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The Lead Doctors, scientists, and researchers shared new research about ways to tackle cancer at the 2026 American Society of Clinical Oncology (Asco) annual meeting, the world's largest cancer conference. Breakthroughs in Cancer Treatment The event in Chicago, attended by 40,000 health professionals, featured more than 200 sessions and 2,700 poster presentations on this year's theme, “the science and practice of translation: improving cancer outcomes worldwide”. Smart Drugs in Cancer Treatment Researchers have developed a smart drug that stops cancer cells hiding. The experimental tablet, GRWD5769, can help shrink tumours by at least 30% in six of the world’s most common forms of the disease, delegates in Chicago were told. 26 of 83 patients with cervical, bladder, liver, bowel, lung or head and neck cancers who were given GRWD5769 alongside cemiplimab had tumour reductions of at least 30%. 15 had tumour reductions of at least 30%. A Daily Pill for Pancreatic Cancer A pill that doubles survival time in patients with pancreatic cancer was presented at the conference. In a trial of 500 patients, all of whom had pancreatic cancer that had spread, the pill, daraxonrasib, doubled survival time, with fewer side-effects compared with chemotherapy. Patients who took the drug lived substantially longer, for an average of 13.2 months, compared with 6.6 to 6.7 months for patients who had chemotherapy. Safely Skipping Some Treatments Some patients can safely skip some treatments, according to research presented at the conference. A genomic test could pave the way for a new era of personalised medicine, enabling doctors to determine which patients can safely skip chemotherapy. The Optima trial, led by University College London, followed 4,000 patients with newly diagnosed breast cancer in the UK, Norway, Sweden, Australia, New Zealand and Thailand. Those with a low score on the genomic test could be treated safely with hormone therapy alone. The Future of Cancer Treatment Urgent action is required to cope with rising cancer cases. The world faces a cancer workforce crisis, experts said, with a shortage of 100 million staff expected by 2050 when 100,000 people will be being diagnosed every day. A 21% increase in cancer incidence is predicted, according to a report presented at the conference. The rate is set to rise from 165 per 100,000 people in 2025 to 200 per 100,000 in 2050.

The Lead: Mexico's World Cup 2026 QuestMexicans call their inability to reach the World Cup quarterfinals the Curse of El Quinto Partido (The Fifth Game). El Tri – short for the Tricolour – lost in the last 16 in seven consecutive World Cups, from 1994-2018. Now, coach Javier "Vasco" Aguirre is optimistic about surpassing the barrier, partly because Mexico will be playing at home, the only country to play host to three World Cups.The Home Advantage: Breaking the Quarterfinal CurseMexico's only quarterfinals appearances were when they hosted in 1970 and 1986. Aguirre was in the midfield as El Tri took Germany to penalties in a controversial match in Monterrey at Mexico '86. Colombian referee Jesus Palacio Diaz, who had earlier in the tournament red-carded Iraq's Basil Gorgis in a case of mistaken identity, this time ejected Germany's Thomas Berthold in the 65th minute.Mexico could not capitalise, playing 35 minutes with a numerical advantage before Aguirre was sent off. Aguirre has told his players home advantage "is priceless – England