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The Challenges of FDA Approval Surviving the long road to FDA approval isn’t just about building great technology — it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain. Lessons from BioticsAI This week on Build Mode, Isabelle Johannessen sits down with Robhy Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an AI copilot for ultrasound to help detect fetal abnormalities. From a $100,000 prototype to FDA clearance, Bustami shares what it actually takes to build in one of the most regulated industries in the world. Building a Medtech Startup In this episode, they break down what it really looks like to build a medtech startup, including where you can’t “move fast and break things” and that every milestone takes time, coordination, and trust. Key Takeaways Team motivation is crucial during the long FDA approval process Finding the right investors is essential for medtech startups Adaptability is key when dealing with uncertain timelines Future Outlook As the medtech industry continues to evolve, startups like BioticsAI will play a critical role in shaping the future of healthcare technology. With the right approach and mindset, these companies can overcome the challenges of FDA approval and make a lasting impact.

The Trial Continues Elon Musk's court case against Sam Altman continues on Thursday, after a day of contentious exchanges during OpenAI's cross-examination of the Tesla CEO. Musk will face another round of questioning before his lawyer calls more witnesses, including OpenAI's president, Greg Brockman. The Dispute Over OpenAI's Founding Witness testimony and evidence has revealed formerly private emails, text messages and diary entries surrounding the formation of OpenAI, giving a behind-the-scenes look at how the tech behemoth was created. Many of the tech industry's most powerful players are named as witnesses and will give their account on the origins of Musk and Altman's bitter feud. Altman is set to testify later in the trial, which will last three weeks. Musk's Allegations Against OpenAI Musk, who co-founded OpenAI in 2015, is arguing that Altman, Brockman and OpenAI broke a foundational agreement when they shifted the company from a non-profit intent on bettering humanity into a for-profit structure. Musk claims that Altman and Brockman unjustly enriched themselves and should be removed from the company. He is also seeking the undoing of the for-profit conversion and $134bn in damages to be redirected to OpenAI's non-profit arm. OpenAI's Response OpenAI rejects Musk's allegations and is attempting to show that he was always aware of plans for creating a for-profit entity. The AI firm's attorneys have stated Musk is "motivated by jealousy" of OpenAI's success after he left the company in 2018 after a failed attempt to take control. OpenAI has emphasized that it is still overseen by a non-profit. The Implications of the Trial The trial, which began on Monday with jury selection at a federal courthouse in Oakland, California, has already produced dramatic moments and bold accusations. Musk and OpenAI's lead attorney William Savitt spent most of Wednesday in a heated back and forth, with the world's richest person becoming noticeably frustrated and saying that Savitt's questions "are designed to trick me". The Future of OpenAI Silicon Valley is intently watching the trial for both its blockbuster testimony and the potential effects it will have on the AI industry. OpenAI is intending to go public later this year at around a $1tn valuation, but if Musk succeeds in this case, it could greatly complicate that effort – an outcome that would also benefit Musk's own xAI artificial intelligence firm.

Salesforce's AI Roadmap Strategy Artificial intelligence continues to advance at a dizzying clip, forcing enterprises to develop and release new products quicker than ever or risk becoming irrelevant to a faster-moving competitor. Salesforce believes it has found a strategy that allows it to keep up even if it isn’t clear where AI is headed next. The customer management software giant is crowdsourcing its AI roadmap in real time. Crowdsourcing AI Development Salesforce is certainly not the only company to work intimately with its customers for feedback on its products. However, it’s notable considering the sheer size of the company, the pace of new product launches or fixes to existing ones, and the granular level of these relationships. These aren’t annual or even quarterly discussions. Salesforce is meeting with some customers as often as once a week. The Benefits of Customer Feedback “The 18,000 customers are a wellspring of information and a wealth of information that is really needed to get to customer success,” Jayesh Govindarajan, executive vice president at Salesforce AI, told TechCrunch in a recent interview. “The stack that we’ve built has resonated with these customers. Over time we can get context to be better, and as it gets better, and LLMs get better, agent systems do more and more fully autonomous behaviors. That’s a long-running innovation track and we’re going to invest in that.” Rapid Product Releases Salesforce credits its customers for the rate of its product releases. The company told TechCrunch that by letting its customers lead the way, it is able to build an AI product roadmap that can quickly react to where AI technology is headed. Real-World Applications Engine, a travel management platform, meets with Salesforce weekly and gets access to AI tools before they’re released. PenFed, a federal credit union, developed an IT service management (ITSM) workflow on its own using existing tools and agents in Agentforce. The Future of AI Development This strategy also allows the company to roll out solutions and workflows built by users to its broader customer base too. However, it relies on the classic service sentiment that the customer is always right. Salesforce is hoping they are despite many enterprises still figuring out what role AI will play in their business, and many having yet to find value from the tech.

