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Entertainment Jun 01, 2026

Sam Campbell: From Australian Standup to Britain's Comedy Oddball Superstar

Australian comedian Sam Campbell has established himself as Britain's most thrillingly irreverent c…
The Rise of Sam Campbell Sam Campbell's journey from Australian standup comedian to Britain's most distinctive comedic voice represents a fascinating evolution in modern comedy. Since moving to the UK in the early 2020s, the 34-year-old has carved out a unique space in the British comedy circuit with his irreverent style that swings between hammy overacting and childish belligerence. His approach forces observational comedy through an absurdist filter, with contrarian takes covering everything from hand sanitiser and dragonflies to Ferrero Rocher and Bratz dolls. This distinctive voice earned him the prestigious Edinburgh comedy award in 2022, followed by an arrogant victory lap the next year with his single 10-minute performance titled Bulletproof Ten. The Unconventional World of "Make That Movie" Channel 4's new series "Make That Movie" represents Campbell's boldest creative venture yet. The show-within-a-show format stars Campbell as an alternative version of himself: a pompous director whose creative well has run dry. He invites the public to share their bizarre movie ideas, which he and his dysfunctional crew then develop into actual feature films within the framework of a shoddy reality program. Each episode concludes with the film's premiere, creating a viewing experience that's equal parts hilarious and bewildering. The production process was remarkably hands-off, with Campbell noting that the production company was busy working on an animated Ricky Gervais series about cats, "so we sort of got left to our own devices." This creative freedom was bolstered by Channel 4's head of comedy, Charlie Perkins, a longtime champion and collaborator of Campbell's who was described as "very trusting" despite initially not fully understanding the concept. Campbell's Comedy Philosophy What sets Campbell apart in the comedy landscape is his instinctive approach to humor. As director Joe Pelling observes, "Sam doesn't really seem like someone who's prone to super analysing his stuff too much. He's just led instinctively by what's funny." This gut-driven creativity manifests in his standup material, which subverts and simultaneously adheres to observational comedy tropes. In "Make That Movie," this translates to embracing obviously "dumb" ideas with deadpan seriousness, finding humor in taking film-making too seriously, especially when disaster strikes. The series features an ensemble cast largely drawn from Campbell's friendship circle, including fellow Australian comic Aaron Chen as the nerdy yet incompetent Sebastian, whose parents fund the entire enterprise. Exuberant standup Helen Bauer plays against type as grumpy sound engineer Pat, while 86-year-old actor David Hargreaves completes the gang as cinematographer Winnie. Dressed in matching purple jumpsuits, the team's aesthetic blends Ghostbusters with Scooby-Doo, creating what Pelling describes as a "real-life cartoon feel" to prevent the show from feeling bleak and strange. Campbell's Impact on British Comedy Campbell's influence extends beyond his own series to reshape the British comedy landscape. His triumphant stint on Taskmaster led to numerous appearances as the resident oddball on panel shows like Would I Lie to You?, 8 Out of 10 Cats Does Countdown, and QI. His most high-profile gig to date was this year's series of Last One Laughing UK, where he battled established comedians like Alan Carr, David Mitchell, and Bob Mortimer with unconventional material including duck impressions and claims of dining next to "mole people" during Eat Out to Help Out. What makes Campbell particularly distinctive is his deadpan delivery that proved more than just a mask during Last One Laughing UK. His composure was so unshakable that producers eventually had to implement a rule change, with Campbell ultimately losing to David Mitchell by virtue of having made marginally fewer contestants crack up. This ability to maintain his comedic vision despite external pressures has solidified his reputation as a uniquely uncompromising comedic voice. The Future of Alternative Comedy As Campbell continues to gain prominence, his success signals a promising future for alternative comedy within mainstream media. His willingness to embrace absurdity while maintaining underlying comedic logic suggests that there's significant appetite for comedy that challenges conventional formats and expectations. The fact that Channel 4 has given him such creative freedom indicates that broadcasters are increasingly recognizing the value of distinctive voices over formulaic approaches. Looking ahead, Campbell's career trajectory suggests he'll continue to push boundaries while maintaining his unique comedic identity. Whether through more television projects, standup specials, or other creative ventures, his instinctive approach to humor and refusal to second-guess himself positions him as a comedian who will likely continue to surprise and delight audiences while expanding the possibilities of what comedy can be.
#Sam Campbell #Make That Movie #British Comedy
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Entertainment Jun 01, 2026

