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The Lead Doctors, scientists, and researchers shared new research about ways to tackle cancer at the 2026 American Society of Clinical Oncology (Asco) annual meeting, the world's largest cancer conference. Breakthroughs in Cancer Treatment The event in Chicago, attended by 40,000 health professionals, featured more than 200 sessions and 2,700 poster presentations on this year's theme, “the science and practice of translation: improving cancer outcomes worldwide”. Smart Drugs in Cancer Treatment Researchers have developed a smart drug that stops cancer cells hiding. The experimental tablet, GRWD5769, can help shrink tumours by at least 30% in six of the world’s most common forms of the disease, delegates in Chicago were told. 26 of 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers who were given GRWD5769 alongside cemiplimab had tumour reductions of at least 30%. 15 had tumour reductions of at least 30%. A Daily Pill for Pancreatic Cancer A pill that doubles survival time in patients with pancreatic cancer was presented at the conference. In a trial of 500 patients, all of whom had pancreatic cancer that had spread, the pill, daraxonrasib, doubled survival time, with fewer side-effects compared with chemotherapy. Patients who took the drug lived substantially longer, for an average of 13.2 months, compared with 6.6 to 6.7 months for patients who had chemotherapy. Safely Skipping Some Treatments Some patients can safely skip some treatments, according to research presented at the conference. A genomic test could pave the way for a new era of personalised medicine, enabling doctors to determine which patients can safely skip chemotherapy. The Optima trial, led by University College London, followed 4,000 patients with newly diagnosed breast cancer in the UK, Norway, Sweden, Australia, New Zealand and Thailand. Those with a low score on the genomic test could be treated safely with hormone therapy alone. The Future of Cancer Treatment Urgent action is required to cope with rising cancer cases. The world faces a cancer workforce crisis, experts said, with a shortage of 100 million staff expected by 2050 when 100,000 people will be being diagnosed every day. A 21% increase in cancer incidence is predicted, according to a report presented at the conference. The rate is set to rise from 165 per 100,000 people in 2025 to 200 per 100,000 in 2050.

The Origins of 'Mogging' Until recently, if someone had said "mog" to me, I probably would have assumed they were talking about the children's book cat created by the late great Judith Kerr. If asked about "mogging" or being "mogged," I would have been completely baffled. But for many members of gen Z and gen Alpha (or anyone who is just a bit too online), the slang term, which means to outdo or outshine others, is everywhere. From Manosphere to Mainstream Mogging's origins are in the manosphere, where it began as a verb derived from the acronym "Amog" (alpha male of the group). In misogynistic forums in the 2010s, to "mog" came to mean to outdo someone in terms of sexual desirability. Mogging has been adopted by "looksmaxxing" influencers such as Braden Peters, known online as Clavicular, who encourage men to try to alter their looks – sometimes in extreme ways – to increase their "sexual market value". Such an influencer might talk of "frame mogging" another person in a photo or video – a variation on mogging that specifically refers to being more muscular. The Evolution of Competitive Language Even now, as the term has begun to be used much more widely, and in a tongue-in-cheek way, it is still typically associated with looks (a friend of mine, for example, was described by her boyfriend's younger siblings as "mogging him" in a photo). But increasingly, mogging can mean besting others at basically anything. The gold medal Olympic figure skater Alysa Liu said in an interview last year that her main competition strategy was "to mog", while a 23-year-old colleague of mine tells me that she and her friends joke about "walk-mogging" when they overtake people on the street. Linguistic Analysis of Modern Slang Tony Thorne, director of the slang and new language archive at King's College London, says a lot of new slang terms "have come recently from the same kind of male-based internet culture", referencing the words "simp" (someone who is excessively attentive), "soy boy" (a derogatory term for a man who is not stereotypically masculine) and "sigma" (someone cool and successful). Not to mention "maxxing," now such an established part of the lexicon that it was tweeted by the US Department of Defense earlier this year. The Cultural Impact of Competitive Slang Thorne thinks it is significant that "mogging" in particular has become fashionable at this time. "What it implies – hyper-competitive, hyper-individualist, aggressive selfishness" has become "mainstream behaviour", he says. Which is why Will Adolphy, a psychotherapist who was himself once an ardent follower of manosphere influencers, has concerns about the word. "Part of me can see how it's a kind of handy, even entertaining word," he says. But the idea of mogging "reinforces this sense that