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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

The Historical Detective's QuestIn the spring of 2011, author Raf Nicholson embarked on a PhD journey to document the history of women's cricket, only to find a startling lack of resources at the MCC library at Lord's. The women's cricket section contained merely three books, including Rachael Heyhoe Flint's 1978 autobiography. This discovery sparked a decade-long mission to uncover the hidden history of women's cricket, culminating in his book 'The Women in Whites: A History of Women's Cricket in England' published in June 2026.The Lancashire Cowshed TreasureThe breakthrough came when Nicholson was directed to the Women's Cricket Association archive, stored in a former cowshed in a tiny hamlet eight miles east of Blackpool. There, amidst garden furniture and farming equipment, he discovered historical treasures including minute books dating back to 1926 when the WCA was formed, scrapbooks, letters, tour diaries, and newspaper cuttings. Spending two weeks in the summer, Nicholson made daily six-mile round trips from a nearby B&B; to meticulously document these invaluable materials.Pioneers of the Women's GameThrough his research, Nicholson brought to light key figures in women's cricket history. Betty Archdale, captain of the 1934-35 Australian tour, earned the nickname 'Hitler' for her distinctive leadership style. Myrtle Maclagan, daughter of an army officer, demonstrated exceptional cricket prowess with seven for 10 in the first women's Test and the first Test hundred in women's cricket. Marjorie Pollard, the WCA founder, maintained strict dress codes that required women to play international cricket in skirts until 1997, believing 'trousers are beyond the pale'.Overcoming Financial and Social BarriersResearch revealed the constant financial struggles faced by the WCA and women's cricket players. England batter Chris Watmough described writing hundreds of letters begging for financial support for the 1968-69 tour to Australia and New Zealand, which resulted in sponsorship from lingerie brand Berlei. Coach Ruth Prideaux had so little money for the 1993 World Cup that players slept on blow-up mattresses in her living room and trained by running along Eastbourne beach. Norma Izard famously borrowed a wok from MCC kitchens to burn a miniature bat, creating the first Women's Ashes trophy in 1998.Preserving a LegacyMany of the pioneering women Nicholson researched and interviewed have since passed away, but their stories live on through his book. The research journey also led to the MCC acquiring the complete WCA archive in 2017, moving the historical materials from the Lancashire farm to Lord's. This collection now serves as a valuable resource for future researchers, ensuring that the rich history of women's cricket is preserved and accessible for generations to come.

Translated Fiction Review Roundup A collection of recent translated fiction has been reviewed, showcasing the diversity and complexity of global literature. The reviews include: 'Sisters in Yellow' by Mieko Kawakami Sisters in Yellow by Mieko Kawakami, translated by Laurel Taylor and Hitomi Yoshio (Picador, £16.99) Kawakami’s latest opens with a bang, as narrator Hana learns that her old friend Kimiko has been charged with abduction. This MacGuffin takes us to their friendship in late-1990s Tokyo, when teen Hana and the older woman open a bar called Lemon: “Yellow attracts money.” But it’s a turbulent ride and soon Hana is in a world of organised crime. “The world is crazy. I feel like I’m living in a manga.” She’s not the only one, and you need an appetite for Kawakami’s style, which prefers to explore rather than explain – people come and go, buildings burn down, cancer is diagnosed, almost at random – but the relentless rush means there’s no time to get bored. At its best – as in a scene where Hana’s unreliable mother wants to borrow 2m yen for investment in lingerie that helps “your spine and organs move back to where they’re supposed to be” – this is a story both absurd and horrifying. 'All Flesh' by Ananda Devi All Flesh by Ananda Devi, translated by Jeffrey Zuckerman (Pushkin, £12.99) “Forgive me for starting this story with bodily, unpalatable origins.” You may as well – it’s all like that. In an unnamed European country, a schoolgirl “born with no urge but to consume” is getting bigger and bigger. “My gut, my ass, my thighs – they were all set on reaching the farthest corners of the world.” She blames her gluttony on the need to silence the voice of her dead twin sister, who was “absorbed into my tissues” in the womb. She hates school, where other kids mock her, as though her own self-disgust weren’t enough. After a blackly comic scene where she gets stuck in her bedroom doorframe like “an uncooperative cork”, she falls in love with the lonely carpenter who arrives to widen the door – but there are more twists to come. This powerful story is deeply physical, but driven by a compelling voice describing the torment of a girl who is “the psychical mirror of our time … immoderation made manifest”. 'The White Desert' by Luis López Carrasco The White Desert by Luis López Carrasco, translated by Rosalind Harvey (Granta, £14.99) This unpredictable book, comprising five linked stories about a Spanish couple, opens with the end of the world and gets weirder from there. A balloon debate about a post-apocalyptic scenario turns nasty when one participant pulls a knife, or thinks he does. A plane crash-lands on an island. “Can [we] go and get our luggage … Lots of people have, you know, soiled themselves.” What links the scenes is a sense of disconnection in our connected world, but the book subverts expectations: when a group of people celebrating New Year’s Eve go missing, it turns out to be a game of hide and seek. Footnotes peppered throughout suggest we’re viewing all this from the future (“Emirates was a well-known passenger airline …”), and discovering what the white desert is turns everything on its head. For readers who like to do their own joining up, and who want a playful, original take on our precarious lives, this is a thought-provoking treat. 'The Home of the Drowned' by Elin Anna Labba The Home of the Drowned by Elin Anna Labba, translated by Elizabeth Clark Wessel (Harvill, £16.99) “You could have waited, you bastards.” In 1942 Lapland, a village occupied by the semi-nomadic Sámi people is flooded by a new hydroelectric plant’s dam. One family watch as their goahti (peat-covered hut) disappears under the water. “It wasn’t the nicest goahti,” says Ánne. “No, but it was mine,” says her sister Rávdná. When Rávdná wants to build a house to replace it, the authorities refuse permission: the Sámi way of life has been rejected but alternatives are not permitted. A local newspaper half-heartedly offers to publicise their case, but “we receive a lot of angry letters if we use any foreign words”. When the government tells local people the new dam “will lift us out of poverty and injustice”, the words reek with irony. This intimate story of infuriating discrimination is, Labba says, based on real events in Sweden.

