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Paul Dano has had a remarkable career in Hollywood, taking on a wide range of roles in films like Little Miss Sunshine, Love & Mercy, and Swiss Army Man. In a recent interview, Dano shared his experiences working with Brian Wilson in Love & Mercy, and how he spent time with the legendary musician before filming.Dano discussed the challenges of playing a character who doesn't speak in Little Miss Sunshine, and how it felt to break his vow of silence in the second half of the film. He also talked about his experience working on the BBC's War and Peace adaptation, and how he read the book before filming to prepare for his role.When asked about his role as the leader of the Animal Liberation Front in Okja, Dano admitted that it changed his relationship to food, but only for a short time. He also discussed his experience working with the Daniels and Daniel Radcliffe on Swiss Army Man, calling it a fun and creative experience.Dano emphasized the importance of staying kind and grounded in the intense film industry, and how it helps him approach difficult characters with empathy. He also shared that he would most like to hang out with his characters Dwayne from Little Miss Sunshine and Brian Wilson from Love & Mercy.Looking ahead, Dano discussed his role in The Wizard of the Kremlin, a film about modern politics and power. He was drawn to the project because of its compelling and intelligent storytelling, and its relevance to current events.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

As rising temperatures push snakes and humans into closer contact, the world faces an estimated 5.5 million snakebites each year, resulting in 138,000 deaths and 400,000 lasting disabilities. In response, a Wisconsin‑based amateur scientist has taken an extreme route to help solve the crisis.For almost 20 years, Tim Friede, a former window cleaner, allowed some of the planet’s most lethal snakes to bite him, accumulating over 200 intentional bites. His goal: to provoke his own immune system into producing antibodies that could be harvested for a near‑universal antivenom.The endeavor has been perilous. Friede survived a coma after being bitten by two cobras within an hour, endured anaphylactic shocks, lost tissue in a finger, and even had to cut necrotic muscle from his leg. Yet he persisted, eventually becoming immune to the inland taipan—the world’s most venomous snake, whose single bite can kill more than 100 people.In 2019, California biotech firm Centivax hired Friede to extract his antibodies. Early laboratory work showed that his serum can neutralise toxins from 19 elapid species, including cobras, mambas, taipans, coral snakes and kraits—roughly half of all venomous snakes worldwide.The next step is a veterinary trial in Australia, slated for later this year, before any human application. If successful, the antivenom could dramatically reduce the burden of snakebite in low‑income regions across Asia and Africa, where most victims live.Climate scientists warn that warming climates will expand snake habitats and increase human exposure, as illustrated by the recent surge of rattlesnake bites in California’s Ventura County. This amplifies the urgency for scalable, affordable antivenoms, especially as international aid budgets face cuts and manufacturing capacity remains insufficient.Friede’s unconventional path underscores a broader lesson: confronting emerging health threats may require bold, unconventional science, but the potential payoff—a life‑saving treatment for millions—could be transformative.

Europe is undergoing a significant transformation in its relationship with the US, marked by a growing desire for independence and a shift away from Trump's aggressive policies. The recent crisis in the Middle East, where Trump's threat to annihilate Iranian civilisation was temporarily called off, has been a turning point in this journey. Initially, many European leaders had tacitly supported the US and Israeli attack on Iran, driven by a desire for a transatlantic detente and antipathy towards the Iranian regime. However, as the war escalated, Europe's stance began to shift, with countries like Italy, Poland, and France taking steps to distance themselves from Trump's policies. The cooling of European support for the war has taken various forms, including Italy denying US warplanes permission to use an airbase in Sicily, Poland refusing to send Patriot air defence systems to the Middle East, and France rejecting overflight rights and opposing a US-sponsored resolution at the UN security council. This shift in European policy is driven by a number of factors, including the realisation that the war has been a windfall for Russia, through higher oil prices and a depletion of air defence interceptors available to Ukraine. European leaders have also been reminded that the erosion of international law is bad news for the world, Europe included. As Europe finds its footing in distancing itself from Trump, it may also find its voice. Europe's diplomatic role in the Iranian nuclear file in the early 2000s grew out of its opposition to the Iraq war. Today, the same dynamic could unfold, with Europe promoting a permanent end of hostilities and a multilateral initiative in the region. The proposal by a group of European, Gulf, and Asian countries to contribute to ensuring safe passage through the strait of Hormuz was originally aimed at placating Trump. Europeans then backed a UN-led fertiliser corridor to prevent a food crisis in the global south. The UK is also leading a coalition of more than 40 countries seeking to reopen the strait once the US and Israel definitively end their offensive. If a sustainable reopening of Hormuz succeeds, it could eventually extend to a new nuclear agreement, a non-aggression pact between the US and Iran, and a similar one between Israel and Iran – including Lebanon. It could involve the release of Iranian funds frozen abroad to rebuild infrastructure destroyed by US and Israeli attacks, and the selective lifting of EU and US sanctions.