007 First Light: A Triumphant James Bond Game Made by Obsessive Fans

007 First Light successfully revitalizes the James Bond video game franchise, offering fans an imme…
The Lead007 First Light successfully revitalizes the James Bond video game franchise after years of absence, offering fans an immersive experience that captures both the action and sophistication of the iconic spy. Developer IO Interactive demonstrates their passion for the Bond universe through meticulous attention to detail and creative gameplay mechanics that honor the franchise's legacy.Gameplay Mechanics and DesignGiven how open-ended Hitman is, it's surprising how well IO has taken to linear storytelling. There are still moments of the "social stealth" that defines the studio's other games, but it's been repurposed for cinematic forward thrust, and blended together with plenty of action. It seems lazy to pigeonhole First Light as Hitman meets Uncharted, but when you see Bond leap on to a cliff edge and scurry along rocky handholds, your mind can't help but go there.You are often playing through moments that would be cutscenes in another game. Sometimes that's as simple as a dramatic approach to a level; driving round a bend to reveal a sprawling Slovakian castle, say. More ambitiously, one whole chapter is given over to a glorified training montage that whips you back and forth between getaway driving, stealth and gunplay, all while charting thawing relations between our fledgling 00 candidates. This is on-rails storytelling done right.Character Development and StorytellingWe join young Bond in his pre-00 days, as a petulant, belligerent rule-breaking trainee. Actor Patrick Gibson begins as a cookie-cutter insubordinate, but warms to the role once he's bouncing off M (herself a green leader looking to make her mark), and an enjoyably urbane Q who drops the frustrated quartermaster routine and introduces Bond to the wonders of vinyl. A scene where he teaches our agent to tie a bow tie is a perfect bit of prequelcraft: arriving at an iconic look through a lovely character touch.In contrast to previous Bond games, First Light understands that action is only a part of the Bond fantasy. He's as much schmoozer as bruiser, and there's plenty of the former here, with socialising setpieces at a chess tournament or swanky product launch. The staging and atmosphere of these rooms is exemplary, but the work mostly boils down to eavesdropping on guests to discover a keycard's location, before shooting its keeper with a toxic dart.Technical Execution and VisualsAs Bond himself is learning the ropes, it sometimes feels as if the developers are feeling their way towards something. Guns are enjoyably punchy, but scripted fights always emphasise explosive theatrics over strategy. Gas tanks erupt, walkways tumble, cranes collapse: you enter fights looking for the red barrel that will trigger a chain of collateral damage. Fail to quell numbers this way and you're quickly overwhelmed.Fist fights are more enjoyable – not because they are any more sophisticated, but because of the commitment of their virtual stuntmen. Bond is a barroom brawler, barging bodies into clattering bookshelves and battering enemies with mugs and keyboards lying around. In the same way that waist-high cover always alerts you to an incoming fight in Gears of War, you learn to eye crockery or wine bottles with suspicion here. If it's not stuck down, you'll be smashing it into a mercenary's face within the next two minutes.Fists and guns are what happen when sneaking goes wrong. On this front, IO finds a punchy take on its classic lurking. A hacking watch introduces some Home Alone hijinks as you lure guards towards misbehaving photocopiers, before electrocuting the device with a laser beam. Gadgets let you run circles around enemies – though you have to accept some silliness as you refuel those toys with batteries stolen from TV remotes, or globs of hand sanitiser. It's hard to picture Daniel Craig scavenging for Carex.Legacy and Future of Bond GamesOn a visit to a Mauritanian market and a luxury hotel getaway, however, there is space to roam, and you're reminded how few developers can tap into that aspirational tourist fantasy. Plenty of games have let us be a gun-toting version of Bond, but this is the first opportunity we've had to be a Bond relaxing beside a glittering infinity pool in Vietnam, or a Bond trying to get one over on a shell game hustler. Games are now much more capable of taking us to specific places than they were in the time of GoldenEye on the N64.It's that full Bond immersion that 007 First Light will ultimately be remembered for, more so than the odd wonky setpiece scene. I have no doubt that this was made by excitable Bond geeks throwing "what if" moments at a whiteboard. What if you got to explore Q Lab watching underlings test malfunctioning prototypes? What if you were tied to a torturer's table and had to talk your way out? What if you found yourself at 15,000ft with no parachute? And what if you had access to John Barry's classic scores and could deploy a staggering needle drop out of nowhere?Very few fans get to play in the sandbox of their obsession like IO has here. As far as Bond video games go, nobody has done it better.
#007 First Light #James Bond #IO Interactive
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Entertainment Jun 01, 2026