The Rumors Surrounding Tom Hardy's Departure Rumors are swirling that Tom Hardy has been fired from the Paramount+ series MobLand due to clashes with cast and crew. The news comes after reports of Hardy's difficult behavior on set, including late arrivals and demands for creative control. Hardy's History of Difficult Behavior This isn't the first time Tom Hardy has been accused of being difficult on set. During the filming of Mad Max: Fury Road, there were reports of blowups between Hardy and his co-star Charlize Theron. Similar incidents have been reported during the making of Star Trek: Nemesis, Lawless, and The Revenant. The Impact on MobLand Hardy is currently the center of gravity in MobLand, providing the series with charm and forward momentum. Without him, the show risks drifting off into nothingness. Production insiders claim that Hardy hasn't been fired and that 'things are being worked through creatively.' The Future of MobLand The choices now available to the MobLand producers are limited and painful. Assuming that the show will be recommissioned, MobLand will have to toy with the idea of letting Hardy go and recalibrating without him. However, this would be a difficult task, as Hardy is the show's main attraction.

Lead: A Milestone Reflection on Climate ActionIn its 250th edition, the Guardian's Down to Earth newsletter pauses to assess how the world's fight against climate change has unfolded since the high‑water mark of Cop26 in Glasgow, 2021.Looking Back: Cop26’s Promise and the Five‑Year Journey2021‑2022: Nations pledged to limit warming to 1.5°C, set net‑zero targets and pledged to phase out coal.2022‑2023: The Russian invasion of Ukraine and the Iran‑oil conflict drove crude prices above $100 /barrel, exposing fossil‑fuel vulnerabilities.2024‑2025: Populist governments rolled back environmental regulations, while renewable technology became cheaper and more widespread.Numbers That Matter: Public Awareness and Emissions GapsThe “Covering Climate Now” survey found that 80‑89 % of the global public recognise the climate threat and demand government action.Current national plans still point to a projected warming of about 2.8 °C, well above the agreed target.Renewable energy costs have fallen by roughly 70 % since 2020, making clean power “cheap, widely available and overwhelmingly popular.”Why the Momentum Slowed: Geopolitics, Economics and PopulismWar‑driven spikes in oil prices, the re‑election of climate‑skeptical leaders and the rise of populist rhetoric have eroded the optimism that surrounded Cop26, pushing many countries to backtrack on commitments.What Lies Ahead: Hopeful Trends and Persistent ChallengesDespite setbacks, advances in clean‑tech, growing public pressure and emerging green‑economy initiatives suggest a pathway forward, but the intertwined climate‑biodiversity‑economy crises demand coordinated global action.