there are certain people that will dominate others based off their physical appearance and status", he says. Psychological Concerns About Competitive Language Dr Emily Sehmer, an NHS child and adolescent psychiatrist, worries too about the "constant sense of competition" that concepts such as mogging help to foster, especially for teenagers, who are developing their socio-emotional skills and typically "have a desire to fit in and to get peer approval". Apart from anything else, she adds, wanting to mog someone is "kind of mean, isn't it?" The Ironical Reappropriation of 'Mogging' "I think people are right to be concerned," about the rise in usage of slang that originates from a toxic subculture, Thorne says – and notes that some of his fellow linguists feel uncomfortable about researching it. But, he adds, "mogging" has moved well beyond its origins, and many people who use it now "tend to understand it and laugh at it, and they use it themselves, but ironically". Certainly, plenty of mogging content on social media now has an irreverence to it: such as the trend of posing for the photo on a rollercoaster in order to "mog" the screaming riders next to you. Making what started as an aggressive concept into something very silly pokes fun at the ridiculousness of the manosphere, my younger colleague explains. She shows me a picture of herself on a recent holiday, standing next to a statue of Napoleon, that she sent to a group chat of her friends. The caption? "I mogged Napoleon!"

The Anticipation Builds The World Cup, one of the most widely viewed and followed sporting events globally, is about to kick off, promising a spectacle that will captivate audiences worldwide. This event is not just a tournament; it's a celebration of football, culture, and national pride, bringing together the best teams and players from around the globe. The Event Details The World Cup is known for its grandeur, with state-of-the-art stadiums, high-level competition, and an electric atmosphere. The tournament will feature a series of matches, starting from the group stages to the knockout rounds, culminating in the final showdown for the coveted title. Fans can expect thrilling matches, stunning goals, and exceptional skill on display. The Global Impact The World Cup's impact extends beyond the football pitch, influencing culture, economy, and society as a whole. It's an event that unites people across different backgrounds and geographies, creating a shared experience that transcends borders. The tournament also provides a platform for nations to showcase their capabilities, hospitality, and cultural heritage to a global audience. The Future Outlook As the World Cup approaches, fans and spectators alike are eagerly anticipating the action-packed tournament. With advancements in technology and social media, the event will be more accessible and engaging than ever, allowing fans to connect, share, and experience the excitement in real-time. The World Cup's legacy continues to grow, solidifying its position as a premier sporting event that captivates and inspires millions worldwide.

Lead: Customers Stuck Between Closed Branches and Unreliable Apps When the Lloyds branch in Staines shut its doors, long‑time customer Patricia Payne—who travels four miles from Chertsey for cash withdrawals—found herself with "one option" left for in‑person banking. The closure coincided with an IT outage that left thousands of Lloyds customers unable to make payments, highlighting the fragility of relying solely on digital channels. Lloyds Shuts Staines Branch Amid Ongoing IT Outage The Staines branch, one of two Lloyds closures in Surrey that week (the other in West Byfleet), was part of a plan to shutter almost 150 outlets by March 2027. The branch’s poster urged customers to use the mobile app, yet many, like the 78‑year‑old Payne, struggle with online banking and depend on physical counters for withdrawals and transaction help. Scale of UK Bank Branch Closures: 6,795 Since 2015 Since January 2015, a total of 6,795 bank branches have closed across the UK, representing 69% of the branches that were open at the start of 2015. Overall, around 7,000 branches have disappeared since 2015, with a peak in closures in 2017. Lloyds and Santander have announced fresh rounds of closures this year. Consequences for Rural Communities and Small Businesses Residents of Surrey’s high streets describe the area as a "banking desert". Without nearby branches, pensioners and tradespeople must queue at post offices or rely on cash machines in supermarkets. Small‑business owners like fruit‑and‑veg stallholder Radhe Mali warn that the loss of local banks hampers cash‑based operations, while customers such as Lynne Bulmer express anxiety over the shift to online banking. Future Outlook: Government Review and Potential Policy Response In response to mounting public concern—a YouGov poll found 76% of Britons consider local branch access important—the government launched an independent review to assess the real‑world impact of branch closures and identify who is most affected. The review may lead to regulatory measures aimed at preserving face‑to‑face banking services, especially in underserved areas.