was champion playing at home, and never again".Squad Analysis: Key Players and Tactical ApproachMexico rely on a quick passing game, playing through midfielders Alvaro Fidalgo and Alexis Vega, with 17-year-old Gilberto Mora and Orbelin Pineda backups. Edson "Machin" Alvarez and Luis Romo occupy holding roles, with Luis Chavez and Erik Lira in reserve. Mexico has speed on the wings with Roberto "Piojo" Alvarado and Cesar "Chino" Huerta.Johan Vasquez and Cesar Montes are the only two natural centre backs in the squad. But Aguirre has been changing the look to get playmaking out of the back by dropping Alvarez or Romo into central defence. Jorge Sanchez is the probable starter at right back, challenged by Club America's Israel Reyes, who has been negotiating for a move to AS Roma. At left back, veteran Jesus Gallardo has the edge on 22-year-old Mateo Chavez.Fulham striker Raul Jimenez, 35, leads the attack. Jimenez sustained a fractured skull in a collision with Arsenal's David Luiz in 2020, and has not replicated his previous scoring proficiency. But Jimenez presents a physical presence and has proven his durability in the Premier League. Jimenez ranks third on the Mexico all-time scoring list with 44 goals. Santi Gimenez and Armando "Hormiga" Gonzalez provide other options.In goal, Raul Rangel has replaced Luis Malagon (Achilles rupture). Guillermo Ochoa, 40, will be participating in his sixth World Cup, surpassing Antonio "Cinco Copas" Carbajal's record of five.Group Stage Analysis: Path to ProgressionMexico will be the favourites in Group A, but could be challenged by Czech Republic and South Korea, with South Africa hoping to surprise. The tournament kicks off with Mexico meeting South Africa, a rematch of the 2010 opener, and history will be on El Tri's side – they have a 5W-0L-2D record in seven games during two World Cups at Estadio Azteca.Climate, elevation and strong home support should boost El Tri in Mexico City and Guadalajara and, should they advance, the next games will likely be in Los Angeles or Houston – Mexican strongholds.Match Schedule: Key Fixtures to Watch⚽ June 11: Mexico vs South Africa (Mexico City, Mexico), 3pm ET (19:00 GMT)⚽ June 18: Mexico vs South Korea (Guadalajara, Mexico), 9pm ET (01:00 GMT)⚽ June 24: Czech Republic vs Mexico (Mexico City, Mexico), 9pm ET (01:00 GMT)World Cup Prediction: Breaking Through to QuarterfinalsAl Jazeera predicts Mexico will reach the quarterfinals. If Mexico advance to the knockout rounds, they can count on strong support not only at home, but almost anywhere in the US. The expanded tournament means the fifth game would only be in the round of 16, and they will need to get to a sixth for the quarterfinals.Complete Squad: Mexico's World Cup 2026 RosterGoalkeepers: Raul Rangel (Guadalajara), Guillermo Ochoa (AEL Limassol), Carlos Acevedo (Santos Laguna)Defenders: Israel Reyes (America), Jorge Sanchez (PAOK), Cesar Montes (Lokomotiv Moscow), Johan Vasquez (Genoa), Jesus Gallardo (Toluca), Mateo Chavez (Alkmaar)Midfielders: Edson Alvarez (West Ham), Luis Romo (Guadalajara), Obed Vargas (Atletico Madrid), Brian Gutierrez (Guadalajara), Orbelin Pineda (AEK Athens), Erik Lira (Cruz Azul), Gilberto Mora (Tijuana), Cesar Huerta (Anderlecht), Alvaro Fidalgo (Real Betis), Luis Chavez (Dynamo Moscow).Forwards: Roberto Alvarado (Guadalajara), Alexis Vega (Toluca), Julian Quinones (Al-Qadisiyah), Santiago Gimenez (AC Milan), Guillermo Martínez (Pumas), Armando Gonzalez (Guadalajara), Raul Jimenez (Fulham).

