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The LeadA daily pill has shown remarkable results in doubling survival time for patients with pancreatic cancer, the world's deadliest form of the disease. According to clinical trial results presented at the American Society of Clinical Oncology's annual meeting, this breakthrough treatment represents a potential revolution in how we approach a cancer that has seen limited progress for decades.The Breakthrough Drug: DaraxonrasibThe drug in question, daraxonrasib, works by targeting a protein called Kras that fuels nearly all pancreatic cancers. This mechanism represents a significant advancement in treatment strategy, as Kras has been notoriously difficult to target effectively. The drug functions as a Ras(On) multi-selective inhibitor, capable of turning off the Kras protein to stop cancer growth regardless of which variant is present.Impressive Trial ResultsIn the clinical trial involving 500 patients with advanced pancreatic cancer, the results were striking. Those who took daraxonrasib lived an average of 13.2 months, compared to just 6.6 to 6.7 months for patients who received chemotherapy. This represents a near doubling of survival time, with the added benefit of fewer side effects compared to traditional chemotherapy treatments.Industry Impact and Expert ReactionsThe findings have been hailed as a "gamechanger" and "grand slam" by experts in the field. Dr. Rachna Shroff, chief of oncology at the University of Arizona Cancer Center, described the results as "landscape-changing" and "unprecedented survival." When she first read the trial results, conducted by researchers at the Dana-Farber Cancer Institute in Boston, she wept, noting the profound impact this could have on patients after 16 years of treating pancreatic cancer.Dr. Julie Gralow, Asco's chief medical officer, echoed these sentiments, calling the study a "home run" and suggesting it was actually a "grand slam" in terms of its significance.The Ras RevolutionOver 90% of patients with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (mPDAC), have a mutation in the Kras gene. This discovery has long been considered the "holy grail" in cancer research, particularly for pancreatic cancer where the mutation is nearly ubiquitous and an early driver of cancer growth.Paula Hanford, chief executive of UK-based Pancreatic Cancer Action, called this one of the most significant developments in treatment she had ever seen. Similarly, Anna Jewell, director of services, research and innovation at Pancreatic Cancer UK, described the results as "exciting," noting that the drug gives patients "months more precious time with their loved ones."Future Outlook and ApplicationsThe success of daraxonrasib opens doors for similar treatments targeting Ras genes in other cancers. Experts at the conference noted that because Ras genes fuel various types of cancer, there is hope for breakthroughs in treating lung and colon cancers as well, with similar drugs already in development for these conditions.However, challenges remain in ensuring these promising treatments become widely available to patients. As Jewell pointed out, tragically half of all people with pancreatic cancer die within just three months of diagnosis, making the rapid implementation of such treatments crucial.

The Landmark Broadcasting Deal CBS Sports has secured a four-year deal to broadcast the Women’s Super League (WSL) live in the US, starting from the next season and running until the end of the 2029-30 campaign. This deal represents a significant increase in valuation, potentially bringing in a fourfold increase in revenue for the WSL compared to previous seasons. Broadcasting Details Under the new agreement, the Paramount+ streaming service will air 183 WSL matches per season. Additionally, the CBS Sports Network will show one live match per week, with select matches also airing on the CBS Sports Golazo Network. This deal was negotiated by IMG, the international media rights representative for WSL Football. The Impact on Women's Football This deal marks a new record high for a US broadcasting agreement in the WSL. CBS Sports already holds rights to other women’s leagues, including the NWSL and the Women’s Champions League. The network had previously held WSL rights during the 2023-24 season. Zarah Al-Kudcy, WSL Football’s chief revenue officer, expressed excitement about welcoming CBS Sports back, highlighting their commitment to women’s football and their extensive talent roster. The Future of WSL Broadcasting The deal was finalized much earlier than previous agreements, which were typically announced shortly before the start of the season. This early conclusion brings stability and excitement ahead of the next WSL season in September. The partnership also comes as several WSL players have been named to the US women’s national team roster, further boosting the league’s profile.

