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The U.S. Food and Drug Administration announced on Wednesday that it has granted expedited approval to Eli Lilly’s oral weight‑loss medication, orforglipron—marketed under the brand name Foundayo. This makes Foundayo the second GLP‑1 pill to reach U.S. consumers, following Novo Nordisk’s Wegovy tablet approved in December. Orforglipron works by mimicking a natural hormone that regulates appetite and satiety, offering a non‑injectable alternative to existing GLP‑1 injectables. David A. Ricks, Eli Lilly’s chair and CEO, highlighted that fewer than one in ten eligible patients are currently using GLP‑1 therapies, citing barriers such as cost, stigma, and perceived complexity. Unlike Wegovy, which must be taken on an empty stomach each morning, Foundayo can be taken anytime of day regardless of meals, simplifying dosing schedules. Patients will start on a low dose that is gradually increased to mitigate side‑effects. Pricing is projected at $149 per month for the initial dose, with higher‑strength formulations potentially reaching $349 monthly. While private‑insurance coverage remains uncertain, a Trump‑administration proposal could allow Medicare to cover certain patients as early as this summer, with copayments as low as $50 per month. Distribution will commence on Monday through LillyDirect’s direct‑to‑consumer channel, with broader availability in pharmacies and telehealth platforms expected shortly thereafter. The convenience of a once‑daily pill is anticipated to improve adherence, especially for individuals who avoid injectables due to needle aversion or rigid dosing requirements. The approval follows a fast‑track submission submitted only months ago, positioning Foundayo to enter the market roughly three months after Wegovy. This rapid rollout is set to intensify competition in the burgeoning GLP‑1 space, where new agents are continually emerging with claims of better efficacy and lower costs.

Mauricio Pochettino, the head coach of the US Men's National Team (USMNT), understands the pressure of playing for your national team in a way few of his players can. Having been a late cut from Argentina's World Cup plans in 1994 and 1998, Pochettino finally made the squad as a veteran in 2002. He recalls the immense pressure Argentina faced during that tournament, with the country in the midst of an unprecedented economic crisis. Pochettino shared his experiences during a press conference ahead of the USMNT's friendlies against Belgium and Portugal. He emphasized that Argentine people feel the pressure deeply, and that football is a battle to survive. The team's performance at the 2002 World Cup was catastrophic, crashing out in the group stage for the first time in half a century. Now, as the US team prepares for the World Cup on home soil, Pochettino aims to shield his players from excessive pressure. He believes that pressure can be heavy if not dealt with properly, and instead focuses on sending good energy to his players. Pochettino encourages his team to perform freely and happily, rather than under the weight of expectation. Christian Pulisic, arguably the most talented player in US soccer history, is likely to feel the burden of pressure. As Captain America, he is the highest-profile player the program has ever seen. Pulisic acknowledged the pressure, stating, "There's pressure, it's a World Cup, it's not because of my position in the team or anything. I'm used to this, I wouldn’t want to be in any other position, I'm lucky to be in this position." Pochettino has created a strong bond with his players, and his motivational approach focuses on building emotional connections. He believes that motivation begins from the first day you meet someone and that words alone are empty without an emotional bond. The coach's positivity is infectious, and his message to the team was simple: "Why not us?" Pochettino's confidence in the team's abilities is clear, stating, "Dreams inspire reality." He genuinely believes the US can compete to win the World Cup, saying, "because we are American." The team's performance will depend on various factors, but Pochettino's faith in his players is evident.

