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Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

Josh Hart recorded a playoff‑career‑high 26 points and seven assists as the New York Knicks beat the Cleveland Cavaliers 109‑93, moving the series to a pivotal Game 3 and putting the Knicks within two wins of the NBA Finals for the first time since 1999. The Knicks Secure a Dominant 109-93 Victory Over Cleveland The win featured an 18‑0 run in the third quarter that stretched the lead to 71‑53. Coach Mike Brown praised Hart’s shooting, noting his five‑for‑eleven performance from beyond the arc. The Knicks’ bench contributed crucial minutes as the crowd chanted “Knicks in four!” throughout the final minute. Statistical Highlights: Scoring, Rebounds, and Historic Streaks Josh Hart: 26 points (5/11 3‑pt), 7 assists Jalen Brunson: 19 points, 14 assists Karl‑Anthony Towns: 18 points, 13 rebounds Mikal Bridges: 19 points Cavaliers: Donovan Mitchell 26 points, James Harden 18 points Cavaliers missed 10 free throws (68.8% FT) Knicks now on a nine‑game postseason winning streak, the longest since the Boston Celtics’ ten‑game run en route to the 2024 championship Implications for the Eastern Conference Finals Landscape The victory solidifies the Knicks’ control of the series, giving them a 2‑0 lead and forcing the Cavaliers to win two straight to stay alive. The dominant third‑quarter run demonstrates the Knicks’ ability to dictate tempo and exploit defensive lapses, while Cleveland’s free‑throw woes highlight a potential vulnerability in close games. Looking Ahead: What Game 3 Could Hold for Both Teams Game 3 shifts to Cleveland, where the Cavs must address shooting consistency and improve free‑throw execution. The Knicks will aim to sustain their defensive intensity and capitalize on the momentum generated by Hart’s hot shooting night. If the Knicks maintain their current pace, a Finals berth appears increasingly likely; a resilient Cavs effort could at least extend the series and test the Knicks’ depth on the road.

The LeadWhen producers of the revived Baywatch series hit unexpected permitting roadblocks on Venice Beach, the incident quickly morphed into a political flashpoint, with opponents of Mayor Karen Bass branding Los Angeles “not film friendly” and using the controversy to sharpen their mayoral campaigns. The Baywatch Production Standoff on Venice BeachAfter receiving a $21 million state tax credit, the Baywatch team arrived in February to film on Venice Beach. Within four days, the County Beaches and Harbors Department barred the use of camera drones, night shooting, and even limited the sand area and parking options, forcing production to halt. Tax credit: $21 million Restrictions: no drones, no night shoots, limited sand and parking Production downtime: four days before a full stop Financial Stakes and Shooting‑Day MetricsThe Baywatch dispute arrived at a moment when the city was trying to reverse a long‑term decline in film activity. Industry loss: nearly 50 % drop in shooting days since 2018 (cited by challenger Nithya Raman) Recent rebound: 10.7 % increase in total productions Q4 2025 → Q1 2026 Feature‑film surge: 45 % rise in shooting days over the same period Political Fallout in the 2026 Los Angeles Mayoral RaceOpponents seized the Baywatch saga to question Bass’s leadership. Right‑wing challenger Spencer Pratt called the incident “political fecklessness,” while left‑leaning councilmember Nithya Raman highlighted the broader decline in shooting days. Bass responded by coordinating with the state coastal commission, FilmLA, and city council to clear the bureaucratic hurdles. What the Next Months Hold for LA’s Film PolicyMayor Bass announced a series of reforms: streamlined permitting across agencies, accelerated sound‑stage certification, waived fees for “microshoots,” and a six‑month pilot by FilmLA to cover permits for low‑impact productions. If these measures sustain the recent 10.7 % production uptick, they could become a cornerstone of Bass’s re‑election narrative, while challengers will likely continue to press for faster, more transparent reforms.

