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The End of Purdue Pharma Purdue Pharma, the manufacturer of OxyContin, is slated to be dissolved by the end of the week as a comprehensive legal settlement takes effect. This settlement resolves thousands of lawsuits filed against the company for its role in the opioid crisis, which has claimed over 900,000 lives in the US since 1999. Terms of the Settlement As part of the deal, Purdue Pharma will admit to not having an effective program to prevent its powerful painkillers from being diverted to the black market. The company will also admit to paying doctors to prescribe the drugs and providing information to encourage more opioid prescriptions. The settlement includes $8.3 billion in forfeitures, fines, and penalties, although the company will only pay $225 million to the federal government. Victims' Reactions Many victims of the opioid crisis expressed frustration with the settlement, arguing that it does not provide them with real justice. Some asked the judge to reject the negotiated sentence, stating that it does not hold individual members of the Sackler family accountable. Over 54,000 people with personal injury claims voted to accept the settlement, while about 200 rejected it. The Sackler Family's Role Members of the Sackler family, who own Purdue Pharma, will contribute up to $7 billion over 15 years to fight the opioid crisis. Most of the funds will go to government entities. The settlement also shields family members from lawsuits over opioids for those who agree to the payments. A New Era for Purdue Pharma Under the settlement, Purdue Pharma will cease to exist and be replaced by Knoa Pharma, a new company with a board appointed by states and a mission to combat the opioid crisis. Millions of internal Purdue documents will be made public, and the Sackler family has agreed not to object to having their names removed from institutions they have supported.

Guardian’s Verdict on “Should I Marry a Murderer?”The Guardian’s review lauds the Netflix series for exposing the extraordinary resilience of Caroline Muirhead, a doctor who risked her life to bring her fiancé Sandy McKellar and his twin brother to justice. While celebrating her courage, the piece condemns the police’s failure to protect her.How the Series Unfolds Caroline Muirhead’s Harrowing TaleThe three‑part documentary follows Caroline from a hopeful Tinder romance to a nightmarish reality after Sandy confesses to a 2023 hit‑and‑run that killed cyclist Tony Parsons. She marks the hidden body with a Red Bull can, endures threats, substance abuse, and constant fear while feeding crucial evidence to investigators.Engagement announced, then the hit‑and‑run confession surfaces.Caroline covertly guides police to the peat‑bog burial site.Police promise anonymity but provide no tangible protection.Viewer Reception and Streaming MetricsExact viewership numbers remain undisclosed, but the series quickly trended on social media upon its 2026 release, sparking debates about victim support in true‑crime narratives. The Guardian notes the show’s “viral” discussion threads as evidence of strong audience engagement.Why the Review Signals a Shift in True‑Crime StorytellingThe critique underscores a growing demand for narratives that center victims’ agency rather than glorify perpetrators. By foregrounding Caroline’s perspective, the series challenges the genre’s traditional male‑centric focus and calls out institutional negligence, especially from Scotland’s homicide division.What Lies Ahead for True‑Crime DocumentariesAccording to the review, future true‑crime productions will likely prioritize ethical storytelling—ensuring victim safety, transparent police cooperation, and nuanced portrayals of trauma. The success of “Should I Marry a Murderer?” may encourage platforms to green‑light more cases where ordinary women confront systemic misogyny.

In a climate where climate denial, vaccine skepticism and "alternative facts" dominate headlines, Helen Pearson shows that the tide of evidence‑based practice is still rising. Drawing on five years of interviews with over 200 experts, she offers concrete steps for citizens, educators and policymakers to push back against the growing rejection of science. The Rise of Anti‑Science Rhetoric in Politics and Public Health Recent statements from high‑profile figures have amplified doubt: Donald Trump labeled climate change a "con job", while U.S. health secretary Robert F. Kennedy Jr. has slashed 25,000 staff positions at science agencies and publicly undermined vaccines. In the UK, only 40% of respondents believe information about science is "generally true". These attacks echo the 1992 backlash against evidence‑based medicine, when a small group of doctors faced accusations of "dangerous innovation". Numbers Showing Declining Trust and Funding Cuts Public trust in scientific institutions fell from 58% in 2018 to 40% in 2025 (Ipsos UK). U.S. federal science staffing reduced by 12% between 2022‑2025, equating to 25,000 jobs lost. Investment in AI‑driven evidence synthesis reached $126 million in 2025, signaling a counter‑trend toward better access to research. Over 70% of English school leaders now report using research to guide decisions, up from 45% in 2010. Evidence‑based anti‑poverty programmes have impacted an estimated 850 million lives worldwide. Why the Erosion of Evidence Matters Across Sectors The decline in trust is not just an abstract concern; it directly affects health outcomes, climate action and economic policy. When citizens reject vaccine data, disease outbreaks become more likely, increasing healthcare costs. Climate denial stalls emissions‑reduction legislation, jeopardizing global temperature targets. In education, ignoring rigorous studies on tutoring and phonics can widen achievement gaps. What Experts Predict for the Future of Evidence‑Based Decision‑Making AI‑powered synthesis tools like Consensus will become mainstream, allowing anyone to query a database of >250 million papers within seconds. Curricula that embed critical‑thinking and "evidence literacy" are expected to be adopted in at least 60% of OECD schools by 2030. Funding bodies are likely to tie grant eligibility to open‑access data sharing, accelerating transparency. Grass‑roots fact‑checking networks will grow, with community‑led platforms verifying claims in real time. Ultimately, Pearson reminds readers that science is a human endeavour—messy, iterative, and sometimes uncertain—but its collective weight still outpaces anecdote. By asking for evidence, checking peer review, and supporting institutions that champion rigorous research, individuals can help tip the balance toward reason.

