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The Earliest Known Dental TreatmentNeanderthals used stone drills to treat cavities almost 60,000 years ago in what is the earliest known evidence of dental treatment. This groundbreaking discovery challenges previous assumptions about Neanderthal capabilities and reveals their sophisticated approach to medical care.The Discovery in SiberiaThe single molar, unearthed in a cave in southern Siberia's Chagyrskaya site, features a deep hole that appears to have been created using a sharp, thin stone tool during the lifetime of the tooth's owner. The tooth, dated to be 59,000 years old, was found alongside the remains of Neanderthals and thousands of stone tools that have been excavated at the site.Scientific Evidence of Ancient DentistryThe lower molar features a deep hole in the centre of the tooth extending into the pulp cavity. Microscopic X-ray imaging revealed changes in mineralization that indicated severe tooth decay. Researchers conducted experiments on three modern human teeth to demonstrate that a hole of the same shape and patterns of microscopic grooves could be created by manually rotating a narrow, elongated tool made from local jasper between two fingers. Penetrating the dentin using this approach took between 35 and 50 minutes of continuous work.Expert Analysis of the ProcedureDr. Kseniya Kolobova, an archaeologist at the Siberian branch of the Russian Academy of Sciences, noted that this discovery "powerfully reinforces the now well-supported view that Neanderthals were not the brutish, inferior cousins of outdated stereotypes but a sophisticated human population with complex cognitive and cultural capacities."A dental professor who reviewed images of the tooth rated the Neanderthal's work as "a decent job." Justin Durham, a professor of orofacial pain at Newcastle University and the British Dental Association's chief scientific adviser, stated: "If I was marking this for a dental student, I wouldn't give it an A, but given the circumstances it's pretty impressive."Implications for Understanding Neanderthal CapabilitiesThis discovery represents the first time dental drilling has been demonstrated outside of Homo sapiens, and it is the oldest example of such behavior by more than 40,000 years. The smoothed edges of the drilled cavity and wear patterns inside it suggest the individual survived and continued to chew with the tooth for some time after the procedure.Dr. Lydia Zotkina, an archaeologist at the Russian Academy of Sciences and co-author, emphasized the remarkable strength of will required: "What struck me, and continues to strike me, is what an incredibly strong-willed person this Neanderthal must have been. They must have surely understood that although the pain of the procedure was greater than the pain of the inflammation, it was only temporary and had to be endured."This finding adds to previous evidence of Neanderthals caring for the sick and vulnerable group members, including an adult man with a withered arm and deformities in both legs, and a child with Down's syndrome who survived until at least the age of six. The latest discovery reveals not only compassion, but an impressive level of self-control by the patient and advanced technical skills by the practitioner.

The Global Obesity Landscape: Not a Uniform EpidemicA continuing rise in obesity around the world is not inevitable, research suggests, with rates in some countries levelling off or potentially in decline. Researchers say focusing on what has been described as a global epidemic of obesity hides large variations in trends across different countries, sexes and age groups.Majid Ezzati, a professor of global environmental health at Imperial College London and author of the study, said: "I think the thing that's really important is this diversity exists even across countries that have really similar economic, environmental, technological features. So countries may look the same on the surface of it but obesity looks different."Comprehensive Analysis Reveals Complex PatternsWriting in the journal Nature, the international team, which involved a network of almost 2,000 researchers, described how for each country they calculated the change in the prevalence of obesity each year between 1980 and 2024. They drew on data from 4,050 population-based studies involving 232 million participants aged five years and above.They found that the prevalence of obesity increased in almost all countries over the 45-year period. However, in most high-income countries, a rapid rise in the prevalence of obesity has been replaced by a slower increase, a plateau, or a potential decline.Regional Variations in Obesity PrevalenceThe rate of growth in obesity is slowing in adults in the US and UK, reaching a prevalence of 40-43% and 27-30% respectively in 2024. Obesity is increasing steadily in Finland, has plateaued in Germany and may have started to decline in France, where 24-25%, 20-23% and 11-12% of adults respectively were thought to have the condition in 2024.Slowdowns were often seen in children and adolescents before adults. For the former group, the slowdown started as early as 1990 in Denmark and rates stabilised in most high-income countries by the mid-2000s. Obesity has plateaued in boys and girls in the UK, US, Germany and Japan at prevalences of 10-12%, 20-23%, 7-12% and 3-7% respectively.Meanwhile, obesity among young people and adults in many low-income and middle-income countries continues to rise and in some cases this is accelerating.Understanding the Drivers Behind Divergent TrendsThe team say it is important now to