The Comedian Who Refuses to Stay SilentNish Kumar has built a career on being unafraid to speak his mind, even when it means confronting fellow comedians like Jimmy Carr about their decisions to perform in controversial venues. The British stand-up, known for his articulate and politically charged humor, recently discussed his confrontations with comics who participated in the Riyadh comedy festival, calling it part of the "cultural-washing of a repressive regime." Kumar's upcoming tour, "Angry Humour from a Really Nice Guy," reflects his concern that comedy has been "co-opted by charlatans in service of autocrats." Despite his willingness to court controversy, Kumar admits there are moments when he questions his approach, joking that "you should not be allowed to give interviews" when discussing fellow comedians.The Confrontation Over Comedy EthicsKumar's most notable public clash came when he confronted Jimmy Carr about his decision to appear on Jordan Peterson's podcast, which Kumar described as "a radicalisation event that's happening on an unprecedented scale." His criticism extends to other comics who performed in Saudi Arabia, including Bill Burr, Dave Chappelle, and Jack Whitehall. Kumar alleges that some comics "signed a contract agreeing to not have a go at MBS [Mohammed bin Salman, the crown prince of Saudi Arabia]" and expressed particular frustration with those who have complained about cancel culture while participating in such events. "I don't want to hear about free speech from any of these cunts again," he stated emphatically. These confrontations highlight Kumar's commitment to what he sees as ethical boundaries in comedy, even when it means alienating his peers.A Career Forged in Debate and DeterminationNow 40, Kumar has been performing stand-up for two decades, though his love for comedy began much earlier. At age five, he was studying The VHS of The Simpsons, analyzing its intricate references and in-jokes. His influences included Chris Rock and the sketch show Goodness Gracious Me, which helped him see comedy as a viable path for someone of his background. "Until then, the only people I'd seen do comedy were either white or African American. You see a bunch of Indians doing it, you think: Oh, this is viable for me." Kumar's early career involved temping while struggling to make inroads in comedy, buoyed only by "the persistent encouragement of my friends." His big break came in 2015 when his fourth fringe show was nominated for an Edinburgh comedy award, followed by regular TV appearances and eventually becoming a household name after joining The Mash Report in 2017.The Impact of a Progressive Voice in ComedyKumar's outspoken progressive politics made him both celebrated and controversial. His appearances on Question Time prompted social media abuse, and figures like Piers Morgan and Andrew Neil criticized him for an "anti-British" episode of Horrible Histories. Despite these controversies, Kumar believes his involvement in culture wars ultimately did more harm than good. "It's a fucking relief. It didn't do anybody any good; me being in the conversation didn't benefit any of the causes that I was passionate about. I worry sometimes that it actually actively hindered them." Despite this, his influence has grown internationally, with The New York Times suggesting he might be "the angry progressive standup the US badly needs." His cross-generational appeal has also expanded, with audiences ranging from 14-year-olds to septuagenarians, reflecting his ability to connect with diverse audiences through his blend of political commentary and personal vulnerability.Anger and Authenticity in a New Era of ComedyAs he approaches his 40s, Kumar continues to refine his approach to comedy that balances anger with authenticity. He has been open about his mental health struggles, including diagnoses of PTSD and ADHD, which inform his work. His upcoming tour "Angry Humour from a Really Nice Guy" suggests a continued commitment to comedy that challenges both audiences and the industry itself. Despite his success in the US, where he performed his new show and appeared on Have I Got News for You, Kumar's material remains rooted in UK concerns, with American audiences showing enough interest in British politics to appreciate his takes on figures like Angela Rayner. As he continues to navigate the complexities of comedy that both entertains and provokes, Kumar remains committed to what he sees as the essential role of comedy in holding power accountable, even when it means making enemies in the process.

The Safety Concerns A giant statue of football superstar Lionel Messi erected in India to mark his visit last year is “swaying in the wind” and will be removed, a lawmaker has said. Workers have scrambled up the 21-metre (70ft) golden-coloured statue in the eastern city of Kolkata in West Bengal, throwing ropes around its shoulders to secure it. The Statue's Construction and Purpose The sculpture showing the 38-year-old Argentina and Inter Miami player raising the World Cup trophy was unveiled during Messi’s GOAT Tour (Greatest of all Time Tour) of India in December. The Removal Process But West Bengal state legislator Sharadwat Mukherjee said it was no longer safe. “The statue of the Argentine football legend in the city of Kolkata was found unsafe by engineers of the West Bengal government,” he told the AFP news agency. “We have noticed that the statue is swaying in the wind.” Workers on Wednesday used ropes to attempt to secure the statue, which looms over a busy road. Mukherjee said it was not clear when it would be brought down. “Removal has proved easier said than done,” he said. “We are planning to remove the statue at the earliest opportunity.” He did not say whether the statue would be re-erected at another site. The Context of Football in India India – a nation of 1.4 billion – is a cricket powerhouse, but struggles on the football pitch and is 142nd on the FIFA rankings. Football, however, is the country’s second favourite sport, according to research by data company Nielsen released on Wednesday.

