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Eli Lilly, the US pharmaceutical group behind the Mounjaro weight-loss drug, is seeking to resume its investments in the UK after pausing them last year. The company is in talks with UK ministers to regularly increase NHS drug prices and end a rebate scheme. Patrik Jonsson, president of Eli Lilly's international business, expressed optimism about reaching an agreement this summer.The talks will also explore 'innovative' pricing plans, such as linking payments for anti-obesity drugs to whether the treatment helps patients return to work. This comes as the US pharmaceutical industry increases pressure on the UK, with Keir Starmer agreeing to the first increase in NHS cost-effectiveness thresholds in 27 years. The threshold was raised from £20,000 to £30,000 a year for every year of life gained to £25,000 to £35,000.Eli Lilly was one of several pharmaceutical companies that ditched or paused almost £25bn in planned investments in the UK last year. The company paused its plans to invest in a laboratory site in central London. Jonsson stated that the resumption of Eli Lilly's investment would depend on the outcome of its talks with the government.He emphasized that prices for medicines in the UK had been 'far too low for far too long' and that the threshold couldn't remain static for another three decades. The UK agreed to pay 25% more for new medicines by 2035 as part of a US-UK drug pricing deal, which could eventually reach £9bn a year.Large pharmaceutical companies have protested about a 'rebate' scheme, under which they are required to pay back a chunk of revenue from sales of branded medicines. This scheme is expected to fall in 2026, although Jonsson believes payments 'should actually get down to zero' over time.

A recent survey conducted by the Football Supporters' Association has revealed that 91% of football fans believe the game is better off without Video Assistant Referees (VAR). The survey, which polled over 7,000 fans, found that the vast majority of respondents are dissatisfied with the VAR system, which has been in use for over eight years.The survey results show that only 2% of fans agree that VAR makes football more enjoyable, while 3% said it improves the experience of attending a match. In contrast, 81% of fans prefer watching matches without video technology. The survey also found that 96% of fans disagree with the statement that VAR decisions are generally resolved in a reasonable amount of time.While some fans approve of the introduction of in-stadium communication from referees to explain VAR decisions, other extensions of the VAR protocol were largely unpopular. For example, only 21% of fans agreed that VAR should adjudicate on whether corner kicks are awarded, a system set to be trialled at this summer's World Cup.The survey results may not necessarily influence the game's decision-makers, as competition organisers and big clubs are committed to the use of VAR. However, the International Football Association Board (Ifab) has announced a two-year review into the system's performance, which may lead to changes in how VAR is used.

Pakistan has become a key player in diplomatic efforts to end the conflict between the US and Iran, hosting a meeting of foreign ministers from Turkey, Saudi Arabia, Egypt, and Pakistan in Islamabad. The two-day consultations aim to align regional positions and prepare the ground for possible direct US-Iran engagement, with Pakistan acting as the central interlocutor between the two nations. Pakistani Prime Minister Shehbaz Sharif held a 90-minute phone call with Iranian President Masoud Pezeshkian, focusing on de-escalation and trust-building measures. Pezeshkian stressed that confidence-building measures are required before Tehran can consider direct dialogue. The Islamabad meeting is not a negotiation, but rather preparation for potential talks. Its goals are to consolidate regional backing for de-escalation and harmonize positions on ceasefire sequencing. Iran has transmitted its response to the US proposal via Islamabad, with demands including an end to hostilities, reparations for damages, guarantees against future attacks, and recognition of its strategic leverage in the Strait of Hormuz. The next 48 to 72 hours will determine whether this diplomatic push produces a meeting between US and Iranian officials. If successful, it could provide the political cover both Washington and Tehran need to enter talks without appearing to concede.

Donald Trump has indicated a shift in his administration's stance on oil shipments to Cuba, stating that he has 'no problem' with countries sending oil to the island, whether it's Russia or not. This development comes as a Russian oil tanker, under US sanctions, was set to arrive in the Caribbean island. The Russian tanker, Anatoly Kolodkin, carrying 730,000 barrels of crude, could soon discharge at Cuba's Matanzas port. This shipment would provide significant relief to Cuba, which has not received any oil imports for three months, leading to strict rationing of gasoline and exacerbating an energy crisis that has resulted in multiple power outages across the island. Cuba lost its main regional ally and oil supplier in January when US forces captured Venezuela's president, Nicolás Maduro. Trump subsequently threatened to impose tariffs on any country sending oil to Cuba and has mused about 'taking' the island. The US oil blockade has forced Cuba to impose emergency measures to conserve fuel, including strict rationing of gasoline. Fuel prices have soared, public transport has dwindled, and some airlines have suspended flights to Cuba, hitting the country's fragile economy. Jorge Pinon, an expert on Cuba's energy sector at the University of Texas at Austin, noted that once the Russian tanker enters Cuban waters, it 'is almost impossible for the US government to stop it.' The Russian shipment could be converted into 250,000 barrels of diesel, enough to cover the country's demand for about 12.5 days, according to Pinon.