The Lead: Democracy's Tipping Point in GhanaAccra, Ghana – Ghana has recorded 14 arrests linked to false news and offensive speech in less than 16 months, nearly double the number documented during the previous administration's entire eight-year tenure, according to the Media Foundation for West Africa (MFWA).The rise has triggered a sharp debate in one of West Africa's most stable democracies over whether authorities are simply enforcing long-standing laws in a new digital environment, or edging into a more restrictive approach to public speech.The Political Irony: Mahama's Past WarningsThe controversy carries added political weight because President John Mahama, while in opposition in 2022, warned that using state power to intimidate dissent was a "dangerous blueprint" for democracy.Government Position: Enforcement Not RepressionA senior ruling party official dismissed allegations that the arrests amount to a crackdown."The opposition intentionally sponsors people to insult the President," he told Al Jazeera. "When the law catches up with them, they cry persecution to score cheap political points."He pointed to the case of TikToker Prince Ofori, known as "Fante Comedy", who was arrested last August over alleged threats to President Mahama.Days after his arrest, Ofori appeared at a political rally alongside opposition figures, a development the official said showed how quickly such cases become politicized."They paraded him at an opposition rally," he said.Opposition Response: A Warning Sign for DemocracyOpposition leaders see something more troubling taking shape.Minority leader Alexander Afenyo-Markin has been among the most outspoken critics."The state-sponsored persecution must stop," he told Al Jazeera. "Arresting citizens for words that do not constitute genuine threats is not justice. It is intimidation."He said free speech has limits, but argued that the state is increasingly crossing a line."Excessive use of state power risks undoing Ghana's hard-won democratic gains," he said.Legal Framework: Where is the Line?At the centre of the debate are long-standing provisions in Ghana's Criminal Code and Electronic Communications Act, which authorities say are now being applied to a fast-moving digital landscape.Government supporters argue the increase in arrests reflects the explosion of anonymous and unregulated online content.Critics say the problem is not the laws themselves, but how they are being used.A legal consultant who reviewed recent cases said he counted at least 16 alleged misapplications of Section 208 in the past 18 months, compared with roughly a dozen in the previous eight years."The law has been abused beyond repair," he said. "Repeal is the only remedy."Media Freedom and Blurred BoundariesVeteran journalist Ben Ephson said Ghana needs clearer guidance on where free expression ends and harm begins."The government must properly explain the arrests so people can draw the line between press freedom and responsible journalism," he said.He added that both journalists and state institutions risk overstepping if the rules remain unclear."When you compare the freedom of the media and the rights of the individual, we need to be careful that the media, in trying to do their work, don't trample on people's rights," he said.Global Context: Shrinking Civic SpaceOthers say Ghana's debate mirrors tensions playing out in other democracies.Tegha King of the Universal Peace Federation Ghana said concerns about shrinking civic space are not unique to Ghana."The global civic space must cultivate more free speech, not less," he told Al Jazeera.He said stronger institutions, not more arrests, are needed to manage the pressures of the digital age."There must be independent courts, transparent enforcement, media self-regulation and digital literacy," he said.Civic Awareness and External ConcernSome analysts point to gaps in public understanding of constitutional