The Lead An important Islamic seminary in Kashmir has been declared unlawful under anti-terror laws, prompting backlash from prominent religious and political leaders in the Indian-administered territory. Seminary Under Scrutiny Kashmir Divisional Commissioner Anshul Garg issued the order based on a police dossier that alleged “sustained and covert links” between the seminary, Jamia Siraj-ul-Uloom, and the banned political party Jamaat-e-Islami (JeI), local media reported. The seminary, one of the largest in southern Kashmir, is recognised by the Jammu and Kashmir Board of School Education and has over 800 students. The Data Analysis The seminary has more than 800 students and has “produced doctors, scholars and professionals from homes that could never afford private education”. The move was handed down under the Unlawful Activities Prevention Act (UAPA), a much-criticised law that allows authorities to designate someone a “terrorist” without evidence. The Impact Analysis Leaders in Muslim-majority Kashmir criticised the move as part of an ongoing campaign of overreach by New Delhi. “Declaring Jamia Siraj-ul-Uloom ‘unlawful’ under UAPA is the latest act in a calculated dismantling of Kashmir’s civic life,” wrote Aga Syed Ruhullah Mehdi, a member of Jammu and Kashmir parliament, on X. The Prediction The decision is likely to escalate tensions in the region, where Kashmiri leaders have pushed back against what they describe as a curtailing of religious and other freedoms. Kashmir voters elected local officials in 2024, in the first elections in a decade. However, most powers remain with the New Delhi-appointed lieutenant governor, including control over police, public order and the transfer and posting of officials.

The Detention Crisis in El-Fasher Thousands of people remain detained in poor conditions by the paramilitary Rapid Support Forces (RSF) in el-Fasher in western Sudan, according to a local NGO. The Scale of Detention The Sudan Doctors Network said on Monday that 20 doctors, more than 1,470 civilians, and 907 military personnel are being held in “dire” conditions in multiple detention facilities in the city. 20 doctors detained Over 1,470 civilians detained 907 military personnel detained Conditions in Detention Centers The NGO said in a statement that the RSF is reportedly committing “severe violations” inside the detention centers in el-Fasher, “including killings during torture and interrogation, as well as ethnically motivated killings”. The group reports that 370 women and 426 children are among those held in facilities including Shalla Prison, a children’s hospital, and cargo containers. Humanitarian Crisis The detention centers have faced a cholera outbreak since early February, with poor environmental conditions, a lack of clean water, and malnutrition making the spread of diseases more rampant. The capture of the doctors, alongside a “critical” shortage of medical supplies, has debilitated the health sector, the NGO warned. The Background of the Conflict Sudan descended into conflict three years ago when a rivalry between army chief Abdel Fattah al-Burhan and RSF commander Mohamed Hamdan “Hemedti” Dagalo exploded into all-out war. The RSF and the Sudanese Armed Forces (SAF) have been fighting a vicious civil war since April 2023, which has killed hundreds of thousands and displaced millions to create the “world’s worst humanitarian crisis”, according to the United Nations.

A Stark Warning from the PitchMissy Bo Kearns, the 25-year-old Aston Villa midfielder, has opened up about a harrowing experience that nearly cost her life. After announcing her pregnancy, Kearns suffered a miscarriage that triggered a severe sepsis infection, a condition she credits her club doctor with saving her from.The Medical Emergency: From 42°C to SurvivalOn 18 March, Kearns experienced severe symptoms—shaking and a fever of 42°C—which she initially attributed to her pregnancy. It was only after consulting Aston Villa team doctor Dr Jodie Blackadder-Weinstein that the severity of the situation was realized. Kearns described the four days spent in hospital as "hell," highlighting the rapid deterioration of her condition.Beyond the Physical: The Psychological Toll of Pregnancy LossThe psychological impact of the loss has been profound. Kearns described a "different type of grief" caused by the sudden hormonal crash and the stark contrast between the excitement of pregnancy and the sudden loss. She emphasized that the physical symptoms of sepsis were secondary to the emotional devastation, noting that sufferers often "suffer in silence" due to the stigma surrounding miscarriage.Breaking the Silence: The Importance of Open Dialogue in SportsKearns' decision to share her story is a significant step in destigmatizing pregnancy loss in elite sports. By highlighting the physical risks—such as sepsis—and the mental health toll, she is encouraging others to seek help. Her resilience is evident as she prepares to return to the England national team for the World Cup next year, viewing football with a renewed sense of urgency and appreciation.