Overview: A Posthumous Premiere of Tavener’s ‘Mystical Pantomime’The Guardian’s review highlights the debut of John Tavener’s 2005 opera Krishna at Grange Park Opera, West Horsley. Framed as a mystical pantomime, the work arrives in a climate where cultural sensitivities and economic pressures shape opera programming.The Staging of Krishna at Grange Park OperaDavid Pountney’s production presents the opera in fifteen vignette‑like scenes, each introduced by a Celestial Narrator. Key artistic contributions include:Ross Ramgobin as the Celestial Narrator, delivering a poised, intense narration.Eliran Kadussi as the adolescent Krishna, offering a flexible countertenor line.The Gascoigne Orchestra, under conductor Mark Shanahan, providing bass drones, brass bursts, and a palette of gongs that underscore Tavener’s post‑Wagnerian, post‑minimalist style.Onstage drumming by Nao Masuda, described as both brutal and balletic, marking scene changes.The visual design leans into Orientalist tropes: static poses, inflatable serpents, and a chorus performing Mexican‑wave‑like motions, all of which underscore the work’s “wide‑eyed, white‑British‑authored riff” on Hindu mythology.Why the Production Challenges Modern AudiencesCritics note several friction points:Vocal lines often soar into high, melismatic registers, rendering text unintelligible and leaving surtitles lagging behind the music.The libretto, penned by Tavener with input from scholar Ranchor Prime, mixes Sanskrit and English but suffers from muddy orchestral textures that obscure lyrical clarity.Staging choices echo 19th‑century operatic Orientalism, clashing with contemporary expectations for cultural sensitivity.Despite these issues, the performance earned warm applause for the musicians, suggesting that technical execution can momentarily outweigh conceptual dissonance.What This Means for Future Performances of Tavener’s WorksGrange Park’s willingness to mount a costly world premiere in a strained economic climate signals a commitment to adventurous repertoire. However, the review argues that some works—especially those rooted in dated cultural perspectives—may be better left unperformed unless re‑imagined with a more nuanced approach. The reception of Krishna could prompt opera houses to reassess how they present Tavener’s catalog, balancing artistic ambition with contemporary cultural awareness.

The Enduring Magic of Baseball Baseball's relationship with superstitions and curses stretches back to its earliest days, with the infamous Curse of the Billy Goat being just one example. When Chicago bar owner William Sianis was denied entry to the 1945 World Series with his pet goat Murphy, he allegedly cursed the team, which then went 71 years without winning another championship. This story, along with countless other rituals and beliefs, forms the foundation of baseball's unique relationship with the magical and supernatural. A New Book Explores Baseball's Mystical Side Author, journalist, and New York Mets fan Addy Baird has chronicled baseball's rich tradition of superstitions in her new book, "The Magical Game: The Spirit and History of Baseball's Superstitions, Rituals, and Curses." Baird became fascinated with baseball's magical elements while cheering for the Mets, finding herself becoming increasingly superstitious as the team had successful stretches. "I changed the way I acted, things I did, wore, watched, said, ate," she admits, trying to influence the team's performance through her own rituals. Legendary Superstitions and Rituals The book documents numerous baseball superstitions throughout history. Turn-of-the-century managers like Connie Mack and John McGraw relied on human mascots to bring their teams good luck. Wade Boggs famously ate chicken before every game during his career in the 1980s and 1990s. More recently, a Seattle Mariners fan believes that holding a pair of slippers somehow negatively affected his team's performance, while a Tampa Bay Rays fan plays Middle Earth music during difficult innings despite having no interest in Lord of the Rings. Even in softball, superstitions persist—this week it was revealed that a top college player eats ladybugs in the dugout for good luck. The Psychology Behind Baseball's Magic When asked what makes baseball particularly prone to magical thinking, Baird identifies several factors: the presence of luck, the game's unique structure, and its repetitive nature. "Basically, when a sport has fewer instances of scoring, luck is a bigger factor," she explains. Baseball's structure is also distinctive as "one of the only games we play, and the only major North American sport, where the defense has the ball," creating an uncertain environment. The repetitive nature of the game—with batters facing dozens of pitches over a 162-game season—further compounds the uncertainty, creating what Baird calls "a perfect environment for magic to thrive." Baseball's Mythological Foundations Baird connects baseball's structure to ancient mythological patterns, noting that MLB's official historian John Thorn observed that "the form of the game itself mirrors that of the Odyssey." The nine innings represent the hero's journey: starting at home, facing potential failure, and embarking on a journey with the goal of returning home. "The story of this myth is embedded in the game itself. Magic is in its very structure," Baird concludes. This connection helps explain why baseball has developed such rich traditions and superstitions throughout its history. Evolution of Baseball's Magic The book also examines how recent changes to baseball, including sabermetrics and new rules like the pitch clock, might affect the game's magical elements. Initially, Baird believed these changes were killing baseball's magic, but her research revealed a long tradition of people claiming "baseball is dying" since the 1860s. She now believes "the game should evolve, an unchanging thing is a dead thing." Interestingly, she finds that sabermetrics actually "help us to see what makes [baseball] unique, what makes it special, what makes players exceptionally good... Those numbers reveal to us the magic." Baseball's Appeal Beyond the Field Through her research, Baird not only completed a manuscript but also discovered a new career path. In addition to her journalism work, she has become a practicing astrologer. "It was one of my really interesting side quests," she says. "I do readings for people, reading charts." Whether you're a baseball enthusiast or someone interested in magic and ritual, "The Magical Game" offers something for everyone. As Baird explains, "it's a book for people who love baseball, also for those who do not care about baseball at all" and "for the people who love magic, looking at it through a lens they may never have considered before."