Brighton & Hove Albion Women will take the field against Manchester City Women at Wembley on 31 May 2026 for the Women's FA Cup final. City aim to complete a first-ever double, while Brighton chase their inaugural major trophy, playing under the emotional weight of the recent passing of Rado Vidosic, the club’s former head of coaching. Brighton Chasing First Major Trophy Amid Tribute to Late Coach Rado Vidosic The match carries deep personal significance for Brighton. Rado Vidosic, who died from cancer four months earlier, was a pivotal figure in the club’s development. His son, Dario Vidosic, who grew up watching Wembley finals, now leads the team onto the pitch, honoring his father's legacy. Match Timing, Historical Context and Key Figures Kick‑off: 3:00 pm BST (13:00 GMT) City’s ambition: First domestic double in club history. Brighton’s goal: First Women’s FA Cup title since the competition’s inception. Key players: Khadija “Bunny” Shaw (City) – recently secured a four‑year contract extension; Ruth Keenan (Brighton) – leading scorer this season. Historical note: City have won the league this season; Brighton have never lifted the cup. Potential Shift in Women’s Football Power Balance A Brighton victory would signal a breakthrough for clubs outside the traditional powerhouses, potentially encouraging greater investment in smaller teams. Conversely, a City win would cement their dominance and could accelerate the professionalisation of the women's game across England, attracting more sponsors and media attention. What the Result Could Mean for Both Clubs If City wins: Reinforces their status as the premier English women’s side, boosting brand value and likely influencing future player recruitment. If Brighton wins: Provides a morale boost, validates the club’s development pathway, and may spur increased fan engagement and funding. Long‑term outlook: Either outcome will shape the narrative for the 2026‑27 season, affecting league dynamics, TV rights negotiations and grassroots participation.

Iga Swiatek's Unhappy Birthday at French Open Iga Swiatek's 25th birthday celebrations turned sour at the French Open on Sunday as the former champion lost 7-5, 6-1 in the fourth round to the Ukrainian 15th seed Marta Kostyuk, her challenge for a fifth title ending just when she had looked to be rediscovering her rhythm. The Match Turning Point There was little to separate the duo in the early exchanges as they twice traded breaks, before Kostyuk came up with a tight hold in the 11th game and raised her level at the end to claim the opening set with a backhand crosscourt winner. Kostyuk's Historic Win It was the first time that Kostyuk had taken a set off the third-seeded Pole after three straight-set defeats in their previous meetings, and she sensed a big upset when she went ahead 3-1 in the next set after a battling effort. The Impact on Swiatek's Title Hopes The Rouen and Madrid champion held her nerve from there to take her record on clay this season to 15-0, and book a meeting with the seventh-seeded Ukrainian Elina Svitolina or the 11th-seeded Swiss Belinda Bencic in the next round at Roland Garros. What's Next Tumaini Carayol’s report to follow