Thunder Even Series Behind MVP's Strong PerformanceShai Gilgeous-Alexander bounced back from a subpar series opener to score 30 points, Alex Caruso added 17 off the bench and the host Oklahoma City Thunder beat the San Antonio Spurs 122-113 on Wednesday night in Game 2 of the Western Conference finals. The victory evens the series at 1-1 as it shifts to San Antonio for Game 3 on Friday.Thunder's Adjusted Defense Contains WembanyamaThe Thunder playbook in Game 2 was about making life as difficult as possible for Victor Wembanyama, hoping to prevent outbursts like the 41-point, 24-rebound gem he put together in San Antonio's 122-115 win in Game 1. Coach Mark Daigneault adjusted his defensive strategy after the first game, implementing a more varied approach to contain the Spurs' star."Every good player, they have to feel the defense," Gilgeous-Alexander said. "It's tough. He's very different to scout. You've got to try to mix things up, you've got try different things. And that's just what we did. Coach tried something in the first game, didn't like it, tried something else. That's what it's about."Bench Depth and Turnovers Prove DecisiveThe Thunder finished with a 57-25 edge in bench scoring, plus a 27-10 advantage in points off turnovers. Chet Holmgren scored 13 points and reserves Jared McCain and Cason Wallace each had 12 for Oklahoma City, demonstrating the team's depth beyond their star players."I thought we all played better," Thunder coach Mark Daigneault said. "I had a quiet confidence about that. I didn't know if we'd win or lose the game, but I was pretty sure after watching Game 1 and knowing our team that we were going to come out and play better tonight."Injuries Mount as Series Shifts to San AntonioThe win was not without cost for the Thunder, who lost guard Jalen Williams in the first half with a recurrence of a hamstring issue. He had already missed six games in these playoffs with a left hamstring strain, putting his availability for Friday into doubt.The Spurs also got banged up. Already without All-Star guard De'Aaron Fox because of ankle soreness, San Antonio lost his replacement in the starting lineup, Dylan Harper, to a right leg injury after he took a couple of awkward falls in the third quarter."Obviously this team is as good as anybody at turning you over, so when you're down some of your primary creators and initiators it causes a little bit of an extra strain, whether that's who to play, what to play, what to run, etc, etc," Spurs coach Mitch Johnson said. "We'll just have to be sharper in that area because it's tough fully loaded against these guys."Series Outlook Shifts After Thunder's ResponseWith the series now tied and heading to San Antonio, both teams face questions about health and adjustments. The Thunder showed their ability to respond after a poor Game 1 performance, while the Spurs must determine how to compensate for their growing list of injuries."The guys brought it tonight," said Gilgeous-Alexander, who was recently named the league MVP for the second straight season. "Knowing what it would have meant if we lost this one, we brought the energy from the jump." The series now becomes a best-of-three with Game 3 set for Friday in San Antonio.

The Lead A video posted by Israel's far-right National Security Minister Itamar Ben-Gvir, in which he is seen taunting abducted flotilla activists who sought to break the siege on Gaza, has triggered a backlash and dealt a huge blow to Israel's multimillion-dollar public relations campaign, known as 'Hasbara'. The Event Details The footage, posted on the social media platform X, showed Ben-Gvir gloating as activists from the Global Sumud Flotilla knelt on the floor, blindfolded, with their hands bound at the Port of Ashdod. Israeli naval forces had intercepted the flotilla's vessels in international waters off the coast of Cyprus, illegally abducting 430 participants. Among them, at least 87 have launched a hunger strike in solidarity with the more than 9,500 Palestinian prisoners held in Israeli jails. The Diplomatic Fallout The images of activists being dragged across the floor prompted several countries – including Italy, France, the Netherlands, Canada, and Spain – to summon Israeli ambassadors, condemning the 'unacceptable' treatment and violation of human dignity. The Collapse of the 'Hasbara' Illusion Experts argue that the frantic damage control by Israeli officials, including Prime Minister Benjamin Netanyahu, who ordered the rapid deportation of the activists, stems not from moral outrage over the abuses, but from the catastrophic damage done to Israel's global image. For decades, Israel has relied on 'Hasbara' – a Hebrew term translating to 'explanation' – a propaganda campaign to justify its policies and military actions against Palestinians to the international community. US Double Standards and 'Pro-Terror' Sanctions The diplomatic fallout also laid bare the glaring contradictions in United States policy. Following the video's release, US ambassador to Israel Mike Huckabee criticised Ben-Gvir, stating the minister had 'betrayed the dignity of his nation'. However, critics were quick to point out that Huckabee's condemnation rang hollow, as it focused entirely on the indignity of the broadcast rather than the human rights violations committed. A Microcosm of Palestinian Suffering For Palestinians, the humiliation endured by the European and international activists is merely a glimpse into a much darker, systemic reality. Mustafa Barghouti, secretary-general of the Palestinian National Initiative, said the bound and blindfolded activists represent a 'microcosm' of what Palestinian prisoners endure daily. The Hammer and the Flotillas Despite the military interceptions and the US sanctions, activists and analysts agree that the flotilla campaigns, which began in 2009 in response to Israeli land, sea and air blockades, have succeeded in exposing the limits of Israeli force.

