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Recent CDC data reveal a dramatic 1,200% increase in kratom‑related poisonings across the United States over the last ten years, with the most pronounced surge recorded in 2025. Researchers link this rise to the growing presence of 7‑hydroxymitragynine (7‑OH), a synthetically produced compound that mimics kratom’s effects but carries opioid‑like risks. Walter Prozialeck, pharmacology professor at Midwestern University, said the trend was expected, noting that the synthetic alkaloid has entered the market through energy drinks and other products since 2024. Christopher McCurdy of the University of Florida warned that marketing 7‑OH as “enhanced kratom” blurs the line for consumers, turning poison‑control calls into a conflated metric for both natural and synthetic products. By contrast, natural kratom (Mitragyna speciosa)—a Southeast Asian plant used for centuries as a pain reliever—has demonstrated a relatively favorable safety profile in animal and human studies. A 2018 statement from then‑HHS Secretary Brett Giroir rejected the DEA’s push to schedule kratom as a Schedule I substance, citing insufficient evidence of harm. Despite the scientific distinction, several states have moved to implement or propose blanket bans on all kratom products, prompting concern from clinicians and patient advocates. A recent user survey indicated that about 50% of respondents rely on kratom for chronic pain, while roughly 40% use it during addiction recovery. Personal testimonies underscore the plant’s therapeutic role. Jeff Maslan, a 68‑year‑old Californian with severe osteoarthritis, credits kratom with easing opioid withdrawal after multiple surgeries. Similarly, “Steven,” a disabled California resident, describes how kratom eliminated unbearable oxycodone withdrawal symptoms without producing the euphoric “warm fuzzy” feeling typical of opioids. Researchers emphasize that 7‑OH carries genuine opioid hazards, including addiction, severe withdrawal, and respiratory depression that can lead to fatal overdose. In animal models, 7‑OH demonstrated the same respiratory‑depression risk as classic opioids, whereas kratom’s primary alkaloid did not. Prozialeck and colleagues explain that kratom’s pharmacology is more nuanced: it partially activates opioid receptors while also engaging adrenergic and serotonin pathways, resembling a hybrid of a weak opioid and an SNRI‑type antidepressant. This multimodal action likely accounts for its lower euphoric potential and the reported boost in energy among users. Nevertheless, experts caution that kratom is not without risk. Fatal poisonings often involve co‑ingestion of potent opioids such as fentanyl, suggesting that some users may cycle between kratom and stronger substances, raising overdose danger due to reduced opioid tolerance. Additionally, heavy‑metal contamination has been detected in certain kratom batches, though the source—soil, processing, or storage—remains unclear. Given these complexities, the consensus among scholars like Austin Zamarripa (Johns Hopkins) is that natural kratom should remain accessible, while concentrated 7‑OH products merit stricter regulation. “These products may offer meaningful benefits to some individuals, and those benefits could be lost if access is restricted too broadly,” Zamarripa said, urging a differentiated policy approach. As the debate unfolds, patients like Steven worry that a sweeping ban would ignore the nuanced safety profile of the plant. “There’s corn on the cob, there’s high‑fructose corn syrup, there’s whiskey— all derived from corn but fundamentally different,” he remarked, highlighting the need for targeted, evidence‑based regulation rather than a one‑size‑fits‑all prohibition.

How shaky is the Iran‑US ceasefire? The question underscores growing concerns among analysts about the durability of the truce that has held between Tehran and Washington since the latest diplomatic outreach.While the ceasefire has prevented direct military clashes, underlying mistrust and competing strategic interests continue to cast doubt on its long‑term viability. Observers point to recent diplomatic exchanges, economic sanctions, and regional proxy activities as potential flashpoints that could reignite hostilities.Experts caution that any misstep—whether a perceived violation of the agreement or an escalation in proxy conflicts—could quickly erode the fragile peace, prompting a renewed cycle of confrontation that would affect not only the two nations but also the broader stability of the Middle East.