Nish Kumar on Courting Controversy and Clashing with Comics

Comedian Nish Kumar discusses his confrontations with fellow comics over performing in Saudi Arabia…
The Comedian Who Refuses to Stay SilentNish Kumar has built a career on being unafraid to speak his mind, even when it means confronting fellow comedians like Jimmy Carr about their decisions to perform in controversial venues. The British stand-up, known for his articulate and politically charged humor, recently discussed his confrontations with comics who participated in the Riyadh comedy festival, calling it part of the "cultural-washing of a repressive regime." Kumar's upcoming tour, "Angry Humour from a Really Nice Guy," reflects his concern that comedy has been "co-opted by charlatans in service of autocrats." Despite his willingness to court controversy, Kumar admits there are moments when he questions his approach, joking that "you should not be allowed to give interviews" when discussing fellow comedians.The Confrontation Over Comedy EthicsKumar's most notable public clash came when he confronted Jimmy Carr about his decision to appear on Jordan Peterson's podcast, which Kumar described as "a radicalisation event that's happening on an unprecedented scale." His criticism extends to other comics who performed in Saudi Arabia, including Bill Burr, Dave Chappelle, and Jack Whitehall. Kumar alleges that some comics "signed a contract agreeing to not have a go at MBS [Mohammed bin Salman, the crown prince of Saudi Arabia]" and expressed particular frustration with those who have complained about cancel culture while participating in such events. "I don't want to hear about free speech from any of these cunts again," he stated emphatically. These confrontations highlight Kumar's commitment to what he sees as ethical boundaries in comedy, even when it means alienating his peers.A Career Forged in Debate and DeterminationNow 40, Kumar has been performing stand-up for two decades, though his love for comedy began much earlier. At age five, he was studying The VHS of The Simpsons, analyzing its intricate references and in-jokes. His influences included Chris Rock and the sketch show Goodness Gracious Me, which helped him see comedy as a viable path for someone of his background. "Until then, the only people I'd seen do comedy were either white or African American. You see a bunch of Indians doing it, you think: Oh, this is viable for me." Kumar's early career involved temping while struggling to make inroads in comedy, buoyed only by "the persistent encouragement of my friends." His big break came in 2015 when his fourth fringe show was nominated for an Edinburgh comedy award, followed by regular TV appearances and eventually becoming a household name after joining The Mash Report in 2017.The Impact of a Progressive Voice in ComedyKumar's outspoken progressive politics made him both celebrated and controversial. His appearances on Question Time prompted social media abuse, and figures like Piers Morgan and Andrew Neil criticized him for an "anti-British" episode of Horrible Histories. Despite these controversies, Kumar believes his involvement in culture wars ultimately did more harm than good. "It's a fucking relief. It didn't do anybody any good; me being in the conversation didn't benefit any of the causes that I was passionate about. I worry sometimes that it actually actively hindered them." Despite this, his influence has grown internationally, with The New York Times suggesting he might be "the angry progressive standup the US badly needs." His cross-generational appeal has also expanded, with audiences ranging from 14-year-olds to septuagenarians, reflecting his ability to connect with diverse audiences through his blend of political commentary and personal vulnerability.Anger and Authenticity in a New Era of ComedyAs he approaches his 40s, Kumar continues to refine his approach to comedy that balances anger with authenticity. He has been open about his mental health struggles, including diagnoses of PTSD and ADHD, which inform his work. His upcoming tour "Angry Humour from a Really Nice Guy" suggests a continued commitment to comedy that challenges both audiences and the industry itself. Despite his success in the US, where he performed his new show and appeared on Have I Got News for You, Kumar's material remains rooted in UK concerns, with American audiences showing enough interest in British politics to appreciate his takes on figures like Angela Rayner. As he continues to navigate the complexities of comedy that both entertains and provokes, Kumar remains committed to what he sees as the essential role of comedy in holding power accountable, even when it means making enemies in the process.
#Nish Kumar #Jimmy Carr #Comedy
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Business Jun 01, 2026