The Revamped Ad Platform X, under the leadership of Elon Musk, has initiated a phased rollout of its new, AI-powered ad platform. This platform is designed to offer more modern retrieval and ranking systems, making it easier for marketers to create targeted campaigns. Key Features and Expectations The new platform utilizes AI to enhance campaign results, ad placements, and targeting precision. Advertisers can expect continuous improvements and new features. The platform aims to enable rapid and seamless integration of ongoing innovation. The Business Impact Forecasts from eMarketer suggest X's ad business is recovering, with estimated revenues of $2.26 billion in 2025 and $2.46 billion in 2026. This growth is significant, though still half the size of Twitter's 2021 ad business. The Role of AI in Ad Revenue Growth The integration of AI in advertising has contributed to revenue growth across the tech industry. Companies like Google and Meta have experienced a 'digital ad boom,' with AI automating various aspects of marketing and lowering barriers for smaller businesses. The Future Outlook With its new ad platform, X is poised to capitalize on the growing trend of AI-driven advertising. The company's bold move to rebuild its ad platform in a short timeframe reflects its ambition to offer substantially better solutions for advertisers.

The Palantir Manifesto ControversyJust weeks after publishing a manifesto on X that implied some cultures are inferior to others, described by one UK MP as the "ramblings of a supervillain," the US spy tech company Palantir faces growing calls for a ban in Australia. The company, which has significant government contracts in Australia, now claims it is "just a software company" amid mounting public and political backlash.Cultural Statements Spark Global ConcernEarlier this month, Palantir published a manifesto on X, arguing the benefits of American power and stating: "Some cultures have produced vital advances; others remain dysfunctional and regressive." This public pronouncement, combined with concern over Palantir's software being used by ICE immigration enforcement in the United States and the Israeli military, has led to calls in Australia and the UK for governments to cease using Palantir in their operations.Financial Footprint in Australian GovernmentState and federal contracts with Palantir in Australia have reached nearly $80m, with federal investment in the company reportedly more than $160m. Federal agencies including the financial intelligence agency Austrac and the defense department have spent an estimated $60m in contracts with Palantir. Australia's sovereign wealth fund, the Future Fund, holds $100m worth of shares in the company. In Victoria, the prison system has spent nearly $20m on Palantir contracts since 2012, with a current contract valued at $9m and not due to expire until 2028.Government Response and Company DefenseAustralian Greens senator David Shoebridge has called for a "blanket ban on all new contracts with Palantir, pending a comprehensive public audit of their existing Government agreements." In response, a Palantir spokesperson emphasized that the company is "proud its software supports the Australian defense force and other government agencies" and claimed, "We don't collect or monetize data – we simply provide the tools to help customers organize and understand their own information."Regulatory Scrutiny and Future ImplicationsPalantir has identified Australia as a lucrative market for its surveillance software, achieving "protected level" in the Australian Signals Directorate's information security program. However, questions remain about compliance with the Commonwealth supplier code of conduct, which requires suppliers to avoid bringing the federal government into disrepute. With the recent termination of its lobbying relationship with Cmax Advisory and growing public concern, Palantir's future in Australia's government sector faces significant uncertainty as political pressure mounts for greater transparency and accountability.

Careless People by Sarah Wynn‑Williams is an audiobook memoir that pulls back the curtain on her seven years inside Meta (formerly Facebook) and the legal gag order that tried to keep the story quiet.The Insider’s Tale: A Memoir of Meta’s Dark SideBegins with a childhood shark‑attack that shaped Wynn‑Williams’s worldview.Joined Meta’s public‑policy team in 2011, witnessing unchecked power, privacy neglect, and a 24/7 “always‑on” work culture.Features an introduction by Naomi Alderman, who explains the contractual gag order imposed by Meta.Numbers Behind the Narrative: Awards, Length, and ReachAudio runtime: 13 hr 26 min.Winner of the 2025 British Audio Award for nonfiction.Published by Macmillan.Why This Memoir Matters: Cultural and Ethical Implications for TechExposes how senior staff at a leading tech platform prioritized rapid expansion over privacy and misinformation concerns.Highlights the personal toll on employees, including responding to emails while in labour.Illustrates the use of contractual clauses to suppress whistle‑blowing, raising questions about legal protections for former staff.Looking Ahead: What Careless People Signals for Future WhistleblowingSets a precedent for insiders to narrate their experiences directly, bypassing traditional publishing constraints.May encourage stricter scrutiny of gag orders and push regulators to consider new safeguards for employee speech.Signals a growing appetite for transparent, first‑hand accounts of tech‑industry culture.