rights."There is a lack of constitutional education among many Ghanaians," said David Adofo of the African Chamber of Content Producers. "People must know the consequences of their actions before they act, not after."Concerns are also being voiced outside the country."We have had many concerns from diasporans about perceived erosion of press and political freedoms, especially news of blogger arrests," said Nana Kofi Opoku-Agyemang of the NuGhana Expat Center. "Negative news sells fast. The government must be cautious so it does not project a negative image of Ghana in the diasporan community."Government Stance: Existing Laws, New ChallengesOfficials insist there is no coordinated effort to silence dissent.An NDC communicator said the legal framework in question predates the current administration and defended the approach."Ghana's laws, Section 208 of the Criminal Code and Section 76 of the Electronic Communications Act, have been on the books for decades," he said. "What has changed is the sheer volume of reckless, anonymous and sometimes dangerous content on social media. There is no systematic crackdown. There is simply enforcement of existing law."The Path Forward: Breaking the CycleGhana remains one of West Africa's more open democracies, with a competitive political system and active media landscape.But the rise in speech-related arrests has sharpened scrutiny of how far the state can go in policing online expression without undermining the democratic culture that helped define its reputation.The debate is also politically charged because of Mahama's own past warnings.As opposition leader, he described the use of state power against dissent as a "dangerous blueprint." Today, critics say his government faces accusations it once condemned.For Alexander Afenyo-Markin, the moment calls for restraint — and reflection."We should not continue to say that because it happened yesterday, it should happen today and tomorrow. That cycle must end," he said. "President Mahama has an opportunity to leave a legacy of tolerance and free speech. I hope he takes it."

The Rise of Cringe Culture In a TikTok video, Katie Whitney, a 25-year-old with 2.5 million followers, addresses Cynthia Erivo in a way that is described as 'toe-curling' or 'cringe' to watch. This type of content is part of what is known online as CringeTok, a subsection of the internet that deals in content designed to make your toes curl. The Psychology of Cringe Cringe has been identified by some working in mental health as a relatively new form of shame. According to Roger Giner-Sorolla, a professor of social psychology at the University of Kent, cringe is a slang term for the feeling of 'vicarious shame'. This places a person who has done something embarrassing or even morally shameful 'under the dim regard of other people'. Mark Beal, a professor of communications at Rutgers University, describes cringe as 'feeling awkward, feeling embarrassed, feeling uncool'. A key aspect of cringe is a lack of self-awareness. The Impact on Gen Z According to a Yahoo/YouGov poll, the fear of coming across as cringe has stopped more than half of Gen Z from expressing themselves freely online, and 55% of those surveyed said it had stopped them from opening up emotionally. This fear is affecting not only online behavior but also offline interactions, with some people feeling hesitant to participate in activities or express themselves for fear of being ridiculed. The Future of Cringe Culture So can Gen Z get over the fear of cringe? According to Giner-Sorolla, the way to survive is to 'narrow your focus ... have a reference group of people you can be authentic with, and even if other people think your authenticity is cringe, at least you've got your people.' Having connections, having friends, having people you can relate to and share with, is good for the brain. However, not everyone benefits from an audience.