Anthropic soars to $965bn valuation, leapfrogging OpenAI

Anthropic has surpassed OpenAI as the world's most valuable AI startup with a $965 billion valuatio…
The AI Startup Valuation ShiftAnthropic has usurped OpenAI as the world's most valuable artificial intelligence startup, soaring to a $965bn valuation ahead of expected public listings by the rival firms. Anthropic, the maker of the Claude family of chatbots, said on Thursday that it had raised $65bn from private investors after a fundraising round led by Altimeter Capital, Greenoaks, Dragoneer and Sequoia Capital.Funding and Leadership PositionThe announcement catapults Anthropic, led by CEO and cofounder Dario Amodei, ahead of ChatGPT maker OpenAI in value, which attracted an $852bn valuation in its last fundraising round in March. "This funding will help us serve the historic demand we are experiencing, stay at the research frontier, and bring Claude to more of the places where work happens," Anthropic's Chief Financial Officer Krishna Rao said in a statement.Market Recognition and AdoptionAltimeter Capital CEO Brad Gerstner hailed the adoption of Claude among the "world's most demanding organisations" as evidence of Anthropic's command in the field. "This momentum positions Anthropic to lead the next phase of AI innovation and capture the enormous opportunity ahead," Gerstner said.Rapid Growth and Market PositionFounded in 2021 by former OpenAI researchers, Anthropic has rapidly emerged as one of the leading players in Silicon Valley's scramble to dominate AI. Anthropic's Claude, first launched in 2023, is among the most popular AI models worldwide. In March, the San Francisco-based company said that the chatbot was receiving more than 1 million new sign-ups each day.Challenges and Recent DevelopmentsWhile achieving stellar success in rapid time, Anthropic has also faced challenges – in particular, a high-profile dispute with US President Donald Trump's administration, which has labelled the firm a "supply chain risk" over its refusal to allow unrestricted access to its tools for military purposes. Anthropic unveiled its latest iteration of Claude, Opus 4.8, in a separate announcement on Thursday, calling it a "modest but tangible improvement" on its predecessor.Future Outlook and Market DynamicsAnthropic, OpenAI and Elon Musk's rocket company SpaceX are all expected to go public in the near future in what are expected to be among the biggest initial public offerings in history. Jay R Ritter, an emeritus professor at the University of Florida who specialises in IPOs, said Anthropic has generated a lot of market excitement due to its widespread use by companies for software coding. "This is a big market where apparently Anthropic has the best product," Ritter told Al Jazeera.Valuation Trends and Market Analysis"The increase in valuation in a short period of time is unprecedented for a startup, although publicly traded tech companies such as SK Hynix, Nvidia, and Alphabet have seen even bigger increases, although not as much in percentage terms," Ritter said, referring to the South Korean and US chip giants, and Google's parent company. While it remains to be seen whether the massive investments pouring into AI are creating a bubble, Ritter said, the handful of successful firms that are likely to emerge in the field could see enormous profits.Industry Consolidation and Future Prospects"Nobody wants to use the eighth best product, so these companies are either one of the handful of successful firms, or they will have a zero market share," he said. "The tech industry is different than the restaurant industry, where there are not large economies of scale, and where competition limits the profit margins."
#Anthropic #OpenAI #Claude
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Sports May 31, 2026