East Darfur, Sudan — Hawa Adam did not expect a childhood illness to kill her son. Ali was two years old when he fell sick on February 25 in Labado, in Sudan’s East Darfur state. He died two days later.“I thought it was one of the ordinary childhood diseases,” the 37-year-old told Al Jazeera. “I never imagined I would lose my child to this epidemic.”Hawa attributes his death to the absence of basic medical care – no vaccination, no qualified doctors. “Most doctors”, she says, “left the area after the war broke out, forcing those with means to seek treatment abroad, in South Sudan or Uganda.”The Collapse of Routine Immunization in East DarfurA measles outbreak has struck several Labado districts since March, killing approximately 70 people and infecting about 1,000 others across 12 residential neighbourhoods, in a population of roughly 12,000, which includes displaced people who arrived during the war, according to Mohamed Abdel Aziz, 32, coordinator of the Labado crisis unit.Those numbers were disputed by East Darfur’s health director, Dr Jabir al-Nadeef, who confirmed to Al Jazeera that measles has struck four districts of the state, but only reported 300 cases and 26 deaths, figures that diverge substantially from those documented by the Labado emergency room.“Vaccines only arrived on April 11 from Chad via UNICEF [United Nations Children’s Fund ], after a prolonged period with no supply, and a vaccination campaign is scheduled to run from April 18 to 24 across the state,” he said.Measles is one of the world’s most contagious diseases, spread by contact with infected nasal or throat secretions or breathing in air that was breathed out by someone with measles, according to the World Health Organization (WHO). Outbreaks can result in severe complications and deaths, especially among young, malnourished children.Transmission: Contact with infected secretions or airborne particles.Current Coverage: Measles vaccination has fallen to 46 percent.Routine Immunization: First dose of diphtheria, tetanus, and pertussis dropped to 48 percent in 2024.Quantifying the Human Cost: Disputed Death Toll and Economic BarriersThe first measles cases in Darfur in the current outbreak were recorded in January, according to UNICEF. It is unfolding against the backdrop of a near-total collapse of public health infrastructure across Darfur, where war has gutted facilities, halted routine vaccination and driven out medical personnel.“We discovered the outbreak by accident,” Abdel Aziz, the coordinator, told Al Jazeera. The teams had been conducting home visits for a fire-prevention workshop when they saw the scale of the outbreak, with almost half of the homes visited having measles cases.In the al-Nil neighbourhood, Ismail Issa, 38, lost his two-year-old daughter Makarem on March 11. His brother Ahmed lost an 18-month-old son, Issa, on March 25. Then Hasan, the three-year-old son of Ismail’s sister Medeeha, died on March 23. All three families live in adjoining homes, and the infection passed between them.Abdel Aziz traced much of the death toll directly to a supply failure. Medicines ran out at the government health centre on February 23. Drugs remain available at private pharmacies, but most residents cannot afford them.Intravenous fluids: 8,000 Sudanese pounds ($20.50).Antibiotics: 10,000 to 15,000 pounds ($25.60 to 38.40).A Public Health Catastrophe UnfoldingAsmaa Jalaluddin, 28, lives in the Dar al-Naim West neighbourhood of Labado with her three children. Her three-year-old daughter, Mashaer Rajab al-Sheikh, fell ill on April 5 with fever, diarrhoea and persistent vomiting. She stopped eating and kept her eyes shut for four days.On April 8, Asmaa took her to the Labado health centre, where she was told her daughter had measles. With no medicines available, she was directed to travel to Shuairiya, 40 kilometres north. There, on April 10, Mashaer received fever reducers and vitamins and slowly began to open her eyes again. She was discharged two days later.Local doctors are now calling for intervention from international health organisations, noting that diseases that had been eliminated are returning.UNICEF spokesperson for Sudan, Eva Hinds, told Al Jazeera that “measles cases continue to be reported across Darfur, with insecurity, displacement, damaged health facilities, and prolonged disruption to routine immunisation all constraining the response.”UNICEF says that a measles-rubella vaccine catch-up campaign has been completed across all localities in Central Darfur and West Darfur, as well as parts of North and South Darfur, reaching approximately 2.1 million children aged nine to 14. Vaccination in remaining areas, including East Darfur, is scheduled for mid to end of April, aiming to reach close to 750,000 children across all nine of the state’s localities.The Long Road to RecoveryFor the families of Labado, the calendar offers little comfort. In the al-Nil neighbourhood, three siblings buried their children within days of one another over the Eid holiday. In Dar al-Naim West, a mother counts the days until her daughter’s 14-day isolation ends. In the Safaa neighbourhood, Hawa Adam has already buried hers.“They could have still been alive,” Hawa Adam said. “Those without money die in Darfur.”