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Major League Baseball has handed down seven-game suspensions to Los Angeles Angels designated hitter Jorge Soler and Atlanta Braves pitcher Reynaldo López after a heated brawl during a game between the two teams. The suspensions, announced by MLB's senior vice-president for on-field operations, Michael Hill, also come with undisclosed fines. Both players are appealing their suspensions, which were set to begin on Wednesday but are currently on hold.The incident occurred on Tuesday night when Soler homered off López in the first inning, and later was hit by a 96mph fastball from López. The situation escalated when López threw a high-and-inside wild pitch, prompting Soler to charge the mound. The two players began throwing punches, leading to a brawl that involved players and coaches from both teams.Atlanta Braves manager Walt Weiss described the situation as a 'big man' on a 'warpath,' saying he had to intervene to prevent Soler from hurting someone. Soler and López were teammates during the second half of the 2024 season with the Braves.The Braves went on to win the game 7-2, with Soler's two-run shot in the first inning contributing to the victory. Soler has impressive stats against López, going 14 for 23 with five homers and three doubles.Both players expressed regret over the incident, with López stating there was 'never any intent to hit him' and Soler criticizing López for missing 'way too high and close to my head.'

The recent escalation between the US and Iran has brought the world to the edge of a potentially devastating conflict. US President Donald Trump's threat to attack Iran if it didn't reopen the Strait of Hormuz sparked a global outcry and raised concerns of a wider conflict.Trump's public threat to commit genocide sent shockwaves through the United States, with over 70 Democratic members of Congress calling for his removal from office. The Iranian government and people were also shocked, with thousands forming human chains around bridges and power stations that Trump might strike.Faced with the prospect of a catastrophic war, Trump chose to back away from his threat and instead claimed that he had granted Pakistan's request for a two-week ceasefire. However, the Iranian foreign minister tweeted that Trump had agreed to accept Tehran's 10-point plan as a general framework for negotiations.The chasm between the two sides remains vast, with major differences on issues such as sanctions relief and Iran's ballistic missile stocks. A mega-deal remains the only path to averting a return to full-scale war, but it will require compromises and adept diplomacy from both sides.If there's no firm deal, the conflict will almost certainly reignite. The US and Iran have agreed to a temporary ceasefire, but Iran still controls the Strait of Hormuz and retains the military muscle to spark a worldwide recession.

Miles Jupp, a well-known actor, writer, and comedian, recently shared his thoughts on how the 2005 Ashes series had a profound impact on his life. Sitting at the Oval cricket ground, a place he considers one of his favorites, Jupp reminisced about the life-changing experience of watching the final day of the series on September 12, 2005. Jupp was in his early 20s at the time, working as a standup comedian and actor. He had won the So You Think You're Funny? competition in 2001, which helped launch his career. However, it was the 2005 Ashes that truly altered his path. The series, which ended with England's first victory in 18 years, sparked something in Jupp. He recalls feeling inspired by the journalists in the press box and decided that he wanted to be part of that world. Jupp's passion for cricket and his desire to be part of the action led him to blag his way into the press corps for England's Test tour of India in March 2006. He documented his experiences in his standup show and book, Fibber in the Heat. While Jupp admits that part of him thought the experience would be good material for a story, he claims he was genuinely invested in becoming a cricket journalist. Jupp's journey as a cricket journalist was not without its challenges. He struggled to understand the workings of the press box and found it difficult to maintain the theatrical neutrality required. Ultimately, he concluded that he preferred to watch cricket as a fan, enjoying the excitement of the stands rather than the press box. Despite the difficulties, Jupp's love for cricket runs deep. He reflects on his experiences, including battling a brain tumor and undergoing surgery, and emphasizes that cricket remains massively important to him. His story serves as a testament to the power of sports to inspire and transform lives.