The War Economy: A Billionaire’s Perspective from the FrontlineUkraine is reeling from its heaviest aerial raid in months, with at least 25 people killed in the night sky. In the aftermath, Rinat Akhmetov, the country's wealthiest oligarch and owner of Shakhtar Donetsk, gives a rare interview from a location outside Kyiv. This conversation marks the 90th anniversary of the club and the 30th year of Akhmetov's leadership, offering a unique insight into how the war has reshaped his personal and professional life.From Coal Traders to Champions: The Akhmetov StrategyAkhmetov’s rise from a child in 1970s Donbas to the owner of one of eastern Europe’s most influential football clubs is a story of calculated risk and strategic foresight. His journey began not in football, but in the volatile economy of the 1990s.The Proximity of Danger: Akhmetov was five seconds away from death when his business partner and predecessor, Akhat Bragin, was killed in a stadium explosion in 1995. This tragedy left the club abandoned, with players earning as little as $200 or $300 a month.Industrial Expansion: Leveraging the collapse of the Soviet Union, Akhmetov moved from trading coke and coal to acquiring cheap stakes in metallurgy plants. He revitalized the Yenakiieve plant, where workers previously earned $45 a month, transforming it into a globally competitive enterprise.Breaking the Mold: To break Dynamo Kyiv's dominance, Akhmetov hired foreign managers like Nevio Scala and Mircea Lucescu. He argued that a patriot is someone who works for Ukraine's benefit, regardless of origin, a philosophy that yielded 22 trophies over 12 years.The Financial Toll of Occupation and the Iron and Steelworks of AzovstalThe conflict in Donbas has been devastating for Akhmetov’s industrial empire. Since the occupation began in 2014, his businesses have suffered severe losses. The Azovstal iron and steelworks became a global symbol of Ukraine's resilience during the 2022 siege, though it came at a massive cost to the local economy.Shakhtar was forced to flee their home, losing the Donbas Arena—a stadium that once held 40,000 to 50,000 fans—to the occupying forces. The club's relocation to Lviv and Poland turned them into a powerful ambassador for the Ukrainian state, using the Conference League semi-finals to keep the world's attention on the war.Shakhtar as a Symbol of Ukrainian ResilienceAkhmetov reveals that Shakhtar has always been pro-Ukrainian, evidenced by their 2007 decision to use the Ukrainian spelling of their name over the Russian one. However, the full-scale invasion has crystallized this identity. The club is now viewed globally as a symbol of the fight for independence, sovereignty, and freedom.The Road to Donbas: A Promise Kept and BrokenFor years, Akhmetov maintained a moral imperative: he vowed not to attend another game until Shakhtar returned to their beloved Donbas Arena. This promise was broken last month when he returned for the Conference League quarter-final following the death of his long-time manager, Mircea Lucescu. The spontaneous decision was driven by emotion, as the players' applause during the warm-up moved him to tears. It marks a significant moment in the club's history, signaling a potential return to the region that birthed them, even as the war continues.

The LeadCall of Duty: Modern Warfare 4, the latest installment in the popular shooter game series, has stirred controversy with its depiction of a fictional Korean War. The game's storyline, which imagines a full-scale invasion of South Korea by North Korea, has raised concerns among South Korean journalists and gamers. The Event DetailsThe game, developed by Infinity Ward and published by Activision, takes players on a globetrotting journey, featuring levels set in Paris, Russia, New York, and Mumbai. However, the vast majority of the story will be divided across virtual recreations of both North and South Korea. This setting has sparked concerns that the game may be insensitive to the ongoing tensions between the two nations and the families of Korean War veterans. The Data AnalysisWhile there are no specific numbers available on the game's expected sales or player base, the game's developer has taken great pains to portray the region as respectfully as possible. Infinity Ward co-studio head, Jack O'Hara, says that the team has consulted with advisers, people whose parents came over across the border, military folks that have served in that area, and people from shadowy governmental organisations that might have some information as well. The Impact AnalysisThe game's setting and storyline have significant implications for the gaming industry and the Korean community. The game's depiction of a fictional Korean War has raised concerns that it may be perceived as a sensitive issue by the families of Korean War veterans, as well as employees of government agencies and related organisations. South Korean journalist Hyeonju Song believes that creating fiction based on the Korean War is bound to cause pain to someone, given that the conflict has not yet ended and continues to directly impact the lives of Koreans. The PredictionAs the game's release approaches, it remains to be seen how the gaming community and the Korean public will react to the game's depiction of a fictional Korean War. While some may view the game as a bold and thought-provoking take on the genre, others may see it as insensitive and exploitative. One thing is certain, however: Call of Duty: Modern Warfare 4 is a game that will spark conversation and debate.