The Schreiber family, presiding over a nationwide commercial portfolio via the Midos Group, is at the center of a growing controversy involving two distinct business models: aggressive tax avoidance and the profiteering from the UK's housing crisis. The Dual Nature of the Schreiber Business Empire The investigation reveals a complex web of family-owned entities that appear to operate on opposite ends of the social spectrum. On one side, the Midos Group is accused of exploiting a controversial tax scheme to avoid business rates on empty commercial properties. On the other, a similarly named but ostensibly separate entity, Midos Management Co, is profiting from the UK's chronic shortage of social housing by arranging temporary accommodation for homeless residents. Midos Group: Accused of using the 'faith room' scheme to avoid rates on empty units. Midos Management Co: Collecting fees for arranging temporary accommodation for councils. Key Figures: David Schreiber (Midos Group) and Elizabeth Endzweig (Midos Management Co). Financial Impact of the 'Faith Room' Tax Loophole The core of the tax avoidance allegations centers on a provision that exempts property owners from paying business rates if the space is made available for religious worship. The 'faith room' scheme, marketed by Verity, allegedly involves minimal activity—such as placing a notice and a staff member reading scripture—to create the appearance of worship. Total Savings: Landlords have saved at least £18m through this scheme. Specific Case: Dover District Council is suing for £1.7m of unpaid tax. Properties Involved: Discovery Park in Kent and a disused pub in Clapham, London. Profiting from the Homelessness Crisis While the family allegedly avoids taxes on empty buildings, they are simultaneously capitalizing on the housing emergency. Midos Management Co acts as an intermediary, matching councils with private landlords to house homeless residents. Despite claims of separation, evidence suggests significant overlap between the two entities. Revenue Collected: At least £43m collected on behalf of landlords since 2019. Client Base: Lambeth council and at least four other councils. Directorship Overlap: Elizabeth Endzweig, daughter of David Schreiber, is a co-director of multiple companies sharing the same address as Midos Group. The Future of UK Property Tax Compliance The revelations highlight a growing tension between private profit and public service obligations. With MPs and councils increasingly scrutinizing these arrangements, the 'faith room' exemption is likely to face tighter regulatory oversight. The case sets a precedent for how closely connected family businesses can be without violating anti-avoidance rules, potentially leading to stricter audits of corporate structures in the property sector.

The Incursion Israeli forces have entered Lebanon, crossing the Litani River, a significant geographical and political boundary in the region. This move marks a serious escalation in the ongoing tensions between Israel and Lebanon. Capture of the 12th Century Castle The Israeli forces have successfully seized a 12th century castle in Lebanon. The castle, a historical and cultural landmark, is now under Israeli control, adding a layer of complexity to the conflict. Regional Implications This incursion and capture have significant implications for the region. The Litani River crossing and the seizure of the castle could lead to increased military presence and potential conflict escalation. International Response The international community is likely to respond to this development, with potential condemnations and calls for de-escalation. The incident may lead to increased diplomatic efforts to resolve the conflict. Future Outlook The situation remains volatile, with potential for further escalation. The capture of the castle and the crossing of the Litani River may lead to a prolonged period of heightened tensions and military activity in the region.

In April 2024, a local wildlife ranger recorded a pale horseshoe whip snake gliding through the turquoise waters between Ibiza and the tiny islet of Santa Eulària, providing the first indisputable visual proof that the invasive snake can swim and expand its range across the Balearics.The First Video Confirms Snakes Swimming Between Ibiza and Santa EulàriaThe footage, shot on a minuscule island 450 metres off Ibiza’s east coast, validates long‑standing anecdotal reports from fishermen and tourists. Biologist Oriol Lapiedra of the Centre for Ecological Research and Forestry Applications (Creaf) noted that while snake sightings were common, this was “the first proper evidence” of a snake making the crossing.Captures and Projections Reveal a Rapidly Expanding Snake PopulationMore than 3,500 horseshoe whip snakes were captured on Ibiza in 2025 alone.Since 2016, over 16,000 individuals have been culled.Scientists forecast that the species will occupy 100 % of the island by the end of 2027.On the mainland, snakes rarely exceed 1.8 m in length, but Ibiza specimens have been recorded at over 2 m and weighing 2.5 times as much.Ecological Fallout: Endangered Wall Lizards Face Near‑ExtinctionThe Ibiza wall lizard (Podarcis pityusensis) was upgraded by the IUCN in October 2022 from “near threatened” to “endangered”, reflecting the mounting pressure from the snake. On Santa Eulària, researchers counted 72 lizards in 2016 but only three in 2023. Across the ten islets that once hosted unique lizard populations, many have now lost their native reptiles entirely, erasing thousands of years of isolated evolution.Future Outlook: Management Strategies and the Likelihood of Island‑Wide InfestationRegional authorities, in partnership with Creaf and conservation NGOs, are intensifying capture programmes and exploring “Noah’s ark” captive‑breeding projects to preserve genetic stock. However, the sheer scale of the snake invasion—driven by imported olive trees that provide hidden refuges—means that without sustained effort, the horseshoe whip snake could dominate the Balearic archipelago, reshaping its ecosystems for decades to come.