The latest S&P; Global purchasing managers' index shows UK services activity slipping to a 48.5 reading in May, marking the steepest drop in a decade and signalling a broader economic slowdown.Sharp Drop in UK Services PMI Marks Decade‑Worst DeclineIndex fell to 48.5 in May, down from 52.6 in April.Lowest reading since January 2021 and the lowest since July 2016 when Covid data are excluded.Services sector accounts for roughly 80% of UK GDP.PMI Numbers Reveal Contraction Below Growth ThresholdThe composite output index, which blends manufacturing and services data, dropped below the critical 50‑point mark, indicating contraction. Economists had forecast a reading of 51.6, making the actual figure notably worse.Payrolls fell for the 20th consecutive month, echoing ONS data that showed a loss of 100,000 payrolled employees in April.Manufacturing showed a modest rebound, hitting a three‑month high as firms front‑loaded orders.Broader Economic Implications for GDP and Monetary PolicyAndrew Wishart of Berenberg warned that a sustained PMI slump could push quarterly GDP growth from 0.6% in Q1 to -0.2% in Q2. Meanwhile, the Bank of England may keep its policy rate at 3.75% after recent inflation data showed a slowdown to 2.8% in April and wage growth easing to 3.4%.Outlook: Potential Further Slowdown Amid Geopolitical TensionsAnalysts attribute the downturn primarily to the ongoing Iran war and heightened uncertainty around Keir Starmer's leadership. If these pressures persist, the services sector could see continued job cuts and reduced spending, while manufacturers may face tighter order books, as noted by the CBI.Overall, the flash PMI suggests a cautious near‑term outlook for the UK economy, with policymakers likely to adopt a wait‑and‑see stance on interest‑rate adjustments.

The Lead: International Outrage Over Ben-Gvir's Video Israel's far-right National Security Minister Itamar Ben-Gvir has posted a video of himself taunting foreign activists abducted from a Gaza-bound aid flotilla at a makeshift holding pen in Israel's city of Ashdod. The activists, abducted by Israeli forces in international waters, are seen cable-tied and kneeling while Israel's national anthem blares in the video, which was released on Wednesday. Several countries, including Italy and France, have summoned Israeli ambassadors to explain the stunt. As well as a global backlash, the video has even been met with sharp rebukes from Israeli Prime Minister Benjamin Netanyahu and staunch ally, United States ambassador to Israel, Mike Huckabee. Who is Ben-Gvir: The Far-Right Minister at the Center of Controversy The 50-year-old lawyer and politician has led the far-right Jewish Power (Otzma Yehudit) party in Israel since 2019. He was sworn into the cabinet after the 2022 elections and was later appointed as national security minister and given control of Israel's Border Police division in the occupied West Bank. A settler in Kiryat Arba, one of the most radical settlements on Palestinian land in the occupied West Bank – all of which are illegal under international law – Ben-Gvir has convictions for incitement to racism, destroying property, possessing a "terror" organisation's propaganda material and supporting a "terror" organisation – Meir Kahane's outlawed Kach group, whose founder advocated for expelling non-Jews from Israel and which Ben-Gvir joined when he was 16. He frequently carries out anti-Palestinian acts, including regularly storming the Al-Aqsa Mosque compound in occupied East Jerusalem's Old City, Islam's third holiest site, alongside Israeli settlers and under the protection of Israeli forces. The Flotilla Activists: International Aid Efforts to Gaza This refers primarily to the Gaza aid flotillas – groups of boats carrying activists from different countries which have set out across the Mediterranean in an attempt to deliver aid and raise awareness at various times since October 2023, when Israel launched its brutal assault on the Gaza Strip, which has killed more than 72,000 Palestinians, mostly civilians. The modern flotilla movement emerged in 2006 during Israel's war on Lebanon and expanded after Israel imposed its blockade on Gaza in 2007. Since then, hundreds of vessels organised by international