US Vice‑President JD Vance addressed a podium in Pakistan, confirming that after a marathon 21‑hour negotiation no settlement had been secured to end the conflict with Iran. Meanwhile, President Donald Trump was in Miami watching a mixed‑martial‑arts fight, a stark contrast that underscored the administration’s focus on spectacle over substantive diplomacy. The breakdown was not accidental. Washington insists Iran must relinquish any capacity to develop a nuclear weapon, whereas Tehran maintains its right to a civilian nuclear programme and rejects the notion of a weapons agenda. The US “final and best offer” demanded a complete surrender of that capability, a condition more akin to imposing victory than fostering negotiation. Compounding the impasse, the United States sought unrestricted navigation through the Strait of Hormuz, a critical artery for global energy supplies. Iran, however, pressed for transit fees, lifted sanctions, unfrozen assets, reparations, and a broader regional cease‑fire. The divergent demands meant that a single round of talks could not bridge the gap, resulting in negotiations devoid of trust and a war without a clear resolution. Historical wisdom, echoed by Winston Churchill’s famous remark that "jaw‑jaw is better than war‑war", highlights the high cost of continued fighting. Ironically, the current US‑Iran dispute revolves around a nuclear programme that was once restrained by a deal the Trump administration later abrogated, and a maritime route that the same administration helped ignite by launching the conflict. The fragile cease‑fire’s survival now hinges not only on Washington and Tehran but also on Israel’s expanding offensive in southern Lebanon against Hezbollah, an operation that has drawn accusations of war crimes and threatens to widen the regional conflagration. Financial markets are unlikely to react positively to recent developments. American voters are already feeling the impact of surging fuel prices, and Trump’s consideration of a naval blockade of the Strait of Hormuz could exacerbate the situation. Disrupting a route that carries roughly one‑fifth of global oil would push prices higher, with ripple effects far beyond the Gulf. The current cease‑fire is set to expire in just over a week. While diplomatic talks have not formally ended, a stalemate persists and the logic of escalation is gaining traction. Iran appears unlikely to concede, opting instead to test US resolve at sea. Seasonal heat may limit a full‑scale ground offensive for now, but the risk of a shift toward naval confrontations, airstrikes, and proxy warfare looms, offering no winners—only further loss.

Argentina's glacier law has been in effect since 2010, and was the first legislation in Latin America to protect glaciers. It has been a point of contention for mining companies and provincial authorities ever since.The law bans 'any activity' that can affect the 'natural condition' of a glacier or the periglacial frozen land surrounding it, or that results in 'its destruction, movement or interferes with its advance'. That includes the construction of infrastructure not for scientific purposes and any industrial activity. Mining companies, including Barrick, have previously sought to have the law deemed unconstitutional, but the supreme court rejected the challenge.However, a recent reform to the glacier law driven by the far-right government of Javier Milei will relax restrictions, paving the way for mines in high-altitude areas blanketed with ice and snow, which are sources of water. The new law, approved on Wednesday by 137 votes to 111, with three abstentions, will enable provincial authorities to decide which glaciers are protected and which are open for development based on whether they represent a 'relevant water function'.Environmentalists and community members such as Zeballos, a 51-year-old accountant turned activist, have long alleged that Veladero, owned by Canada-based Barrick Mining Corporation and China's Shandong Gold, is operating illegally in an area considered off-limits by Argentina's Ley de Glaciares – or glacier law. The reform has sparked a wave of protests, with Greenpeace activists staging a demonstration on the steps of the National Congress.'What is at stake is the protection of key water reserves in Argentina,' says Andrés Nápoli, a lawyer and executive director of the Foundation of Environment and Natural Resources (Farn), an environmental and human rights NGO. 'Saying that you have to destroy glaciers to guarantee the energy transition is an oxymoron.'About 7 million people, 16% of the population in Argentina, live in areas that depend on glaciers, according to environmental organisations. Glaciers don't just feed rivers; they balance fragile ecosystems hit hard by a heating planet. In Argentina's northwest, scientists say they have shrunk by 17% in the past 10 years.