Liverpool's Arne Slot Sacked: A Necessary Move

Liverpool has sacked manager Arne Slot just a year after he led the team to their 20th league title…
The End of an Era: Arne Slot's Departure from Liverpool Inevitable and necessary. Despite the continual briefings coming out of the UK side of the club’s operation, the silence from Liverpool’s American ownership was deafening. No vote of confidence, no contract extension talks and – most significant – no official appointment of Etiënne Reijnen to Arne Slot’s coaching staff. The Event Details: Slot's Sacking Eventually, on Saturday lunctime, six days after the final game of a season in which the Reds lost 19 games, Slot was gone. Regardless of what happens next, it was the correct decision. If the next guy does not do well, that does not mean sacking Slot was a mistake. It made no sense for Liverpool’s ownership to allow this to continue, regardless of how much Michael Edwards and Richard Hughes reportedly wanted to stick with the status quo. The Data Analysis: A Disappointing Season 19 losses in a single season Lack of identity in the team's play Disappointing results and performances The Impact Analysis: A United Fanbase I can’t remember Liverpool fans being more united in wanting a trophy-winning manager removed. Usually there’s a split in the fanbase and it can get quite ugly but this time it was pretty unanimous. We all knew. Some may have half-heartedly railed against the idea of “sacking a league-winning manager” but when it happened there was very little condemnation. Mostly it was relief. The Prediction: A New Era for Liverpool The dream is that our real dad (Klopp) comes home but it’s probably going to be another stepdad – this time a fun Spanish one. Andoni Iraola ticks plenty of boxes, but not all of them. He hasn’t experienced the goldfish bowl of a big club like Liverpool, he hasn’t had to navigate the demands of playing twice, or three times, a week and teams don’t set up against Bournemouth in the same way they do Liverpool.
#Liverpool FC #Arne Slot #Premier League
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Sports May 31, 2026

CBS Sports Secures Record Four-Year Deal to Broadcast WSL Games in the US

CBS Sports has signed a record four-year deal to broadcast the Women's Super League (WSL) live in t…
The Landmark Broadcasting Deal CBS Sports has secured a four-year deal to broadcast the Women’s Super League (WSL) live in the US, starting from the next season and running until the end of the 2029-30 campaign. This deal represents a significant increase in valuation, potentially bringing in a fourfold increase in revenue for the WSL compared to previous seasons. Broadcasting Details Under the new agreement, the Paramount+ streaming service will air 183 WSL matches per season. Additionally, the CBS Sports Network will show one live match per week, with select matches also airing on the CBS Sports Golazo Network. This deal was negotiated by IMG, the international media rights representative for WSL Football. The Impact on Women's Football This deal marks a new record high for a US broadcasting agreement in the WSL. CBS Sports already holds rights to other women’s leagues, including the NWSL and the Women’s Champions League. The network had previously held WSL rights during the 2023-24 season. Zarah Al-Kudcy, WSL Football’s chief revenue officer, expressed excitement about welcoming CBS Sports back, highlighting their commitment to women’s football and their extensive talent roster. The Future of WSL Broadcasting The deal was finalized much earlier than previous agreements, which were typically announced shortly before the start of the season. This early conclusion brings stability and excitement ahead of the next WSL season in September. The partnership also comes as several WSL players have been named to the US women’s national team roster, further boosting the league’s profile.
#CBS Sports #Women's Super League #WSL
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Environment May 31, 2026