The Postpartum Health Window: A New Prevention StrategyNew mothers who experienced hypertension during pregnancy could significantly reduce their long-term risk of heart attack, stroke, and premature death by implementing daily home blood pressure monitoring, according to a pivotal study from the University of Oxford.Methodology: The Oxford Intervention TrialThe research, published in the journal Hypertension, involved 220 women who had developed hypertension during pregnancy. The study compared two approaches to postpartum care:Standard Care: 108 women received routine care with infrequent blood pressure checks and medication adjustments.Home Monitoring: 112 women used home monitors to check their blood pressure daily. Readings were shared via an app, allowing doctors to adjust medication day-to-day for optimal control.Quantifying the Benefit: Arterial Health and Risk ReductionThe data reveals a tangible physiological improvement in the home monitoring group. Six to nine months after birth, women who managed their blood pressure at home had significantly less stiff arteries compared to those in the standard care group. This reduction in arterial stiffness is clinically significant because it directly correlates with better blood flow and reduced clot formation.Researchers estimate that this specific intervention could reduce the future risk of heart attack or stroke by 10%. Furthermore, the study highlights a broader statistical reality: Harvard researchers found that high blood pressure in pregnancy is linked to a 42% rise in the risk of premature death.Why the Postpartum Period is Critical for Long-Term Cardiovascular HealthProfessor Paul Leeson, who led the study, emphasized that the weeks following birth represent a "powerful and often overlooked opportunity" to protect women's future health. High blood pressure in pregnancy, whether gestational or pre-eclampsia, affects 5-10% of pregnant women and can damage organs immediately.Beyond immediate threats, the condition creates a lasting legacy. Women with a history of hypertensive pregnancy are three times more likely to develop high blood pressure later in life and twice as likely to develop heart disease.The Path Forward: NHS Integration and Future ResearchThe findings are paving the way for a shift in postpartum care standards. Trials are currently underway to determine the most effective methods for rolling out blood pressure monitoring to women after hypertensive pregnancies, with specialist NHS clinics being a primary option.Dr. Sonya Babu-Narayan, clinical director at the British Heart Foundation, noted that this research underscores the importance of the renewed women's health strategy, ensuring that heart health advice is integrated into care at key life stages, from pregnancy through menopause.

LeadThe Guardian’s review of Heartsink critiques Sean Turner’s new stage drama that follows Dr Jeffrey Longford (Aden Gillett) as he transitions from physician to terminal‑cancer patient, exposing tensions between medical authority and patient vulnerability.The Play’s Premise and Moral QuandariesSet in a London NHS clinic, the narrative uses “heartsink” patients—those who drain clinicians’ emotional reserves—to explore:the ethical friction surrounding euthanasia,the impact of digitalisation on doctor‑patient interaction,the gender‑neutral redesign of hospital spaces.Critical Assessment of Writing and DirectionReviewer Farine Clarke, herself a doctor‑turned‑patient, argues that the script remains “brief and simplistic,” with jokes about artificial intelligence feeling “off‑the‑cuff.” The pacing is described as “slow,” diluting the urgency that similar NHS‑focused plays like Tiger Country achieved.Performance HighlightsAden Gillett as Dr Longford delivers a pedantic, complaint‑laden performance that borders on Luddite caricature.Megan Marszal as receptionist Suzie provides the only consistent “gallows humour,” though it falls short of genuine wit.Kathy Kiera Clarke (of Derry Girls fame) adds a quirky edge as hypochondriac Cara, briefly hinting at supernatural possibilities.Vikash Bhai offers a gentle counterpoint as a younger GP looking up to Longford.Heartsink’s Place in Contemporary NHS DramaWhile the play raises relevant debates about resource‑strained NHS care, it lacks the “necessary compromises” and “urgency” found in earlier works. The reviewer notes that the dialogue often feels “crude” and the characters “flat,” limiting the audience’s emotional investment.Future Outlook and Audience ReceptionRunning at Riverside Studios in London until 10 May 2026, the production may attract theatre‑goers interested in medical ethics, but its mixed critical reception suggests limited longevity beyond the current run.