unpick what is behind the trends in different countries. The situation is complex: while there may be shared reasons for obesity, such easy access to unhealthy foods or a decrease in physical activity, the team say country-specific factors rooted in social, economic and policy considerations could also be important, from perceptions around body image to the presence or absence of interventions such as healthy school meals.Naveed Sattar, a professor of metabolic medicine at the University of Glasgow, who was not involved in the work, said the study highlighted how obesity trends were diverging sharply across countries. "English-speaking nations are doing particularly poorly, with the UK now among the countries with the highest obesity levels worldwide," he said.Sattar said it was encouraging that some countries appeared to have reached a plateau in obesity rates. "Understanding what has worked in those settings is crucial as it could help shape more effective public health strategies for the UK," he said, although he noted there could be country-specific aspects or customs at play.Future Outlook and Potential InterventionsHe said the rapid rise in obesity across many developing countries was especially concerning, not least as it could result in increases in diabetes and cardiovascular conditions.He added: "Looking ahead, it will be important to see how wider use of effective weight-loss medicines affects obesity trends, particularly in the UK and the United States. Recent signs of stabilisation in the USA suggest there may be room for cautious optimism. Combining evidence-based medicines with strong public health measures could begin to shift obesity rates in the right direction."

The Discovery of a Lost Musical MasterpieceThe discovery of a new work by Ralph Vaughan Williams has set the world alight this week. In a box in the archives of London's Morley College, Elaine Andrews came across a previously unknown Vaughan Williams song titled "Before the Mirror," which sets a Swinburne poem inspired by a Whistler painting. The manuscript's workings, its crossings-out and corrections, offer a fascinating insight into Vaughan Williams's creative process, revealing music of surprising tonal adventure and expressive ambiguity written shortly after his marriage in 1897.The Vast Landscape of Lost Musical WorksBut a single song pales into comparison compared to the musical riches that may be lying dormant in libraries, archives and lofts all over the world. One of the most significant musical finds of all time was the treasure-trove of manuscripts by Florence Price found in a derelict house in Illinois in 2009, which included her two violin concertos, Fourth Symphony and dozens of other pieces. This discovery revealed not only wonderful music, but also pointed to the priorities – and prejudices – of music historians.The Systematic Erasure of Female ComposersThat discovery revealed not only wonderful music, but also pointed to the priorities – and prejudices – of music historians. The discovery of previous unknown manuscripts by the most familiar composers – a single page of Mozart, an exercise by Beethoven, a sketch by Haydn – often happen because historians know where to look for ephemera of lives whose every artefact has been combed over for centuries. But that had not been the case for Price, or for other composers who have been musicologically marginalised. Their work is supposed to be "lost" simply because no one had been looking for it.Rediscovering Forgotten Female VoicesThat's why some of the deepest holes in musical history – works that we know composers wrote and that were performed in their lifetimes, but which their biographies say are now "lost" – are by female composers. Francesca Caccini wrote more than 13 stage works in her lifetime in 17th-century Italy, but only one survives today. Caccini's dozen other operas may currently be "lost," but have researchers been looking for them as assiduously as they search for a page by Bruckner or a letter by Mahler?The Case of Joseph BologneThe same goes for at least three complete operas by Joseph Bologne, who lived an extraordinary life in 18th-century France, as composer, violinist, orchestral leader, fencer and soldier, becoming a colonel in the revolution's only all-black regiment. But Bologne's legacy suffered the prejudices of a culture that reinstated slavery and which erased his contribution to the revolution and to musical society after his death in 1799. Now that Bologne's work is at last finding its place there must be renewed focus on recovering these vital "lost" operas from the oblivion that they never deserved.Legendary Lost Works We Can Only Dream OfMind you, there is also lost music whose absence has been known of for centuries – we can only dream of what could be. Bach's St Mark Passion and scores of his cantatas, Monteverdi's Arianna and other stage works, the dozens of quartets and sonatas that Brahms threw out as unworthy, or Sibelius's Eighth Symphony, likely consigned to the flames by Sibelius himself.New Leadership in Classical MusicIn other classical music news, the Royal Scottish National Orchestra has announced that Lithuanian conductor Giedrė Šlekytė is to be their next music director, succeeding Thomas Søndergård from the 2027 season. The appointment comes after just two projects: a well-received week of Mahler's First Symphony, and a subsequent recording session. As the RSNO's chief executive Alistair Mackie said: "When she joined us last year, her musical ideas and the way she works with players spoke for themselves. Giedrė gives the orchestra room to breathe and to play."