The war in Iran has sent shockwaves through the UK economy, causing gilt yields to surge to their highest levels since the 2008 global financial crisis. This increase in borrowing costs has significant implications for Chancellor Rachel Reeves' fiscal policy, potentially eroding the £23bn in 'headroom' she had built up against her fiscal rules.Reeves had hoped that this cushion would allow her to focus on tackling inflation and stimulating growth, but with oil prices up 50% since the onset of the war, investors are now expecting higher inflation and interest rates. As a result, the government's cost of borrowing is set to rise, impacting its ability to fund public spending.The yield on 10-year gilts has jumped to nearly 5%, pushing up the cost of borrowing and forcing Reeves to reconsider her spending plans. This development has also raised concerns about the UK's economic fragility and the potential for a Labour leadership contest to be triggered after the May local elections.Economists warn that the chancellor has probably already lost a third to half of her headroom due to the combination of higher inflation, weaker employment, and surging gilt yields. The situation is further complicated by the UK's high debt levels and reliance on global markets, leaving little room for maneuver for any future government.The implications of this crisis extend beyond Reeves, raising questions about the economic pitch of any potential steward of the economy, whether from Labour or other parties. As Angela Rayner considers John Healey as a potential chancellor, the need for a carefully plotted economic policy that balances growth and fiscal responsibility has become increasingly urgent.

Tiger Woods, one of the greatest golfers of all time, has once again found himself in the spotlight for all the wrong reasons. His recent arrest on suspicion of driving under the influence (DUI) has raised questions about why golf remains so beholden to him, despite his repeated run-ins with the law and declining performance.In 2010, Woods delivered a 14-minute mea culpa on his transgressions, including his extramarital affairs, in front of a hand-picked audience at the PGA Tour. However, 16 years later, it appears that not much has changed. Woods has continued to struggle with his personal life and has had multiple encounters with the law, including a 2021 car crash in Los Angeles and a 2017 incident where he was found asleep at the wheel of his car.Despite his declining performance, Woods remains a central figure in golf. He is being considered to captain the United States Ryder Cup team and is the chairman of a committee tasked with reshaping the PGA Tour's schedule. However, his behavioral pattern raises questions about the validity of his role in the sport.Woods' actions have consequences not only for himself but also for others. His reckless driving puts not only his own life at risk but also the lives of others on the road. It is unacceptable that an athlete of his standing continues to engage in such behavior and expects to be treated differently than others.The golf community must reassess its relationship with Woods and consider whether his actions align with the values of the sport. While it is possible to feel sympathy for Woods' plight, it is also important to acknowledge that there are consequences for one's actions. The sport must prioritize accountability and responsibility over its dependence on a single individual, no matter how great they may be.

The Houthis, a Shia sect backed by Iran, have entered the conflict with missile attacks on Israeli military sites. The true significance of their involvement depends on whether they intend to launch sporadic attacks or effectively close off the Red Sea to shipping. Disruption of the Bab al-Mandab strait and the Strait of Hormuz could have a devastating impact on global trade and economy. The Houthis' ability to interdict ships poses a significant threat, and their actions could drive up shipping costs and oil prices. The Houthis have a complex relationship with Iran, receiving arms from Tehran but not directly fighting on its behalf. A ceasefire with the US, mediated by Oman, has been in place since May 2025, but it does not apply to Israel. Saudi Arabia's role in Yemen's future is crucial, as it seeks to reach deals with the Houthis and former Southern Transitional Council (STC) supporters. The Houthis may act cautiously, seeking financial rewards from Saudi Arabia. The conflict could drag Yemen further into regional war, making peace more difficult and prolonging civilian suffering. The UN special envoy for Yemen, Hans Grundberg, has warned of the escalation's risks, stating it will deepen economic repercussions and prolong the suffering of civilians.

Formula One drivers and leading figures have urged immediate action to address safety concerns in the sport following a massive crash involving Oliver Bearman at the Japanese Grand Prix. The incident, which Bearman described as 'scary,' has highlighted the potential dangers of the sport's new regulations, which allow for large closing speeds between cars.Bearman, a British driver, was involved in a huge accident at the Japanese Grand Prix after he had to swerve to avoid hitting Franco Colapinto's car, which was going relatively slowly. The crash resulted in a 50G impact and could have had severe consequences. However, Bearman escaped with only bruising.The Haas team principal, Ayao Komatsu, agreed that Bearman had a lucky escape, stating, 'Yes, it could have been a lot worse.' He emphasized that safety should always be top of the list and that the incident cannot be ignored.The world champion, Lando Norris, had previously warned that the new regulations posed a risk to the sport. His McLaren team principal, Andrea Stella, had also highlighted the potential danger before the season began during testing.After the accident, Carlos Sainz of Williams was unequivocal that action had to be taken, stating, 'We've been warning them about this happening.' He emphasized that the current regulations create massive closing speeds and a safer way of racing is needed.The FIA has confirmed that the regulations will be reviewed before the next round in Miami in five weeks. A number of meetings are scheduled in April to assess the operation of the new regulations and determine whether any refinements are required.

The UK vape industry is sounding the alarm about the proliferation of fake vapes on the market, which can pose serious health risks to users. These counterfeit devices are often sold in high street shops and can look identical to legitimate products, making them difficult to spot.According to the UK Vaping Industry Association (UKVIA), around 5m illegal devices have been seized over the last three years, with a street value of £39m. These devices often lack safety features, such as circuit protection to prevent overheating, which can cause them to catch fire.John Dunne, head of the UKVIA, warns that fake vapes may cause damage to people's health as they have not undergone the same testing regime as legal devices. 'Where the packaging might look similar and the product itself may look similar, these companies may not have the same safety features built into the device, because the copycats tend to try and make the product as cheap as possible,' he says.So, how can you spot a fake vape? One of the key telltale signs is if the box does not have a UK distributor's address on it. Other signs include poor-quality packaging with low-resolution photos or labels, and missing nicotine warnings and ingredient lists. The device name or labelling may also be written in a foreign language.If you suspect that you have bought a fake vape, you can file a report through the UKVIA or contact your local Trading Standards office. You can also check whether a brand has been registered with the MHRA through its website.