solidarity groups have attempted to reach the territory, carrying humanitarian aid and activists. In 2008, two boats from the Free Gaza Movement became the first to successfully reach Gaza by sea despite the blockade. But since 2010, Israeli forces have intercepted nearly every flotilla in international waters. On Tuesday, at least 430 activists from more than 46 countries were abducted during Israeli interceptions of the latest flotilla. The Video: Ben-Gvir's Taunting of Detained Activists In the video released on Wednesday, a woman approaches the minister and says in English, "Free Palestine!" before masked security officers put their hands on her head as they snap it down and push her away. "Good job," Ben-Gvir says to the officers, before stating, "Welcome to Israel. We are the landowners here; that is how it should be." Activists are then seen on their knees with their heads on the ground and arms tied behind their backs in "stress positions" as the figures of armed Israeli security officers look down on them from atop shipping containers. Ben-Gvir, waving an Israeli flag and heavily protected by security personnel, can be seen weaving in between the activists, appearing to relish the moment as he taunts them. International Response: Global Condemnation of Israel's Actions Several countries, including Italy, France, the Netherlands and Canada, have summoned Israeli ambassadors to their capitals to express their "indignation" over Israel's treatment of the abducted Gaza flotilla activists and to demand the release of their citizens. French Foreign Minister Jean-Noel Barrot also denounced Ben-Gvir's actions as "unacceptable", calling for the release of French citizens "as soon as possible". Canadian Foreign Minister Anita Anand called the incident "deeply troubling". United Kingdom Foreign Secretary Yvette Cooper said the video showed "totally disgraceful scenes". "The images of Israeli Minister Ben Gvir are unacceptable. It is unacceptable that these protesters, including many Italian citizens, are subjected to this treatment that violates their human dignity," Italian Prime Minister Giorgia Meloni said in a statement on X. Previous Treatment of Activists: A Pattern of Controversy In May 2010, when Israeli commandos stormed the Turkish ship Mavi Marmara, 10 activists were killed and dozens were wounded. Allegations of mistreatment by activists who have been brought to Israel after naval interceptions have been common, and organisers say they fear sanctions and accusations of Hamas links are being used to justify further crackdowns. The concerns come amid previous allegations by activists of abuse, including sexual abuse, during past interceptions by Israeli officials. Organisers have also accused Israeli naval forces of firing "rubber bullets" at activists during the latest interception, which occurred in international waters. Many activists who have previously been detained have been eager to point out that the focus should be on Palestinian prisoners in Israeli jails who are subjected to torture and do not have the option to be deported. In 2025, high-profile activist Greta Thunberg, who was on board a previous flotilla, told Swedish newspaper Aftonbladet that activists had been beaten, kicked and threatened with being gassed in cages. Palestinian Prisoners: The Broader Context of Detention Nearly 10,000 Palestinians are currently being held in Israeli prisons in Israel and in the occupied territory, according to the prisoners' rights group Addameer. Some 3,532 of them are administrative detainees – people held without charge or trial – while 342 are children. Israel is the only country in the world that tries children in military courts, often denying them their basic rights. Palestinians detained in Israeli prisons suffer near-constant dehumanising treatment by guards and soldiers. Under a new law passed this year and spearheaded by Ben-Gvir, military courts are now able to impose the death penalty on Palestinians convicted of killing Israelis in acts of "terror". This law will not impose the same penalty on Jewish Israelis convicted of killing Palestinians, which reinforces the legal inequalities that grant privileges to Jewish citizens while targeting Palestinians.