Israeli Prime Minister Benjamin Netanyahu has made a significant statement regarding potential ceasefire negotiations with Iran. According to Netanyahu, a ceasefire with Iran will not include Hezbollah, the Shiite militant group based in Lebanon and a key ally of Iran. This declaration underscores the complexity of the Middle East peace landscape, where Iran's influence extends beyond its borders through various proxy groups, including Hezbollah. Netanyahu's stance suggests that Israel views Hezbollah as a distinct entity that will not be part of any agreement aimed at de-escalating tensions with Iran. The relationship between Israel, Iran, and Hezbollah has been a focal point of Middle East conflict for years. Israel has been concerned about Iran's nuclear program and its support for militant groups across the region, viewing these as direct threats to its security. Netanyahu's comments come at a time when diplomatic efforts are underway to address the Iranian nuclear issue and regional instability. The Israeli Prime Minister's firm stance on Hezbollah's exclusion from any ceasefire agreement highlights the challenges in achieving a comprehensive peace that addresses the concerns of all parties involved.

Glass Lewis, a leading proxy adviser, has advised investors to vote against BP's chair Albert Manifold because the board chose to exclude a climate‑strategy resolution from the upcoming annual general meeting.The resolution, put forward by activist shareholder group Follow This, sought a discussion of BP's long‑term strategy under scenarios of declining oil and gas demand.BP, currently pivoting back to oil and gas after a faltering renewable push, appointed Manifold in October with a promise to help the company “reach its full potential”.In a parallel leadership change, the firm named Meg O’Neill, a former ExxonMobil executive, as chief executive – making her the first woman to lead BP and its fourth CEO since 2023.Glass Lewis argued that the board’s decision to drop the climate proposal raises serious questions about transparency, shareholder communication and responsiveness, according to a note first reported by Reuters.Manifold responded on BP’s website, stating that the board concluded the Follow This proposal was invalid and would be ineffective if passed.Another proxy adviser, ISS, also recommended voting against BP’s request to retire two older climate‑impact reporting resolutions, contending that the proposals remain relevant despite newer reporting frameworks.Follow This disclosed that 12 institutional investors plan to oppose BP’s move to scrap its climate disclosures, and its CEO Mark van Baal warned that more than 25% of shareholders could vote against the resolution, enough to block it.O’Neill, addressing staff, highlighted the “significant complexity” of today’s environment – geopolitical tension, rapid technological change, and shifting global energy demand – and reaffirmed BP’s mission to deliver energy safely, reliably and efficiently.

The global oil trade is facing a chokepoint crisis, with Libya's oil disputes mirroring the situation in the Hormuz Strait. The Strait of Hormuz, a critical waterway for oil transportation, was briefly closed after US and Israeli strikes on Iran in late February, causing Brent crude oil prices to soar to nearly $120 a barrel.Libya, with its strategically located oil terminals on the northeastern coast, has become a crucial player in the global oil trade. The country's light, sweet grades of oil are particularly valuable to European refiners. However, Libya's political instability and factional oil deals are threatening to disrupt oil supplies, with Europe's energy security hanging in the balance.The Libyan National Army (LNA), led by Khalifa Haftar, controls the territory where Libya's oil is located, while the Government of National Unity (GNU) in Tripoli signs oil contracts. This has led to a situation where Tripoli may sign oil contracts, but Haftar decides whether oil actually flows. The Arkenu agreement, a private oil company linked to the Haftar family, was recently terminated due to corruption allegations, leaving the future of Libya's oil supplies uncertain.The US is attempting to broker new talks between Tripoli and Haftar's camp, but a deal is not yet certain. Meanwhile, European energy security is at risk, with the Mediterranean Sea becoming a battleground for proxy wars between Russia and Ukraine. The sabotage of oil infrastructure and attacks on tankers are exacerbating the situation, highlighting the need for a stable and secure oil supply to Europe.