Study Shows Fetal Exposure to Vegetable Flavours Influences Post‑Birth PreferencesThe research team gave pregnant volunteers powdered kale or carrot capsules during the third trimester and later measured their children’s facial reactions to the same smells. Reactions were recorded via ultrasound before birth, repeated at three weeks, and again when the children were about three years old.Methodology: Kale and Carrot Powder Capsules Administered to Expectant MothersParticipants were asked to swallow a capsule each day containing either kale or carrot powder. The study avoided large volumes of juice, which many volunteers found unpalatable, opting for a low‑cost capsule format.Capsules administered in late pregnancy (around 32 weeks gestation).Initial chemosensory response captured with ultrasound imaging.Follow‑up assessments at 3 weeks and 3 years post‑birth.Sample Size and Observed Reactions Reveal Early Flavor MemoryAlthough the cohort was modest, the findings were consistent:12 children were observed at age three.Infants exposed to carrot powder smiled when presented with a carrot scent and grimaced at kale, and vice‑versa for the kale group.The same preference pattern was evident in the ultrasound scans before birth.These results suggest that flavour exposure in utero can create a durable chemosensory memory.Potential Public‑Health Benefits of Early Dietary ConditioningIf replicated on a larger scale, the approach could offer a low‑cost strategy for improving population nutrition:Reducing childhood resistance to vegetables may lower long‑term risks of obesity and diet‑related diseases.Capsules are inexpensive and could be integrated into routine prenatal supplements.The concept is adaptable to different cultural diets, as noted by the researchers’ interest in fish‑rich Japanese diets.Next Steps: Larger Trials and Cross‑Cultural ApplicationsThe authors acknowledge the need for a bigger, funded study to confirm the effect across diverse populations. Future research aims to:Expand the sample size to hundreds of mother‑child pairs.Test additional flavours and odourants, including artificial sweeteners.Explore policy pathways for incorporating flavour‑exposure capsules into prenatal care guidelines.Published in Developmental Psychobiology, the paper titled “Do Human Fetuses Form Long‑Lasting Chemosensory Memories?” opens a new avenue for early nutritional interventions.

The Lead A recent study has provided evidence that crickets may experience pain in a similar way to humans and other animals. Researchers at the University of Sydney have found that crickets exhibit behaviors that resemble pain responses when injured, such as stroking and grooming a sore antenna. Cricket Pain Response Study Associate Professor Thomas White, an entomologist from the University of Sydney, led the study, which was published in Proceedings of the Royal Society. The researchers applied a heated soldering iron to the antennae of dozens of crickets, causing a temporary but unpleasant sensation. The crickets that received the hot probe 'overwhelmingly' directed their attention to the affected antenna, grooming it more frequently and for a longer period than those that did not receive the treatment. The Data Analysis The study found that: Crickets that received the hot probe directed their attention to the affected antenna. They groomed the antenna more frequently and for a longer period. The soldering iron was set to 65C, hot enough to be unpleasant but not causing lasting harm. The Impact Analysis This research has significant implications for our understanding of insect cognition and pain. The study's findings suggest that insects may be capable of experiencing pain, which challenges traditional views of their cognitive abilities. This has important implications for animal welfare, particularly for insects that are farmed for food, feed, and research. The Prediction As science continues to reveal more about insect brains, behavior, and experiences, it is likely that our understanding of their capacity for pain and consciousness will evolve. This may lead to changes in animal welfare laws and our treatment of insects in various industries. Ultimately, this research encourages us to reevaluate our relationship with insects and consider their well-being.