The Philippine justice secretary ordered law‑enforcement agencies on Thursday to apprehend Ronald “Bato” dela Rosa, a senator wanted by the International Criminal Court for alleged crimes against humanity, following a Supreme Court decision rejecting his bid to block the arrest.Justice Secretary Fredderick Vida Issues Nationwide Arrest DirectiveJustice Secretary Fredderick Vida announced that any individual assisting the fugitive senator would "face consequences." He emphasized that the pursuit aims to ensure "the ends of justice may be achieved." The Philippine National Police chief, Jose Melencio Nartatez, confirmed the police will act within legal bounds but stopped short of confirming an immediate arrest.Human Toll of the Duterte Drug Campaign Cited by the ICCThe ICC estimates that between 12,000 to 30,000 people were killed during the 2016‑2019 period of President Rodrigo Duterte's "war on drugs," a campaign in which Ronald Dela Rosa served as the top enforcer.Six months of hiding ended when Dela Rosa briefly sought refuge in the Senate.He fled the Senate in the early hours of May 14 after a night of chaos and gunfire.The ICC indictment also targets former President Duterte, who remains in custody in The Hague since March 2025.Political Repercussions for the Philippines' International StandingThe arrest order intensifies diplomatic pressure on Manila, highlighting tensions between domestic political maneuvers and international accountability mechanisms. It underscores the Philippines' challenge in balancing sovereign legal processes with obligations to the ICC, potentially affecting foreign aid, trade negotiations, and its reputation in multilateral forums.What the Next Steps Could Mean for Philippine GovernanceIf authorities locate and detain Ronald Dela Rosa, the case could set a precedent for ICC cooperation and signal a shift toward greater adherence to international legal norms. Conversely, prolonged evasion may embolden other officials facing ICC scrutiny and deepen internal political divisions ahead of upcoming elections.

The Chancellor's Composure Amidst Political HecklingDuring a broadcast interview at a Leeds petrol station where she announced the scrapping of a planned fuel duty rise, Chancellor Rachel Reeves demonstrated remarkable composure when confronted by a foul-mouthed heckler. The incident, which quickly gained attention across political divides, showcased Reeves' commitment to maintaining civility in public discourse even when faced with aggressive opposition.The Heckling Incident: A Display of Political FrustrationThe heckler, identified as a Reform UK supporter, approached the chancellor while shouting expletives and demanding that Keir Starmer be "fucking out." As he left in his van adorned with St George's flags, he continued his tirade, questioning whether displaying English flags would lead to arrest and repeatedly denouncing the Labour government as "useless." Despite the aggressive nature of the confrontation, Reeves maintained her composure, responding with a firm but measured statement about the importance of good manners in British society.Unexpected Political Alliances Form Around DecorumWhat made this incident particularly noteworthy was the unexpected cross-party agreement on the importance of civil discourse. Conservative politicians including shadow chancellor Mel Stride and Tory peer Daniel Hannan publicly defended Reeves' response, emphasizing that political discourse should remain civil and polite. Stride specifically stated that "civility matters in politics and if we stop policing the boundaries, things slide very quickly," while Hannan commended Reeves for not tolerating such behavior.Political Divides Emerge Over Heckler's BehaviorThe incident highlighted deepening political divides, with Reform UK members taking a markedly different stance. Party leader Nigel Farage appeared to endorse the heckler's behavior, posting on social media that he'd "like to buy this man a pint" and asking how to find him. Reform spokesperson Robert Jenrick claimed the man "sounds British to me" and criticized Reeves for "rarely leaving her bunker in Westminster." Home affairs spokesperson Zia Yusuf went even further, offering the heckler a peerage for his "outstanding public service."The Future of Political Discourse in BritainThis incident reflects broader tensions in British political discourse, where increasingly aggressive confrontations are becoming more common. The fact that even Conservative politicians are defending the importance of civility suggests a growing concern about the tone of political debate. As the next election approaches, the ability of political leaders to maintain composure while facing public criticism may become an increasingly important factor in how voters perceive their temperament and suitability for office.