Gulf countries are increasingly concerned about the threat posed by Iran-backed militias and proxy armed groups in the region. These groups, which include Hezbollah in Lebanon and the Houthis in Yemen, have been used by Iran as a pillar of its foreign and security policy for decades.In a joint statement, Qatar, Kuwait, the UAE, Bahrain, Saudi Arabia, and Jordan condemned Iranian attacks on their soil, both as strikes carried out directly from Iran and “through their proxies and armed factions they support in the region”. The statement also called on the Iraqi government to take measures to halt attacks launched by factions, militias, and armed groups from Iraqi territory.Kuwait recently foiled a plot to kill state leaders and arrested six suspects believed to be associated with Hezbollah. The Houthis also confirmed they had launched a missile strike on Israel, the first time the proxy group have admitted involvement in the war in the Middle East.The threat of these groups is seen as particularly worrying for countries such as Saudi Arabia and Bahrain, which have a history of Iran-backed militia carrying out violent attacks. Analysts warn that the presence and danger of Iranian proxy groups in the Gulf had not reached levels anything close to those during the Iran-Iraq war in the 1980s, but the threat remains greater the longer the conflict with Iran drags on.Bilal Saab, a senior managing director of the Trends US thinktank, said: “If this war escalates, the worst-case scenario for the Gulf countries is Iran activating their sleeper cells and these Shia militia movements in the region. We could see a whole lot more if things really escalate.”

Mohaddeseh Fallahat recalled the ordinary morning of February 28 when she prepared her children for school, never imagining it would be the last time she would see them alive. That simple morning routine now haunts her as she struggles to cope with the devastating loss of her two children.Speaking through tears to the United Nations Human Rights Council in Geneva via videolink, Fallahat described the unbearable pain of sending her children off with a smile, only to be met with silence. "My heart burns with pain," she shared, as the memory of their final words—"Mum, come pick us up after school"—repeats endlessly in her mind.Her children were among more than 170 people killed when United States Tomahawk missiles struck the Shajareh Tayyebeh Girls' School in Minab, southern Iran, during the initial hours of the US-Israeli assault. The majority of victims were schoolgirls, marking one of the deadliest attacks on educational facilities in recent memory.Iran's Foreign Minister Abbas Araghchi addressed the council with strong condemnation, asserting that the attack was no mere miscalculation. "No one can believe that the attack on the school was anything other than deliberate and intentional," he stated, pointing to the advanced precision technologies claimed by American and Israeli forces.Araghchi accused the US and Israel of "slaughtering [victims] in cold blood" and committing "the worst humanitarian crimes with impunity." He called on UN member states to denounce what he described as a "blatantly unjustified" war on Iran, warning that indifference would bring no lasting security or peace.UN special rapporteur on the right to education, Farida Shaheed, presented evidence suggesting the school was "each struck individually by precision munition," indicating intentional targeting. However, ongoing investigations suggest the attack may have resulted from "outdated intelligence" used by the US military.Shaheed emphasized that "the killing of children can never, ever be justified" and highlighted the broader impact on education in Iran, where more than 600 schools and education facilities have been destroyed or severely damaged by US-Israeli attacks, with at least 230 children and teachers confirmed dead.UN Human Rights chief Volker Turk reinforced that targeting schools constitutes a grave violation of international law, stating: "Whatever differences countries have, we can all agree they will not be solved by killing schoolchildren."

Electropop artist Slayyyter has found success with her new album Worst Girl in America, a chaotic and over-stimulating concoction that scratches an anarchic itch in the listener. The album's sound is a far cry from her earlier work, embracing a midwest trash aesthetic that's both nostalgic and visionary.Slayyyter, born Catherine Grace Garner, has been making music for over a decade, but it's taken her several cycles of chasing hits and experimenting with different sounds to find her true voice. Her aim was simple but risky: to make something cool – fuck anything that sounds commercial, fuck TikTok. And it seems she's succeeded, with fans and critics alike praising her new direction.The album's singles, such as Crank and Cannibalism, have introduced a sound that's sharper, sleeker, and filthier, with a vibe tuned to a precise heartland sleaze. Slayyyter's music is a hedonistic kaleidoscope of motel parties, unfinished basements, trucker hats, and taxidermy, a unique blend of influences that's both captivating and refreshing.Slayyyter's journey to this point has been marked by burnout and depression, but she's emerged with a newfound sense of creative freedom and a determination to make music that's true to herself. As she says, “I’m not, like, looking for a mainstream moment. But if one happens, that’s great.”With Worst Girl in America, Slayyyter is poised to make a significant impact on the music scene, offering a fresh perspective and a bold new sound that's sure to resonate with fans and critics alike.