Opening new oil and gas fields in the North Sea would send a shock wave around the world, senior climate diplomats warned, saying the move would imperil international climate targets, erode the United Kingdom’s reputation as a climate leader and embolden developing countries to exploit their own fossil‑fuel reserves.The UK government faces intense lobbying from the oil industry, Conservative MPs, Nigel Farage’s Reform UK party, certain trade unions and factions within the Treasury. Yet research shows that new drilling would do little to lower energy prices and would have almost no impact on gas imports.Two of the remaining large North Sea prospects – the Rosebank and Jackdaw fields – sit in a basin that is over 90% depleted and increasingly costly to develop. Even if fully exploited, they would displace only about 1% and 2% of the UK’s gas imports respectively, according to recent analysis.Senior figures in international climate diplomacy described the prospect of new drilling as dangerous for global emissions‑reduction efforts and a step back from the phase‑out of fossil fuels.Lord Nicolas Stern, professor at the London School of Economics, warned that “new drilling and a slowdown in climate action would be bad for growth and for energy security in the UK, and a damaging signal for the world.” He added that the UK’s pioneering climate legislation and its role as the first G7 nation to commit to net‑zero by 2050 give its actions “extra weight” on the global stage.An anonymous senior African negotiator reacted angrily to the proposal, stating that Africa would “reject any proposal for the UK to expand oil drilling” because it is “fundamentally inconsistent with both the letter and spirit of the Paris Agreement” and would “weaken trust with climate‑vulnerable nations”.Christiana Figueres, former UN climate chief and co‑founder of the Global Optimism think‑tank, argued that true energy independence lies in “scaling clean, domestic energy, not in extending the life of declining industries”. She cautioned that reverting to old‑fashioned oil expansion would lock in infrastructure at odds with the direction of the global energy system.The UK has been a vocal supporter of an upcoming conference in Colombia on the “transition away from fossil fuels”, a pledge made three years ago at COP28 that remains largely unfulfilled. However, the Guardian learned that Ed Miliband, the UK secretary of state for energy security and net‑zero, will not attend; the government’s climate envoy, Rachel Kyte, will travel in his place.Campaigners had urged Miliband’s presence, citing his pivotal role in securing a last‑minute deal at COP30 in Brazil last November.Experts caution that licensing new fields before the Colombian summit could undermine progress in persuading developing nations to forgo fossil‑fuel‑based economies and adopt cleaner energy pathways.Mohamed Adow, director of the Power Shift Africa think‑tank, warned that a UK approval would “send a shock wave around the world that short‑term interests are being prioritised over long‑term responsibility”. He stressed that many African countries are being asked to leapfrog to clean energy with limited financial support, and that wealthy nations continuing to invest in fossil fuels “undermine this message and diminish their credibility”.Several developing‑country officials echoed this concern, asking, “Why shouldn’t we tap into our own fossil‑fuel resources if the UK is doing so?” They argued that leadership on climate must be consistent with actions.An ally of Miliband praised the UK’s stance, calling “no new exploration licences” a “landmark global leadership position” that shows a major oil‑producing country can align policy with climate science to avoid a 3‑4°C warming scenario.A government spokesperson reaffirmed the administration’s commitment, stating that the UK has placed “clean energy and climate at the heart of its agenda”, and that it will continue to “stop issuing licences to explore new fields, in line with the science and in securing a just transition in the North Sea”.