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An Iranian missile has struck central Tel Aviv, causing widespread damage to buildings and vehicles, and injuring at least six people. The attack has led to a significant escalation of tensions in the region, with Israeli Prime Minister Benjamin Netanyahu vowing to continue striking Tehran and Lebanon.“There’s more to come,” Netanyahu said in remarks that appeared to corroborate those of three Israeli officials who told Reuters they thought it was improbable that Iran would accept US demands in any new round of negotiations. This development has dimmed hopes of de-escalation after US President Donald Trump played up the chances of a deal to end the conflict.In a statement released on Tuesday, Iran’s Islamic Revolutionary Guard Corps said it would launch heavy missile and drone attacks at Israeli troops in northern Israel and the area near Gaza “without restraint” unless Israel ceased attacks in Lebanon and Palestine. The threat has raised concerns about the potential for further escalation in the region.Police said an Iranian munition carrying a substantial explosive payload struck the central city, causing widespread damage to buildings and vehicles. At least six people were lightly injured. Several buildings were damaged across Tel Aviv, with emergency services reporting casualties at one of the impact sites. One building and the adjacent road were heavily affected, with cars set ablaze.Israel’s health ministry reports 4,829 injured people have been brought to hospitals since the onset of the war. Of those people, 111 remain in hospital and 12 are in a serious condition. The strikes were the latest in a cycle of retaliation after Israeli operations announced on Monday.About 40 minutes after Trump said he would delay action against Iran’s power infrastructure, Israel said on X that it had “just begun another wave of strikes targeting infrastructure of the Iranian terror regime across Tehran”. The Israel Defense Forces said energy facilities would be spared, suggesting that Israel may be aligning with Washington in suspending attacks on Iranian power plants and related sites.The US-based Human Rights Activists’ News Agency said in the previous 24 hours it had recorded at least 206 attacks across 15 provinces in Iran, resulting in at least four casualties (killed and injured, both civilian and military). At least six people were killed in strikes on homes in the city of Tabriz, according to Iran’s Fars news agency.Since US-Israeli bombs started falling on Iran, estimates of total deaths (military and civilian) in the country have exceeded 1,500, with some rights groups reporting figures as high as 3,230 as of 21 March. The escalation has also spilled beyond Israel, with Iranian strikes extending into Gulf states.

Israel and the United States have launched a new wave of attacks against Iran, escalating the conflict in the region. The Israeli military confirmed that it carried out a second round of strikes, hours after initiating a wide-scale wave of attacks on infrastructure targets in Tehran. Al Jazeera Arabic's correspondent in Tehran reported that the size and volume of the explosions in the Iranian capital were unprecedented, especially on the eastern side of the city. Iranian air defense systems were activated in response to US-Israeli drones hovering over the city. According to Mohamad Elmasry of the Doha Institute for Graduate Studies, the war is escalating, with US and Israeli forces hitting not only military installations but also hospitals, schools, and over 5,000 residential units. He warned that the situation is becoming increasingly dangerous, especially for the people of Iran. Iran's Fars news agency reported that a strike on a residential building in Khorramabad killed one child and wounded several people, while at least six people were killed in strikes on homes in Tabriz city. The Iranian Red Crescent Society stated that over 80,000 civilian building units have been hit, with some fully demolished. The US military targeted a turbine engine production site in Qom province, used for drone and aircraft components linked to the Islamic Revolutionary Guard Corps (IRGC). Meanwhile, Iranian missile strikes continued overnight in Israel, with falling shrapnel reported across several locations. Iran's Foreign Ministry denied any dialogue with the US, claiming that President Trump's comments aimed to reduce energy prices and buy time to implement military plans. The IRGC warned that if the US targets Iran's power plants, it will hit power plants in areas supplying electricity to US bases and American interests. The conflict has resulted in over 1,500 deaths in Iran and 15 deaths in Israel. The situation has also unsettled oil markets, with prices fluctuating as Asian trading opened. The head of the International Energy Agency warned that the situation in the Middle East is very severe and worse than the two energy crises of the 1970s combined.