The US war on Iran has now entered its sixth week, with the conflict showing no signs of abating. What was initially touted as a 'precise, overwhelming military campaign' to eliminate 'an imminent nuclear threat' has instead become a protracted and costly endeavor. The war has resulted in rising costs for the US in military equipment and personnel, and has had a significant impact on energy markets, with forecasts of a potential global economic recession in the event of a prolonged conflict.The conflict has also highlighted the Iranian regime's capacity for asymmetric warfare, with the country deploying cheap drones and missiles to disrupt energy facilities and compromise economies in the Gulf region. The closure of the Strait of Hormuz, a critical waterway for global oil shipments, has also had a significant impact on the war effort, with the US and its allies struggling to reopen it.The US's failure to understand the Iranian regime's subjective complex dynamics has been a significant factor in the conflict's prolongation. The regime's ability to withstand pain and prolonged escalation without a clear scenario of military victory against a superpower has been underestimated, and its proxy groups, such as Hezbollah and the Houthis, have proven to be effective in advancing its interests and preventing outcomes that weaken or isolate it further.The conflict has also highlighted the diverging definitions of victory between the US and Iran, with the US seeking a swift and decisive victory, while Iran is focused on maintaining its viability on its own terms in the face of American hegemony. As the war continues, the question remains: how will this conflict end?

Iran is experiencing the longest nationwide internet blackout ever recorded, according to the global monitoring group NetBlocks. Since the United States and Israel launched their war on Iran on February 28, connectivity has hovered at about 1% of pre‑war levels, effectively cutting the country off from the global web. The blackout follows a prior 20‑day shutdown in January, which coincided with deadly nationwide protests. Combined, these measures mean that Iranian civilians have spent close to two‑thirds of 2026 in digital darkness, relying only on a slow, state‑controlled intranet for basic services and state‑run news. NetBlocks highlighted that while regions such as Myanmar, Sudan, Kashmir and Tigray have endured longer intermittent outages, no other war has forced an entire nation offline to this extent. The monitor added that Iran is the first country to lose previously functional internet connectivity by reverting to a national network. Economic analysts warned that the January shutdown already caused the economy to lose tens of millions of dollars each day in direct damages, with far‑reaching indirect effects. Companies reported that many online businesses could not survive more than three weeks without connectivity, leading to a wave of layoffs and reduced pay raises. One affected worker, Kamran, a product designer in Karaj, said he was dismissed after the latest wave of cuts. He now relies on a local skill‑matching group, but fears competition from thousands of similarly displaced workers. A senior data analyst from a Tehran firm disclosed that the firm is offering lower-than‑expected raises and shifting to three‑month contracts, creating uncertainty about future employment. Compounding the digital crisis, the war has targeted Iran’s steel factories, petrochemical plants and other civilian infrastructure, aggravating pre‑existing problems of high inflation and unemployment. Only a limited segment of the population can access the global internet—either because they are whitelisted by the state or because they pay steep fees for proxy connections that often disappear after a few hours. Government spokeswoman Fatemeh Mohajerani stated that internet access is being granted only to those who can “get the voice out,” such as officials, state‑affiliated entities and news agencies. Citizens on the ground describe a grim reality: frequent power outages, uncertainty about water supplies, and an inability to use services like Google Search or AI tools, even as they watch live feeds from space missions that remain inaccessible. In response to the prolonged shutdown, authorities have begun rolling out a tiered system dubbed “Internet Pro.” Business groups have received a “guide to connect to international internet,” urging them to contact a state‑run messaging app, Bale, for registration. Parallel efforts by a major telecom carrier offer one‑year data packages at prices higher than normal plans, while existing providers have not refunded customers for services they cannot deliver. President Masoud Pezeshkian’s administration, which campaigned on unblocking Iran’s internet, has offered no official explanation for the shutdown, leaving both the battered digital sector and the broader economy facing an uncertain future.