The PlayStation Strategic ShiftPlayStation's future has looked a little uncertain these past few years. Although the PS5 has sold well and been very profitable, the brand is far from the runaway market leader it was in the PS2 days. Earlier this week, Game File dug into Sony's most recent earnings reports to illustrate how PlayStation has been selling fewer and fewer of its own flagship games since a peak during the pandemic. About 54.1m copies of games either developed or published by Sony were sold in the 2018 financial year; in 2025, it sold 32.1m.The State of Play Event OverviewSo what is Sony going to do in the next few years, as we enter a later stage of the PS5 lifecycle? Will it play safe, or diversify? Perhaps revive some older games for nostalgic millennials? Thanks to a State of Play live-stream last night, we now have some answers. Here's what's on the slate:Marvel's Wolverine: A Violent DepartureCalifornian developer Insomniac's next Marvel adaptation after the somewhat wholesome Spider-Man adventures is an exceptionally violent Wolverine game. Seriously, we see those claws go through about seven people in the first 30 seconds of the demo, before fellow mutant Jean Grey shows up and starts killing people with telekinesis instead. A motorbike chase follows, and a showdown atop a moving vehicle. Truly all the Hollywood-esque action a player could possibly want, if also rather more blood spatter than some of us can take. There was also less 18-rated Marvel action in the form of comic-book-style fighting game Marvel Tokon: Fighting Souls (coming 6 August).Horror Revival with Silent Hill: TownfallThis Silent Hill spin-off, from the Scottish developer Screen Burn, looks excellent. It's a horror game set in a misty town on the east coast of Scotland. Expect: many disgusting creatures that arise from the depths of its characters' worst imaginings. Many eerily abandoned little seaside homes. Many ominous shots of closed doors at the end of hallways. And much creepy radio static.Classic Franchises ReturnCapcom revives another of its classic PlayStation series in this Japanese-mythology action game, in which you slice up demons with a katana. (It will have to work hard to compete with the Nioh games and FromSoftware's Sekiro, which have filled this niche in the two decades Onimusha has been away.) The demo is available to try now.Although this was announced late last year, we've just got our first good look at it. It's a remake of the very first Tomb Raider, and they really mean it – it looks like a new Uncharted game. It's got all the classics: Egyptian tombs, jungle temples, T-Rexes, and Lara Croft looks badass in a modernised version of her classic outfit.Market Competition ContextSony has put out some great homegrown games since the PS5 was released in 2020, from Astro Bot to Ghost of Yōtei, but it has also had some expensive and very public failures and cancellations; PlayStation boss Jim Ryan, who retired in 2024, placed big bets on live-service games and only a few panned out (hello, Helldivers). Sony also seems to have rolled back on releasing its single-player PS5 games on PC after a polite interval of time, suggesting it wants to preserve what advantage and exclusivity it has.Meanwhile, its longtime console rival Xbox may have faded into the background as a sales competitor – the PS5 has outsold the Xbox Series S/X by approximately three to one – but it has become a strong publishing competitor, having bought up tens of development studios alongside Activision and Bethesda. Then there's Nintendo, whose exclusive games for the Switch and Switch 2 consoles have performed significantly better than Sony's over the last decade. (The top-selling Sony-developed PS4 game was Spider-Man, at 22.68m. The top-selling Nintendo-developed Switch game was Mario Kart 8 Deluxe at … 71m.)Strategic Implications for SonyThe State of Play event reveals Sony's strategic approach to the next phase of the PS5 lifecycle. By reviving classic franchises like Onimusha and Tomb Raider while investing in high-profile exclusives like Marvel's Wolverine and horror properties like Silent Hill, Sony appears to be balancing nostalgia with innovation. The company seems to be acknowledging its need to strengthen exclusive content while also diversifying its portfolio beyond live-service games that haven't always met expectations.Future Outlook for PlayStationWith releases spanning from late 2026 into 2027, Sony appears to be building a substantial pipeline of exclusive content designed to maintain PS5 momentum. The emphasis on both established franchises and new intellectual properties suggests a strategy to appeal to multiple segments of the gaming audience. As the console market matures and competition intensifies, Sony's ability to deliver compelling exclusive experiences will be crucial in maintaining its market position against Microsoft's expanded publishing arm and Nintendo's consistently strong first-party offerings.