GLP‑1 Medications Show Promise in Reducing Breast Cancer IncidenceRecent analyses presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago suggest that patients using GLP‑1 receptor agonists—a class of weight‑loss drugs—experienced a 30% lower likelihood of being diagnosed with breast cancer compared with non‑users.Study cohort: 110,000 women aged 45‑80.Risk reduction: 30% for breast cancer onset.Lead researcher: Dr Elizabeth McDonald, University of Pennsylvania.Adjunctive Use of GLP‑1 Drugs Cuts Breast Cancer MortalityA separate investigation involving 27,000 breast‑cancer patients in Italy reported that adding a GLP‑1 agent to standard therapy was associated with a 30% decrease in cancer‑related death.Institution: IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori, Meldola.Outcome: 30% lower mortality risk.Broad Cancer‑Spread Benefits Observed Across Multiple Tumor TypesData from the Cleveland Clinic, covering 12,000 patients with breast, lung, colorectal or liver cancer, indicated a 38‑50% reduction in progression to stage‑four disease among GLP‑1 users.Study size: 12,000 patients.Risk reduction range: 38%–50% for metastatic spread.Why These Findings Matter for Public Health and OncologyThe consistency of risk‑reduction signals across incidence, mortality and metastasis points to a potential paradigm shift: drugs originally designed for diabetes and obesity may become adjunct tools in cancer prevention and treatment. If confirmed, the impact could be substantial given the prevalence of obesity and the high incidence of breast cancer worldwide.Next Steps: Clinical Trials and Regulatory ConsiderationsExperts caution that the current evidence is observational. Ongoing randomized controlled trials will be needed to disentangle the effects of weight loss from direct pharmacologic actions of GLP‑1 agonists. Regulatory bodies may eventually evaluate these agents for oncologic indications, pending robust trial data.