Swimming Snakes Threaten Ibiza's Iconic Wall Lizards

A grainy video captured in April 2024 shows a horseshoe whip snake swimming from Ibiza to the islet…
In April 2024, a local wildlife ranger recorded a pale horseshoe whip snake gliding through the turquoise waters between Ibiza and the tiny islet of Santa Eulària, providing the first indisputable visual proof that the invasive snake can swim and expand its range across the Balearics.The First Video Confirms Snakes Swimming Between Ibiza and Santa EulàriaThe footage, shot on a minuscule island 450 metres off Ibiza’s east coast, validates long‑standing anecdotal reports from fishermen and tourists. Biologist Oriol Lapiedra of the Centre for Ecological Research and Forestry Applications (Creaf) noted that while snake sightings were common, this was “the first proper evidence” of a snake making the crossing.Captures and Projections Reveal a Rapidly Expanding Snake PopulationMore than 3,500 horseshoe whip snakes were captured on Ibiza in 2025 alone.Since 2016, over 16,000 individuals have been culled.Scientists forecast that the species will occupy 100 % of the island by the end of 2027.On the mainland, snakes rarely exceed 1.8 m in length, but Ibiza specimens have been recorded at over 2 m and weighing 2.5 times as much.Ecological Fallout: Endangered Wall Lizards Face Near‑ExtinctionThe Ibiza wall lizard (Podarcis pityusensis) was upgraded by the IUCN in October 2022 from “near threatened” to “endangered”, reflecting the mounting pressure from the snake. On Santa Eulària, researchers counted 72 lizards in 2016 but only three in 2023. Across the ten islets that once hosted unique lizard populations, many have now lost their native reptiles entirely, erasing thousands of years of isolated evolution.Future Outlook: Management Strategies and the Likelihood of Island‑Wide InfestationRegional authorities, in partnership with Creaf and conservation NGOs, are intensifying capture programmes and exploring “Noah’s ark” captive‑breeding projects to preserve genetic stock. However, the sheer scale of the snake invasion—driven by imported olive trees that provide hidden refuges—means that without sustained effort, the horseshoe whip snake could dominate the Balearic archipelago, reshaping its ecosystems for decades to come.
#Horseshoe whip snake #Ibiza #Balearic Islands
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Lifestyle May 31, 2026

The Healing Power of Nature: Why Being Outdoors Matters

A recent study found that almost half of UK adults spend less than three hours a week in natural se…
The Connection to Nature As a recent study revealed almost half of UK adults now spend less than three hours a week in natural settings such as gardens, parks, fields or woods, we asked readers to tell us about what being outside means to them. Personal Stories of Healing The replies – heartfelt and passionate – came flooding in, with some admitting they just did not have the words to say how important it is. “It’s my happy place, my therapy and a reason to slow down and pause during my busy week,” wrote Hannah Powell from Perrywood garden centres. “I HAVE to look at plants every day. I notice every change in the garden. I sit facing the garden for my breakfast. I look out for nature on the way to work (recently seeing a little owl, red kites, foxes, hares, and more). It helped me get better when I had burnout and FND in London. I wouldn’t (couldn’t) be without it.” The Science Behind Nature's Benefits David Lynch esaid about his love of being outside. “Anxiety levels drop, all worldly concerns are put in perspective and [I] feel younger.” He agreed with others that there was plenty of recent science explaining the health benefits, but added: “I also read about ancient wisdom of Buddhism, which advocates solitary time in nature. All sources uphold the truth that better connection with nature brings better self-awareness and increased sensitivity to the needs of our ecosystem, plus better connection with each other.” The Impact on Mental Health Isabel Romaniw, who is working towards becoming a forest bathing guide, wrote passionately about the basic human need to be outside and to connect with nature. “We are animal, a simultaneously ordinary and yet utterly remarkable part of the great, miraculous tapestry of life on Earth. We have done much to shape our world and influence the fates of almost all other species we share our world with, but we must remember that we are but a tiny chapter, perhaps a footnote, in the ongoing story of the universe, in order to start to heal the damage and repair our relationships with ourselves, with each other, with our other-than-human kin, and with our one precious home.” For Romaniw, as for many others, our disconnection with nature is closely linked to “the worsening physical, mental and spiritual health crises that seem to be going on”. Cherished Memories of Nature Many of you had wonderful memories of times outside. “I was a sickly, pasty, shy, anxious kid,” wrote Mat Jordan. “In the early 70s my parents couldn’t afford to take us to the seaside one year so we went camping in the Peak District instead. It was a revelation. I absolutely loved it. The landscape and dry-stone walls of the white peak are still a favourite, although I spent some years in my 20s living in the Lake District too. One of my favourite memories is driving out of Sheffield into the Peaks with my then baby son to get him to fall asleep and still being awe-struck at the beauty on our doorstep.”
#Nature #Mental Health #Wellness
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Health May 31, 2026