Uncovering Family History Through Fiction Maggie O'Farrell's journey into her family's past began with a childhood myth about an ancestor who worked on the first maps of Ireland. Years later, a hand-drawn map and an old photograph led her to discover the truth about her great-great-grandfather's role in the Ordnance Survey. The Mapper's Story O'Farrell's ancestor was a labourer and translator who worked on mapping divisions in Ireland during the aftermath of the great famine. His task was to ensure that the changes caused by the disaster were marked on the new post-famine versions of Ireland's maps. A Window into the Past The photograph showed O'Farrell's great-great-grandfather with a child on his knee, wearing a worn jacket and a low-brimmed hat. A hand-drawn map, beautifully rendered in coloured inks, revealed a tiny medallion with a red-jacketed soldier and O'Farrell's ancestor. The discovery sparked O'Farrell's curiosity about her family's history and the history of Ireland. The Impact of the Great Famine The great famine, which occurred between 1846 and 1852, had a devastating impact on Ireland, with over a million people dying of starvation or famine-related disease, and another million forced to emigrate. Fiction as a Tool for Discovery O'Farrell believes that fiction comes from what you don't know, and her book 'Land' is a testament to this. The novel tells the story of a man, Tomás, and his family, striving to emerge from the long shadow of the great famine. A New Perspective O'Farrell's book offers a new perspective on the history of Ireland and the impact of the great famine on families. Her research and writing have shed light on a little-known aspect of her family's history and the history of Ireland.

The Connection to Nature As a recent study revealed almost half of UK adults now spend less than three hours a week in natural settings such as gardens, parks, fields or woods, we asked readers to tell us about what being outside means to them. Personal Stories of Healing The replies – heartfelt and passionate – came flooding in, with some admitting they just did not have the words to say how important it is. “It’s my happy place, my therapy and a reason to slow down and pause during my busy week,” wrote Hannah Powell from Perrywood garden centres. “I HAVE to look at plants every day. I notice every change in the garden. I sit facing the garden for my breakfast. I look out for nature on the way to work (recently seeing a little owl, red kites, foxes, hares, and more). It helped me get better when I had burnout and FND in London. I wouldn’t (couldn’t) be without it.” The Science Behind Nature's Benefits David Lynch esaid about his love of being outside. “Anxiety levels drop, all worldly concerns are put in perspective and [I] feel younger.” He agreed with others that there was plenty of recent science explaining the health benefits, but added: “I also read about ancient wisdom of Buddhism, which advocates solitary time in nature. All sources uphold the truth that better connection with nature brings better self-awareness and increased sensitivity to the needs of our ecosystem, plus better connection with each other.” The Impact on Mental Health Isabel Romaniw, who is working towards becoming a forest bathing guide, wrote passionately about the basic human need to be outside and to connect with nature. “We are animal, a simultaneously ordinary and yet utterly remarkable part of the great, miraculous tapestry of life on Earth. We have done much to shape our world and influence the fates of almost all other species we share our world with, but we must remember that we are but a tiny chapter, perhaps a footnote, in the ongoing story of the universe, in order to start to heal the damage and repair our relationships with ourselves, with each other, with our other-than-human kin, and with our one precious home.” For Romaniw, as for many others, our disconnection with nature is closely linked to “the worsening physical, mental and spiritual health crises that seem to be going on”. Cherished Memories of Nature Many of you had wonderful memories of times outside. “I was a sickly, pasty, shy, anxious kid,” wrote Mat Jordan. “In the early 70s my parents couldn’t afford to take us to the seaside one year so we went camping in the Peak District instead. It was a revelation. I absolutely loved it. The landscape and dry-stone walls of the white peak are still a favourite, although I spent some years in my 20s living in the Lake District too. One of my favourite memories is driving out of Sheffield into the Peaks with my then baby son to get him to fall asleep and still being awe-struck at the beauty on our doorstep.”