The Lead: Trump's Wartime Coal Funding InitiativePresident Donald Trump is utilizing the Defense Production Act, a cold war-era statute typically reserved for national emergencies, to allocate $700 million in grants to coal-fired power plants across the United States. This move represents the latest effort by the administration to bolster what Trump calls "clean, beautiful coal," despite scientific consensus that coal remains the dirtiest of fossil fuels and a leading contributor to climate change.The Defense Production Act: A Novel Application for CoalTrump's announcement came during a White House press conference where he detailed how the $700 million investment would protect 14 coal plants and 42 coal mines across 10 states that all voted for him in the previous election. The funds will also finance the construction of two new coal plants in Alaska and West Virginia, as well as a new coal export terminal in Oakland, California, and the restart of an existing facility in Maryland."As a result of the $700m investment that I'm announcing today, we will protect 14 coal plants and 42 coalmines, a tremendous number, and build two new coal plants and one massive new export terminal," Trump stated.The administration's attempts to provide a cuddly rebranding to coal have even extended to creating a new mascot with giant eyes, called Coalie, and gushing social media posts that include an image of a lump of coal wearing sunglasses as if it were on the TV show Love Island."You're not allowed to say 'coal' within the Trump administration unless it's preceded by the words 'clean, beautiful,'" Trump said on Thursday. "Complicates our life, but it's good."Financial Implications: Cost of Coal vs. RenewablesDespite Trump's claims that the initiative will lower energy costs, energy experts maintain that coal plants are more expensive to build and operate than renewable power sources. The administration has previously doled out hundreds of millions of dollars to the coal industry, signed orders forcing ratepayers to pay extra for aging plants to remain operational, and dismantled environmental regulations limiting toxins from coal.The coal industry, however, applauded the new order, with Rich Nolan, chief executive of the National Mining Association, arguing that "coal generation shields consumers from the impacts of volatile energy prices and supply challenges" and will help meet increased electricity demand from the artificial intelligence sector.Environmental and Health ConsequencesEnvironmental groups have strongly criticized the administration's latest aid for coal, with Patrick Drupp of the Sierra Club calling it "disgusting and reprehensible" that taxpayer dollars are being given to "deadly and expensive coal plants that will make Americans sicker and drive up electricity prices even more."Scientific evidence shows coal is the most carbon-dense fossil fuel and a leading cause of the climate crisis when burned. Research has estimated that as many as 460,000 deaths in the US from 1999 to 2020 were attributable to air pollution from coal plants alone, which releases tiny toxic particles that sicken miners and trigger widespread respiratory and heart health problems.Future Outlook: Coal's Declining Market ShareDespite Trump's efforts to revive the coal industry, the sector continues to face significant headwinds. US coal production is currently less than half of what it was in 2008, with coal declining as both a fuel for electricity and as an input for manufacturing materials. The number of people working in coal has declined by more than 90% in the past century, with more people now employed at Waffle House restaurants across the US than in coal mining.Environmental advocates question the long-term viability of Trump's coal strategy, with Kit Kennedy of the Natural Resources Defense Council asking, "What's next, a taxpayer bailout to build new phone booths?" She characterized the move as "going to mean higher bills and dirtier air," calling it "a waste" of taxpayer resources.

The Struggle to Find Employment in Grimsby In the Lincolnshire seaside town of Cleethorpes, a 19-year-old man named Cohen is sitting in the back seat of a car, putting on an Easter bunny outfit. He is hoping to use new photographs to advertise his mascot business for the upcoming holidays. Cohen, who has a learning disability, lives with his parents in neighbouring Grimsby and set up Co Co Mascots last year as one of his many attempts to find work. The Challenges of Job Hunting with a Disability Cohen has been applying for roles in holiday parks, retail, charity shops, and even the local football club Grimsby Town FC, which was recruiting for a new mascot. Despite his efforts, he has yet to find paid work. "The hardest thing is not hearing back [from a job application] and not getting feedback," says Cohen. "I start overthinking because I want it [a job] too much. A lot of the time, I think they [employers] will see you have a disability and will pick the person without one because they think the person with a disability is more work." The Economic Reality of Grimsby Grimsby was recently dubbed Britain's "worklessness capital" by the Telegraph due to the large proportion of its working-age people claiming benefits. The town has a higher number of working-age adults out of employment than the national average, and 41% of under-16s in the town live in relative low-income families. Once one of the world's largest fishing ports, Grimsby is still the UK's biggest fish-processing hub, reportedly making every other fish finger eaten across the country. The Impact on Young People For many young people in coastal places such as Grimsby, finding paid employment is hard – and having a disability compounds the issue. Cohen has been volunteering in charity shops and at food banks for more than a year now, and doesn't see his disability as a barrier to working. "My mind can wander a bit when I work so I need a nudge every so often. I just need a bit of support until I get used to the job and what is expected of me." The Future Outlook The Guardian's Against the Tide project aims to report on the lives of young people in coastal communities across England and Wales. The project will examine what kind of changes young people need to build the futures they want for themselves. For Cohen, he will continue to throw everything at his job search, hoping to find a permanent role that suits his needs and abilities.