Breakthrough Cancer Jab Shows Unprecedented Results in Eradicating Tumors

A revolutionary cancer treatment called amivantamab has shown unprecedented results in clinical tri…
The Lead: Unprecedented Cancer Treatment SuccessDoctors have hailed "unprecedented" trial results that show a triple-action cancer jab can eradicate entire tumours in patients. In an international trial spanning 11 countries, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments.The Breakthrough: Amivantamab's Triple-Action ApproachThe jab, called amivantamab, shrank the tumours of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumours altogether.The smart jab targets cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumours grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack the tumour.The Clinical Trial Data: Impressive Response RatesIn the trial, 102 patients with head and neck cancer, the world's sixth most common cancer, were given the jab. Tumours shrank or disappeared completely in 43 patients, including 28 whose tumours shrank significantly and 15 who saw them eradicated entirely.Patients receiving amivantamab lived for a median of 12.5 months overall after starting treatment, despite having a form of cancer with very poor outcomes, once standard treatments stop working.The Impact Analysis: New Hope for Treatment-Resistant CancersKevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, London (ICR), said: "These are unprecedentedly strong responses in patients whose disease has become resistant to both chemotherapy and immunotherapy. This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking."Researchers also highlighted that the trial focused on people with head and neck cancers that did not include those with human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. That is particularly significant, they said, since head and neck cancers not caused by HPV are usually harder to treat, making progress in this group hugely important.The Patient Experience: Transforming Quality of LifeOne of the first patients to benefit was Carl Walsh, 56, who was diagnosed with tongue cancer in May 2024 and joined the OrigAMI-4 trial at the Royal Marsden in July 2025. "I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," he said. "At that point, I was recommended for the OrigAMI-4 trial. I'm now on my 17th cycle of treatment and I'm very pleased with the progress so far."Unlike many cancer treatments, amivantamab is given as a tiny jab under the skin rather than via an intravenous drip, making treatment quicker and more convenient for patients and much easier to deliver in outpatient clinics.The Future Outlook: Expanding Treatment ApplicationsThe results will be presented on Sunday in Chicago at the world's largest cancer conference, the annual meeting of the American Society of Clinical Oncology (Asco).Amivantamab, developed by Johnson & Johnson, is now being evaluated in about 60 clinical trials, primarily for lung cancer, but also for colorectal, brain and gastric cancers.Prof Kristian Helin, the chief executive of the ICR, said: "This study demonstrates how the development of new treatments through rigorous cancer research may lead to meaningful advances, even for patients with very limited treatment options. Achieving this level of tumour response and encouraging survival outcomes in such a challenging-to-treat group represents a significant step forward."
#Cancer #Amivantamab #Johnson & Johnson
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