Ryan Murphy's drama series 'Love Story' has become Disney+'s most-streamed drama ever, captivating audiences worldwide with its schlocky, glossy portrayal of the doomed marriage between John F Kennedy Jr and Carolyn Bessette. The series, which consists of nine episodes, tells the story of the couple's whirlwind romance and tragic fate.The show's success can be attributed to its unique blend of camp nostalgia, paparazzi exposure, and cultural symbolism. According to TV critic Scott Bryan, Murphy's formula for success involves targeting subjects with tragic backstories and workable legal margins, which in practice means the longer they have been dead, the smoother the adaptation.The series begins as a Cinderella romance between a Kennedy scion and a Calvin Klein publicist who became the most famous and scrutinised couple in the US – and evolves into a lesson in what happens when marriage becomes a form of branding. The show's relatability factor also lies in its portrayal of universal dating themes, great hair, and a wardrobe full of Prada and Kangol caps worn backwards.Social media searches for JFK Jr and Bessette grew by more than 9,100% in the past month, according to FX, which created the show. The show's success has also sparked speculation about Murphy's next subject, with names like Brad Pitt and Jennifer Aniston, John Lennon and Yoko Ono, and Liz Taylor and Richard Burton being floated on social media.The show's impact can be seen in its ability to resonate with audiences, particularly Gen Z women, who have connected with the show's themes of relationships, style, and tragedy. As Bryan noted, 'Love Story' is 'unapologetically schmaltzy' and doesn't try to be anything more than a show that looks the part, making it a refreshing change from the usual prestige television dramas.

Five Guys' chief executive officer, Jerry Murrell, revealed that he gave a $1.5m bonus to employees of his US-based burger restaurant chain to make up for the chaos caused by a recent promotion. The buy-one-get-one-free offer, which was intended to celebrate the company's 40th anniversary, proved to be much more popular than expected, causing the chain's app to crash and many locations to become overwhelmed.Murrell stated that he gave the bonus because "I didn't want anybody shooting me in the back or anything … because we really screwed it up." The comment was made in an interview with Fortune, where he also joked that he preferred the employees receiving the bonus over his wife getting "a new fur coat."The promotion, which was launched in February, was initially met with intense criticism on social media, prompting Five Guys to apologize and restart the offer for four days. Murrell attributed the chaos to the company's underestimation of the promotion's popularity, stating that "we had no idea that we were going to get that kind of response."Five Guys currently operates 1,900 locations and employs 30,000 people in 28 countries worldwide. The company's CEO since its founding in 1986, Murrell has taken steps to address the backlash and improve customer satisfaction.

Russia has carried out one of its largest aerial attacks on Ukraine, launching 948 drones in a 24-hour period as it moves troops and equipment to the front line in what appears to be the start of its new offensive.The attacks have resulted in civilian casualties, with two people killed in the western Ukrainian city of Ivano-Frankivsk and one person killed in the region of Vinnytsia. The city of Lviv has also been targeted, with footage showing a drone crashing into an old building next to a church in the historic centre.Ukraine's President Volodymyr Zelenskyy has issued a new appeal for allies to supply Kyiv with air defence munitions, warning that Kyiv will face a deficit of missiles while Washington is focused on the US-Israeli war on Iran.The Institute for the Study of War (ISW) has reported that Russia has moved heavy equipment and more troops to the front line, with General Oleksandr Syrskii, the commander-in-chief of Ukraine's armed forces, saying Russian troops have made simultaneous attempts to break through defensive lines in several strategic areas.Russia's new offensive is seen as an escalation of its war of attrition, which has been unable to capture cities but has made incremental gains across rural areas.

The recent escalation of tensions between Iran and Israel has sent shockwaves through the global energy market, leading to a significant increase in oil and gas prices. The conflict has raised concerns about the potential disruption of oil supplies from the region, which could have a lasting impact on prices.Despite expectations that the price shock will be temporary, experts believe that the effects of the conflict will be felt for some time. The Iran war has already led to a significant increase in oil prices, with many analysts predicting that prices will continue to rise in the coming weeks and months.The conflict has also raised concerns about the potential for further escalation, which could lead to even higher prices. As the situation continues to unfold, it is clear that the oil and gas price shock sparked by the Iran war is unlikely to fade away anytime soon.