Lindsey Vonn is still grappling with the physical and emotional fallout from her crash in the women’s downhill at the 2026 Winter Olympics in Cortina d’Ampezzo. While she has made strides in rehab, the decision to race again remains on hold as she faces additional surgery and a lengthy recovery timeline. Olympic Crash Leaves Vonn Facing a Prolonged Recovery On February 8, 2026, Vonn crashed just 13 seconds into the downhill run, sustaining a complex left tibia fracture that nearly required amputation. The injury forced her out of a season where she led the World Cup downhill standings and had never finished worse than fourth. Recovery Numbers: Surgeries, Timeline, and Physical Setbacks Eight surgeries already performed since the crash, covering fracture fixation and soft‑tissue repair. One additional surgery needed to remove metal hardware and reconstruct the ACL. Estimated 6‑9 months post‑ACL surgery before she can train at full capacity. Overall, Vonn projects a minimum of 18 months before she could consider competitive skiing again. She has progressed from a wheelchair to crutches and expects to begin short walks within a week, but full mobility remains months away. Implications for U.S. Alpine Skiing and Athlete Health Management Vonn’s situation underscores the high‑risk nature of downhill skiing and raises questions about long‑term athlete health protocols. Her experience may prompt U.S. Ski & Snowboard to revisit injury‑prevention strategies, especially for veteran athletes returning after extended absences. Additionally, Vonn’s partnership with biopharma firm Invivyd highlights a growing trend of elite athletes endorsing medical‑technology campaigns, potentially influencing public perception of advanced treatment options. What Lies Ahead: Possible Return Timeline and Retirement Scenarios Vonn has not spoken to her medical team about a definitive comeback plan, preferring to focus on the current recovery phase. She indicated that any competitive return would not be realistic until the 2027‑2028 season at the earliest. Possible outcomes include: Full comeback: Completing the remaining surgery, rehabilitating the ACL, and returning to training for a 2028 Olympic bid. Retirement: Choosing to end her racing career, which would add to her legacy of 84 World Cup wins, second only to Mikaela Shiffrin. Extended hiatus: Remaining involved in the sport through mentorship or commentary while focusing on health. Vonn’s own words capture her mindset: “Tell me I can’t, and I’ll prove you wrong,” reflecting both her competitive spirit and the uncertainty that lies ahead.

The Shift in Russia-Iran Relations Russia has given Iran something more important than weapons, signaling a deepening alliance between the two countries. This development comes at a time when both nations are seeking to strengthen their positions on the global stage. The Nature of Russia's Gift While specific details about the nature of this gift are scarce, it is clear that Russia is investing in Iran's capabilities, potentially in areas such as technology, energy, or defense systems. This move is seen as a strategic effort to bolster Iran's position in the region. The Implications of this Alliance The growing partnership between Russia and Iran has significant implications for the global balance of power. It reflects a broader trend of nations forming strategic alliances to counterbalance Western influence. The Future of Russia-Iran Cooperation As both countries continue to navigate the complexities of international relations, their cooperation is likely to expand into new areas. This could include joint military exercises, economic partnerships, and technological exchanges. The Global Response The international community is closely watching the developments in Russia-Iran relations. Western nations, in particular, are concerned about the potential for this alliance to challenge their interests in the region.

A Landmark Summit Sets the Stage for a Global Fossil‑Fuel Phase‑outGovernments in a coalition of 59 countries gathered in Santa Marta, Colombia, to draft voluntary 'roadmaps' that detail how each nation will end production and use of coal, oil and gas. The talks, co‑hosted by Colombia and the Netherlands, aim to move climate ambition from slogans to concrete policy.Voluntary National Roadmaps Proposed at Colombia’s Climate CoalitionThe summit asked participants to develop national plans that map out the transition away from fossil fuels, with the first draft released by Colombia during the meeting. France became the first developed country to publish a full roadmap, signalling broader uptake.Scale of the “Coalition of the Willing”: GDP, Energy Demand and Fossil SupplyRepresents > 50 % of global GDP.Accounts for nearly 33 % of worldwide energy demand.Controls roughly 20 % of global fossil‑fuel supply.Why This Shift Challenges the Traditional UN Climate ProcessUnlike the three‑decade‑old UN negotiations, the Colombian talks focus on export‑related emissions and the role of fossil‑fuel producers, gaps that the Paris‑agreement NDCs have left open. Irene Vélez Torres, Colombia’s environment minister, warned that existing NDCs allow producers to sidestep the climate impact of their exports.What Comes Next: Roadmap Adoption, Financing and Global ExpansionCountries will receive technical assistance to flesh out their plans, while a new scientific panel will advise on feasibility. Future meetings, including a second conference slated for early next year in the Pacific, will aim to broaden participation and lock in financing for debt‑strapped nations.