The World Cup's Slow Build-Up Organizationally speaking, the 2026 World Cup began on 13 June 2018, when then-Fifa general secretary Fatma Samoura sternly instructed the delegates to cast their vote in a cavernous conference hall in Moscow. Yet mere days away from the tournament’s kickoff in Mexico City, it doesn’t really feel like the thing is here yet. At least, not in the US. And not in New York, the host city for the final. Player Perspectives on the World Cup Tyler Adams and Weston McKennie, who will probably make up much of the United States men’s national team midfield this summer, were 19 when their home country was named as a co-host. That’s when they knew that their nation, for which both men had made their senior debuts on the same day seven months earlier, had qualified automatically as one of the three co-hosts. “For me, it started to feel real probably after [this past] season finished, because we had a lot of pressure at our club level,” said McKennie. “So I wanted to just finish my season off with Juventus and then, after that … I think it’ll start to hit me more. Obviously, whenever you get the message that you’re named to the roster, that’s another big moment where you realize, OK, it’s starting.” The Marketing and Branding of the World Cup The most evidence of the impending tournament can be found in the various businesses that sponsor the thing. Shop for a bucket of paint or a rake at a hardware chain and you may stumble on some signage, if you’re paying attention. Pharmacies have plush mascots for sale among other officially licensed trinkets. “To see all the different branding and things that are being put up around the country has made it that much more real in the past couple weeks,” said the US captain, Tim Ream. Anticipation and Reality Weighing anticipation and the present is a tricky balance for players to strike. They are expected to live day to day, practice to practice, game to game. And for the US, absent a qualification process that stretched over a year or two, they lacked the usual signage that demarcates the cycle. “I think I kind of felt it on the horizon,” said Christian Pulisic. “Obviously, you’re focusing on what you’re doing at your club, but I’d say once I got here and kind of was with the team and felt these fans and support and buzz around the World Cup, is when I really started to feel it.”

The world’s largest randomised trial of a multi‑cancer early detection (MCED) blood test, involving 142,942 NHS participants, did not achieve its main aim of cutting late‑stage cancer diagnoses, according to data presented at the ASCO annual meeting in Chicago.Trial Overview and Primary ObjectiveThe study enrolled adults aged 50‑77 with no cancer symptoms, assigning half to annual Galleri testing alongside standard screening and the other half to standard screening alone. Positive Galleri results triggered diagnostic follow‑up, mirroring the protocol for symptomatic participants in both arms.Key Findings and Statistical OutcomesParticipants: 142,942 screened over three years.Primary endpoint: Combined stage III and IV diagnoses across 12 pre‑specified cancers.Result: No statistically significant reduction in advanced‑stage cancers in the Galleri arm versus control.Secondary signal: Stage IV cancers fell by 14% in the Galleri group, a finding the company Grail highlighted as encouraging.Dr Julie Gralow, ASCO’s chief medical officer, noted the trial showed “some encouraging trends toward tumour downstaging” but emphasized the primary endpoint was not met.Implications for NHS Cancer Screening StrategyExperts such as Prof Richard Houlston (Institute of Cancer Research) warned that the lack of a primary‑endpoint hit undermines any justification for nationwide adoption of Galleri. Prof Peter Johnson, NHS England’s national clinical director for cancer, said the NHS will scrutinise the full data before deciding on future implementation.The trial’s outcome raises questions about the cost‑effectiveness of MCED tests at population scale and may temper enthusiasm for rapid integration into existing screening programmes.Future Directions and Remaining QuestionsMortality outcomes, expected in the next few years, will be critical to assess whether earlier detection translates into survival benefits. Researchers and policymakers will likely await these results before committing to broader rollout, while Grail may refine its assay based on the secondary findings.