The Mythical Champions of European FootballParis Saint-Germain has been re-enthroned as Champions League winners, with French newspaper L'Équipe declaring them "mythical" and "storied." The victory over Arsenal in Budapest showcased a team that has evolved from a celebrity machine into a sensationally good, beautifully watchable unit under Luis Enrique. While the celebration of Parisian exceptionalism might seem overstated, the team's performance and retention of Europe's premier trophy deserves recognition.A New Kind of Champion QualityUnlike their record 5-0 win over Inter in Munich the previous year, this Champions League victory demonstrated a different kind of champion quality. The team showed resilience and tactical intelligence, finding ways to win even when playing below their best. This victory came against a well-organized Arsenal side that had clearly prepared specifically to counter PSG's strengths.The Financial and Structural AdvantagePSG's success must be viewed in the context of their unique setup. The team has essentially created a spring mini-season, focusing their resources on nine key games from February to May over the past two years. This approach, backed by Qatari investment through Nasser al-Khelaifi's leadership, allows for specialized preparation that traditional clubs cannot match. Players like Nuno Mendes and Marquinhos have played significantly more Champions League minutes than domestic league matches, while Ousmane Dembélé has essentially become a midweek specialist.Subverting Traditional Football PathwaysPSG represents a fundamental challenge to the traditional European football model. Instead of emerging from a domestic league's crucible as its strongest representative, PSG bypasses Ligue 1 almost entirely to focus solely on Champions League success. This has transformed the team into a luxury good, comparable to products found behind velvet ropes in elite private airport suites. The article questions whether this model truly deserves the same recognition as teams that balance multiple competitions throughout a demanding season.The Luis Enrique RevolutionDespite the financial advantages, credit must be given to Luis Enrique for transforming PSG into a team of tactical coherence and focus. The current PSG bears little resemblance to the previous incarnation characterized by Neymar's extravagant lifestyle. Instead, Enrique has implemented a fusion of Pep-style possession football with the direct attacking energy of peak Klopp's Liverpool. The team's training methods have been innovative, utilizing immersive video simulators, individual USB stick tactical notes, and even training-ground speakers pumping out stadium noise for psychological preparation.The Soft-Power ParadoxPSG presents a fascinating paradox: they are simultaneously seen as European football's "good guys"—purists who play beautiful, aesthetically pleasing football—while representing a carbon dictatorship's soft-power project. This contradiction highlights the performative nature of sport, where beauty and success often override questions about the source of funding. The team's cultural initiatives, including the "Ici c'est Paris la maison" events in LA and New York that combine sport with music, fashion, art, and gastronomy, further enhance their brand appeal.The Future of European Football's ElitePSG's model appears sustainable and potentially replicable, though few clubs can match their financial backing. The team's success with young talent—six academy players made professional debuts this season, and the average starting XI age is 24—suggests they've found a balance between financial power and genuine sporting development. As European football continues to evolve, PSG's approach may represent the future of elite competition: a fusion of exceptional talent, tactical innovation, and sophisticated branding that creates a global brand rather than just a football club.

The Devastating Explosion in Shan State Dozens of people have been killed in a massive explosion at an explosives depot in Myanmar's northeastern Shan State near the border with China. The blast occurred on Sunday in the village of Kaung Tat, causing significant destruction and casualties in an area already affected by ongoing conflict. Details of the Kaung Tat Disaster The explosion took place around 12:30pm local time (05:50 GMT) at a depot housing explosives used in mining operations. Footage shared on social media showed an enormous plume of smoke followed by secondary explosions, with several buildings completely destroyed in the aftermath. The area is under the control of the Ta'ang National Liberation Army (TNLA), one of the most powerful rebel groups in Myanmar that has been fighting for decades for greater autonomy. Casualty Figures and Aftermath Local news website The Irrawaddy reported that at least 46 people, including six children, were killed and more than 70 other people were wounded in the blast. However, a rescue worker told the Shwe Phee Myay news agency that the death toll was 55. Several houses were damaged in the explosion, and rescue operations were ongoing at the time of reporting. Regional Implications in Conflict Zone The blast occurred in a region known for its ruby-rich mines and has been a site of ongoing conflict between rebel groups and the central government. The TNLA confirmed the explosion in a statement on Facebook, saying that the stored explosive material was used in mining operations. The group stated that an investigation into the cause of the blast was underway and that those responsible would be held accountable. This incident highlights the ongoing security challenges in Myanmar's conflict zones, particularly in areas controlled by ethnic rebel groups. Future Outlook for Mining Safety This tragic explosion is likely to prompt increased scrutiny on mining safety practices in conflict-affected areas of Myanmar. Given the region's valuable mineral resources and the presence of multiple armed groups, the incident may lead to calls for better regulation of explosive materials and improved safety protocols. The international community may also increase pressure on all parties to ensure civilian protection in areas affected by both conflict and resource extraction activities.