The Lead OpenAI CEO Sam Altman took the stand to defend himself against Elon Musk's lawsuit challenging OpenAI's corporate structure. Musk's lawsuit alleges that OpenAI's founders "stole a charity" when they launched a for-profit subsidiary. Musk's Allegations and Altman's Response Altman described Musk's allegations as "difficult to wrap my head around" and emphasized that OpenAI's foundation, with $200 billion in assets, is doing "incredible work." Musk's attorneys pointed out that OpenAI's foundation didn't have full-time employees until earlier this year, but OpenAI board chair Bret Taylor explained that this was due to the challenge of converting equity to cash. The Safety Commitment Debate Musk's lawyers questioned whether OpenAI's commitment to safety had been compromised as its commercial power grew. Altman revealed that in 2017, Musk's "specific plans on safety made me worry." He described a pivotal moment when Musk suggested that OpenAI should pass to his children if he were to die. Altman's Concerns About Musk's Management Altman testified that Musk's management tactics, which might have worked for engineering and manufacturing, didn't suit OpenAI. He claimed that Musk had demotivated key researchers and damaged the organization's culture. Altman defended the "sweat equity" of fellow cofounders Greg Brockman and Ilya Sutskever. The Aftermath and Current Lawsuit Musk ultimately left OpenAI's board and started competing AI initiatives. OpenAI's lawyers noted that Musk had been kept up to date and asked to participate in investments, which his lawsuits now claim corrupted the non-profit. A 2018 discussion about a Microsoft investment was described as a "good vibes meeting" where Musk shared memes on his phone.

The LeadRobert Smith, a distinguished pharmacologist and professor at St Mary's medical school in London (now part of Imperial College), has died aged 92. His groundbreaking work on how genetic variations affect drug responses helped shape the field of personalized medicine.The Discovery of Debrisoquine PolymorphismBob became well known for his role in the discovery of "debrisoquine polymorphism." In 1975, as one of five volunteer researchers who took debrisoquine, a blood pressure medication, he was the only one to suffer adverse effects (hypotension) and collapse. This led to the discovery of a genetic polymorphism where certain individuals cannot break down specific drugs efficiently. While Bob described this as an "accident waiting to happen," it positioned him at the forefront of pharmacogenetics.Awards and RecognitionSmith's contributions to pharmacology were formally recognized when he became the first recipient of the Paton prize in 1998 for his work in understanding how genes affect drug response. His academic achievements included becoming professor of pharmacology in 1978 and serving as deputy dean of the medical school from 1980-88.Impact on Medicine and SportsSmith's research fundamentally changed how medical professionals understand drug responses, paving the way for personalized medicine approaches. Beyond human medicine, he applied these principles to horse racing, chairing the UK Horserace Scientific Advisory Committee (1979-99) and its pan-European equivalent (1992-2005). He also served as a director of the Horseracing Forensic Laboratory in Newmarket during the 1990s, helping shape anti-doping protocols.Enduring LegacySmith never fully retired, continuing his research as emeritus professor until publishing his last paper in 2020. His legacy extends beyond scientific contributions to include the principles, warmth, kindness and generosity he embodied throughout his career. His work continues to influence pharmacology and personalized medicine, ensuring his impact will be felt for generations to come.

