at least four months of base pay, along with other benefits tied to tenure at the company. The layoffs have sparked controversy, with many questioning the decision to let go of over 1,000 employees despite the company's annual profits of $4 billion. Fortnite is the world's fourth most-played PC game, and the company's financial situation has raised concerns about the impact of the layoffs on employees and their families. Griffin's post, which included a picture of her husband's brain scan, quickly went viral, prompting Sweeney to respond and offer support to the family. The incident has highlighted the human impact of corporate decisions and the need for companies to consider the well-being of their employees.