The Lead The hantavirus outbreak on the MV Hondius cruise ship has sparked fears, but health experts emphasize that it is distinct from COVID-19 in several critical ways. As the last passengers are evacuated and quarantined, researchers are working to understand the origins of the outbreak and mitigate its spread. What is the Hantavirus? Hantaviruses are a family of viruses that cause two main illnesses in humans: hantavirus pulmonary syndrome (HPS) and haemorrhagic fever with renal syndrome (HFRS). The viruses are transmitted to humans by rodents, primarily through their urine, saliva, and droppings. HPS has a high fatality rate of about 40%, while the death rate for HFRS varies from 1% to 15%. Can Hantavirus Spread from Person to Person? The Andes strain of the hantavirus, which causes HPS, is the only hantavirus clearly shown to spread from person to person, but only to a limited extent. This transmission occurs through close, prolonged contact, such as within a household or intimate contact. It does not spread like an airborne virus through casual social contact. The Event Details The MV Hondius cruise ship, which departed from South America on April 1, had 150 people from 23 countries on board. Three people have died in the outbreak on the ship. The European Centre for Disease Prevention and Control (ECDC) hypothesizes that some passengers caught the hantavirus while in Argentina, where the virus is endemic. The Data Analysis 11 confirmed hantavirus infections from the MV Hondius outbreak 3 deaths reported 94 people evacuated and repatriated to about 20 countries 18 American passengers evacuated, with 1 testing positive in a biocontainment unit in Nebraska The Impact Analysis The hantavirus outbreak highlights the need for vigilance and proper public health measures. While the risk of a pandemic is low due to the limited human-to-human transmission, experts stress the importance of monitoring for symptoms and quarantine measures for those exposed. The Prediction Experts believe that the chances of hantaviruses causing the next pandemic are low due to their transmission dynamics. The risk to the general population in Europe remains low, and widespread transmission is not expected. Proper precautions, including quarantine and protective gear for healthcare workers, are crucial to controlling the spread.

Executive Summary: War‑Driven Rerouting Endangers South African WhalesThe United States-Israel war on Iran has disrupted global energy and commodity flows, pushing commercial shipping around the Cape of Good Hope. The resulting traffic spike has heightened the danger of vessels colliding with whales along South Africa’s southwestern coast.Shipping Surge Along the Cape of Good HopeSince the conflict escalated, vessels that once transited the Red Sea and the Strait of Hormuz are now forced to navigate the longer route around southern Africa. Key figures from the IMF’s PortWatch Monitor show:89 commercial vessels passed the Southern African coast between 1 Mar 2026 and 24 Apr 2026.Only 44 vessels made the same journey in the comparable period of 2023.Overall traffic in the region has almost doubled, with fast‑traffic lanes quadrupling.These numbers illustrate a rapid shift in global shipping patterns directly linked to the war.Quantifying the Collision RiskResearchers presented at the International Whaling Commission (IWC) highlighted historical and emerging collision data:1999‑2019: 11 fatal ship strikes out of 97 recorded whale deaths in the Western Cape.Additional 16 non‑fatal strikes recorded in the same period.Fast‑moving vessels, now four times more common, pose the greatest lethal risk.Modest lane adjustments could cut strike risk by 20‑50 % for vulnerable species.These statistics suggest that current strike counts are likely underestimates, as many incidents go unreported when whales sink after impact.Ecological Consequences for Endangered SpeciesSouth Africa’s waters host over 40 whale species, including:Southern right whales and humpback whales – populations have rebounded but remain exposed to ship traffic.Bryde’s whales, Orcas, sperm whales, Minke whales and various dolphin species.Critically endangered species such as Antarctic Blue, Fin and Sei whales are listed on South Africa’s Red List.Super‑pods of humpbacks, numbering between 11,000‑13,000 individuals, feed off the west coast and are especially vulnerable during feeding bouts when they are less likely to detect approaching vessels.Pathways to Mitigation and Future OutlookExperts propose several mitigation strategies:Shift traffic lanes a few nautical miles offshore – projected 20‑50 % reduction in strike risk.Implement speed‑reduction programmes for vessels in high‑density whale zones.Adopt real‑time whale detection systems (radio alerts, dedicated apps) to warn captains.Corporate action – the Swiss‑based MSC is already rerouting ships to protect sperm and blue whale habitats in Greece and Sri Lanka.South Africa’s Environment Ministry has pledged to examine all available solutions, and maritime authorities are expected to coordinate with scientific bodies to chart a protective course. If these measures are adopted, the outlook for South African whale populations could shift from heightened risk to a more resilient future.